A hypoxia-dependent upregulation of hypoxia-inducible factor-1 by nuclear factor-B promotes gastric tumour growth and angiogenesis

British Journal of Cancer

Volumn 104, Issue 1, 2011, Pages 166-174

  Nam, S Y ^a   Ko, Y S ^b   Jung, J ^b   Yoon, J ^b   Kim, Y H ^c   Choi, Y J ^b   Park, J W ^b   Chang, M S ^b   Kim, W H ^b   Lee, B L ^b  

^a Korea Hydro & Nuclear Power Co   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

^c Inha University School of Medicine   (South Korea)

Author keywords

angiogenesis; gastric cancer; HIF 1 ; hypoxia; NF B; tumour growth

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; MUTANT PROTEIN; RETROVIRUS VECTOR;

ANGIOGENESIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH CANCER; STOMACH CARCINOMA; TISSUE MICROARRAY; TUMOR GROWTH; TUMOR XENOGRAFT; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ANOXIA; APOPTOSIS; BLOTTING, WESTERN; CELL MOVEMENT; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; I-KAPPA B PROTEINS; IMMUNOENZYME TECHNIQUES; LUCIFERASES; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM INVASIVENESS; NEOVASCULARIZATION, PATHOLOGIC; NF-KAPPA B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 78650903440     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6606020     Document Type: Article

References (37)

