Characterization of human nicotinate phosphoribosyltransferase: Kinetic studies, structure prediction and functional analysis by site-directed mutagenesis

Biochimie

Volumn 94, Issue 2, 2012, Pages 300-309

  Galassi, Lucia ^a   Di Stefano, Michele ^a,b   Brunetti, Lucia ^a   Orsomando, Giuseppe ^a   Amici, Adolfo ^a   Ruggieri, Silverio ^a   Magni, Giulio ^a  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Enzyme kinetics; Homology modeling; Human NaPRT; Molecular docking; Site directed mutagenesis

Indexed keywords

ACYL COENZYME A; AGENTS AFFECTING CARBOHYDRATE METABOLISM; COENZYME A; DIHYDROXYACETONE PHOSPHATE; FRUCTOSE 1,6 BISPHOSPHATE; GLYCERALDEHYDE 3 PHOSPHATE; NICOTINATE PHOSPHORIBOSYLTRANSFERASE; NUCLEOSIDE; NUCLEOTIDE; PHOSPHATE; PHOSPHOENOLPYRUVATE; PYRUVIC ACID; RECOMBINANT ENZYME; RECOMBINANT HUMAN NICOTINATE PHOSPHORIBOSYLTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME KINETICS; ENZYME STABILITY; ENZYME STRUCTURE; METABOLITE; MOLECULAR DOCKING; MOLECULAR MODEL; MOLECULAR RECOGNITION; SITE DIRECTED MUTAGENESIS; STRUCTURAL HOMOLOGY;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; CLONING, MOLECULAR; ENZYME ACTIVATION; ESCHERICHIA COLI; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NAD; NIACIN; NIACINAMIDE; NICOTINAMIDE MONONUCLEOTIDE; PENTOSYLTRANSFERASES; PLASMIDS; RECOMBINANT PROTEINS; STRUCTURAL HOMOLOGY, PROTEIN; SUGAR PHOSPHATES;

EID: 84855840670     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2011.06.033     Document Type: Article

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