-
1
-
-
0345830631
-
Physiological roles and therapeutic potential of metabotropic glutamate receptors
-
Conn PJ. Physiological roles and therapeutic potential of metabotropic glutamate receptors. Ann NY Acad Sci 2003; 1003:12-21.
-
(2003)
Ann NY Acad Sci
, vol.1003
, pp. 12-21
-
-
Conn, P.J.1
-
2
-
-
0034192772
-
NAALADase inhibitors: A novel approach to glutamate regulation
-
Whelan J. NAALADase inhibitors: a novel approach to glutamate regulation. Drug Discov Today 2000;5:171-2.
-
(2000)
Drug Discov Today
, vol.5
, pp. 171-172
-
-
Whelan, J.1
-
3
-
-
0032908247
-
Neuroprotection for acute stroke: Making clinical trials work
-
Muir K, Grosset D. Neuroprotection for acute stroke: making clinical trials work. Stroke 1999;30:180-2.
-
(1999)
Stroke
, vol.30
, pp. 180-182
-
-
Muir, K.1
Grosset, D.2
-
4
-
-
13544268511
-
N-methyl-D-aspartate receptor subtypes: Multiple roles in excitotoxicity and neurological disease
-
Waxman EA, Lynch DR. N-methyl-D-aspartate receptor subtypes: multiple roles in excitotoxicity and neurological disease. Neuroscientist 2005;11:37-49.
-
(2005)
Neuroscientist
, vol.11
, pp. 37-49
-
-
Waxman, E.A.1
Lynch, D.R.2
-
5
-
-
0024365739
-
The role of excitatory amino acids and NMDA receptors in traumatic brain injury
-
Faden AI, Demediuk P, Panter SS, et al. The role of excitatory amino acids and NMDA receptors in traumatic brain injury. Science 1989;244:798-800.
-
(1989)
Science
, vol.244
, pp. 798-800
-
-
Faden, A.I.1
Demediuk, P.2
Panter, S.S.3
-
6
-
-
0025242563
-
Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury
-
Katayama Y, Becker DP, Tamura T, et al. Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury. J Neurosurg 1990;73:889-900.
-
(1990)
J Neurosurg
, vol.73
, pp. 889-900
-
-
Katayama, Y.1
Becker, D.P.2
Tamura, T.3
-
7
-
-
0035934214
-
Localization of metabotropic glutamate receptors 2/3 on primary afferent axons in the rat
-
Carlton SM, Hargett GL, Coggeshall RE. Localization of metabotropic glutamate receptors 2/3 on primary afferent axons in the rat. Neuroscience 2001;105:957-69.
-
(2001)
Neuroscience
, vol.105
, pp. 957-969
-
-
Carlton, S.M.1
Hargett, G.L.2
Coggeshall, R.E.3
-
8
-
-
0036295881
-
Metabotropic glutamate receptors-important modulators of nociception and pain behavior
-
Neugebauer V. Metabotropic glutamate receptors-important modulators of nociception and pain behavior. Pain 2002; 98:1-8.
-
(2002)
Pain
, vol.98
, pp. 1-8
-
-
Neugebauer, V.1
-
9
-
-
1842562427
-
Protection against glucose-induced neuronal death by NAAG and GCP II inhibition is regulated bymGluR3
-
Berent-Spillson A, Robinson AM, Golovoy D, et al. Protection against glucose-induced neuronal death by NAAG and GCP II inhibition is regulated bymGluR3. JNeurochem 2004;89:90-9.
-
(2004)
JNeurochem
, vol.89
, pp. 90-99
-
-
Berent-Spillson, A.1
Robinson, A.M.2
Golovoy, D.3
-
10
-
-
18944407753
-
Upregulation of mRNAs coding for AMPA and NMDA receptor subunits and metabotropic glutamate receptors in the dorsal horn of the spinal cord in a rat model of diabetes mellitus
-
Tomiyama M, Furusawa K, Kamijo M, et al. Upregulation of mRNAs coding for AMPA and NMDA receptor subunits and metabotropic glutamate receptors in the dorsal horn of the spinal cord in a rat model of diabetes mellitus. Brain Res Mol Brain Res 2005;136:275-81.
-
(2005)
Brain Res Mol Brain Res
, vol.136
, pp. 275-281
-
-
Tomiyama, M.1
Furusawa, K.2
Kamijo, M.3
-
11
-
-
0037380729
-
Of mice and men: Reconciling preclinical ALS mouse studies and human clinical trials
-
Rothstein JD. Of mice and men: reconciling preclinical ALS mouse studies and human clinical trials. Ann Neurol 2003;53:423-6.
-
(2003)
Ann Neurol
, vol.53
, pp. 423-426
-
-
Rothstein, J.D.1
-
12
-
-
10344263378
-
Amyotrophic lateral sclerosis: Contemporary concepts in etiopathogenesis and pharmacotherapy
-
Strong MJ. Amyotrophic lateral sclerosis: contemporary concepts in etiopathogenesis and pharmacotherapy. Expert Opin Investig Drugs 2004;13:1593-614.
