The P2Y2 receptor mediates the epithelial injury response and cell migration

American Journal of Physiology - Cell Physiology

Volumn 299, Issue 2, 2010, Pages

  Boucher, Ilene ^a   Rich, Celeste ^a   Lee, Albert ^a   Marcincin, Meredith ^a   Trinkaus Randall, Vickery ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Epithelium; Imaging; P2Y receptors; Wound healing

Indexed keywords

ADENOSINE TRIPHOSPHATE; APYRASE; PURINERGIC P2Y2 RECEPTOR; PURINERGIC P2Y4 RECEPTOR; PURINERGIC RECEPTOR; SMALL INTERFERING RNA; URIDINE TRIPHOSPHATE; PURINERGIC P2 RECEPTOR;

ARTICLE; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CELL DAMAGE; CELL MIGRATION; CONTROLLED STUDY; CORNEA EPITHELIUM; DOWN REGULATION; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; FLUORESCENCE; GENE EXPRESSION REGULATION; GENE SEQUENCE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; WOUND CLOSURE; WOUND HEALING; ANIMAL; CATTLE; CELL LINE; CELL MOTION; COMPARATIVE STUDY; CORNEA; CYTOLOGY; GENE SILENCING; GENETICS; INJURY; MIGRATION INHIBITION; PHYSIOLOGY;

ANIMALS; CATTLE; CELL LINE, TRANSFORMED; CELL MIGRATION INHIBITION; CELL MOVEMENT; CORNEA; DOWN-REGULATION; EPITHELIAL CELLS; GENE KNOCKDOWN TECHNIQUES; HUMANS; RECEPTORS, PURINERGIC P2; WOUND HEALING;

EID: 77955890437     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00100.2009     Document Type: Article

References (37)

