-
1
-
-
44049090235
-
Notch signaling mediates hypoxia-induced tumor cell migration and invasion
-
Sahlgren C, Gustafsson MV, Jin S et al. Notch signaling mediates hypoxia-induced tumor cell migration and invasion. Proc Natl Acad Sci U S A 2008; 105: 6392-7.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 6392-6397
-
-
Sahlgren, C.1
Gustafsson, M.V.2
Jin, S.3
-
2
-
-
0036359548
-
Hypoxia-a key regulatory factor in tumour growth
-
Harris AL. Hypoxia-a key regulatory factor in tumour growth. Nat Rev Cancer 2002; 2: 38-47.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 38-47
-
-
Harris, A.L.1
-
3
-
-
0032581277
-
Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
-
Carmeliet P, Dor Y, Herbert JM et al. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 1998; 394: 485-90.
-
(1998)
Nature
, vol.394
, pp. 485-490
-
-
Carmeliet, P.1
Dor, Y.2
Herbert, J.M.3
-
4
-
-
0035069527
-
Heterogeneous vascular dependence of tumor cell populations
-
Yu JL, Rak JW, Carmeliet P et al. Heterogeneous vascular dependence of tumor cell populations. Am J Pathol 2001; 158: 1325-34.
-
(2001)
Am J Pathol
, vol.158
, pp. 1325-1334
-
-
Yu, J.L.1
Rak, J.W.2
Carmeliet, P.3
-
6
-
-
78650903440
-
A hypoxia-dependent upregulation of hypoxia-inducible factor-1 by nuclear factor-kappaB promotes gastric tumour growth and angiogenesis
-
Nam SY, Ko YS, Jung J et al. A hypoxia-dependent upregulation of hypoxia-inducible factor-1 by nuclear factor-kappaB promotes gastric tumour growth and angiogenesis. Br J Cancer 2011; 104: 166-74.
-
(2011)
Br J Cancer
, vol.104
, pp. 166-174
-
-
Nam, S.Y.1
Ko, Y.S.2
Jung, J.3
-
7
-
-
0034176782
-
Exploiting the hypoxic cancer cell: mechanisms and therapeutic strategies
-
Brown JM. Exploiting the hypoxic cancer cell: mechanisms and therapeutic strategies. Mol Med Today 2000; 6: 157-62.
-
(2000)
Mol Med Today
, vol.6
, pp. 157-162
-
-
Brown, J.M.1
-
8
-
-
17144416875
-
Anoxia is necessary for tumor cell toxicity caused by a low-oxygen environment
-
Papandreou I, Krishna C, Kaper F et al. Anoxia is necessary for tumor cell toxicity caused by a low-oxygen environment. Cancer Res 2005; 65: 3171-8.
-
(2005)
Cancer Res
, vol.65
, pp. 3171-3178
-
-
Papandreou, I.1
Krishna, C.2
Kaper, F.3
-
9
-
-
70449527638
-
Hypoxia, Snail and incomplete epithelial-mesenchymal transition in breast cancer
-
Lundgren K, Nordenskjold B, Landberg G. Hypoxia, Snail and incomplete epithelial-mesenchymal transition in breast cancer. Br J Cancer 2009; 101: 1769-81.
-
(2009)
Br J Cancer
, vol.101
, pp. 1769-1781
-
-
Lundgren, K.1
Nordenskjold, B.2
Landberg, G.3
-
10
-
-
0029775242
-
Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
-
Hockel M, Schlenger K, Aral B et al. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 1996; 56: 4509-15.
-
(1996)
Cancer Res
, vol.56
, pp. 4509-4515
-
-
Hockel, M.1
Schlenger, K.2
Aral, B.3
-
11
-
-
36949000697
-
Hypoxia-inducible factor-1 alpha contributes to hypoxia-induced chemoresistance in gastric cancer
-
Liu L, Ning X, Sun L et al. Hypoxia-inducible factor-1 alpha contributes to hypoxia-induced chemoresistance in gastric cancer. Cancer Sci 2008; 99: 121-8.
-
(2008)
Cancer Sci
, vol.99
, pp. 121-128
-
-
Liu, L.1
Ning, X.2
Sun, L.3
-
12
-
-
77951739494
-
Cetuximab enhances the effect of oxaliplatin on hypoxic gastric cancer cell lines
-
Luo HY, Wei W, Shi YX et al. Cetuximab enhances the effect of oxaliplatin on hypoxic gastric cancer cell lines. Oncol Rep 2010; 23: 1735-45.
