Inhibition of GluN2A-containing N-methyl-D-aspartate receptors by 2-naphthoic acid

Molecular Pharmacology

Volumn 84, Issue 4, 2013, Pages 541-550

  Yu, Han ^a   Popescu, Gabriela K ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 NAPHTHOIC ACID; GLUN2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG; 2-NAPHTHOIC ACID; AMINO ACID RECEPTOR BLOCKING AGENT; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N-METHYL D-ASPARTATE RECEPTOR SUBTYPE 2A; NAPHTHALENE DERIVATIVE;

ALLOSTERISM; ARTICLE; CELL STRAIN HEK293; EMBRYO; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LIGAND BINDING; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; REACTION ANALYSIS; SYNAPTIC TRANSMISSION; WHOLE CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; DOSE RESPONSE; HEK293 CELL LINE; PHYSIOLOGY; RAT;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; HEK293 CELLS; HUMANS; NAPHTHALENES; RATS; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 84884685295     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.113.087189     Document Type: Article

References (52)

1. Acker T, Yuan H, Hansen KB, Vance KM, Ogden KK, Jensen HS, Burger PB, Mullasseril P, Snyder JP, and Liotta DC, et al. (2011) Mechanism for non-competitive inhibition by novel GluN2C/D NMDA receptor subunit-selective modulators. Mol Pharmacol 80:782-795.
2. Albers GW, Clark WM, Atkinson RP, Madden K, Data JL, and Whitehouse MJ (1999) Dose escalation study of the NMDA glycine-site antagonist licostinel in acute ischemic stroke. Stroke 30:508-513. (Pubitemid 29115384)
3. Amico-Ruvio SA and Popescu GK (2010) Stationary gating of GluN1/GluN2B receptors in intact membrane patches. Biophys J 98:1160-1169.
4. Amico-Ruvio SA, Murthy SE, Smith TP, and Popescu GK (2011) Zinc effects on NMDA receptor gating kinetics. Biophys J 100:1910-1918.
5. Amico-Ruvio SA, Paganelli MA, Myers JM, and Popescu GK (2012) Ifenprodil effects on GluN2B-containing glutamate receptors. Mol Pharmacol 82:1074-1081.
6. Banke TG and Traynelis SF (2003) Activation of NR1/NR2B NMDA receptors. Nat Neurosci 6:144-152. (Pubitemid 36182783)
7. Bell KF and Hardingham GE (2011) The influence of synaptic activity on neuronal health. Curr Opin Neurobiol 21:299-305.
8. Bettini E, Sava A, Griffante C, Carignani C, Buson A, Capelli AM, Negri M, Andreetta F, Senar-Sancho SA, and Guiral L et al. (2010) Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors. J Pharmacol Exp Ther 335:636-644.
9. Bliss TV, Collingridge GL, and Morris RG (2003) Introduction. Long-term potentiation and structure of the issue. Philos Trans R Soc Lond B Biol Sci 358:607-611. (Pubitemid 36536686)
10. Borschel WF, Murthy SE, Kasperek EM, and Popescu GK (2011) NMDA receptor activation requires remodelling of intersubunit contacts within ligand-binding heterodimers. Nat Commun 2:498.
11. Brickley SG, Misra C, Mok MH, Mishina M, and Cull-Candy SG (2003) NR2B and NR2D subunits coassemble in cerebellar Golgi cells to form a distinct NMDA receptor subtype restricted to extrasynaptic sites. J Neurosci 23:4958-4966. (Pubitemid 36793222)
12. Cameron K, Bartle E, Roark R, Fanelli D, Pham M, Pollard B, Borkowski B, Rhoads S, Kim J, Rocha M, Kahlson M, Kangala M, and Gentile L (2012) Neurosteroid binding to the amino terminal and glutamate binding domains of ionotropic glutamate receptors. Steroids 77 :774-779.
13. Clements JD (1996) Transmitter timecourse in the synaptic cleft: its role in central synaptic function. Trends Neurosci 19:163-171.
