Structural and Kinetic Characterization of Quinolinate Phosphoribosyltransferase (hQPRTase) from Homo sapiens

Journal of Molecular Biology

Volumn 373, Issue 3, 2007, Pages 755-763

  Liu, Huanting ^a   Woznica, Kerry ^a   Catton, Gemma ^a   Crawford, Amanda ^a   Botting, Nigel ^a   Naismith, James H ^a  

^a UNIVERSITY OF ST ANDREWS   (United Kingdom)

Author keywords

5 phosphoribosylpyrophosphate; Homo sapiens quinolinate phosphoribosyltransferase; NAD biosynthesis; nicotinic acid mononucleotide; quinolinic acid

Indexed keywords

PHOSPHORIBOSYLTRANSFERASE; QUINOLINIC ACID; RIBOSEPHOSPHATE PYROPHOSPHOKINASE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONTROLLED STUDY; DECARBOXYLATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; ENZYME STRUCTURE; ESCHERICHIA COLI; KINETICS; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; HOMO SAPIENS;

EID: 34748882326     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2007.08.043     Document Type: Article

References (42)

1. Iwai K., and Taguchi H. Distribution of quinolinate phosphoribosyl-transferase in animals, plants and microorganisms. J. Nutr. Sci. Vitaminol. (Tokyo) 19 (1973) 491-499
2. Foster A.C., Whetsell Jr. W.O., Bird E.D., and Schwarcz R. Quinolinic acid phosphoribosyltransferase in human and rat brain: activity in Huntington's disease and in quinolinate-lesioned rat striatum. Brain Res. 336 (1985) 207-214
3. Feldblum S., Rougier A., Loiseau H., Loiseau P., Cohadon F., Morselli P.L., and Lloyd K.G. Quinolinic-phosphoribosyl transferase activity is decreased in epileptic human brain tissue. Epilepsia 29 (1988) 523-529
4. Foster A.C., and Schwarcz R. Characterization of quinolinic acid phosphoribosyltransferase in human blood and observations in Huntington's disease. J. Neurochem. 45 (1985) 199-205
5. Speciale C., Okuno E., and Schwarcz R. Increased quinolinic acid metabolism following neuronal degeneration in the rat hippocampus. Brain Res. 436 (1987) 18-24
6. Nakagawa Y., Asai H., Kitoh J., Mori H., and Nakano K. Increase in the level of mRNA for 3-hydroxyanthranilate 3,4-dioxygenase in brain of epilepsy-prone El mice. Biosci. Biotechnol. Biochem. 59 (1995) 2191-2192
7. Tao W., Grubmeyer C., and Blanchard J.S. Transition state structure of Salmonella typhimurium orotate phosphoribosyltransferase. Biochemistry 35 (1996) 14-21
8. Scapin G., Grubmeyer C., and Sacchettini J.C. Crystal structure of orotate phosphoribosyltransferase. Biochemistry 33 (1994) 1287-1294
9. Eads J.C., Scapin G., Xu Y., Grubmeyer C., and Sacchettini J.C. The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound GMP. Cell 78 (1994) 325-334
10. Smith J.L. Glutamine PRPP amidotransferase: snapshots of an enzyme in action. Curr. Opin. Struct. Biol. 8 (1998) 686-694
11. Schumacher M.A., Carter D., Scott D.M., Roos D. S., Ullman B., and Brennan R.G. Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding. EMBO J. 17 (1998) 3219-3232
12. Eriksen T.A., Kadziola A., Bentsen A.K., Harlow K.W., and Larsen S. Structural basis for the function of Bacillus subtilis phosphoribosyl-pyrophosphate synthetase. Nature Struct. Biol. 7 (2000) 303-308
13. Eads J.C., Ozturk D., Wexler T.B., Grubmeyer C., and Sacchettini J.C. A new function for a common fold: the crystal structure of quinolinic acid phosphoribosyltransferase. Structure 5 (1997) 47-58
14. Smith J.L. Forming and inhibiting PRT active sites. Nature Struct. Biol. 6 (1999) 502-504
15. Sharma V., Grubmeyer C., and Sacchettini J.C. Crystal structure of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis: a potential TB drug target. Structure 6 (1998) 1587-1599
16. Kim M.K., Im Y.J., Lee J.H., and Eom S.H. Crystal structure of quinolinic acid phosphoribosyltransferase from Helicobacter pylori. Proteins: Struct. Funct. Genet. 63 (2006) 252-255
17. Schwarzenbacher R., Jaroszewski L., von Delft F., Abdubek P., Ambing E., Biorac T., et al. Crystal structure of a type II quinolic acid phosphoribosyltransferase (TM1645) from Thermotoga maritima at 2.50 Å resolution. Proteins: Struct. Funct. Genet. 55 (2004) 768-771
18. Packman P.M., and Jakoby W.B. Crystalline quinolinate phosphoribosyltransferase. J. Biol. Chem. 240 (1965) 4107-4108
