Synthesis and structure activity relationship of tetrahydroisoquinoline- based potentiators of GluN2C and GluN2D containing N-Methyl-D-aspartate receptors

Journal of Medicinal Chemistry

Volumn 56, Issue 13, 2013, Pages 5351-5381

  Santangelo Freel, Rose M ^a   Ogden, Kevin K ^b   Strong, Katie L ^a   Khatri, Alpa ^b   Chepiga, Kathryn M ^a   Jensen, Henrik S ^c   Traynelis, Stephen F ^b   Liotta, Dennis C ^a  

^a EMORY UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c H LUNDBECK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

((3 CHLOROPHENYL)[1 [[4 (DIMETHYLAMINO)PHENOXY]METHYL] 6,7 DIMETHOXY 3,4 DIHYDROISOQUINOLIN 2(1H) YL]METHANONE; (3 BROMOPHENYL)[1 [(4 ETHOXYPHENOXY)METHYL] 6,7 DIMETHOXY 3,4 DIHYDROISOQUINOLIN 2(1H) YL]METHANONE; (3 BROMOPHENYL)[6,7 DIMETHOXY 3,4 DIHYDROISOQUINOLIN 2(1H) YL]METHANON; (3 BROMOPHENYL)[6,8 DIMETHOXY 1 [(4 METHOXYPHENOXY)METHYL] 3,4 DIHYDROISOQUINOLIN 2(1H) YL]METHANONE; (3 CHLOROPHENYL)[1 [(4 ETHOXYPHENOXY)METHYL] 6,7 DIMETHOXY 3,4 DIHYDROISOQUINOLIN 2(1H) YL]METHANONE; (3 CHLOROPHENYL)[6,7 DIMETHOXY 1 [(2 METHOXYPHENOXY)METHYL] 3,4 DIHYDROISOQUINOLIN 2(1H) YL]METHANONE; (3 CHLOROPHENYL)[6,7 DIMETHOXY 1 [[4 (METHYLTHIO)PHENOXY]METHYL] 3,4 DIHYDROISOQUINOLINE 2(1H) YL]METHANONE; (3 CHLOROPHENYL)[6,7 DIMETHOXY 3,4 DIHYDROISOQUINOLIN 2(1H) YL]METHANONE; (3 CHLOROPHENYL)[6,8 DIMETHOXY 1 [(4 METHOXYPHENOXY)METHYL] 3,4 DIHYDROISOQUINOL 2(1H) YL]METHANONE; 1 [3 [6,7 DIMETHOXY 1 [(4 METHOXYPHENOXY)METHYL] 1,2,3,4 TETRAISOQUINOLINE 2 CARBONYL]PHENYL]ETHANONE; 3 [6,7 DIMETHOXY1 [(4 METHOXYPHENOXY)METHYL] 1,2,3,4 TETRAHYDROISOQUINOLINE 2 CARBONYL]BENZONITRILE; 6,7 DIMETHOXY 1 (PHENOXYMETHYL) 3,4 DIHYDROISOQUINOLIN 2(1H) YL(PHENYL)METHANONE; [(3 BROMOPHENYL)[1 [[4 (DIMETHYLAMINO)PHENOXY]METHYL] 6,7 DIMETHOXY 3,4 DIHYDROIISOQUINOLIN 2(1H) YL]METHANONE; [1 [(4 (DIMETHYLAMINO)PHENOXY]METHYL] 6,7 DIMETHOX 3,4 DIHYDROISOQUINOLIN 2(1H) YL](PHENYL)METHANONE; [1 [[4 (BENZYLOXY)PHENOXY]METHYL] 6,7 DIMETHOXY 3,4 DIHYDROISOQUINOLIN 2(1H) YL](3 CHLOROPHENYL)METHANONE; [6 (BENZYLOXY) 1 [(4 METHOXYPHENOXY)METHYL] 3,4 DIHYDROISOQUINOLIN 2(1H) YL](3 BROMOPHENYL)METHANON; [6 (BENZYLOXY) 1 [(4 METHOXYPHENOXY)METHYL] 3,4 DIHYDROISOQUINOLIN 2(1H) YL](3 CHLOROPHENYL)METHANONE; [6 (BENZYLOXY) 1 [(4 METHOXYPHENOXY)METHYL] 3,4 DIHYDROISOQUINOLIN 2(1H) YL](PHENYL)METHANONE; [6,7 DIMETHOXY 1 [(3 METHOXYPHENOXY)METHYL] 3,4 DIHYDROISOQUINOLIN 2(1H) YL](PHEYL)METHANONE; [6,7 DIMETHOXY 1 [(4 (METHYLTHIO)PHENOXY]METHYL] 3,4 DIHYDROISOQUINOLIN 2(1H) YL](PHENYL)METHANONE; [6,7 DIMETHOXY 1 [(4 METHOXYPHENOXY)METHYL] 3,4 DIHYDROISOQUINOLIN 2(1H) YL](3 HYDROXYPHENYL)METHANONE; [6,7 DIMETHOXY 1 [(4 METHOXYPHENOXY)METHYL] 3,4 DIHYDROISOQUINOLIN 2(1H) YL](3 IODOPHENYL]METHANONE; [6,7 DIMETHOXY 1 [(4 METHOXYPHENOXY)METHYL] 3,4 DIHYDROISOQUINOLIN 2(1H) YL](3 NITROPHENYL )METHANONE; [6,7 DIMETHOXY 3,4 DIHYDROISOQUINOLIN 2(1H) YL](PHENYL)METHANONE; BINDING PROTEIN; GLUN2C PROTEIN; GLUN2D PROTEIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG SCREENING; DRUG SYNTHESIS; DRUG TARGETING; FEMALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; RAT; STRUCTURE ACTIVITY RELATION; VOLTAGE CLAMP; XENOPUS LAEVIS;

ANIMALS; CELL LINE; EXCITATORY AMINO ACID AGONISTS; FEMALE; GLUTAMIC ACID; GLYCINE; MEMBRANE POTENTIALS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; OOCYTES; PROTEIN SUBUNITS; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROISOQUINOLINES; XENOPUS LAEVIS;

EID: 84880159894     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400177t     Document Type: Article

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