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Volumn 14, Issue 8, 2011, Pages 1017-1022

Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit

Author keywords

[No Author keywords available]

Indexed keywords

CAPSAICIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; ZINC CHLORIDE;

EID: 79960837047     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/nn.2844     Document Type: Article
Times cited : (103)

References (49)
  • 1
    • 34247137277 scopus 로고    scopus 로고
    • Zinc deficiency: A special challenge
    • Hambidge, K.M. & Krebs, N.F. Zinc deficiency: a special challenge. J. Nutr. 137, 1101-1105 (2007). (Pubitemid 46596920)
    • (2007) Journal of Nutrition , vol.137 , Issue.4 , pp. 1101-1105
    • Hambidge, K.M.1    Krebs, N.F.2
  • 3
    • 0033712121 scopus 로고    scopus 로고
    • The actions of synaptically released zinc at hippocampal mossy fiber synapses
    • Vogt, K., Mellor, J., Tong, G. & Nicoll, R. The actions of synaptically released zinc at hippocampal mossy fiber synapses. Neuron 26, 187-196 (2000).
    • (2000) Neuron , vol.26 , pp. 187-196
    • Vogt, K.1    Mellor, J.2    Tong, G.3    Nicoll, R.4
  • 4
    • 0035544396 scopus 로고    scopus 로고
    • The effects of Zn2+ on long-term potentiation of C fiber-evoked potentials in the rat spinal dorsal horn
    • Ma, J.Y. & Zhao, Z.Q. The effects of Zn2+ on long-term potentiation of C fiber-evoked potentials in the rat spinal dorsal horn. Brain Res. Bull. 56, 575-579 (2001).
    • (2001) Brain Res. Bull. , vol.56 , pp. 575-579
    • Ma, J.Y.1    Zhao, Z.Q.2
  • 5
    • 0037157834 scopus 로고    scopus 로고
    • Mossy fiber Zn2+ spillover modulates heterosynaptic N-methyl-D-aspartate receptor activity in hippocampal CA3 circuits
    • Ueno, S. et al. Mossy fiber Zn2+ spillover modulates heterosynaptic N-methyl-D-aspartate receptor activity in hippocampal CA3 circuits. J. Cell Biol. 158, 215-220 (2002).
    • (2002) J. Cell Biol. , vol.158 , pp. 215-220
    • Ueno, S.1
  • 7
    • 33750978141 scopus 로고    scopus 로고
    • 2+ as an Essential Endogenous Modulator of Glycinergic Neurotransmission
    • DOI 10.1016/j.neuron.2006.09.035, PII S0896627306007732
    • Hirzel, K. et al. Hyperekplexia phenotype of glycine receptor alpha1 subunit mutant mice identifies Zn(2+) as an essential endogenous modulator of glycinergic neurotransmission. Neuron 52, 679-690 (2006). (Pubitemid 44750561)
    • (2006) Neuron , vol.52 , Issue.4 , pp. 679-690
    • Hirzel, K.1    Muller, U.2    Latal, A.T.3    Hulsmann, S.4    Grudzinska, J.5    Seeliger, M.W.6    Betz, H.7    Laube, B.8
  • 9
    • 0033559447 scopus 로고    scopus 로고
    • The distribution of zinc selenite and expression of metallothionein-III mRNA in the spinal cord and dorsal root ganglia of the rat suggest a role for zinc in sensory transmission
    • Velázquez, R.A., Cai, Y., Shi, Q. & Larson, A.A. The distribution of zinc selenite and expression of metallothionein-III mRNA in the spinal cord and dorsal root ganglia of the rat suggest a role for zinc in sensory transmission. J. Neurosci. 19, 2288-2300 (1999). (Pubitemid 29133404)
    • (1999) Journal of Neuroscience , vol.19 , Issue.6 , pp. 2288-2300
    • Velazquez, R.A.1    Cai, Y.2    Shi, Q.3    Larson, A.A.4
  • 10
    • 41049101009 scopus 로고    scopus 로고
    • Depletion of vesicular zinc in dorsal horn of spinal cord causes increased neuropathic pain in mice
