Stimulation of the P2X7 receptor kills rat retinal ganglion cells in vivo

Experimental Eye Research

Volumn 91, Issue 3, 2010, Pages 425-432

  Hu, Huiling ^a,b   Lu, Wennan ^a   Zhang, Mei ^a   Zhang, Xiulan ^b   Argall, Arthur J ^a   Patel, Shaun ^a   Lee, Ga Eun ^c   Kim, Yong Chul ^c   Jacobson, Kenneth A ^d   Laties, Alan M ^a   Mitchell, Claire H ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b SUN YAT SEN UNIVERSITY   (China)

^c Gwangju Institute of Science and Technology (GIST)   (South Korea)

^d NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

A3 adenosine receptor; In vivo models; Neuroprotection; P2X receptor; Purinergic signaling; Retinal ganglion cells

Indexed keywords

ADENOSINE A3 RECEPTOR; ADENOSINE A3 RECEPTOR ANTAGONIST; BRILLIANT BLUE; PURINERGIC P2X7 RECEPTOR; STILBAMIDINE; 3' O (4 BENZOYL)BENZOYLADENOSINE 5' TRIPHOSPHATE; 3'-O-(4-BENZOYL)BENZOYLADENOSINE 5'-TRIPHOSPHATE; 4 (2 CHLORO 6 (3 CHLOROBENZYLAMINO) 9H PURIN 9 YL) 2,3 DIHYDROXY N METHYLBICYCLO(3.1.0)HEXANE 1 CARBOXAMIDE; 4 (3 (4 BENZOYLPIPERAZIN 1 YL) 2 (BENZYLOXYCARBONYLAMINO) 3 OXOPROPYL) 3,5 DIMETHYLPHENYL 4 METHYLBENZENESULFONATE; 4-(2-CHLORO-6-(3-CHLOROBENZYLAMINO)-9H-PURIN-9-YL)-2,3-DIHYDROXY-N-METHYLBICYCLO(3.1.0)HEXANE-1-CARBOXAMIDE; 4-(3-(4-BENZOYLPIPERAZIN-1-YL)-2-(BENZYLOXYCARBONYLAMINO)-3-OXOPROPYL)-3,5-DIMETHYLPHENYL 4-METHYLBENZENESULFONATE; ADENOSINE TRIPHOSPHATE; BENZENESULFONIC ACID DERIVATIVE; CALCIUM; COOMASSIE BRILLIANT BLUE; DRUG DERIVATIVE; FUCHSINE; LIPOCORTIN 5; PIPERAZINE DERIVATIVE; PURINE DERIVATIVE; PURINERGIC P2 RECEPTOR;

ADOLESCENT; ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CELL COUNT; CELL DEATH; CELL LOSS; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FEMALE; GLIA; NONHUMAN; PRIORITY JOURNAL; RAT; RETINA GANGLION CELL; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; INJECTION; LONG EVANS RAT; METABOLISM; NEWBORN; PATHOLOGY; PHYSIOLOGY; VITREOUS BODY;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANIMALS, NEWBORN; ANNEXIN A5; BENZENESULFONATES; CALCIUM; CELL COUNT; CELL DEATH; CELL SURVIVAL; INJECTIONS; PIPERAZINES; PURINES; RATS; RATS, LONG-EVANS; RECEPTOR, ADENOSINE A3; RECEPTORS, PURINERGIC P2; RETINAL GANGLION CELLS; ROSANILINE DYES; VITREOUS BODY;

EID: 77955848047     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2010.06.017     Document Type: Article

References (36)