1. Abbracchio MP, Burnstock G. Purinergic signalling: pathophysiological roles. Jpn J Pharmacol 78: 113-145, 1998.
2. Abbracchio MP, Burnstock G, Boeynaems JM, Barnard EA, Boyer JL, Kennedy C, Knight GE, Fumagalli M, Gachet C, Jacobson KA, Weisman GA. International Union of Pharmacology LVIII: Update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol Rev 58: 281-341, 2006.
3. 2 receptor activation: novel pathways for neuronal survival. J Neurosci 26: 3798-3804, 2006.
4. Arthur DB, Akassoglou K, Insel PA. P2Y2 and TrkA receptors interact with Src family kinase for neuronal differentiation. Biochem Biophys Res Commun 347: 678-682, 2006.
5. Berridge MJ. Inositol trisphosphate and diacyglycerol: two interacting second messengers. Annu Rev Biochem 56: 159-193, 1987.
6. Blake RA, Broome MA, Liu X, Wu J, Gishizky M, Sun L, Courtneidge SA. Su6656, a selective Src family kinase inhibitor, used to probe growth factor signaling. Mol Cell Biol 23: 9018-9027, 2000.
7. Bobe R, Yin X, Roussanne MC, Stepien O, Polidano E, Faverdin C, Marche P. Evidence for ERK1/2 activation by thrombin that is independent of EGFR transactivation. Am J Physiol Heart Circ Physiol 285: H745-H754, 2003.
8. Boucher I, Yang L, Mayo C, Klepeis V, Trinkaus-Randall V. Injury and nucleotides induce phosphorylation of epidermal growth factor receptor: MMP and HB-EGF dependent pathway. Exp Eye Res 85: 130-141, 2007.
9. Burnstock G. The past, present and future of purine nucleotides as signalling molecules. Neuropharmacology 36: 1127-1139, 1997.
10. 2 and A3 receptors. Science 314: 1792-1795, 2006.
11. Cornell-Bell AH, Finkbeiner SH, Cooper MS, Smith SJ. Glutamate induces calcium waves in cultured astrocytes: long range glial signaling. Science 247: 470-473, 1990.
12. Corriden R, Insel PA, Junger WG. A novel method using fluorescence microscopy for real-time assessment of ATP release from individual cells. Am J Physiol Cell Physiol 293: C1420-C1425, 2007.
13. Courtneidge SA. Role of Src in signal transduction pathways-the Jubilee Lecture. Biochem Soc Trans 2: 11-17, 2002.
14. o-mediated signal transduction. J Cell Biol 153: 491-502, 2001.
15. Gipson IK, Spurr-Michaud S, Argüeso P, Tisdale A, Ng TF, Russo CL. Mucin gene expression in immortalized human corneal-limbal and conjunctival epithelial cell lines. Invest Ophthalmol Vis Sci 44: 2496-2506, 2003.
16. Gonzalez FA, Weisman GA, Erb L, Seye CI, Sun GY, Velázquez B, Hernández-Pérez M, Chorna NE. Mechanisms for inhibition of P2 receptor signaling in neural cells. Mol Neurobiol 31: 65-79, 2005.
17. Kanno H, Hoikawa Y, Hodges RR, Zoukhri D, Shatos MA, Rios JD, Dartt DA. Cholinergic agonists transactivate EGFR and stimulate MAPK to induce goblet cell secretion. Am J Physiol Cell Physiol 284: C988-C998, 2003.
18. 2+ waves in epithelial cells. J Cell Sci 114: 4185-4195, 2001.
19. Klepeis VE, Weinger I, Kaczmarek E, Trinkaus-Randall V. P2Y receptors play a critical role in epithelial cell communication and migration. J Cell Biochem 93: 1115-1133, 2004.
20. 2+ waves in keratinocytes are transmitted to sensory neurons: the involvement of extracellular ATP and P2Y2 receptor activation. Biochem J 380: 329-338, 2004.
21. 2 nucleotide receptor interact with Src and regulate activities of Src, proline-rich tyrosine kinase 2, and growth factor receptors. J Biol Chem 279: 8212-8218, 2004.
22. Mayo C, Ren R, Rich C, Stepp MA, Trinkaus-Randall V. Regulation by P2X7: epithelial migration and stromal organization in the cornea. Invest Ophthalmol Vis Sci 49: 4384-4391, 2008.
23. McGarrigle D, Huang X-Y. GPCRs signaling directly through Src-family kinases. Sci Stke 392: 35, 2007.
24. Mediero A, Peral A, Pintor J. Dual roles of diadenosine polyphosphates in corneal epithelial cell migration. Invest Ophthalmol Vis Sci 10: 4500-4506, 2006.
25. Neary JT, Kang Y, Bu Y, Yu E, Akong K, Peters CM. Mitogenic signaling by ATP/P2Y purinergic receptors in astrocytes: involvement of a calcium-independent protein kinase C, extracellular signal-regulated protein kinase pathway distinct from the phosphatidylinositol-specific phospholipase C/calcium pathway. J Neurosci 19: 4211-4220, 1999.
26. Neary JT, Kang Y, Willoughby KA, Ellis EF. Activation of extracellular signal-regulated kinase by stretch-induced injury in astrocytes involves extracellular ATP and P2 purinergic receptors. J Neurosci 23: 2348-2356, 2003.
27. Pintor J, Bautista A, Carracedo G, Peral A. UTP and diadenosine tetraphosphate accelerate wound healing in the rabbit cornea. Ophthalmic Physiol Opt 24: 186-193, 2004.
28. Ralevic V, Burnstock G. Receptors for purines and pyrimidines. Pharmacol Rev 50: 413-492, 1998.
29. Schauwienold D, Perez Sastre A, Genzel N, Schaefer M, Reusch HP. The transactivated epidermal growth factor receptor recruits Pyk2 to regulate Src kinase activity. J Biol Chem 283: 27748-27756, 2008.
30. Soltoff SP, Avraham H, Avraham S, Cantley LC. Activation of P2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C. J Biol Chem 273: 2653-2660, 1998.
31. Trinkaus-Randall V, Gipson IK. Role of calcium and calmodulin in hemidesmosome formation in vitro. J Cell Biol 98: 1565-1571, 1984.
32. Trinkaus-Randall V, Kewalramani R, Payne J, Cornell-Bell A. Calcium signaling induced by adhesion mediates protein tyrosine phosphorylation and is independent of pHi. J Cell Physiol 184: 385-399, 2000.
33. Wang M, Kong Q, Gonzalez FA, Sun G, Erb L, Seye C, Weisman GA. P2Y nucleotide receptor interaction with alpha integrin mediates astrocyte migration. J Neurochem 95: 630-640, 2005.
34. Weinger I, Klepeis V, Trinkaus-Randall V. Tri-nucleotide receptors play a critical role in epithelial cell wound repair. Purinergic Signal 1: 281-292, 2005.
35. Yang L, Cranson D, Trinkaus-Randall V. Cellular injury induces activation of MAPK via P2Y receptors. J Cell Biochem 91: 938-950, 2004.
36. 2 nucleotide receptor to filamin A regulates migration of vascular smooth muscle cells. Circ Res 102: 581-588, 2008.
37. 2+ signaling and re- endothelialization. J Cell Physiol 214: 595-603, 2008.