14. Costa BM, Irvine MW, Fang G, Eaves RJ, Mayo-Martin MB, Laube B, Jane DE, and Monaghan DT (2012) Structure-activity relationships for allosteric NMDA receptor inhibitors based on 2-naphthoic acid. Neuropharmacology 62:1730-1736.
15. Costa BM, Irvine MW, Fang G, Eaves RJ, Mayo-Martin MB, Skifter DA, Jane DE, and Monaghan DT (2010) A novel family of negative and positive allosteric modulators of NMDA receptors. J Pharmacol Exp Ther 335:614-621.
16. Davis SM, Lees KR, Albers GW, Diener HC, Markabi S, Karlsson G, and Norris J (2000) Selfotel in acute ischemic stroke : possible neurotoxic effects of an NMDA antagonist. Stroke 31:347-354. (Pubitemid 30078164)
17. Erreger K, Dravid SM, Banke TG, Wyllie DJ, and Traynelis SF (2005) Subunitspecific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles. J Physiol 563:345-358. (Pubitemid 40360896)
18. Hansen KB and Traynelis SF (2011) Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors. J Neurosci 31:3650-3661.
19. Hardingham GE and Bading H (2002) Coupling of extrasynaptic NMDA receptors to a CREB shut-off pathway is developmentally regulated. Biochim Biophys Acta 1600:148-153. (Pubitemid 38224409)
20. Hardingham GE and Bading H (2003) The Yin and Yang of NMDA receptor signalling. Trends Neurosci 26:81-89. (Pubitemid 36110542)
21. Hardingham GE and Bading H (2010) Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders. Nat Rev Neurosci 11:682-696.
22. Hardingham GE, Fukunaga Y, and Bading H (2002) Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat Neurosci 5:405-414. (Pubitemid 34454245)
23. Kaufman AM, Milnerwood AJ, Sepers MD, Coquinco A, She K, Wang L, Lee H, Craig AM, Cynader M, and Raymond LA (2012) Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons. J Neurosci 32:3992-4003.
24. Korn SJ and Horn R (1991) Electrophysiology and microinjection; discrimination of kinetic models of ion channel gating, in Methods in Neurosciences Vol 4 (Conn MP ed) pp 428-456, Academic Press, San Diego, CA.
25. Kussius CL, Kaur N, and Popescu GK (2009) Pregnanolone sulfate promotes desensitization of activated NMDA receptors. J Neurosci 29:6819-6827.
26. Lau D and Bading H (2009) Synaptic activity-mediated suppression of p53 and induction of nuclear calcium-regulated neuroprotective genes promote survival through inhibition of mitochondrial permeability transition. J Neurosci 29: 4420-4429.
27. Léveillé F, Papadia S, Fricker M, Bell KF, Soriano FX, Martel MA, Puddifoot C, Habel M, Wyllie DJ, and Ikonomidou C, et al. (2010) Suppression of the intrinsic apoptosis pathway by synaptic activity. J Neurosci 30:2623-2635.
28. Lipton SA and Rosenberg PA (1994) Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med 330:613-622.
29. Lozovaya NA, Grebenyuk SE, Tsintsadze TSh, Feng B, Monaghan DT, and Krishtal OA (2004) Extrasynaptic NR2B and NR2D subunits of NMDA receptors shape 'superslow' afterburst EPSC in rat hippocampus. J Physiol 558:451-463. (Pubitemid 39117594)
30. Metman LV, Konitsiotis S, and Chase TN (2000) Pathophysiology of motor response complications in Parkinson's disease: hypotheses on the why, where, and what. Mov Disord 15:3-8. (Pubitemid 30037981)
31. Momiyama A (2000) Distinct synaptic and extrasynaptic NMDA receptors identified in dorsal horn neurones of the adult rat spinal cord. J Physiol 523:621-628.
32. Morris GF, Bullock R, Marshall SB, Marmarou A, Maas A, and Marshall LF; The Selfotel Investigators (1999) Failure of the competitive N-methyl-D-aspartate antagonist Selfotel (CGS 19755) in the treatment of severe head injury: results of two phase III clinical trials. J Neurosurg 91:737-743. (Pubitemid 30053144)