1. Abbracchio M.P., Burnstock G., Verkhratsky A., Zimmermann H. Purinergic signalling in the nervous system: an overview. Tr. Neurosci. 2009, 32:19-29.
2. Bianchi B.R., Lynch K.J., Touma E., Niforatos W., Burgard E.C., Alexander K.M., Park H.S., Yu H., Metzger R., Kowaluk E., Jarvis M.F., Van Biesen T. Pharmacological characterization of recombinant human and rat P2X receptor subtypes. Eur. J. Pharmacol. 1999, 376:127-138.
3. Bo X., Jiang L.H., Wilson H.L., Kim M., Burnstock G., Surprenant A., North R.A. Pharmacological and biophysical properties of the human P2X5 receptor. Mol. Pharmacol. 2003, 63:1407-1416.
4. Bringmann A., Iandiev I., Pannicke T., Wurm A., Hollborn M., Wiedemann P., Osborne N.N., Reichenbach A. Cellular signaling and factors involved in Müller cell gliosis: neuroprotective and detrimental effects. Prog. Ret. Eye Res. 2009, 28:423-451.
5. Carrasquero L.M.G., Delicado E.G., Bustillo D., Gutiérrez-Martín Y., Artalejo A.R. Miras-Portugal MT P2X7 and P2Y13 purinergic receptors mediate intracellular calcium responses to BzATP in rat cerebellar astrocytes. J. Neurochem. 2009, 110:879-889.
6. Communi D., Robaye B., Boeynaems J.-M. Pharmacological characterization of the human P2Y11 receptor. Br. J. Pharmacol. 1999, 128:1199-1206.
7. Enaida H., Hisatomi T., Goto Y., Hata Y., Ueno A., Miura M., Kubota T., Ishibashi T. Preclinical investigation of internal limiting membrane staining and peeling using intravitreal brilliant blue G. Retina 2006, 26:623-630.
8. Guo L., Moss S.E., Alexander R.A., Ali R.R., Fitzke F.W., Cordeiro M.F. Retinal ganglion cell apoptosis in glaucoma Is related to intraocular pressure and IOP-induced effects on extracellular matrix. Invest. Ophthalmol. Vis. Sci. 2005, 46:175-182.
9. Halfter W., Willem M., Mayer U. Basement membrane-dependent survival of retinal ganglion cells. Invest. Ophthalmol. Vis. Sci. 2005, 46:1000-1009.
10. Hu H., Lu W., Laties A.M. Mitchell CH Stimulation of P2X7 receptor kills rat retinal ganglion cells in vivo. Invest. Ophthalmol. Vis. Sci. 2008, 49. ARVO E abstract:2063.
11. Iandiev I., Wurm A., Pannicke T., Wiedemann P., Reichenbach A., Robson S.C., Zimmermann H., Bringmann A. Ectonucleotidases in Muller glial cells of the rodent retina: involvement in inhibition of osmotic cell swelling. Puriner Signal. 2007, 3:423-433.
12. Jacobson K.A., Gao Z.-G., Tchilibon S., Duong H.T., Joshi B.V., Sonin D., Liang B.T. Semirational design of (north)-methanocarba nucleosides as dual acting A1 and A3 adenosine receptor agonists: novel prototypes for cardioprotection. J. Med. Chem. 2005, 48:8103-8107.
13. Kukley M., Stausberg P., Adelmann G., Chessell I.P., Dietrich D. Ecto-Nucleotidases and nucleoside transporters mediate activation of adenosine receptors on hippocampal mossy fibers by P2X7 receptor agonist 2'-3'-O-(4-benzoylbenzoyl)-ATP. J. Neurosci. 2004, 24:7128-7139.
14. Lee G.E., Joshi B.V., Chen W., Jeong L.S., Moon H.R., Jacobson K.A. Kim Y-C Synthesis and structure-activity relationship studies of tyrosine-based antagonists at the human P2X7 receptor. Bioorgan Med. Chem. Letts 2008, 18:571-575.
15. Lee, G.E., Joshi, B.V., Chen, W., Jeong, L.S., Moon, H.R., Jacobson, K.A., Kim, Y.-C., 2009. Corrigendum to "Synthesis and structure-activity relationship studies of tyrosine-based antagonists at the human P2X7 receptor. Bioorg. Med. Chem. Lett. 18, 2008, 571-575" , Bioorgan Med Chem Letts 19, p. 556.
16. Lu W., Hu H., Laties A.M., Sevigney J., Mitchell C.H. Upregulation of retinal NTPDase 1 and vitreal ATP levels in an experimental rat glaucoma model. Invest. Ophthalmol. Vis. Sci. 2008, 49. ARVO E abstract:869.