-
(2010)
Oncol Rep
, vol.23
, pp. 1735-1745
-
-
Luo, H.Y.1
Wei, W.2
Shi, Y.X.3
-
13
-
-
36849021771
-
Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition
-
Higgins DF, Kimura K, Bernhardt WM et al. Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. J Clin Invest 2007; 117: 3810-20.
-
(2007)
J Clin Invest
, vol.117
, pp. 3810-3820
-
-
Higgins, D.F.1
Kimura, K.2
Bernhardt, W.M.3
-
14
-
-
0042411985
-
Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies
-
Shannon AM, Bouchier-Hayes DJ, Condron CM et al. Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies. Cancer Treat Rev 2003; 29: 297-307.
-
(2003)
Cancer Treat Rev
, vol.29
, pp. 297-307
-
-
Shannon, A.M.1
Bouchier-Hayes, D.J.2
Condron, C.M.3
-
15
-
-
23644453292
-
Reactive oxygen species-linked regulation of the multidrug resistance transporter P-glycoprotein in Nox-1 overexpressing prostate tumor spheroids
-
Wartenberg M, Hoffmann E, Schwindt H et al. Reactive oxygen species-linked regulation of the multidrug resistance transporter P-glycoprotein in Nox-1 overexpressing prostate tumor spheroids. FEBS Lett 2005; 579: 4541-9.
-
(2005)
FEBS Lett
, vol.579
, pp. 4541-4549
-
-
Wartenberg, M.1
Hoffmann, E.2
Schwindt, H.3
-
16
-
-
4143110440
-
HIF-1: master and commander of the hypoxic world. A pharmacological approach to its regulation by siRNAs
-
Mazure NM, Brahimi-Horn MC, Berta MA et al. HIF-1: master and commander of the hypoxic world. A pharmacological approach to its regulation by siRNAs. Biochem Pharmacol 2004; 68: 971-80.
-
(2004)
Biochem Pharmacol
, vol.68
, pp. 971-980
-
-
Mazure, N.M.1
Brahimi-Horn, M.C.2
Berta, M.A.3
-
17
-
-
0034682783
-
Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
-
Cockman ME, Masson N, Mole DR et al. Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein. J Biol Chem 2000; 275: 25733-41.
-
(2000)
J Biol Chem
, vol.275
, pp. 25733-25741
-
-
Cockman, M.E.1
Masson, N.2
Mole, D.R.3
-
18
-
-
0034663894
-
Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein
-
Tanimoto K, Makino Y, Pereira T et al. Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein. EMBO J 2000; 19: 4298-309.
-
(2000)
EMBO J
, vol.19
, pp. 4298-4309
-
-
Tanimoto, K.1
Makino, Y.2
Pereira, T.3
-
19
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell PH, Wiesener MS, Chang GW et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 1999; 399: 271-5.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
-
21
-
-
0034681378
-
A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) 1alpha and the HIF-like factor
-
Lando D, Pongratz I, Poellinger L et al. A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) 1alpha and the HIF-like factor. J Biol Chem 2000; 275: 4618-27.
-
(2000)
J Biol Chem
, vol.275
, pp. 4618-4627
-
-
Lando, D.1
Pongratz, I.2
Poellinger, L.3
-
22
-
-
77958065302
-
The VHL-dependent regulation of microRNAs in renal cancer
-
Neal CS, Michael MZ, Rawlings LH et al. The VHL-dependent regulation of microRNAs in renal cancer. BMC Med 2010; 8: 64.
-
(2010)
BMC Med
, vol.8
, pp. 64
-
-
Neal, C.S.1
Michael, M.Z.2
Rawlings, L.H.3
-
23
-
-
78049472624
-
von Hippel-Lindau-dependent patterns of RNA polymerase II hydroxylation in human renal clear cell carcinomas
-
Yi Y, Mikhaylova O, Mamedova A et al. von Hippel-Lindau-dependent patterns of RNA polymerase II hydroxylation in human renal clear cell carcinomas. Clin Cancer Res 2010; 16: 5142-52.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 5142-5152
-
-
Yi, Y.1
Mikhaylova, O.2
Mamedova, A.3
-
24
-
-
0034532675
-
The biology of the mammalian Kruppel-like family of transcription factors
-
Dang DT, Pevsner J, Yang VW. The biology of the mammalian Kruppel-like family of transcription factors. Int J Biochem Cell Biol 2000; 32: 1103-21.
-
(2000)
Int J Biochem Cell Biol
, vol.32
, pp. 1103-1121
-
-
Dang, D.T.1
Pevsner, J.2
Yang, V.W.3
-
25
-
-
0037218919
-
Sp1- and Kruppel-like transcription factors
-
Kaczynski J, Cook T, Urrutia R. Sp1- and Kruppel-like transcription factors. Genome Biol 2003; 4: 206.
