Allosteric modulators of NMDA receptors: Multiple sites and mechanisms

Current Opinion in Pharmacology

Volumn 20, Issue , 2015, Pages 14-23

  Zhu, Shujia ^a,b   Paoletti, Pierre ^a  

^a ECOLE NORMALE SUPÉRIEURE   (France)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(3 CHLOROPHENYL) [3,4 DIHYDRO 6,7 DIMETHOXY 1 [(4 METHOXYPHENOXY)METHYL] 2(1H) ISOQUINOLINYL]METHANONE; 3 CHLORO 4 FLUORO N [[4 [[(2 PHENYLCARBONYL)HYDRAZINO]CARBONYL]PHENYL]METHYL]BENZENESULFONAMIDE; 4 BENZYL ALPHA (4 HYDROXYPHENYL) BETA METHYL 1 PIPERIDINEPROPANOL; 4 [5 (4 BROMOPHENYL) 3 (6 METHYL 2 OXO 4 PHENYL 1,2 DIHYDROQUINOLIN 3 YL) 4,5 DIHYDRO 1H PYRAZOL 1 YL] 4 OXOBUTANOIC ACID; 4 [6 METHOXY 2 (3 NITROSTYRYL) 4 OXOQUINAZOLIN 3(4H) YL]BENZOIC ACID; AMPA RECEPTOR AGONIST; CYCLOTHIAZIDE; IFENPRODIL; N (CYCLOHEXYLMETHYL) 2 [[5 [(PHENYLMETHYL)AMINO] 1,3,4 THIADIAZOL 2 YL]THIO]ACETAMIDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2C; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2D; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT; PREGNENOLONE SULFATE; SPERMIDINE; SPERMINE; UBP 512; UBP 551; UBP 608; UBP 710; UNCLASSIFIED DRUG;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ARTICLE; BRAIN FUNCTION; BRAIN REGION; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG TARGETING; IC50; LIGAND BINDING; MOLECULAR DYNAMICS; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY; BINDING SITE; BRAIN; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; HUMAN; METABOLISM; MOLECULARLY TARGETED THERAPY; NERVE CELL PLASTICITY; NERVOUS SYSTEM DISEASES; PATHOPHYSIOLOGY; PHYSIOLOGY;

ALLOSTERIC REGULATION; BINDING SITES; BRAIN; DRUG DESIGN; HUMANS; MOLECULAR TARGETED THERAPY; NERVOUS SYSTEM DISEASES; NEURONAL PLASTICITY; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 84909947167     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2014.10.009     Document Type: Review

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