Purines in the eye: Recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, Müller cells, lens, trabecular meshwork, cornea and lacrimal gland

Experimental Eye Research

Volumn 127, Issue , 2014, Pages 270-279

  Sanderson, Julie ^a   Dartt, Darlene A ^b   Trinkaus Randall, Vickery ^c   Pintor, Jesus ^d   Civan, Mortimer M ^e,f   Delamere, Nicholas A ^g   Fletcher, Erica L ^h   Salt, Thomas E ⁱ   Grosche, Antje ^j   Mitchell, Claire H ^e,k  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^b SCHEPENS EYE RESEARCH INSTITUTE   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

^f UNIVERSITY OF PENNSYLVANIA   (United States)

^g UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^h UNIVERSITY OF MELBOURNE   (Australia)

ⁱ UNIVERSITY COLLEGE LONDON   (United Kingdom)

^j Institute of Human Genetics   (Germany)

^k UNIVERSITY OF PENNSYLVANIA   (United States)

more..

Author keywords

Adenosine; ATP; Cornea; Diadenosine polyphosphates; Eye; Lacrimal gland; Lens; Neurotransmitter; P2X; P2Y; Retina; RPE; Trabecular meshwork

Indexed keywords

ALPHA 1D ADRENERGIC RECEPTOR; DIADENOSINE POLYPHOSPHATE; LIPOFUSCIN; MUSCARINIC M3 RECEPTOR; PURINE; PURINE DERIVATIVE; PURINERGIC P2X7 RECEPTOR; ADENOSINE; ADENOSINE TRIPHOSPHATE; NEUROTRANSMITTER; PURINE NUCLEOSIDE; PURINE NUCLEOTIDE;

ASTROCYTE; CORNEA; CORNEA INJURY; HUMAN; INTRAOCULAR PRESSURE; LACRIMAL FLUID; LACRIMAL GLAND; LENS; MUELLER CELL; NERVE DEGENERATION; NONHUMAN; OSMOTIC STRESS; PHYSIOLOGICAL PROCESS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA; RETINA GANGLION CELL; RETINA NERVE CELL; REVIEW; SIGNAL TRANSDUCTION; TRABECULAR MESHWORK; VISION; WOUND HEALING; ANIMAL; CYTOLOGY; DIADENOSINE POLYPHOSPHATES; EYE; EYE DISEASE; LACRIMAL APPARATUS; MACROGLIA; METABOLISM; P2X; P2Y; PATHOLOGY; PHYSIOLOGY; RPE;

ADENOSINE; ATP; CORNEA; DIADENOSINE POLYPHOSPHATES; EYE; LACRIMAL GLAND; LENS; NEUROTRANSMITTER; P2X; P2Y; RETINA; RPE; TRABECULAR MESHWORK;

ANIMALS; ASTROCYTES; CORNEA; EPENDYMOGLIAL CELLS; EYE; EYE DISEASES; HUMANS; LACRIMAL APPARATUS; LENS, CRYSTALLINE; PURINE NUCLEOSIDES; PURINE NUCLEOTIDES; RETINAL NEURONS; RETINAL PIGMENT EPITHELIUM; SIGNAL TRANSDUCTION; TRABECULAR MESHWORK;

EID: 84910131176     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2014.08.009     Document Type: Review

References (60)