-
(2003)
Genome Biol
, vol.4
, pp. 206
-
-
Kaczynski, J.1
Cook, T.2
Urrutia, R.3
-
26
-
-
48949118340
-
Kruppel-like transcription factors: a functional family
-
Pearson R, Fleetwood J, Eaton S et al. Kruppel-like transcription factors: a functional family. Int J Biochem Cell Biol 2008; 40: 1996-2001.
-
(2008)
Int J Biochem Cell Biol
, vol.40
, pp. 1996-2001
-
-
Pearson, R.1
Fleetwood, J.2
Eaton, S.3
-
27
-
-
46649092797
-
Activation of KLF8 transcription by focal adhesion kinase in human ovarian epithelial and cancer cells
-
Wang X, Urvalek AM, Liu J et al. Activation of KLF8 transcription by focal adhesion kinase in human ovarian epithelial and cancer cells. J Biol Chem 2008; 283: 13934-42.
-
(2008)
J Biol Chem
, vol.283
, pp. 13934-13942
-
-
Wang, X.1
Urvalek, A.M.2
Liu, J.3
-
28
-
-
34547620873
-
Kruppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion
-
Wang X, Zheng M, Liu G et al. Kruppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion. Cancer Res 2007; 67: 7184-93.
-
(2007)
Cancer Res
, vol.67
, pp. 7184-7193
-
-
Wang, X.1
Zheng, M.2
Liu, G.3
-
29
-
-
77954591527
-
Small interference RNA targeting Kruppel-like factor 8 inhibits the renal carcinoma 786-0 cells growth in vitro and in vivo
-
Fu WJ, Li JC, Wu XY et al. Small interference RNA targeting Kruppel-like factor 8 inhibits the renal carcinoma 786-0 cells growth in vitro and in vivo. J Cancer Res Clin Oncol 2010; 136: 1255-65.
-
(2010)
J Cancer Res Clin Oncol
, vol.136
, pp. 1255-1265
-
-
Fu, W.J.1
Li, J.C.2
Wu, X.Y.3
-
30
-
-
79955471486
-
KLF8 promotes human breast cancer cell invasion and metastasis by transcriptional activation of MMP9
-
Wang X, Lu H, Urvalek AM et al. KLF8 promotes human breast cancer cell invasion and metastasis by transcriptional activation of MMP9. Oncogene 2011; 30: 1901-11.
-
(2011)
Oncogene
, vol.30
, pp. 1901-1911
-
-
Wang, X.1
Lu, H.2
Urvalek, A.M.3
-
31
-
-
83655201108
-
Lentivirus-delivered Kruppel-like factor 8 small interfering RNA inhibits gastric cancer cell growth in vitro and in vivo
-
Liu L, Liu N, Xu M et al. Lentivirus-delivered Kruppel-like factor 8 small interfering RNA inhibits gastric cancer cell growth in vitro and in vivo. Tumour Biol 2012; 33: 53-61.
-
(2012)
Tumour Biol
, vol.33
, pp. 53-61
-
-
Liu, L.1
Liu, N.2
Xu, M.3
-
32
-
-
0034326273
-
Coordinate up-regulation of hypoxia inducible factor (HIF)-1alpha and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing
-
Elson DA, Ryan HE, Snow JW et al. Coordinate up-regulation of hypoxia inducible factor (HIF)-1alpha and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing. Cancer Res 2000; 60: 6189-95.
-
(2000)
Cancer Res
, vol.60
, pp. 6189-6195
-
-
Elson, D.A.1
Ryan, H.E.2
Snow, J.W.3
-
33
-
-
0034652779
-
Candidate genes for the hypoxic tumor phenotype
-
Koong AC, Denko NC, Hudson KM et al. Candidate genes for the hypoxic tumor phenotype. Cancer Res 2000; 60: 883-7.
-
(2000)
Cancer Res
, vol.60
, pp. 883-887
-
-
Koong, A.C.1
Denko, N.C.2
Hudson, K.M.3
-
34
-
-
0030816109
-
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
-
Maxwell PH, Dachs GU, Gleadle JM et al. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc Natl Acad Sci U S A 1997; 94: 8104-9.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 8104-8109
-
-
Maxwell, P.H.1
Dachs, G.U.2
Gleadle, J.M.3
-
35
-
-
0037279517
-
The hypoxic tumour microenvironment and metastatic progression
-
Subarsky P, Hill RP. The hypoxic tumour microenvironment and metastatic progression. Clin Exp Metastasis 2003; 20: 237-50.
