Characterization of [3H]-LY354740 binding to rat mGlu2 and mGlu3 receptors expressed in CHO cells using Semliki Forest virus vectors

Neuropharmacology

Volumn 39, Issue 10, 2000, Pages 1700-1706

  Schweitzer, Christophe ^a   Kratzeisen, Claudia ^a   Adam, Geo ^a   Lundstrom, Kenneth ^a   Malherbe, Pari ^a   Ohresser, Serge ^a   Stadler, Heinz ^a   Wichmann, Jürgen ^a   Woltering, Thomas ^a   Mutel, Vincent ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

3H LY354740; Binding; mGlu2; mGlu3; Pharmacology

Indexed keywords

EGLUMETAD; METABOTROPIC RECEPTOR; VIRUS VECTOR;

ANIMAL CELL; ARTICLE; BINDING SITE; CHO CELL; CONTROLLED STUDY; DRUG RECEPTOR BINDING; HAMSTER; IC 50; NONHUMAN; PRIORITY JOURNAL; SEMLIKI FOREST ALPHAVIRUS;

AMINO ACIDS; ANIMALS; BICYCLO COMPOUNDS; BINDING, COMPETITIVE; CELL MEMBRANE; CHLORIDES; CHO CELLS; CRICETINAE; DNA, RECOMBINANT; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; GENE EXPRESSION; GENETIC VECTORS; GLUTAMIC ACID; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); KINETICS; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; SEMLIKI FOREST VIRUS; TRITIUM; XANTHENES; ZINC COMPOUNDS;

EID: 0034086461     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(99)00265-8     Document Type: Article

References (30)