-
(2004)
Expert Opin Investig Drugs
, vol.13
, pp. 1593-1614
-
-
Strong, M.J.1
-
13
-
-
0036174640
-
Glutamatergic mechanisms in schizophrenia
-
Tsai G, Coyle JT. Glutamatergic mechanisms in schizophrenia. Annu Rev Pharmacol Toxicol 2002;42:165-79.
-
(2002)
Annu Rev Pharmacol Toxicol
, vol.42
, pp. 165-179
-
-
Tsai, G.1
Coyle, J.T.2
-
14
-
-
0346277091
-
Decoding schizophrenia
-
Javitt DC, Coyle JT. Decoding schizophrenia. Sci Am 2004;290:48-55.
-
(2004)
Sci Am
, vol.290
, pp. 48-55
-
-
Javitt, D.C.1
Coyle, J.T.2
-
15
-
-
0032839242
-
Current status of neuroprotection trials for traumatic brain injury: Lessons from animal models and clinical studies
-
Bullock R, Lyeth BG, Muizelaar JP. Current status of neuroprotection trials for traumatic brain injury: lessons from animal models and clinical studies. Neurosurgery 1999;45:207-17.
-
(1999)
Neurosurgery
, vol.45
, pp. 207-217
-
-
Bullock, R.1
Lyeth, B.G.2
Muizelaar, J.P.3
-
18
-
-
23944474406
-
The neurotransmitter N-acetylaspartylglutamate in models of pain, ALS, diabetic neuropathy, CNS injury and schizophrenia
-
Neale JH, Olszewski RT, Gehl LM, et al. The neurotransmitter N-acetylaspartylglutamate in models of pain, ALS, diabetic neuropathy, CNS injury and schizophrenia. Trends Pharmacol Sci 2005;26:477-84.
-
(2005)
Trends Pharmacol Sci
, vol.26
, pp. 477-484
-
-
Neale, J.H.1
Olszewski, R.T.2
Gehl, L.M.3
-
19
-
-
33644700192
-
NAAG peptidase inhibitors and their potential for diagnosis and therapy
-
Zhou J, Neale JH, Pomper MG, et al. NAAG peptidase inhibitors and their potential for diagnosis and therapy. Nat Rev Drug Discov 2005;4:1015-26.
-
(2005)
Nat Rev Drug Discov
, vol.4
, pp. 1015-1026
-
-
Zhou, J.1
Neale, J.H.2
Pomper, M.G.3
-
20
-
-
84857589525
-
Glutamate carboxypeptidase II in diagnosis and treatment of neurologic disorders and prostate cancer
-
Barinka C, Rojas C, Slusher B, et al. Glutamate carboxypeptidase II in diagnosis and treatment of neurologic disorders and prostate cancer. Curr Med Chem 2012;19:856-70.
-
(2012)
Curr Med Chem
, vol.19
, pp. 856-870
-
-
Barinka, C.1
Rojas, C.2
Slusher, B.3
-
21
-
-
84872164218
-
MGlu3 receptor and astrocytes: Partners in neuroprotection
-
Durand D, Carniglia L, Caruso C, et al. mGlu3 receptor and astrocytes: partners in neuroprotection. Neuropharmacology. 2013;66:1-11.
-
(2013)
Neuropharmacology.
, vol.66
, pp. 1-11
-
-
Durand, D.1
Carniglia, L.2
Caruso, C.3
-
22
-
-
0030690403
-
The nagging question of the function of Nacetylaspartylglutamate
-
Coyle JT. The nagging question of the function of Nacetylaspartylglutamate. Neurobiol Dis 1997;4:231-8.
-
(1997)
Neurobiol Dis
, vol.4
, pp. 231-238
-
-
Coyle, J.T.1
-
23
-
-
79960554601
-
Advances in understanding the peptide neurotransmitter NAAG and appearance of a new member of the NAAG neuropeptide family
-
Neale JH, Olszewski RT, Zuo D, et al. Advances in understanding the peptide neurotransmitter NAAG and appearance of a new member of the NAAG neuropeptide family. J Neurochem, 2011;118:490-8.
-
(2011)
J Neurochem
, vol.118
, pp. 490-498
-
-
Neale, J.H.1
Olszewski, R.T.2
Zuo, D.3
-
24
-
-
0027184291
-
Nacetylaspartylglutamate inhibits forskolin-stimulated cyclic AMP levels via a metabotropic glutamate receptor in cultured cerebellar granule cells
-
Wroblewska B, Wroblewski JT, Saab OH, et al. Nacetylaspartylglutamate inhibits forskolin-stimulated cyclic AMP levels via a metabotropic glutamate receptor in cultured cerebellar granule cells. J Neurochem 1993;61:943-8.
-
(1993)
J Neurochem
, vol.61
, pp. 943-948
-
-
Wroblewska, B.1
Wroblewski, J.T.2
Saab, O.H.3
-
25
-
-
0030968255
-
Nacetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells
-
Wroblewska B, Wroblewski JT, Pshenichkin S, et al. Nacetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells, J Neurochem 1997;69:174-81.
