Novel assay for simultaneous measurement of pyridine mononucleotides synthesizing activities allows dissection of the NAD + biosynthetic machinery in mammalian cells

FEBS Journal

Volumn 281, Issue 22, 2014, Pages 5104-5119

  Zamporlini, Federica ^a   Ruggieri, Silverio ^a   Mazzola, Francesca ^a   Amici, Adolfo ^a   Orsomando, Giuseppe ^a   Raffaelli, Nadia ^a,b  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^b Food and Environmental Sciences ^*  (Italy)

Author keywords

NAD + biosynthesis; nicotinamide phosphoribosyltransferase; nicotinamide riboside kinase; nicotinate phosphoribosyltransferase; quinolinate phosphoribosyltransferase

Indexed keywords

CELL EXTRACT; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE RIBOSIDE; NICOTINAMIDE RIBOSIDE KINASE; PHOSPHORIBOSYLTRANSFERASE; PHOSPHOTRANSFERASE; PYRIDINE DERIVATIVE; PYRIDINE MONONUCLEOTIDE; QUINOLINATE PHOSPHORIBOSYLTRANSFERASE; QUINOLINIC ACID; UNCLASSIFIED DRUG; GLYCOSYLTRANSFERASE; NICOTINAMIDE NUCLEOTIDE; NICOTINAMIDE NUCLEOTIDE ADENYLYLTRANSFERASE; NICOTINATE MONONUCLEOTIDE; NICOTINATE PHOSPHORIBOSYLTRANSFERASE;

ANIMAL TISSUE; ARTICLE; BODY FLUID; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LOCALIZATION; FLUOROMETRY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE METABOLISM; PLASMA; PRIORITY JOURNAL; SCREENING TEST; ANALOGS AND DERIVATIVES; ANIMAL; ANTIBODY SPECIFICITY; BIOSYNTHESIS; C57BL MOUSE; CELL FREE SYSTEM; CELL LINE; CHEMISTRY; ENZYME ASSAY; ENZYMOLOGY; LIVER; PHYSIOLOGY;

ANIMALS; BIOSYNTHETIC PATHWAYS; CELL LINE; CELL-FREE SYSTEM; ENZYME ASSAYS; FLUOROMETRY; HUMANS; LIVER; MICE; MICE, INBRED C57BL; NAD; NICOTINAMIDE MONONUCLEOTIDE; NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE; ORGAN SPECIFICITY; PENTOSYLTRANSFERASES; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR);

EID: 84910142746     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.13050     Document Type: Article

References (53)