1. Annoura H., Fukunuga A., Uesugi M., Tatsuoka T., Horikawa Y. A novel class of antagonists for metabotropic glutamate receptors, 7-(hydroximino)cyclopropachromen-1a-carboxylates. Bioorganic and Medicinal Chemistry Letters. 6:1996;763-766.
2. Aramori I., Nakanishi S. Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluR1, in transfected CHO cells. Neuron. 8:1992;757-765.
3. 2+ from brain tissue during activity. Nature. 308:1984;734-736.
4. Berg J.M., Shi Y. The galvanization of biology: a growing appreciation for the roles of zinc. Science. 271:1996;1081-1085.
5. Berglund P., Sjöberg M., Garoff H., Atkins G.J., Sheahan B.J., Lilijeström P. Semliki Forest virus expression system: production of conditionally infectious recombinant particles. Bio/Technology. 11:1993;916-920.
6. 3H]ketanserin label two affinity states of the cloned human 5-hydroxytryptamine2 receptor. Molecular Pharmacology. 38:1990;604-609.
7. Cartmell J., Adam G., Chaboz S., Henningsen R., Kemp J.A., Klingelschmidt A., Metzler V., Monsma F., Schaffhauser H., Wichmann J., Mutel V. Characterization of [3H]-(2S,2′R,3′R)-2-(2′,3′-dicarboxy-cyclopropyl)glycine ([3H]-DCG IV) binding to metabotropic mGlu2 receptor-transfected cell membranes. British Journal of Pharmacology. 123:1998;497-504.
8. 50) of an enzymatic reaction. Biochemical Pharmacology. 22:1973;3099-3108.
9. Conn P.J., Pin J.-P. Pharmacology and functions of metabotropic glutamate receptors. Annual Review of Pharmacology and Toxicology. 37:1997;205-237.
10. Doherty A.J., Palmer M.J., Henley J.M., Collingridge G.L., Jane D.E. (R,S)-2-Chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but not mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus. Neuropharmacology. 36:1997;265-267.
11. Gasparini, F., Lingenhoehl, K., Flor, P.J., Munier, N., Heinrich, M., Vranesic, I., et al., 1999. Methyphenylethynylpyridine (MPEP): a novel potent, subtype-selective and systemically active antagonist at metabotropic glutamate receptor subtype 5. British Pharmacological Society Winter Meeting, Brighton, UK.
12. Ito I., Kohda A., Tanabe S., Hirose E., Hayashi M., Mitsunaga S.et al. 3,5-Dihydroxyphenyl-glycine: a potent agonist of metabotropic glutamate receptors. Neuroreport. 3:1992;1013-1016.
13. Kingston A.E., Ornstein P.L., Wright R.A., Johnson B.G., Mayne N.G., Burnett J.P.et al. LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors. Neuropharmacology. 37:1998;1-12.
14. 2+-sensing function of the metabotropic glutamate receptors. Science. 279:1998;1722-1725.
15. Laurie D.J., Danzeisen M., Boddeke H.W.G.M., Sommer B. Ligand binding profile of the rat metabotropic glutamate receptor mGluR3 expressed in a transfected cell line. Naunyn-Schmiedeberg's Archives of Pharmacology. 351:1995;565-568.
16. Litschig S., Gasparini F., Rueegg D., Stoehr N., Flor P.J., Vranesic I.et al. CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding. Molecular Pharmacology. 55:1999;453-461.
17. Lundstrom K., Mills A., Buell G., Allet E., Adami N., Liljeström P. High-level expression of the human neurokinin-1 receptor in mammalian cell lines using the Semliki Forest virus expression system. European Journal of Biochemistry. 224:1994;917-921.
18. Malherbe P., Kratzeisen C., Lundstrom K., Richards J.G., Mutel V. Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8. Molecular Brain Research. 67:1999;201-210.
19. 2+ ion. Biochimica et Biophysica Acta. 1220:1993;76-84.
20. Perez-Clausell J., Danscher G. Intravesicular localization of zinc in rat telencephalic boutons: a histochemical study. Brain Research. 337:1985;91-98.
21. 3H]LY354740 radioautography. Society for Neuroscience Meeting, Los Angeles, USA.
22. Salt T.E., Turner J.P. Reduction of sensory and metabotropic glutamate receptor responses in the thalamus by the novel metabotropic glutamate receptor-1-selective antagonist S-2-methyl-4-carboxy-phenylglycine. Neuroscience. 85:1998;655-658.
23. 3H]LY354740, in rat brain. Molecular Pharmacology. 53:1998;228-233.
24. Schlaeger E.-J., Lundstrom K. Effect of temperature on recombinant protein expression in Semliki Forest virus infected mammalian cell lines grown in serum-free suspension cultures. Cytotechnology. 28:1999;205-211.
25. Schoepp D.D., Johnson B.G., Wright R.A., Salhoff C.R., Mayne N.G., Wu S.et al. LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors. Neuropharmacology. 36:1997;1-11.
26. Tanabe Y., Masu M., Ishii T., Shigemoto R., Nakanishi S. A family of metabotropic glutamate receptors. Neuron. 8:1992;169-179.
27. Tanabe Y., Nomura A., Masu N., Shigemoto R., Nakanishi S. Signal transduction, pharmacological properties, and expression of two rat metabotropic glutamate receptors, mGluR3 and mGluR4a. Journal of Neuroscience. 13:1993;1372-1378.
28. Toms N.J., Jane D.E., Kemp M.C., Bedingfield J.S., Roberts P.J. The effects of (RS)-alpha-cyclopropyl-4-phosphonophenylglycine ((RS)-CPPG), a potent and selective metabotropic glutamate receptor antagonist. British Journal of Pharmacology. 119:1996;851-854.
29. Wroblewska B., Wroblewski J.T., Pshenichkin S., Surin A., Sullivan S.E., Neale J.H. N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells. Journal of Neurochemistry. 69:1997;174-181.
30. Wu S., Wright R.A., Rockey P.K., Burgett S.G., Arnold J.S., Rosteck P.R. Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression and comparison of pharmacological properties in RGT cells. Molecular Brain Research. 53:1998;88-97.