Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists

Journal of Medicinal Chemistry

Volumn 53, Issue 15, 2010, Pages 5476-5490

  Mosley, Cara A ^a   Acker, Timothy M ^a,b   Hansen, Kasper B ^b   Mullasseril, Praseeda ^b   Andersen, Karen T ^b,c   Le, Phuong ^b   Vellano, Kimberly M ^b   Bräuner Osborne, Hans ^c   Liotta, Dennis C ^a   Traynelis, Stephen F ^b  

^a EMORY UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 CHLOROPHENYL) 2 [2 (6 DIETHYLAMINOMETHYLPYRIDIN 2 YL)VINYL] 6 FLUORO 3H QUINAZOLIN 4 ONE; AMPA RECEPTOR; CP 465022; KAINIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; QUINAZOLINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; RECEPTOR BLOCKING;

ANIMALS; BINDING SITES; FEMALE; MODELS, MOLECULAR; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN SUBUNITS; QUINAZOLINONES; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 77955365676     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100027p     Document Type: Article

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