1. + metabolism: A therapeutic target for age-related metabolic disease. Crit Rev Biochem Mol Biol 48, 397-408.
2. Chiarugi A, Dolle C, Felici R, &, Ziegler M, (2012) The NAD metabolome-a key determinant of cancer cell biology. Nat Rev Cancer 12, 741-752.
3. + homeostasis in man. Cell Mol Life Sci 61, 19-34.
4. Dolle C, Skoge RH, Vanlinden MR, &, Ziegler M, (2013) NAD biosynthesis in humans-enzymes, metabolites and therapeutic aspects. Curr Top Med Chem 13, 2907-2917.
5. + precursor vitamins in human nutrition. Annu Rev Nutr 28, 115-130.
6. Rongvaux A, Shea RJ, Mulks MH, Gigot D, Urbain J, Leo O, &, Andris F, (2002) Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis. Eur J Immunol 32, 3225-3234.
7. + in fungi and humans. Cell 117, 495-502.
8. Liu H, Woznica K, Catton G, Crawford A, Botting N, &, Naismith JH, (2007) Structural and kinetic characterization of quinolinate phosphoribosyltransferase (hQPRTase) from homo sapiens. J Mol Biol 373, 755-763.
9. Hara N, Yamada K, Shibata T, Osago H, Hashimoto T, &, Tsuchiya M, (2007) Elevation of cellular NAD levels by nicotinic acid and involvement of nicotinic acid phosphoribosyltransferase in human cells. J Biol Chem 282, 24574-24582.
10. Sorci LKO, Rodionov DA, &, Osterman AL, (2010) Comprehensive Natural Products II, Chemistry and Biology. Elsevier, Oxford.
11. Gazzaniga F, Stebbins R, Chang SZ, McPeek MA, &, Brenner C, (2009) Microbial NAD metabolism: lessons from comparative genomics. Microbiol Mol Biol Rev 73, 529-541, Table of Contents.
12. + as a signaling molecule modulating metabolism. Cold Spring Harb Symp Quant Biol 76, 291-298.
13. Di Stefano M, &, Conforti L, (2013) Diversification of NAD biological role: The importance of location. FEBS J 280, 4711-4728.
14. Nikiforov A, Dolle C, Niere M, &, Ziegler M, (2011) Pathways and subcellular compartmentation of NAD biosynthesis in human cells: From entry of extracellular precursors to mitochondrial NAD generation. J Biol Chem 286, 21767-21778.
15. Revollo JR, Korner A, Mills KF, Satoh A, Wang T, Garten A, Dasgupta B, Sasaki Y, Wolberger C, Townsend RR, et al,. (2007) Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. Cell Metab 6, 363-375.
16. + biosynthesis in FK866-treated tumor cells. J Biol Chem 288, 25938-25949.
17. Hinsch N, Frank M, Doring C, Vorlander C, &, Hansmann ML, (2009) QPRT: A potential marker for follicular thyroid carcinoma including minimal invasive variant; a gene expression. RNA and immunohistochemical study. BMC Cancer 9, 93.
18. + precursor quinolinic acid confers resistance of gliomas to oxidative stress. Cancer Res 73, 3225-3234.
19. Li Y, Zhang Y, Dorweiler B, Cui D, Wang T, Woo CW, Brunkan CS, Wolberger C, Imai S, &, Tabas I, (2008) Extracellular Nampt promotes macrophage survival via a nonenzymatic interleukin-6/STAT3 signaling mechanism. J Biol Chem 283, 34833-34843.
20. + synthesis, suppresses spontaneous cell death by inhibiting overproduction of active-caspase-3. Biochim Biophys Acta 1803, 527-533.
21. Elliott GC, Ajioka J, &, Okada CY, (1980) A rapid procedure for assaying nicotinamide phosphoribosyltransferase. Anal Biochem 107, 199-205.
22. Hasmann M, &, Schemainda I, (2003) FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis. Cancer Res 63, 7436-7442.
23. + metabolites. Comput Struct Biotechnol J 4, e201301012.
24. Galeazzi L, Bocci P, Amici A, Brunetti L, Ruggieri S, Romine M, Reed S, Osterman AL, Rodionov DA, Sorci L, et al,. (2011) Identification of nicotinamide mononucleotide deamidase of the bacterial pyridine nucleotide cycle reveals a novel broadly conserved amidohydrolase family. J Biol Chem 286, 40365-40375.
25. Graeff R, &, Lee HC, (2002) A novel cycling assay for nicotinic acid-adenine dinucleotide phosphate with nanomolar sensitivity. Biochem J 367, 163-168.
26. Graeff R, &, Lee HC, (2002) A novel cycling assay for cellular cADP-ribose with nanomolar sensitivity. Biochem J 361, 379-384.
27. Lowry OH, Passonneau JV, &, Rock MK, (1961) The stability of pyridine nucleotides. J Biol Chem 236, 2756-2759.
28. Miksic JR, &, Brown PR, (1978) Reactions of reduced nicotinamide adenine dinucleotide in acid: Studies by reversed-phase high-pressure liquid chromatography. Biochemistry 17, 2234-2238.
