Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators

Molecular Pharmacology

Volumn 80, Issue 5, 2011, Pages 782-795

  Acker, Timothy M ^a,b   Yuan, Hongjie ^b   Hansen, Kasper B ^b   Vance, Katie M ^b   Ogden, Kevin K ^b   Jensen, Henrik S ^c   Burger, Pieter B ^a   Mullasseril, Praseeda ^b   Snyder, James P ^a   Liotta, Dennis C ^a   Traynelis, Stephen F ^b  

^a EMORY UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c H LUNDBECK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

4 [5 (4 BROMOPHENYL) 3 (6 METHYL 2 OXO 4 HENYL 1,2 DIHYDROQUINOLIN 3 YL) 4,5 DIHYDRO 1H PYRAZOL 1 YL] 4 OXOBUTANOIC ACID; DQP 1105; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG INHIBITION; DRUG MECHANISM; HUMAN; HUMAN CELL; IC 50; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELLS, CULTURED; CRICETINAE; DNA, COMPLEMENTARY; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; HUMANS; PATCH-CLAMP TECHNIQUES; PYRAZOLES; QUINOLONES; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80054781460     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.111.073239     Document Type: Article

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