33. Mosley CA, Acker TM, Hansen KB, Mullasseril P, Andersen KT, Le P, Vellano KM, Bräuner-Osborne H, Liotta DC, and Traynelis SF (2010) Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-Daspartate receptor antagonists. J Med Chem 53:5476-5490.
34. Muir KW(2006) Glutamate-based therapeutic approaches: clinical trials with NMDA antagonists. Curr Opin Pharmacol 6:53-60.
35. Nowak L, Bregestovski P, Ascher P, Herbet A, and Prochiantz A (1984) Magnesium gates glutamate-activated channels in mouse central neurones. Nature 307: 462-465. (Pubitemid 14132062)
36. Ogden KK and Traynelis SF (2011) New advances in NMDA receptor pharmacology. Trends Pharmacol Sci 32:726-733.
37. Paoletti P, Ascher P, and Neyton J (1997) High-affinity zinc inhibition of NMDA NR1-NR2A receptors. J Neurosci 17:5711-5725. (Pubitemid 27310487)
38. Papadia S, Soriano FX, Léveillé F, Martel MA, Dakin KA, Hansen HH, Kaindl A, Sifringer M, Fowler J, and Stefovska V, et al. (2008) Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses. Nat Neurosci 11:476-487. (Pubitemid 351441886)
39. Petralia RS, Wang YX, Hua F, Yi Z, Zhou A, Ge L, Stephenson FA, and Wenthold RJ (2010) Organization of NMDA receptors at extrasynaptic locations. Neuroscience 167:68-87.
40. Popescu G (2005) Mechanism-based targeting of NMDA receptor functions. Cell Mol Life Sci 62:2100-2111.
41. Popescu G and Auerbach A (2003) Modal gating of NMDA receptors and the shape of their synaptic response. Nat Neurosci 6:476-483. (Pubitemid 36514695)
42. Popescu G and Auerbach A (2004) The NMDA receptor gating machine: lessons from single channels. Neuroscientist 10:192-198. (Pubitemid 38657087)
43. Popescu G, Robert A, Howe JR, and Auerbach A (2004) Reaction mechanism determines NMDA receptor response to repetitive stimulation. Nature 430:790-793. (Pubitemid 39071350)
44. Qin F, Auerbach A, and Sachs F (1997) Maximum likelihood estimation of aggregated Markov processes. Proc Biol Sci 264:375-383. (Pubitemid 27144045)
45. Qin F, Auerbach A, and Sachs F (2000) A direct optimization approach to hidden Markov modeling for single channel kinetics. Biophys J 79:1915-1927.
46. Rothman SM and Olney JW (1986) Glutamate and the pathophysiology of hypoxic-ischemic brain damage. Ann Neurol 19:105-111. (Pubitemid 16114163)
47. Schorge S, Elenes S, and Colquhoun D (2005) Maximum likelihood fitting of single channel NMDA activity with a mechanism composed of independent dimers of subunits. J Physiol 569:395-418. (Pubitemid 41830110)
48. Stark DT and Bazan NG (2011) Synaptic and extrasynaptic NMDA receptors differentially modulate neuronal cyclooxygenase-2 function, lipid peroxidation, and neuroprotection. J Neurosci 31:13710-13721.
49. Traynelis SF and Cull-Candy SG (1990) Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons. Nature 345:347-350.
50. Traynelis SF, Wollmuth LP, McBain CJ, Menniti FS, Vance KM, Ogden KK, Hansen KB, Yuan H, Myers SJ, and Dingledine R (2010) Glutamate receptor ion channels: structure, regulation, and function. Pharmacol Rev 62:405-496.
51. Wyllie DJ, Livesey MR, and Hardingham GE (2013) Influence of GluN2 subunit identity on NMDA receptor function. Neuropharmacology DOI: 10.1016/j.neuropharm.2013.01.016 [published ahead of print].
52. Zhang W, Howe JR, and Popescu GK (2008) Distinct gating modes determine the biphasic relaxation of NMDA receptor currents. Nat Neurosci 11:1373-1375.