The discovery and structure-activity relationships of indole-based inhibitors of glutamate carboxypeptidase II

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 24, 2010, Pages 7222-7225

  Grella, Brian ^a   Adams, Jessica ^a   Berry, James F ^b   Delahanty, Greg ^a,b   Ferraris, Dana V ^a,b   Majer, Pavel ^a   Ni, Chiyou ^a   Shukla, Krupa ^b,c   Shuler, Scott A ^b   Slusher, Barbara S ^a,b,c   Stathis, Marigo ^b   Tsukamoto, Takashi ^a,b,c  

^a EISAI INC   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Glutamate carboxypeptidase II; Indole; Inhibitor; Metallopeptidase; Thiol

Indexed keywords

CARBOXYL GROUP; GLUTAMATE CARBOXYPEPTIDASE II INHIBITOR; INDOLE DERIVATIVE; N ACETYLASPARTYLGLUTAMIC ACID;

ARTICLE; DRUG POTENCY; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SUBSTRATE; IC 50; STRUCTURE ACTIVITY RELATION;

DRUG EVALUATION, PRECLINICAL; GLUTAMATE CARBOXYPEPTIDASE II; INDOLES; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78449273601     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.10.109     Document Type: Article

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