1. Avila M.Y., Stone R.A., Civan M.M. Knockout of A3 adenosine receptors reduces mouse intraocular pressure. Investig. Ophthalmol. Vis. Sci. 2002, 43:3021-3026.
2. Beckel J.M., Argall A.J., Lim J.C., Xia J., Lu W., Coffey E.E., Macarak E.J., Shahidulla M., Delamere N.A., Zode G.S., Sheffield V.C., Laties A.M., Mitchell C.H. Mechanosensitive release of ATP through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: a mechanism for purinergic involvement in chronic strain. Glia 2014, 46:1486-1501.
3. Boucher I., Kehasse A., Marcincin M., Rich C., Rahimi N., Trinkaus-Randall V. Distinct activation of epidermal growth factor receptor by UTP contributes to epithelial cell wound repair. Am. J. Pathol. 2011, 178:1092-1105.
4. Boucher I., Rich C., Lee A., Marcincin M., Trinkaus-Randall V. The P2Y2 receptor mediates the epithelial injury response and cell migration. Am. J. Physiol. Cell Physiol. 2010, 299:C411-C421.
5. Burnstock G. Pathophysiology and therapeutic potential of purinergic signaling. Pharmacol. Rev. 2006, 58:58-86.
6. Carracedo G., Peral A., Pintor J. Diadenosine polyphosphates in tears of Sjogren syndrome patients. Investig. Ophthalmol. Vis. Sci. 2010, 51:5452-5459.
7. Chavda S., Luthert P.J., Salt P.E. P2X7 receptor activation modulates light-evoked retinal ganglion cell synaptic responses and microglial morphology. Soc. Neurosci. Abstr. 2013, 553:513.
8. Corriden R., Insel P.A. Basal release of ATP: an autocrine-paracrine mechanism for cell regulation. Sci. Signal. 2010, 3:re1.
9. Crooke A., Guzman-Aranguez A., Peral A., Abdurrahman M.K., Pintor J. Nucleotides in ocular secretions: their role in ocular physiology. Pharmacol. Ther. 2008, 119:55-73.
10. Crosson C.E., Sloan C.F., Yates P.W. Modulation of conventional outflow facility by the adenosine A1 agonist N6-cyclohexyladenosine. Investig. Ophthalmol. Vis. Sci. 2005, 46:3795-3799.
11. Dartt D.A. Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases. Prog. Retin. Eye Res. 2009, 28:155-177.
12. Dartt D.A., Hodges R.R. Cholinergic agonists activate P2X7 receptors to stimulate protein secretion by the rat lacrimal gland. Investig. Ophthalmol. Vis. Sci. 2011, 52:3381-3390.
13. Dartt D.A., Hodges R.R. Interaction of alpha1D-adrenergic and P2X(7) receptors in the rat lacrimal gland and the effect on intracellular [Ca2+] and protein secretion. Investig. Ophthalmol. Vis. Sci. 2011, 52:5720-5729.
14. Fitz J.G. Regulation of cellular ATP release. Trans. Am. Clin. Climatol. Assoc. 2007, 118:199-208.
15. Guha S., Baltazar G.C., Coffey E.E., Tu L.-A., Lim J.C., Beckel J.M., Eysteinsson T., Lu W., O'Brien-Jenkins A., Patel S., Laties A.M., Mitchell C.H. Lysosomal alkalinization, lipid oxidation, impaired autophagy and reduced phagosome clearance triggered by P2X7 receptor activation in retinal pigmented epithelial cells. Faseb J. 2013, 27:4500-4509.
16. Guha S., Coffey E.E., Lu W., Lim J.C., Beckel J.M., Laties A.M., Mitchell C.H. Approaches for detecting lysosomal alkalinization and impaired degradation in fresh and cultured RPE cells: evidence for a role in retinal degenerations. Exp. Eye Res. 2014, 68-76.
17. Guzman-Aranguez A., Crooke A., Peral A., Hoyle C.H., Pintor J. Dinucleoside polyphosphates in the eye: from physiology to therapeutics. Prog. Retin. Eye Res. 2007, 26:674-687.
18. Guzman-Aranguez A., Loma P., Pintor J. Focus on molecules: diadenosine tetraphosphate. Exp. Eye Res. 2011, 92:96-97.
19. Guzman-Aranguez A., Santano C., Martin-Gil A., Fonseca B., Pintor J. Nucleotides in the eye: focus on functional aspects and therapeutic perspectives. J.Pharmacol. Exp. Ther. 2013, 345:331-341.
20. Hartwick A.T., Lalonde M.R., Barnes S., Baldridge W.H. Adenosine A1-receptor modulation of glutamate-induced calcium influx in rat retinal ganglion cells. Investig. Ophthalmol. Vis. Sci. 2004, 45:3740-3748.