-
(1997)
J Neurochem
, vol.69
, pp. 174-181
-
-
Wroblewska, B.1
Wroblewski, J.T.2
Pshenichkin, S.3
-
26
-
-
0032190403
-
N-acetylaspartylglutamate activates cyclic AMP-coupledmetabotropic glutamate receptors in cerebellar astrocytes
-
Wroblewska B, SantiMR, Neale JH. N-acetylaspartylglutamate activates cyclic AMP-coupledmetabotropic glutamate receptors in cerebellar astrocytes. Glia 1998;24:172-9.
-
(1998)
Glia
, vol.24
, pp. 172-179
-
-
Wroblewska, B.1
Santi, M.R.2
Neale, J.H.3
-
27
-
-
0033844601
-
Regulation of neurotransmitter release by metabotropic glutamate receptors
-
Cartmell J, Schoepp DD. Regulation of neurotransmitter release by metabotropic glutamate receptors. J Neurochem 2000;75:889-907.
-
(2000)
J Neurochem
, vol.75
, pp. 889-907
-
-
Cartmell, J.1
Schoepp, D.D.2
-
28
-
-
0034852645
-
Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs
-
Bruno V, Battaglia G, Copani A, et al. Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs. J Cereb Blood Flow Metab 2001;21:1013-33.
-
(2001)
J Cereb Blood Flow Metab
, vol.21
, pp. 1013-1033
-
-
Bruno, V.1
Battaglia, G.2
Copani, A.3
-
29
-
-
0034086461
-
Characterization of -LY354740 binding to rat mGlu2 and mGlu3 receptors expressed in CHO cells using Semliki Forest virus vectors
-
Schweitzer C, Kratzeisen C, Adam G, et al. Characterization of -LY354740 binding to rat mGlu2 and mGlu3 receptors expressed in CHO cells using Semliki Forest virus vectors. Neuropharmacology 2000;39:1700-6.
-
(2000)
Neuropharmacology
, vol.39
, pp. 1700-1706
-
-
Schweitzer, C.1
Kratzeisen, C.2
Adam, G.3
-
30
-
-
0029764279
-
Glutamate and Nacetylaspartylglutamate block HVA calcium currents in frog olfactory bulb interneurons via an mGluR2/3-like receptor
-
Bischofberger J, Schild D. Glutamate and Nacetylaspartylglutamate block HVA calcium currents in frog olfactory bulb interneurons via an mGluR2/3-like receptor. J Neurophysiol 1996;76:2089-92.
-
(1996)
J Neurophysiol
, vol.76
, pp. 2089-2092
-
-
Bischofberger, J.1
Schild, D.2
-
31
-
-
0035122565
-
NAAG inhibits KClinduced [3)H]-GABA release via mGluR3, cAMP, PKA and L-type calcium conductance
-
Zhao J, Ramadan E, Cappiello M, et al. NAAG inhibits KClinduced [(3)H]-GABA release via mGluR3, cAMP, PKA and L-type calcium conductance. Eur J Neurosci 2001;13:340-6.
-
(2001)
Eur J Neurosci
, vol.13
, pp. 340-346
-
-
Zhao, J.1
Ramadan, E.2
Cappiello, M.3
-
32
-
-
0036138249
-
Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens
-
Xi ZX, Baker DA, Shen H, et al. Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens. J Pharmacol Exp Therap 2002;300:162-71
-
(2002)
J Pharmacol Exp Therap
, vol.300
, pp. 162-171
-
-
Xi, Z.X.1
Baker, D.A.2
Shen, H.3
-
33
-
-
0345827429
-
GCP II (NAALADase) inhibition suppresses mossy fiber-CA3 synaptic neurotransmission by a presynaptic mechanism
-
Garrido Sanabria ER, Wozniak KM, Slusher BS, et al. GCP II (NAALADase) inhibition suppresses mossy fiber-CA3 synaptic neurotransmission by a presynaptic mechanism. J Neurophysiol 2004;91:182-93.
-
(2004)
J Neurophysiol
, vol.91
, pp. 182-193
-
-
Garrido Sanabria, E.R.1
Wozniak, K.M.2
Slusher, B.S.3
-
34
-
-
0032539943
-
Isolation and expression of a rat brain cDNA encoding glutamate carboxypeptidase II
-
Luthi-Carter R, Berger UV, Barczak AK, et al. Isolation and expression of a rat brain cDNA encoding glutamate carboxypeptidase II. Proc Natl Acad Sci USA 1998;95:3215-20.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 3215-3220
-
-
Luthi-Carter, R.1
Berger, U.V.2
Barczak, A.K.3
-
35
-
-
2042456725
-
The cloning and characterization of a second brain enzyme with NAAG peptidase activity
-
Bzdega T, Crowe SL, Ramadan ER, et al. The cloning and characterization of a second brain enzyme with NAAG peptidase activity. J Neurochem 2004;89:627-35.