    • DOI 10.1007/s10534-007-9103-x
    • Jo, S.M., Danscher, G., Schroder, H.D. & Suh, S.W. Depletion of vesicular zinc in dorsal horn of spinal cord causes increased neuropathic pain in mice. Biometals 21, 151-158 (2008). (Pubitemid 351421983)
    • (2008) BioMetals , vol.21 , Issue.2 , pp. 151-158
    • Jo, S.M.1    Danscher, G.2    Schroder, H.D.3    Suh, S.W.4
  • 11
    • 4544236080 scopus 로고    scopus 로고
    • 2+ ions: Modulators of excitatory and inhibitory synaptic activity
    • DOI 10.1177/1073858404263463
    • Smart, T.G., Hosie, A.M. & Miller, P.S. Zn2+ ions: modulators of excitatory and inhibitory synaptic activity. Neuroscientist 10, 432-442 (2004). (Pubitemid 39244580)
    • (2004) Neuroscientist , vol.10 , Issue.5 , pp. 432-442
    • Smart, T.G.1    Hosie, A.M.2    Miller, P.S.3
  • 12
    • 20144377557 scopus 로고    scopus 로고
    • The neurobiology of zinc in health and disease
    • DOI 10.1038/nrn1671
    • Frederickson, C.J., Koh, J.Y. & Bush, A.I. The neurobiology of zinc in health and disease. Nat. Rev. Neurosci. 6, 449-462 (2005). (Pubitemid 40774861)
    • (2005) Nature Reviews Neuroscience , vol.6 , Issue.6 , pp. 449-462
    • Frederickson, C.J.1    Koh, J.-Y.2    Bush, A.I.3
  • 14
    • 77952363301 scopus 로고    scopus 로고
    • Glutamate receptor ion channels: Structure, regulation, and function
    • Traynelis, S.F. et al. Glutamate receptor ion channels: structure, regulation, and function. Pharmacol. Rev. 62, 405-496 (2010).
    • (2010) Pharmacol. Rev. , vol.62 , pp. 405-496
    • Traynelis, S.F.1
  • 15
    • 0034625770 scopus 로고    scopus 로고
    • Neuronal plasticity: Increasing the gain in pain
    • Woolf, C.J. & Salter, M.W. Neuronal plasticity: increasing the gain in pain. Science 288, 1765-1769 (2000).
    • (2000) Science , vol.288 , pp. 1765-1769
    • Woolf, C.J.1    Salter, M.W.2
  • 16
    • 68949189686 scopus 로고    scopus 로고
    • Central sensitization: A generator of pain hypersensitivity by central neural plasticity
    • Latremoliere, A. & Woolf, C.J. Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J. Pain 10, 895-926 (2009).
    • (2009) J. Pain , vol.10 , pp. 895-926
    • Latremoliere, A.1    Woolf, C.J.2
  • 17
    • 0030746608 scopus 로고    scopus 로고
    • High-affinity zinc inhibition of NMDA NR1-NR2A receptors
    • Paoletti, P., Ascher, P. & Neyton, J. High-affinity zinc inhibition of NMDA NR1-NR2A receptors. J. Neurosci. 17, 5711-5725 (1997). (Pubitemid 27310487)
    • (1997) Journal of Neuroscience , vol.17 , Issue.15 , pp. 5711-5725
    • Paoletti, P.1    Ascher, P.2    Neyton, J.3
  • 18
    • 0034517709 scopus 로고    scopus 로고
    • Molecular organization of a zinc binding N-terminal modulatory domain in a NMDA receptor subunit
    • DOI 10.1016/S0896-6273(00)00163-X
    • Paoletti, P. et al. Molecular organization of a zinc binding n-terminal modulatory domain in a NMDA receptor subunit. Neuron 28, 911-925 (2000). (Pubitemid 32038081)
    • (2000) Neuron , vol.28 , Issue.3 , pp. 911-925
    • Paoletti, P.1    Perin-Dureau, F.2    Fayyazuddin, A.3    Le Goff, A.4    Callebaut, I.5    Neyton, J.6
  • 19
    • 0033697745 scopus 로고    scopus 로고
    • Four residues of the extracellular N-terminal domain of the NR2A subunit control high-affinity Zn2+ binding to NMDA receptors