21. Hodges R.R., Vrouvlianis J., Scott R., Dartt D.A. Identification of P2X(3) and P2X(7) purinergic receptors activated by ATP in rat lacrimal gland. Investig. Ophthalmol. Vis. Sci. 2011, 52:3254-3263.
22. Hodges R.R., Vrouvlianis J., Shatos M.A., Dartt D.A. Characterization of P2X7 purinergic receptors and their function in rat lacrimal gland. Investig. Ophthalmol. Vis. Sci. 2009, 50:5681-5689.
23. Hu H.L., Lu W.N., Zhang M., Zhang X.L., Argall A.J., Patel S., Lee G.E., Kim Y.C., Jacobson K.A., Laties A.M., Mitchell C.H. Stimulation of the P2X(7) receptor kills rat retinal ganglion cells invivo. Exp. Eye Res. 2010, 91:425-432.
24. Kakurai K., Sugiyama T., Kurimoto T., Oku H., Ikeda T. Involvement of P2X(7) receptors in retinal ganglion cell death after optic nerve crush injury in rats. Neurosci. Lett. 2013, 534:237-241.
25. Kehasse A., Rich B., Lee A., McComb M., Costello C.E., Trinkaus-Randall V. Epithelial wounds induce differential phosphorylation changes in response to purinergic and EGF receptor activation. Am. J. Pathol. 2013, 183:1841-1852.
26. Kiel J.W., Hollingsworth M., Rao R., Chen M., Reitsamer H.A. Ciliary blood flow and aqueous humor production. Prog. Retin. Eye Res. 2011, 30:1-17.
27. Lee A., Derricks K., Minns M., Ji S., Chi C., Nugent M.A., Trinkaus-Randall V. Hypoxia-induced changes in Ca2+ mobilization and protein phosphorylation implicated in impaired wound healing. Am. J. Physiol. Cell Physiol. 2014, 306:C972-C985.
28. Li A., Banerjee J., Peterson-Yantorno K., Stamer W.D., Leung C.T., Civan M.M. Effects of cardiotonic steroids on trabecular meshwork cells: search for mediator of ouabain-enhanced outflow facility. Exp. Eye Res. 2012, 96:4-12.
29. Li A., Leung C.T., Peterson-Yantorno K., Stamer W.D., Mitchell C.H., Civan M.M. Mechanisms of ATP release by human trabecular meshwork cells, the enabling step in purinergic regulation of aqueous humor outflow. J.Cell. Physiol. 2012, 227:172-182.
30. Liu J., Lu W., Reigada D., Nguyen J., Laties A.M., Mitchell C.H. Restoration of lysosomal pH in RPE cells from cultured human and ABCA4(-/-) mice: pharmacologic approaches and functional recovery. Investig. Ophthalmol. Vis. Sci. 2008, 49:772-780.
31. Mankus C., Chi C., Rich C., Ren R., Trinkaus-Randall V. The P2X(7) receptor regulates proteoglycan expression in the corneal stroma. Mol. Vis. 2012, 18:128-138.
32. Mankus C., Rich C., Minns M., Trinkaus-Randall V. Corneal epithelium expresses a variant of P2X(7) receptor in health and disease. PLoS One 2011, 6:e28541.
33. Mathias R.T., Kistler J., Donaldson P. The lens circulation. J.Membr. Biol. 2007, 216:1-16.
34. Mayo C., Ren R., Rich C., Stepp M.A., Trinkaus-Randall V. Regulation by P2X7: epithelial migration and stromal organization in the cornea. Investig. Ophthalmol. Vis. Sci. 2008, 49:4384-4391.
35. Mitchell C.H. Release of ATP by a human retinal pigment epithelial cell line: potential for autocrine stimulation through subretinal space. J.Physiol. 2001, 534:193-202.
36. Mitchell C.H., Reigada D. Purinergic signalling in the subretinal space: a role in the communication between the retina and the RPE. Purinergic Signal 2008, 4:101-107.
37. Newman E.A. Glial modulation of synaptic transmission in the retina. Glia 2004, 47:268-274.
38. Niyadurupola N., Sidaway P., Ma N., Rhodes J.D., Broadway D.C., Sanderson J. P2X7 receptor activation mediates retinal ganglion cell death in a human retina model of ischemic neurodegeneration. Investig. Ophthalmol. Vis. Sci. 2013, 54:2163-2170.
39. Niyadurupola N., Sidaway P., Osborne A., Broadway D.C., Sanderson J. The development of human organotypic retinal cultures (HORCs) to study retinal neurodegeneration. Br. J. Ophthalmol. 2011, 95:720-726.
40. Notomi S., Hisatomi T., Kanemaru T., Takeda A., Ikeda Y., Enaida H., Kroemer G., Ishibashi T. Critical involvement of extracellular ATP acting on P2RX7 purinergic receptors in photoreceptor cell death. Am. J. Pathol. 2011, 179:2798-2809.