-
(2004)
J Neurochem
, vol.89
, pp. 627-635
-
-
Bzdega, T.1
Crowe, S.L.2
Ramadan, E.R.3
-
36
-
-
34247345306
-
Biochemical characterization of human glutamate carboxypeptidase III
-
Hlouchova K, Barinka C, Klusak V, et al. Biochemical characterization of human glutamate carboxypeptidase III. J Neurochem 2007;101:682-96.
-
(2007)
J Neurochem
, vol.101
, pp. 682-696
-
-
Hlouchova, K.1
Barinka, C.2
Klusak, V.3
-
37
-
-
18544378307
-
Deletion of the glutamate carboxypeptidase II gene in mice reveals a second enzyme activity that hydrolyzes N-acetylaspartylglutamate
-
Bacich DJ, Ramadan E, OKeefe DS, et al. Deletion of the glutamate carboxypeptidase II gene in mice reveals a second enzyme activity that hydrolyzes N-acetylaspartylglutamate. J Neurochem 2002;83:20-9.
-
(2002)
J Neurochem
, vol.83
, pp. 20-29
-
-
Bacich, D.J.1
Ramadan, E.2
Okeefe, D.S.3
-
38
-
-
0030053446
-
Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase, N-acetylated-α-linked acidic dipeptidase
-
Jackson PF, Cole DC, Slusher BS, et al. Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated-α-linked acidic dipeptidase. J Med Chem 1996;39:619-22.
-
(1996)
J Med Chem
, vol.39
, pp. 619-622
-
-
Jackson, P.F.1
Cole, D.C.2
Slusher, B.S.3
-
39
-
-
0038748474
-
Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: Discovery of an orally active GCP II inhibitor
-
Majer P, Jackson PF, Delahanty G, et al. Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor. J Med Chem 2003;46:1989-96.
-
(2003)
J Med Chem
, vol.46
, pp. 1989-1996
-
-
Majer, P.1
Jackson, P.F.2
Delahanty, G.3
-
40
-
-
0035254655
-
Design of remarkably simple, yet potent urea-based inhibitors of glutamate carboxypeptidase II (NAALADase
-
Kozikowski AP, Nan F, Conti P, et al. Design of remarkably simple, yet potent urea-based inhibitors of glutamate carboxypeptidase II (NAALADase). J Med Chem 2001;44:298-301.
-
(2001)
J Med Chem
, vol.44
, pp. 298-301
-
-
Kozikowski, A.P.1
Nan, F.2
Conti, P.3
-
41
-
-
34548386578
-
Progress in the discovery and development of glutamate carboxypeptidase II inhibitors
-
Tsukamoto T, Wozniak KM, Slusher BS. Progress in the discovery and development of glutamate carboxypeptidase II inhibitors. Drug Discov Today 2007;12:767-76.
-
(2007)
Drug Discov Today
, vol.12
, pp. 767-776
-
-
Tsukamoto, T.1
Wozniak, K.M.2
Slusher, B.S.3
-
42
-
-
0032710321
-
Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury
-
Slusher BS, Vornov JJ, Thomas AG, et al. Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury. Nat Med 1999;5:1396-402.
-
(1999)
Nat Med
, vol.5
, pp. 1396-1402
-
-
Slusher, B.S.1
Vornov, J.J.2
Thomas, A.G.3
-
43
-
-
0034934693
-
Design of NAALADase inhibitors: A novel neuroprotective strategy
-
Jackson PF, Slusher BS. Design of NAALADase inhibitors: a novel neuroprotective strategy. Curr Med Chem 2001;8:949-57.
-
(2001)
Curr Med Chem
, vol.8
, pp. 949-957
-
-
Jackson, P.F.1
Slusher, B.S.2
-
44
-
-
0037135992
-
Phosphonate and phosphinate analogues of N-acylated-glutamylglutamate: Potent inhibitors of glutamate carboxypeptidase II
-
Tsukamoto T, Flanary JM, Rojas C, et al. Phosphonate and phosphinate analogues of N-acylated-glutamylglutamate: potent inhibitors of glutamate carboxypeptidase II. Bioorg Med Chem Lett 2002;12:2189-92.
-
(2002)
Bioorg Med Chem Lett
, vol.12
, pp. 2189-2192
-
-
Tsukamoto, T.1
Flanary, J.M.2
Rojas, C.3
-
45
-
-
0042334778
-
Conformational and SAR analysis of NAALADase and PSMA inhibitors
-
Oliver AJ, Wiest O, Helquist P, et al. Conformational and SAR analysis of NAALADase and PSMA inhibitors. Bioorg Med Chem 2003;11:4455-61.
-
(2003)
Bioorg Med Chem
, vol.11
, pp. 4455-4461
-
-
Oliver, A.J.1
Wiest, O.2
Helquist, P.3
-
46
-
-
4444317356
-
Probing for a hydrophobic a binding register in prostate-speci. C membrane antigen with phenylalkylphosphonamidates
-
Maung J, Mallari JP, Girtsman TA, et al. Probing for a hydrophobic a binding register in prostate-speci. c membrane antigen with phenylalkylphosphonamidates. Bioorg Med Chem 2004;12:4969-79.