1. Baldwin Jr AS (2001a) Series introduction: the transcription factor NF-kB and human disease. J Clin Invest 107: 3-6
2. Baldwin AS (2001b) Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kB. J Clin Invest 107: 241-246
3. Belaiba RS, Bonello S, Zähringer C, Schmidt S, Hess J, Kietzmann T, Görlach A (2007) Hypoxia up-regulates HIF-1a transcription by involving phosphatidylinositol 3-kinase and NF-kB in pulmonary artery smooth muscle cells. Mol Bio Cell 18: 4691-4697
4. Cho SJ, Park JW, Kang JS, Kim WH, Juhnn YS, Lee JS, Kim YH, Ko YS, Nam SY, Lee BL (2008) Nuclear factor-kB dependency of doxorubicin sensitivity in gastric cancer cells is determined by manganese superoxide dismutase expression. Cancer Sci 99: 1117-1124
5. Chun YS, Choi E, Yeo EJ, Lee JH, Kim MS, Park JW (2001) A new HIF-1a variant induced by zinc ion suppresses HIF-1-mediated hypoxic responses. J Cell Sci 114: 4051-4061
6. Dery MA, Michaud MD, Richard DE (2005) Hypoxia-inducible factor 1: regulation by hypoxic and non-hypoxic activators. Int J Biochem Cell Biol 37: 535-540
7. Forsythe JA, Jiang BH, Iyer NV, Agani F, Leung SW, Koos RD, Semenza GL (1996) Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 16: 4604-4613
8. Giatromanolaki A, Harris AL (2001) Tumour hypoxia, hypoxia signaling pathways and hypoxia inducible factor expression in human cancer. Anticancer Res 21: 4317-4324
9. Gilmore TD (1999) The Rel/NF-kB signal transduction pathway: introduction. Oncogene 18: 6842-6844
10. Gong W, Wang L, Yao JC, Ajani JA, Wei D, Aldape KD, Xie K, Sawaya R, Huang S (2005) Expression of activated signal transducer and activator of transcription 3 predicts expression of vascular endothelial growth factor in and angiogenic phenotype of human gastric cancer. Clin Cancer Res 11: 1386-1393
11. Guttridge DC, Albanese C, Reuther JY, Pestell RG, Baldwin Jr AS (1999) NF-kB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol Cell Biol 19: 5785-5799
12. Hare GM, Tsui AK, McLaren AT, Ragoonanan TE, Yu J, Mazer CD (2008) Anemia and cerebral outcomes: many questions, fewer answers. Anesth Analg 107: 1356-1370
13. Höckel M, Vaupel P (2001) Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst 93: 266-276
14. Hong SS, Lee H, Kim KW (2004) HIF-1a: a valid therapeutic target for tumor therapy. Cancer Res Treat 36: 343-353
15. Hur GC, Cho SJ, Kim CH, Kim MK, Bae SI, Nam SY, Park JW, Kim WH, Lee BL (2003) Manganese superoxide dismutase expression correlates with chemosensitivity in human gastric cancer cell lines. Clin Cancer Res 9: 5768-5775
16. Iyer NV, Kotch LE, Agani F, Leung SW, Laughner E, Wenger RH, Gassmann M, Gearhart JD, Lawler AM, Yu AY, Semenza GL (1998) Cellular and developmental control of O2 homeostasis by hypoxiainducible factor 1a. Genes Dev 12: 149-162
17. Jung YJ, Isaacs JS, Lee S, Trepel J, Neckers L (2003) IL-1b-mediated up-regulation of HIF-1a via an NF-kB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. FASEB J 17: 2115-2117
18. Karashima T, Sweeney P,Kamat A, Huang S,KimSJ, Bar-EliM, McConkeyDJ, Dinney CP (2003) NF-kB mediates angiogenesis and metastasis of human bladder cancer through the regulation of interleukin-8. Clin Cancer Res 9: 2786-2797
19. Kwon HC, Kim SH, Oh SY, Lee S, Kwon KA, Lee JH, Choi HJ, Park KJ, Lee HS, Roh MS, Kim HJ (2010) Clinicopathological significance of nuclear factor-kB, HIF-1a, and vascular endothelial growth factor expression in stage III colorectal cancer. Cancer Sci 101: 1557-1561
20. Lee BL, Lee HS, Jung J, Cho SJ, Chung HY, KimWH, Jin YW, Kim CS, Nam SY (2005) Nuclear factor-kB activation correlates with better prognosis and Akt activation in human gastric cancer. Clin Cancer Res 11: 2518-2525
21. Lee HS, Lee HK, Kim HS, Yang HK, Kim WH (2003) Tumour suppressor gene expression correlates with gastric cancer prognosis. J Pathol 200: 39-46
22. Lee HS, Lee HK, Kim HS, Yang HK, Kim YI, Kim WH (2001) MUC1, MUC2, MUC5AC, and MUC6 expressions in gastric carcinomas: their roles as prognostic indicators. Cancer 92: 1427-1434
23. Li YM, Zhou BP, Deng J, Pan Y, Hay N, Hung MC (2005) A hypoxiaindependent hypoxia-inducible factor-1 activation pathway induced by phosphatidylinositol-3 kinase/Akt in HER2 overexpressing cells. Cancer Res 65: 3257-3263
24. Meir T, Dror R, Yu X, Qian J, Simon I, Pe'er J, Chowers I (2007) Molecular characteristics of liver metastases from uveal melanoma. Invest Ophthalmol Vis Sci 48: 4890-4896
25. Mizokami K, Kakeji Y, Oda S, Irie K, Yonemura T, Konishi F, Maehara Y (2006) Clinicopathologic significance of hypoxia-inducible factor 1a overexpression in gastric carcinomas. J Surg Oncol 94: 149-154 (Pubitemid 44267197)
26. Oh SC, Nam SY, Kwon HC, Kim CM, Seo JS, Seong RH, Jang YJ, Chung YH, Chung HY (2001) Generation of fusion genes carrying drug resistance, green fluorescent protein, and herpes simplex virus thymidine kinase genes in a single cistron. Mol Cells 11: 192-197
27. Parkin DM, Pisani P, Ferlay J (1993) Estimates of the worldwide incidence of eighteen major cancers in 1985. Int J Cancer 54: 594-606
28. Rayet B, Gélinas C (1999) Aberrant Rel/NF-kB genes and activity in human cancer. Oncogene 18: 6938-6947
29. Royds JA, Dower SK, Qwarnstrom EE, Lewis CE (1998) Response of tumour cells to hypoxia: role of p53 and NF-kB. Mol Pathol 51: 55-61
30. Semenza GL (2000) Surviving ischemia: adaptive responses mediated by hypoxia-inducible factor 1. J Clin Invest 106: 809-812
31. Semenza GL (2001) HIF-1 and mechanism of hypoxia sensing. Curr Opin Cell Biol 13: 167-171
32. Stoeltzing O, McCarty MF, Wey JS, Fan F, Liu W, Belcheva A, Bucana CD, Semenza GL, Ellis LM (2004) Role of hypoxia-inducible factor 1a in gastric cancer cell growth, angiogenesis, and vessel maturation. J Natl Cancer Inst 96: 946-956
33. Urano N, Fujiwara Y, Doki Y, Tsujie M, Yamamoto H, Miyata H, Takiguchi S, Yasuda T, Yano M, Monden M (2006) Overexpression of hypoxiainducible factor-1a in gastric adenocarcinoma. Gastric Cancer 9: 44-49
34. Van Uden P, Kenneth NS, Rocha S (2008) Regulation of hypoxia-inducible factor-1a by NF kB. Biochem J 412: 477-484
35. Workman P, Aboagye EO, Balkwill F, Balmain A, Bruder G, Chaplin DJ, Double JA, Everitt J, Farningham DA, Glennie MJ, Kelland LR, Robinson V, Stratford IJ, Tozer GM, Watson S, Wedge SR, Eccles SA (2010) Guidelines for the welfare and use of animals in cancer research. Br J Cancer 102: 1555-1577
36. Yokoi K, Fidler IJ (2004) Hypoxia increases resistance of human pancreatic cancer cells to apoptosis induced by gemcitabine. Clin Cancer Res 10: 2299-2306
37. Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, Buechler P, Isaacs WB, Semenza GL, Simons JW (1999) Overexpression of hypoxia-inducible factor 1a in common human cancers and their metastases. Cancer Res 59: 5830-5835