Mechanosensitive release of adenosine 5′-triphosphate through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: A mechanism for purinergic involvement in chronic strain

GLIA

Volumn 62, Issue 9, 2014, Pages 1486-1501

  Beckel, Jonathan M ^a,b   Argall, Arthur J ^a   Lim, Jason C ^a   Xia, Jingsheng ^a   Lu, Wennan ^a   Coffey, Erin E ^a   Macarak, Edward J ^a   Shahidullah, Mohammed ^c   Delamere, Nicholas A ^c   Zode, Gulab S ^d   Sheffield, Val C ^d   Shestopalov, Valery I ^e,f   Laties, Alan M ^a   Mitchell, Claire H ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF IOWA   (United States)

^e UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^f VAVILOV INSTITUTE OF GENERAL GENETICS   (Russian Federation)

Author keywords

ATP release; Cell swelling; Glaucoma; Mechanosensitive signaling; P2X7 receptor; Pannexin

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYTOSKELETON PROTEIN; EYE PROTEIN; GAP JUNCTION PROTEIN; GLYCOPROTEIN; NERVE PROTEIN; NUCLEOTIDE TRANSPORTER; PANNEXIN 1, RAT; PANNEXIN 3 PROTEIN, MOUSE; PANX1 PROTEIN, MOUSE; PANX2 PROTEIN, MOUSE; PURINERGIC P2X RECEPTOR ANTAGONIST; TRABECULAR MESHWORK-INDUCED GLUCOCORTICOID RESPONSE PROTEIN; VNUT PROTEIN, RAT;

ANIMAL; ASTROCYTE; C57BL MOUSE; CELL CULTURE; DISEASE MODEL; DRUG EFFECTS; FEMALE; GENETICS; GLAUCOMA; KNOCKOUT MOUSE; LONG EVANS RAT; MALE; MECHANICAL STRESS; METABOLISM; OPTIC DISK; OSMOTIC PRESSURE; PATHOPHYSIOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

ADENOSINE TRIPHOSPHATE; ANIMALS; ASTROCYTES; CELLS, CULTURED; CONNEXINS; CYTOSKELETAL PROTEINS; DISEASE MODELS, ANIMAL; EYE PROTEINS; FEMALE; GLAUCOMA; GLYCOPROTEINS; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; NUCLEOTIDE TRANSPORT PROTEINS; OPTIC DISK; OSMOTIC PRESSURE; PURINERGIC P2X RECEPTOR ANTAGONISTS; RATS, LONG-EVANS; STRESS, MECHANICAL;

EID: 84904395911     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.22695     Document Type: Article

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