41. Novak I., Jans I.M., Wohlfahrt L. Effect of P2X(7) receptor knockout on exocrine secretion of pancreas, salivary glands and lacrimal glands. J.Physiol. 2010, 588:3615-3627.
42. Oswald D.J., Lee A., Trinidad M., Chi C., Ren R., Rich C.B., Trinkaus-Randall V. Communication between corneal epithelial cells and trigeminal neurons is facilitated by purinergic (P2) and glutamatergic receptors. PLoS One 2012, 7:e44574.
43. Pearson R.A., Dale N., Llaudet E., Mobbs P. ATP released via gap junction hemichannels from the pigment epithelium regulates neural retinal progenitor proliferation. Neuron 2005, 46:731-744.
44. Peral A., Carracedo G., Acosta M.C., Gallar J., Pintor J. Increased levels of diadenosine polyphosphates in dry eye. Invest. Ophthalmol. Vis. Sci. 2006, 47:4053-4058.
45. Puthussery T., Fletcher E. Extracellular ATP induces retinal photoreceptor apoptosis through activation of purinoceptors in rodents. J. Comp. Neurol 2009, 513:430-440.
46. Puthussery T., Fletcher E.L. Synaptic localization of P2X7 receptors in the rat retina. J. Comp. Neurol 2004, 472:13-23.
47. Puthussery T., Fletcher E.L. P2X2 receptors on ganglion and amacrine cells in cone pathways of the rat retina. J. Comp. Neurol 2006, 496:595-609.
48. Puthussery T., Fletcher E.L. Neuronal expression of P2X3 purinoceptors in the rat retina. Neuroscience 2007, 146:403-414.
49. Reichenbach A., Bringmann A. New functions of Muller cells. Glia 2013, 61:651-678.
50. Schaefer T.L., Lingrel J.B., Moseley A.E., Vorhees C.V., Williams M.T. Targeted mutations in the Na,K-ATPase alpha 2 isoform confer ouabain resistance and result in abnormal behavior in mice. Synapse 2011, 65:520-531.
51. Shahidullah M., Mandal A., Beimgraben C., Delamere N.A. Hyposmotic stress causes ATP release and stimulates Na,K-ATPase activity in porcine lens. J.Cell. Physiol. 2012, 227:1428-1437.
52. Shahidullah M., Mandal A., Delamere N.A. TRPV4 in porcine lens epithelium regulates hemichannel-mediated ATP release and Na-K-ATPase activity. Am. J. Physiol. Cell Physiol. 2012, 302:C1751-C1761.
53. Sugiyama T., Kawamura H., Yamanishi S., Kobayashi M., Katsumura K., Puro D.G. Regulation of P2X7-induced pore formation and cell death in pericyte-containing retinal microvessels. Am. J. Physiol. Cell Physiol. 2005, 288:C568-C576.
54. Tamiya S., Okafor M.C., Delamere N.A. Purinergic agonists stimulate lens Na-K-ATPase-mediated transport via a Src tyrosine kinase-dependent pathway. Am. J. Physiol. Cell Physiol. 2007, 293:C790-C796.
55. Vogler S., Grosche A., Pannicke T., Ulbricht E., Wiedemann P., Reichenbach A., Bringmann A. Hypoosmotic and glutamate-induced swelling of bipolar cells in the rat retina: comparison with swelling of Muller glial cells. J.Neurochem. 2013, 126:372-381.
56. Wurm A., Erdmann I., Bringmann A., Reichenbach A., Pannicke T. Expression and function of P2Y receptors on Muller cells of the postnatal rat retina. Glia 2009, 57:1680-1690.
57. Wurm A., Iandiev I., Hollborn M., Wiedemann P., Reichenbach A., Zimmermann H., Bringmann A., Pannicke T. Purinergic receptor activation inhibits osmotic glial cell swelling in the diabetic rat retina. Exp. Eye Res. 2008, 87:385-393.
58. Wurm A., Pannicke T., Iandiev I., Francke M., Hollborn M., Wiedemann P., Reichenbach A., Osborne N.N., Bringmann A. Purinergic signaling involved in Muller cell function in the mammalian retina. Prog. Retin. Eye Res. 2011, 30:324-342.
59. Zhang X., Zhang M., Laties A.M., Mitchell C.H. Stimulation of P2X7 receptors elevates Ca2+ and kills retinal ganglion cells. Investig. Ophthalmol. Vis. Sci. 2005, 46:2183-2191.
60. Zhang X., Zhang M., Laties A.M., Mitchell C.H. Balance of purines may determine life or death of retinal ganglion cells as A3 adenosine receptors prevent loss following P2X7 receptor stimulation. J.Neurochem. 2006, 98:566-575.