-
(2003)
Clin Exp Metastasis
, vol.20
, pp. 237-250
-
-
Subarsky, P.1
Hill, R.P.2
-
36
-
-
34548226398
-
Hypoxia induced overexpression of PrP(C) in gastric cancer cell lines
-
Liang J, Bai F, Luo G et al. Hypoxia induced overexpression of PrP(C) in gastric cancer cell lines. Cancer Biol Ther 2007; 6: 769-74.
-
(2007)
Cancer Biol Ther
, vol.6
, pp. 769-774
-
-
Liang, J.1
Bai, F.2
Luo, G.3
-
37
-
-
84878343416
-
KLF8 involves in TGF-beta-induced EMT and promotes invasion and migration in gastric cancer cells
-
Zhang H, Liu L, Wang Y et al. KLF8 involves in TGF-beta-induced EMT and promotes invasion and migration in gastric cancer cells. J Cancer Res Clin Oncol 2013; 139: 1033-42.
-
(2013)
J Cancer Res Clin Oncol
, vol.139
, pp. 1033-1042
-
-
Zhang, H.1
Liu, L.2
Wang, Y.3
-
38
-
-
0034674901
-
A family of drug transporters: the multidrug resistance-associated proteins
-
Borst P, Evers R, Kool M et al. A family of drug transporters: the multidrug resistance-associated proteins. J Natl Cancer Inst 2000; 92: 1295-302.
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 1295-1302
-
-
Borst, P.1
Evers, R.2
Kool, M.3
-
39
-
-
0027466646
-
Overexpression of a (Mr) 110000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance
-
Scheper RJ, Broxterman HJ, Scheffer GL et al. Overexpression of a (Mr) 110000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance. Cancer Res 1993; 53: 1475-9.
-
(1993)
Cancer Res
, vol.53
, pp. 1475-1479
-
-
Scheper, R.J.1
Broxterman, H.J.2
Scheffer, G.L.3
-
40
-
-
0035049256
-
Selection and characterization of a high-activity ribozyme directed against the antineoplastic drug resistance-associated ABC transporter BCRP/MXR/ABCG2
-
Kowalski P, Wichert A, Holm PS et al. Selection and characterization of a high-activity ribozyme directed against the antineoplastic drug resistance-associated ABC transporter BCRP/MXR/ABCG2. Cancer Gene Ther 2001; 8: 185-92.
-
(2001)
Cancer Gene Ther
, vol.8
, pp. 185-192
-
-
Kowalski, P.1
Wichert, A.2
Holm, P.S.3
-
41
-
-
0033039159
-
Overexpression of p53 is not associated with drug resistance of gastric cancers to 5-fluorouracil-based systemic chemotherapy
-
Yeh KH, Shun CT, Chen CL et al. Overexpression of p53 is not associated with drug resistance of gastric cancers to 5-fluorouracil-based systemic chemotherapy. Hepatogastroenterology 1999; 46: 610-5.
-
(1999)
Hepatogastroenterology
, vol.46
, pp. 610-615
-
-
Yeh, K.H.1
Shun, C.T.2
Chen, C.L.3
-
42
-
-
0031969286
-
Role of glutathione in cisplatin resistance in osteosarcoma cell lines
-
Komiya S, Gebhardt MC, Mangham DC et al. Role of glutathione in cisplatin resistance in osteosarcoma cell lines. J Orthop Res 1998; 16: 15-22.
-
(1998)
J Orthop Res
, vol.16
, pp. 15-22
-
-
Komiya, S.1
Gebhardt, M.C.2
Mangham, D.C.3
-
43
-
-
84899072235
-
Mitochondria-mediated apoptosis in human lung cancer A549 cells by 4-methlsulfinyl-3-butenyl isothiocyanate from radish seeds
-
Wang N, Wang W, Huo P et al. Mitochondria-mediated apoptosis in human lung cancer A549 cells by 4-methlsulfinyl-3-butenyl isothiocyanate from radish seeds. Asian Pac J Cancer Prev 2014; 15: 2133-9.
-
(2014)
Asian Pac J Cancer Prev
, vol.15
, pp. 2133-2139
-
-
Wang, N.1
Wang, W.2
Huo, P.3
-
44
-
-
78649710234
-
Up-regulation of Kruppel-like factor 8 promotes tumor invasion and indicates poor prognosis for hepatocellular carcinoma
-
Li J, Yang X, Sun H et al. Up-regulation of Kruppel-like factor 8 promotes tumor invasion and indicates poor prognosis for hepatocellular carcinoma. Gastroenterology 2010; 139: 2146-57.
-
(2010)
Gastroenterology
, vol.139
, pp. 2146-2157
-
-
Li, J.1
Yang, X.2
Sun, H.3
|