-
(2004)
Bioorg Med Chem
, vol.12
, pp. 4969-4979
-
-
Maung, J.1
Mallari, J.P.2
Girtsman, T.A.3
-
47
-
-
23044458183
-
The central nervous system effects, pharmacokinetics and safety of the NAALADase-inhibitor GPI 5693
-
van der Post JP, de Visser SJ, de Kam ML, et al. The central nervous system effects, pharmacokinetics and safety of the NAALADase-inhibitor GPI 5693. Br J Clin Pharmacol 2005;60:128-36.
-
(2005)
Br J Clin Pharmacol
, vol.60
, pp. 128-136
-
-
Van Der Post, J.P.1
De Visser, S.J.2
De Kam, M.L.3
-
48
-
-
78449273601
-
The discovery and structure-activity relationships of indole-based inhibitors of glutamate carboxypeptidase II
-
Grella B, Adams J, Berry JF, et al. The discovery and structure-activity relationships of indole-based inhibitors of glutamate carboxypeptidase II. Bioorg Med Chem Lett, 2010;20:7222-25.
-
(2010)
Bioorg Med Chem Lett
, vol.20
, pp. 7222-7225
-
-
Grella, B.1
Adams, J.2
Berry, J.F.3
-
49
-
-
0034624744
-
Dual function glutamate-related ligands: Discovery of a novel, potent inhibitor of glutamate carboxypeptidase II possessing mGluR3 agonist activity
-
Nan F, Bzdega T, Pshenichkin S, et al. Dual function glutamate-related ligands: discovery of a novel, potent inhibitor of glutamate carboxypeptidase II possessing mGluR3 agonist activity. J Med Chem 2000;43:772-4.
-
(2000)
J Med Chem
, vol.43
, pp. 772-774
-
-
Nan, F.1
Bzdega, T.2
Pshenichkin, S.3
-
50
-
-
0035935670
-
Design and pharmacological activity of phosphinic acid based NAALADase inhibitors
-
Jackson PF, Tays KL, Maclin KM, et al. Design and pharmacological activity of phosphinic acid based NAALADase inhibitors. J Med Chem 2001;44:4170-5.
-
(2001)
J Med Chem
, vol.44
, pp. 4170-4175
-
-
Jackson, P.F.1
Tays, K.L.2
Maclin, K.M.3
-
51
-
-
12144289420
-
Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: Efficacy as analgesic agents
-
Kozikowski AP, Zhang J, Nan F, et al. Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents. J Med Chem 2004;47:1729-38.
-
(2004)
J Med Chem
, vol.47
, pp. 1729-1738
-
-
Kozikowski, A.P.1
Zhang, J.2
Nan, F.3
-
52
-
-
58149094592
-
Interactions between human glutamate carboxypeptidase II and urea-based inhibitors: Structural characterization
-
Barinka C, Byun Y, Dusich CL, et al. Interactions between human glutamate carboxypeptidase II and urea-based inhibitors: structural characterization. J Med Chem 2008;51:7737-43.
-
(2008)
J Med Chem
, vol.51
, pp. 7737-7743
-
-
Barinka, C.1
Byun, Y.2
Dusich, C.L.3
-
53
-
-
84885855876
-
Rationally designed sulfamides as glutamate carboxypeptidase II inhibitors
-
Choy CJ, Fulton MD, Davis AL, et al. Rationally designed sulfamides as glutamate carboxypeptidase II inhibitors. Chem Biol Drug Des. 2013;82:612-9.
-
(2013)
Chem Biol Drug Des.
, vol.82
, pp. 612-619
-
-
Choy, C.J.1
Fulton, M.D.2
Davis, A.L.3
-
54
-
-
80455140560
-
Novel substratebased inhibitors of human glutamate carboxypeptidase II with enhanced lipophilicity
-
Plechanovova A, Byun Y, Alquicer G, et al. Novel substratebased inhibitors of human glutamate carboxypeptidase II with enhanced lipophilicity. J Med Chem 2011;54:7535-46.
-
(2011)
J Med Chem
, vol.54
, pp. 7535-7546
-
-
Plechanovova, A.1
Byun, Y.2
Alquicer, G.3
-
55
-
-
34447521874
-
Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II
-
Barinka C, Rovenska M, Mlcochova P, et al. Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II. J Med Chem 2007;250:3267-73.
-
(2007)
J Med Chem
, vol.250
, pp. 3267
-
-
Barinka, C.1
Rovenska, M.2
Mlcochova, P.3
-
56
-
-
68749087539
-
Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III
-
Hlouchova K, Barinka C, Konvalinka J, et al. Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III. FEBS J. 2009;276:4448-62.
-
(2009)
FEBS J.
, vol.276
, pp. 4448-4462
-
-
Hlouchova, K.1
Barinka, C.2
Konvalinka, J.3
-
57
-
-
72049110484
-
Bioisosterism of urea-based GCPII inhibitors: Synthesis and structure-activity relationship studies
-
Wang H, Byun Y, Barinka C, et al. Bioisosterism of urea-based GCPII inhibitors: synthesis and structure-activity relationship studies. Bioorg Med Chem Lett 2010;20:392-7.