29. Revollo JR, Grimm AA, &, Imai S, (2004) The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. J Biol Chem 279, 50754-50763.
30. Kover K, Tong PY, Watkins D, Clements M, Stehno-Bittel L, Novikova L, Bittel D, Kibiryeva N, Stuhlsatz J, Yan Y, et al,. (2013) Expression and regulation of nampt in human islets. PLoS One 8, e58767.
31. Okuno E, White RJ, &, Schwarcz R, (1988) Quinolinic acid phosphoribosyltransferase: purification and partial characterization from human liver and brain. J Biochem 103, 1054-1059.
32. Pawlak D, Tankiewicz A, Matys T, &, Buczko W, (2003) Peripheral distribution of kynurenine metabolites and activity of kynurenine pathway enzymes in renal failure. J Physiol Pharmacol 54, 175-189.
33. Lang R, Yagar EF, Eggers R, &, Hofmann T, (2008) Quantitative investigation of trigonelline, nicotinic acid, and nicotinamide in foods, urine, and plasma by means of LC-MS/MS and stable isotope dilution analysis. J Agric Food Chem 56, 11114-11121.
34. + metabolism. J Biol Chem 284, 158-164.
35. +. PLoS Biol 5, e263.
36. + biosynthesis: Strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors. Mol Cell Biol 29, 5872-5888.
37. Galassi L, Di Stefano M, Brunetti L, Orsomando G, Amici A, Ruggieri S, &, Magni G, (2012) Characterization of human nicotinate phosphoribosyltransferase: kinetic studies, structure prediction and functional analysis by site-directed mutagenesis. Biochimie 94, 300-309.
38. Hara N, Yamada K, Shibata T, Osago H, &, Tsuchiya M, (2011) Nicotinamide phosphoribosyltransferase/visfatin does not catalyze nicotinamide mononucleotide formation in blood plasma. PLoS One 6, e22781.
39. Wintzerith M, Dierich A, &, Mandel P, (1979) Nicotinamide deamidase released by neuroblastoma cell cultures. J Neurochem 33, 677-685.
40. Wintzerith M, Dierich A, &, Mandel P, (1980) Purification and characterization of a nicotinamide deamidase released into the growth medium of neuroblastoma in vitro. Biochim Biophys Acta 613, 191-202.
41. Eichenbaum G, Skibbe J, Parkinson A, Johnson MD, Baumgardner D, Ogilvie B, Usuki E, Tonelli F, Holsapple J, &, Schmitt-Hoffmann A, (2011) Use of enzyme inhibitors to evaluate the conversion pathways of ester and amide prodrugs: A case study example with the prodrug ceftobiprole medocaril. J Pharm Sci 101, 1242-1252.
42. Gasser A, Bruhn S, &, Guse AH, (2006) Second messenger function of nicotinic acid adenine dinucleotide phosphate revealed by an improved enzymatic cycling assay. J Biol Chem 281, 16906-16913.
43. Collins PB, &, Chaykin S, (1972) The management of nicotinamide and nicotinic acid in the mouse. J Biol Chem 247, 778-783.
44. Samal B, Sun Y, Stearns G, Xie C, Suggs S, &, McNiece I, (1994) Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor. Mol Cell Biol 14, 1431-1437.
45. + precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab 15, 838-847.
46. + in muscle morphogenesis. Dev Biol 344, 809-826.
47. Khan NA, Auranen M, Paetau I, Pirinen E, Euro L, Forsstrom S, Pasila L, Velagapudi V, Carroll CJ, Auwerx J, et al,. (2014) Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3. EMBO Mol Med 6, 721-731.
48. Sasaki Y, Araki T, &, Milbrandt J, (2006) Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy. J Neurosci 26, 8484-8491.
49. Moffett JR, &, Namboodiri MA, (2003) Tryptophan and the immune response. Immunol Cell Biol 81, 247-265.
50. Garten A, Petzold S, Barnikol-Oettler A, Korner A, Thasler WE, Kratzsch J, Kiess W, &, Gebhardt R, (2010) Nicotinamide phosphoribosyltransferase (NAMPT/PBEF/visfatin) is constitutively released from human hepatocytes. Biochem Biophys Res Commun 391, 376-381.
51. Sorci L, Martynowski D, Rodionov DA, Eyobo Y, Zogaj X, Klose KE, Nikolaev EV, Magni G, Zhang H, &, Osterman AL, (2009) Nicotinamide mononucleotide synthetase is the key enzyme for an alternative route of NAD biosynthesis in Francisella tularensis. Proc Natl Acad Sci USA 106, 3083-3088.
52. Orsomando G, Cialabrini L, Amici A, Mazzola F, Ruggieri S, Conforti L, Janeckova L, Coleman MP, &, Magni G, (2012) Simultaneous single-sample determination of NMNAT isozyme activities in mouse tissues. PLoS One 7, e53271.
53. Bradford MM, (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72, 248-254.