    • Fayyazuddin, A., Villarroel, A., Le Goff, A., Lerma, J. & Neyton, J. Four residues of the extracellular N-terminal domain of the NR2A subunit control high-affinity Zn2+ binding to NMDA receptors. Neuron 25, 683-694 (2000).
    • (2000) Neuron , vol.25 , pp. 683-694
    • Fayyazuddin, A.1    Villarroel, A.2    Le Goff, A.3    Lerma, J.4    Neyton, J.5
  • 20
    • 0034718494 scopus 로고    scopus 로고
    • Molecular determinants of coordinated proton and zinc inhibition of N-methyl-D-aspartate NR1/NR2A receptors
    • Low, C.M., Zheng, F., Lyuboslavsky, P. & Traynelis, S.F. Molecular determinants of coordinated proton and zinc inhibition of N-methyl-D-aspartate NR1/NR2A receptors. Proc. Natl. Acad. Sci. USA 97, 11062-11067 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 11062-11067
    • Low, C.M.1    Zheng, F.2    Lyuboslavsky, P.3    Traynelis, S.F.4
  • 21
    • 66649086928 scopus 로고    scopus 로고
    • Mechanism of differential control of NMDA receptor activity by NR2 subunits
    • Gielen, M., Siegler Retchless, B., Mony, L., Johnson, J.W. & Paoletti, P. Mechanism of differential control of NMDA receptor activity by NR2 subunits. Nature 459, 703-707 (2009).
    • (2009) Nature , vol.459 , pp. 703-707
    • Gielen, M.1    Siegler Retchless, B.2    Mony, L.3    Johnson, J.W.4    Paoletti, P.5
  • 24
    • 70349845440 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of pain
    • Basbaum, A.I., Bautista, D.M., Scherrer, G. & Julius, D. Cellular and molecular mechanisms of pain. Cell 139, 267-284 (2009).
    • (2009) Cell , vol.139 , pp. 267-284
    • Basbaum, A.I.1    Bautista, D.M.2    Scherrer, G.3    Julius, D.4
  • 25
    • 0030275438 scopus 로고    scopus 로고
    • Nociceptive responses to high and low rates of noxious cutaneous heating are mediated by different nociceptors in the rat: Behavioral evidence
    • DOI 10.1016/S0304-3959(96)03176-4, PII S0304395996031764
    • Yeomans, D.C., Pirec, V. & Proudfit, H.K. Nociceptive responses to high and low rates of noxious cutaneous heating are mediated by different nociceptors in the rat: behavioral evidence. Pain 68, 133-140 (1996). (Pubitemid 126407765)
    • (1996) Pain , vol.68 , Issue.1 , pp. 133-140
    • Yeomans, D.C.1    Pirec, V.2    Proudfit, H.K.3
  • 27
    • 45549094263 scopus 로고    scopus 로고
    • Long-term potentiation at C-fibre synapses by low-level presynaptic activity in vivo
    • Drdla, R. & Sandkuhler, J. Long-term potentiation at C-fibre synapses by low-level presynaptic activity in vivo. Mol. Pain 4, 18 (2008).
    • (2008) Mol. Pain , vol.4 , pp. 18
    • Drdla, R.1    Sandkuhler, J.2
  • 28
    • 72849134291 scopus 로고    scopus 로고
    • Parathyroid hormone 2 receptor is a functional marker of nociceptive myelinated fibers responsible for neuropathic pain
    • Matsumoto, M., Kondo, S., Usdin, T.B. & Ueda, H. Parathyroid hormone 2 receptor is a functional marker of nociceptive myelinated fibers responsible for neuropathic pain. J. Neurochem. 112, 521-530 (2010).
    • (2010) J. Neurochem. , vol.112 , pp. 521-530
    • Matsumoto, M.1    Kondo, S.2    Usdin, T.B.3    Ueda, H.4
  • 29
    • 0042267829 scopus 로고    scopus 로고
    • 2 release and thermal hyperalgesia
    • DOI 10.1097/00001756-200306110-00010
    • Svensson, C.I., Hua, X.Y., Protter, A.A., Powell, H.C. & Yaksh, T.L. Spinal p38 MAP kinase is necessary for NMDA-induced spinal PGE(2) release and thermal hyperalgesia. Neuroreport 14, 1153-1157 (2003). (Pubitemid 36930264)