-
(2010)
Bioorg Med Chem Lett
, vol.20
, pp. 392-397
-
-
Wang, H.1
Byun, Y.2
Barinka, C.3
-
58
-
-
0034711558
-
N-acetylaspartylglutamate protects against transient focal cerebral ischemia in rats
-
Lu XM, Tang Z, Liu W, et al., N-acetylaspartylglutamate protects against transient focal cerebral ischemia in rats. Eur J Pharmacol 2000;408:233-9.
-
(2000)
Eur J Pharmacol
, vol.408
, pp. 233-239
-
-
Lu, X.M.1
Tang, Z.2
Liu, W.3
-
59
-
-
0034807624
-
Electroencephalogram analysis and neuroprotective profile of the N-acetylated-alphalinked acidic dipeptidase inhibitor, GPI5232, in normal and brain-injured rats
-
Williams AJ, Lu XM, Slusher B, et al. Electroencephalogram analysis and neuroprotective profile of the N-acetylated-alphalinked acidic dipeptidase inhibitor, GPI5232, in normal and brain-injured rats. J Pharmacol Exp Ther 2001;299:48-57.
-
(2001)
J Pharmacol Exp Ther
, vol.299
, pp. 48-57
-
-
Williams, A.J.1
Lu, X.M.2
Slusher, B.3
-
60
-
-
26844488305
-
Mice lacking glutamate carboxypeptidase II are protected from peripheral neuropathy and ischemic brain injury
-
Bacich DJ, Wozniak KM, Lu XC, et al. Mice lacking glutamate carboxypeptidase II are protected from peripheral neuropathy and ischemic brain injury. J Neurochem 2005;95:314-23.
-
(2005)
J Neurochem
, vol.95
, pp. 314-323
-
-
Bacich, D.J.1
Wozniak, K.M.2
Lu, X.C.3
-
61
-
-
0037154561
-
Neuroprotective effects of Nacetylaspartylglutamate in a neonatal rat model of hypoxiaischemia
-
Cai Z, Lin S, Rhodes PG. Neuroprotective effects of Nacetylaspartylglutamate in a neonatal rat model of hypoxiaischemia. Eur J Pharmacol 2002;437:139-45.
-
(2002)
Eur J Pharmacol
, vol.437
, pp. 139-145
-
-
Cai, Z.1
Lin, S.2
Rhodes, P.G.3
-
62
-
-
14744296113
-
NAAG peptidase inhibitor reduces acute neuronal degeneration and astrocyte damage following lateral fluid percussion TBI in rats
-
Zhong C, Zhao X, Sarva J, et al. NAAG peptidase inhibitor reduces acute neuronal degeneration and astrocyte damage following lateral fluid percussion TBI in rats. J. Neurotrauma 2005;22:266-76.
-
(2005)
J. Neurotrauma
, vol.22
, pp. 266-276
-
-
Zhong, C.1
Zhao, X.2
Sarva, J.3
-
63
-
-
33646078096
-
NAAG peptidase inhibitor increases dialysate NAAG and reduces glutamate, aspartate and GABA levels in the dorsal hippocampus following fluid percussion injury in the rat
-
Zhong C, Zhao X, Van LC, et al. NAAG peptidase inhibitor increases dialysate NAAG and reduces glutamate, aspartate and GABA levels in the dorsal hippocampus following fluid percussion injury in the rat. J Neurochem 2006;97:1015-25.
-
(2006)
J Neurochem
, vol.97
, pp. 1015-1025
-
-
Zhong, C.1
Zhao, X.2
Van, L.C.3
-
64
-
-
0035800544
-
Spinal Nacetylated- α-linked acidic dipeptidase (NAALADase) inhibition attenuates mechanical allodynia induced by paw carrageenan injection in the rat
-
Yamamoto T, Nozaki-Taguchi N, Sakashita T. Spinal Nacetylated- α-linked acidic dipeptidase (NAALADase) inhibition attenuates mechanical allodynia induced by paw carrageenan injection in the rat. Brain Res 2001;909:138-44.
-
(2001)
Brain Res
, vol.909
, pp. 138-144
-
-
Yamamoto, T.1
Nozaki-Taguchi, N.2
Sakashita, T.3
-
65
-
-
0035863534
-
Inhibition of spinal N-acetylated-α-linked acidic dipeptidase produces an antinociceptive effect in the rat formalin test
-
Yamamoto T, Nozaki-Taguchi N, Sakashita Y, et al. Inhibition of spinal N-acetylated-α-linked acidic dipeptidase produces an antinociceptive effect in the rat formalin test. Neurosci 2001;102:473-9.