17. Newman E.A. Propagation of intercellular calcium waves in retinal astrocytes and Muller cells. J. Neurosci. 2001, 21:2215-2223.
18. Newman E.A. Glial cell inhibition of neurons by release of ATP. J. Neurosci. 2003, 23:1659-1666.
19. Pannicke T., Fischer W., Biedermann B., Schãdlich H., Grosche J., Faude F., Wiedemann P., Allgaier C., Illes P., Burnstock G., Reichenbach A. P2X7 receptors in Muller glial cells from the human retina. J. Neurosci. 2000, 20:5965-5972.
20. Provis J.M., Penfold P.L. Cell death and the elimination of retinal axons during development. Prog. Neurobiol. 1988, 31:331-347.
21. Puthussery T., Yee P., Vingrys A.J., Fletcher E.L. Evidence for the involvement of purinergic P2X7 receptors in outer retinal processing. Eur. J. Neurosci. 2006, 24:7-19.
22. Reigada D., Lu W., Zhang M., Mitchell C.H. Elevated pressure triggers a physiological release of ATP from the retina: possible role for pannexin hemichannels. Neurosci 2008, 157:396-404.
23. Remy M., Thaler S., Schumann R., May C., Fiedorowicz M., Schuettauf F., Grüterich M., Priglinger S., Nentwich M., Kampik A., Haritoglou C. An in vivo evaluation of Brilliant Blue G in animals and humans. Br. J. Ophthalmol. 2008, 92:1142-1147.
24. Resta V., Novelli E., Vozzi G., Scarpa C., Caleo M., Ahluwalia A., Solini A., Santini E., Parisi V., Di Virgilio F., Galli-Resta L. Acute retinal ganglion cell injury caused by intraocular pressure spikes is mediated by endogenous extracellular ATP. Eur. J. Neurosci. 2007, 25:2741-2754.
25. Ribeiro J.A., Sebastião A.M., de Mendonça A. Adenosine receptors in the nervous system: pathophysiological implications. Prog. Neurobiol. 2002, 68:377-392.
26. Ricatti M.J., Alfie L.D., Lavoie Ã.G., Sevigny J., Schwarzbaum P.J., Faillace M.P. Immunocytochemical localization of NTPDases1 and 2 in the neural retina of mouse and zebrafish. Synapse 2009, 63:291-307.
27. Tchilibon S., Joshi B.V., Kim S.K., Duong H.T., Gao Z.G., Jacobson K.A. (N)-methanocarba 2, N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists. J. Med. Chem. 2005, 48:1745-1758.
28. Van Engeland M., Kuijpers H.J.H., Ramaekers F.C.S., Reutelingsperger C.P.M., Schutte B. Plasma membrane alterations and cytoskeletal changes in apoptosis. Exp. Cell Res. 1997, 235:421-430.
29. Wang G.-Y., Ratto G.-M., Bisti S., Chalupa L.M. Functional development of intrinsic properties in ganglion cells of the mammalian retina. J. Neurophysiol. 1997, 78:2895-2903.
30. 2+ and kills retinal ganglion cells. Invest. Ophthalmol. Vis. Sci. 2005, 46:2183-2191.
31. Zhang M., Budak M.T., Lu W., Khurana T.S., Zhang X., Laties A.M., Mitchell C.H. Identification of the A3 adenosine receptor in rat retinal ganglion cells. Mol. Vis. 2006, 12:937-948.
32. Zhang X., Zhang M., Laties A.M., Mitchell C.H. Balance of purines may determine life or death of retinal ganglion cells as A3 adenosine receptors prevent loss following P2X7 receptor stimulation. J. Neurochem. 2006, 98:566-575.
33. Zhang X., Li A., Ge J., Reigada D., Laties A.M., Mitchell C.H. Acute increase of intraocular pressure releases ATP into the anterior chamber. Exp. Eye Res. 2007, 85:637-643.
34. Zhang M., Hu H.-L., Zhang X., Lu W., Lim J., Eysteinsson T., Jacobson K.A., Laties A.M., Mitchell C.H. The A3 adenosine receptor attenuates the calcium rise triggered by NMDA receptors in retinal ganglion cells. Neurochem. Int. 2010, 56:35-41.
35. Zimmermann H. Extracellular metabolism of ATP and other nucleotides. Naunyn-Schmiedebergs Arch. Pharmacol. 2000, 362:299-309.
36. Zuo P., Picher M., Okada S.F., Lazarowski E.R., Button B., Boucher R.C., Elston T.C. Mathematical model of nucleotide regulation on airway epithelia: IImplications for airway homeostasis. J. Biol. Chem. 2008, 283:26805-26819.