19. Hughes K.T., Dessen A., Gray J.P., and Grubmeyer C. The Salmonella typhimurium nadC gene: sequence determination by use of Mud-P22 and purification of quinolinate phosphoribosyltransferase. J. Bacteriol. 175 (1993) 479-486
20. Taguchi H., and Iwai K. Characteristics of quinolinate phosphoribosyltransferase from the "Shiitake" mushroom (Lentinus edodes). J. Nutr. Sci. Vitaminol. 20 (1974) 283-291
21. Taguchi H., and Iwai K. Purification and properties of quinolinate phosphoribosyltransferase from the "Shiitake" mushroom (Lentinus edodes). J. Nutr. Sci. Vitaminol. 20 (1974) 269-281
22. Sinclair S.J., Murphy K.J., Birch C.D., and Hamill J.D. Molecular characterization of quinolinate phosphoribosyltransferase (QPRtase) in Nicotiana. Plant Mol. Biol. 44 (2000) 603-617
23. Iwai K., and Taguchi H. Purification and crystallization of quinolinate phosphoribosyltransferase from hog liver. Biochem. Biophys. Res. Commun. 56 (1974) 884-891
24. Foster A.C., Zinkand W.C., and Schwarcz R. Quinolinic acid phosphoribosyltransferase in rat brain. J. Neurochem. 44 (1985) 446-454
25. Okuno E., White R.J., and Schwarcz R. Quinolinic acid phosphoribosyltransferase: purification and partial characterization from human liver and brain. J. Biochem. (Tokyo) 103 (1988) 1054-1059
26. Kohler C., Eriksson L.G., Flood P.R., Hardie J.A., Okuno E., and Schwarcz R. Quinolinic acid metabolism in the rat-brain-immunohistochemical identification of 3-hydroxyanthranilic acid oxygenase and quinolinic acid phosphoribosyltransferase in the hippocampal region. J. Neurosci. 8 (1988) 975-987
27. Kalikin L., and Calvo K.C. Inhibition of quinolinate phosphoribosyl transferase by pyridine analogs of quinolinic acid. Biochem. Biophys. Res. Commun. 152 (1988) 559-564
28. Bhatia R., and Calvo K.C. The sequencing expression, purification, and steady-state kinetic analysis of quinolinate phosphoribosyl transferase from Escherichia coli. Arch. Biochem. Biophys. 325 (1996) 270-278
29. Cao H., Pietrak B.L., and Grubmeyer C. Quinolinate phosphoribosyltransferase: kinetic mechanism for a type II PRTase. Biochemistry 41 (2002) 3520-3528
30. Okuno E., and Schwarcz R. Purification of quinolinic acid phosphoribosyltransferase from rat liver and brain. Biochim. Biophys. Acta 841 (1985) 112-119
31. Iwai K., and Taguchi H. Crystallization and properties of quinolinate phosphoribosyltransferase from hog liver. Methods Enzymol. 66 (1980) 96-101
32. Moore D., Bice T., Jin L., Grandhi A., DeLucas L.J., and Narayana S.V. Crystallization and preliminary crystallographic investigation of porcine quinolinate phosphoribosyltransferase. Acta Crystallog. sect. D 54 (1998) 119-120
33. Fukuoka S.I., Nyaruhucha C.M., and Shibata K. Characterization and functional expression of the cDNA encoding human brain quinolinate phosphoribosyltransferase. Biochim. Biophys. Acta 1395 (1998) 192-201
34. Krissinel E., and Henrick K. Detection of protein assemblies in crystals. In: Berthold M.R. (Ed). CompLife 2005 (2005), Springer-Verlag, Berlin Heidelberg 163-174
35. Brons-Poulsen J., Petersen N.E., Horder M., and Kristiansen K. An improved PCR-based method for site directed mutagenesis using megaprimers. Mol. Cell. Probes 12 (1998) 345-348
36. Doublie S. Preparation of selenomethionyl proteins for phase determination. Macromol. Crystallog. 276 (1997) 523-530
37. Picot D., Loll P.J., and Garavito R.M. The X-ray crystal-structure of the membrane-protein prostaglandin-H(2) synthase-1. Nature 367 (1994) 243-249
38. Schneider T.R., and Sheldrick G.M. Substructure solution with SHELXD. Acta Crystallog. sect. D 58 (2002) 1772-1779
39. Cowtan K. 'dm': An automated procedure for phase improvement by density modification. Joint CCP4 and ESF-EACBM Newsletter on Protein Crystallography 31 (1994) 34-38
40. Murshudov G.N., Vagin A.A., and Dodson E.J. Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallog. sect. D 53 (1997) 240-255
41. Emsley P., and Cowtan K. Coot: model-building tools for molecular graphics. Acta Crystallog. sect. D 60 (2004) 2126-2132
42. Davis I.W., Murray L.W., Richardson J.S., and Richardson D.C. MolProbity: structure validation and all-atom contact analysis for nucleic acids and their complexes. Nucl. Acids Res. 32 (2004) W615-W619