-
(2001)
Neurosci
, vol.102
, pp. 473-479
-
-
Yamamoto, T.1
Nozaki-Taguchi, N.2
Sakashita, Y.3
-
66
-
-
0036156761
-
Effect of 2- (phosphonomethyl)-pentanedioic acid on allodynia and afferent ectopic discharges in a rat model of neuropathic pain
-
Chen SR, Wozniak KM, Slusher BS, et al. Effect of 2- (phosphonomethyl)-pentanedioic acid on allodynia and afferent ectopic discharges in a rat model of neuropathic pain. J Pharmacol Exp Ther 2002;300:662-7.
-
(2002)
J Pharmacol Exp Ther
, vol.300
, pp. 662-667
-
-
Chen, S.R.1
Wozniak, K.M.2
Slusher, B.S.3
-
67
-
-
0344441376
-
Effects of GCP-II inhibition on responses of dorsal horn neurones after inflammation and neuropathy: An electrophysiological study in the rat
-
Carpenter KJ, Sen S,Matthews EA, et al. Effects of GCP-II inhibition on responses of dorsal horn neurones after inflammation and neuropathy: an electrophysiological study in the rat. Neuropeptides 2003;37:298-306.
-
(2003)
Neuropeptides
, vol.37
, pp. 298-306
-
-
Carpenter, K.J.1
Sen Smatthews, E.A.2
-
68
-
-
3242750466
-
Antinociceptive effects of N-acetylaspartylglutamate (NAAG) peptidase inhibitors ZJ 11, ZJ 17 and ZJ 43 in the rat formalin test and in the rat neuropathic pain model
-
Yamamoto T, Hirasawa S, Wroblewska B, et al. Antinociceptive effects of N-acetylaspartylglutamate (NAAG) peptidase inhibitors ZJ 11, ZJ 17 and ZJ 43 in the rat formalin test and in the rat neuropathic pain model. Eur J Neurosci 2004;20: 483-94.
-
(2004)
Eur J Neurosci
, vol.20
, pp. 483-494
-
-
Yamamoto, T.1
Hirasawa, S.2
Wroblewska, B.3
-
69
-
-
0037082872
-
GCPII (NAALADase) inhibition prevents long-term diabetic neuropathy in type 1 diabetic BB/Wor rats
-
Zhang W., Slusher B., Murakawa Y., et al. GCPII (NAALADase) inhibition prevents long-term diabetic neuropathy in type 1 diabetic BB/Wor rats. J Neurol Sci 2002;194:21-8.
-
(2002)
J Neurol Sci
, vol.194
, pp. 21-28
-
-
Zhang, W.1
Slusher, B.2
Murakawa, Y.3
-
70
-
-
0031901590
-
Neuroprotective activity of N-acetylaspartylglutamate in cultured cortical cells
-
Bruno V, Wroblewska B, Wroblewski JT, et al. Neuroprotective activity of N-acetylaspartylglutamate in cultured cortical cells. Neuroscience 1998;85:751-7.
-
(1998)
Neuroscience
, vol.85
, pp. 751-757
-
-
Bruno, V.1
Wroblewska, B.2
Wroblewski, J.T.3
-
71
-
-
0035955418
-
Neuroprotection mediated by glutamate carboxypeptidase II (NAALADase) inhibition requires TGF-beta
-
Thomas AG, Liu W, Olkowski JL, et al., Neuroprotection mediated by glutamate carboxypeptidase II (NAALADase) inhibition requires TGF-beta. Eur J Pharmacol 2001;430: 33-40.
-
(2001)
Eur J Pharmacol
, vol.430
, pp. 33-40
-
-
Thomas, A.G.1
Liu, W.2
Olkowski, J.L.3
-
72
-
-
0035516124
-
From Charcot to Lou Gehrig: Deciphering selective motor neuron death in ALS
-
Cleveland DW, Rothstein JD. From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS. Nature Rev Neurosci 2001;2:806-19.
-
(2001)
Nature Rev Neurosci
, vol.2
, pp. 806-819
-
-
Cleveland, D.W.1
Rothstein, J.D.2
-
73
-
-
0041421277
-
Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models
-
Ghadge GD, Slusher BS, Bodner A, et al. Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models. Proc Natl Acad Sci USA 2003;100:9554-9.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 9554-9559
-
-
Ghadge, G.D.1
Slusher, B.S.2
Bodner, A.3
-
74
-
-
0025952455
-
Recent advances in the phencyclidine model of schizophrenia
-
Javitt DC, Zukin SR. Recent advances in the phencyclidine model of schizophrenia. Am J Psychiatry 1991;148:1301-8.
-
(1991)
Am J Psychiatry
, vol.148
, pp. 1301-1308
-
-
Javitt, D.C.1
Zukin, S.R.2
-
75
-
-
0036305335
-
Effects of NMDA receptor antagonists: Implications for the pathophysiology of schizophrenia
-
Krystal JH, Anand A, Moghaddam B. Effects of NMDA receptor antagonists: implications for the pathophysiology of schizophrenia. Arch Gen Psychiatry 2002;59:663-4.
-
(2002)
Arch Gen Psychiatry
, vol.59
, pp. 663-664
-
-
Krystal, J.H.1
Anand, A.2
Moghaddam, B.3
-
76
-
-
0032575715
-
Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats
-
Moghaddam B, Adams BW. Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats. Science 1998;281:1349-52.
-
(1998)
Science
, vol.281
, pp. 1349-1352
-
-
Moghaddam, B.1
Adams, B.W.2
-
77
-
-
0032848507
-
The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-amphetaminemotor behaviors in rats
-
Cartmell J, Monn JA, Schoepp DD. The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-amphetaminemotor behaviors in rats. J Pharmacol Exp Ther 1999;291:161-70.
-
(1999)
J Pharmacol Exp Ther
, vol.291
, pp. 161-170
-
-
Cartmell, J.1
Monn, J.A.2
Schoepp, D.D.3
-
78
-
-
19244371242
-
NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR
-
Olszewski R, Buhkari N, Zhou J, et al. NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR. J Neurochem 2004;89:876-85.
-
(2004)
J Neurochem
, vol.89
, pp. 876-885
-
-
Olszewski, R.1
Buhkari, N.2
Zhou, J.3
-
79
-
-
84858001721
-
MGluR3 and not mGluR2 receptors mediate the efficacy of NAAG peptidase inhibitor in validated model of schizophrenia
-
Olszewski RT, Bzdega T, Neale JH. mGluR3 and not mGluR2 receptors mediate the efficacy of NAAG peptidase inhibitor in validated model of schizophrenia. Schizophr Res 2012;136:160-1.
-
(2012)
Schizophr Res
, vol.136
, pp. 160-161
-
-
Olszewski, R.T.1
Bzdega, T.2
Neale, J.H.3
-
80
-
-
85016872313
-
Activated astrocytes in areas of kainate-induced neuronal injury upregulate the expression of the metabotropic glutamate receptors 2/3 and 5
-
Ferraguti F, Corti C, Valerio E, et al. Activated astrocytes in areas of kainate-induced neuronal injury upregulate the expression of the metabotropic glutamate receptors 2/3 and 5. Exp Brain Res 2001;137:1-11.
-
(2001)
Exp Brain Res
, vol.137
, pp. 1-11
-
-
Ferraguti, F.1
Corti, C.2
Valerio, E.3
-
81
-
-
0038810014
-
Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: Opposite regulation of glutamate transporter proteins
-
Aronica E, Gorter JA, Ijlst-Keizers H, et al. Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins. Eur J Neurosci 2003;17:2106-18.
-
(2003)
Eur J Neurosci
, vol.17
, pp. 2106-2118
-
-
Aronica, E.1
Gorter, J.A.2
Ijlst-Keizers, H.3
-
82
-
-
0035955418
-
Neuroprotection mediated by glutamate carboxypeptidase II (NAALADase) inhibition requires TGF-beta
-
Thomas AG, Liu W, Olkowski JL, et al. Neuroprotection mediated by glutamate carboxypeptidase II (NAALADase) inhibition requires TGF-beta. Eur J Pharmacol 2001;430:33-40.
-
(2001)
Eur J Pharmacol
, vol.430
, pp. 33-40
-
-
Thomas, A.G.1
Liu, W.2
Olkowski, J.L.3
-
83
-
-
57749093019
-
Metabotropic glutamate receptors as targets for multipotential treatment of neurological disorders
-
Byrnes KR, Loane DJ, Faden AI. Metabotropic glutamate receptors as targets for multipotential treatment of neurological disorders. Neurotherapeutics 2009;6:94-107.
-
(2009)
Neurotherapeutics
, vol.6
, pp. 94-107
-
-
Byrnes, K.R.1
Loane, D.J.2
Faden, A.I.3
-
84
-
-
0035965727
-
Mechanisms for clearance of released N-acetylaspartylglutamate in crayfish nerve fibers: Implications for axon-glia signaling
-
Urazaev AK, Buttram JG Jr, Deen JP, et al. Mechanisms for clearance of released N-acetylaspartylglutamate in crayfish nerve fibers: implications for axon-glia signaling. Neuroscience 2001;107:697-703.
-
(2001)
Neuroscience
, vol.107
, pp. 697-703
-
-
Urazaev, A.K.1
Buttram, J.G.2
Deen, J.P.3
-
85
-
-
34548386578
-
Progress in the discovery and development of glutamate carboxypeptidase II inhibitors
-
Tsukamoto T, Wozniak KM, Slusher BS. Progress in the discovery and development of glutamate carboxypeptidase II inhibitors. Drug Discov Today 2007;12:767-76
-
(2007)
Drug Discov Today
, vol.12
, pp. 767-776
-
-
Tsukamoto, T.1
Wozniak, K.M.2
Slusher, B.S.3
-
86
-
-
51549089015
-
The astrocyte surface NAAG receptor and NAAG peptidase signaling complex as a therapeutic target
-
Baslow MH. The astrocyte surface NAAG receptor and NAAG peptidase signaling complex as a therapeutic target. Drug News Perspect 2008;21:251-7.
-
(2008)
Drug News Perspect
, vol.21
, pp. 251-257
-
-
Baslow, M.H.1
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