    • (2003) NeuroReport , vol.14 , Issue.8 , pp. 1153-1157
    • Svensson, C.I.1    Hua, X.-Y.2    Protter, A.A.3    Powell, H.C.4    Yaksh, T.L.5
  • 31
    • 61749090102 scopus 로고    scopus 로고
    • COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice
    • Vardeh, D. et al. COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice. J. Clin. Invest. 119, 287-294 (2009).
    • (2009) J. Clin. Invest. , vol.119 , pp. 287-294
    • Vardeh, D.1
  • 33
    • 0030886842 scopus 로고    scopus 로고
    • Manipulations of zinc in the spinal cord, by intrathecal injection of zinc chloride, disodium-calcium-EDTA, or dipicolinic acid, alter nociceptive activity in mice
    • Larson, A.A. & Kitto, K.F. Manipulations of zinc in the spinal cord, by intrathecal injection of zinc chloride, disodium-calcium-EDTA, or dipicolinic acid, alter nociceptive activity in mice. J. Pharmacol. Exp. Ther. 282, 1319-1325 (1997). (Pubitemid 27408310)
    • (1997) Journal of Pharmacology and Experimental Therapeutics , vol.282 , Issue.3 , pp. 1319-1325
    • Larson, A.A.1    Kitto, K.F.2
  • 34
    • 0030152117 scopus 로고    scopus 로고
    • Zinc reduces the hyperalgesia and upregulation of NGF and IL-1β produced by peripheral inflammation in the rat
    • DOI 10.1016/0028-3908(96)84630-2
    • Safieh-Garabedian, B. et al. Zinc reduces the hyperalgesia and upregulation of NGF and IL-1 beta produced by peripheral inflammation in the rat. Neuropharmacology 35, 599-603 (1996). (Pubitemid 26306776)
    • (1996) Neuropharmacology , vol.35 , Issue.5 , pp. 599-603
    • Safieh-Garabedian, B.1    Poole, S.2    Allchorne, A.3    Kanaan, S.4    Saade, N.5    Woolf, C.J.6
  • 35
    • 0033553325 scopus 로고    scopus 로고
    • Zinc alleviates thermal hyperalgesia due to partial nerve injury
    • Liu, T., Walker, J.S. & Tracey, D.J. Zinc alleviates thermal hyperalgesia due to partial nerve injury. Neuroreport 10, 1619-1623 (1999). (Pubitemid 29354358)
    • (1999) NeuroReport , vol.10 , Issue.7 , pp. 1619-1623
    • Liu, T.1    Walker, J.S.2    Tracey, D.J.3
  • 36
    • 49649094455 scopus 로고    scopus 로고
    • The relationship between serum trace element levels and clinical parameters in patients with fibromyalgia
    • Sendur, O.F., Tastaban, E., Turan, Y. & Ulman, C. The relationship between serum trace element levels and clinical parameters in patients with fibromyalgia. Rheumatol. Int. 28, 1117-1121 (2008).
    • (2008) Rheumatol. Int. , vol.28 , pp. 1117-1121
    • Sendur, O.F.1    Tastaban, E.2    Turan, Y.3    Ulman, C.4
  • 37
    • 33845927528 scopus 로고    scopus 로고
    • Peripheral neuropathy: Pathogenic mechanisms and alternative therapies
    • Head, K.A. Peripheral neuropathy: pathogenic mechanisms and alternative therapies. Altern. Med. Rev. 11, 294-329 (2006). (Pubitemid 46037130)
    • (2006) Alternative Medicine Review , vol.11 , Issue.4 , pp. 294-329
    • Head, K.A.1
  • 38
    • 77955984277 scopus 로고    scopus 로고
    • Clinical study of tongue pain: Serum zinc, vitamin B12, folic acid, and copper concentrations, and systemic disease
    • Yoshida, H., Tsuji, K., Sakata, T., Nakagawa, A. & Morita, S. Clinical study of tongue pain: Serum zinc, vitamin B12, folic acid, and copper concentrations, and systemic disease. Br. J. Oral Maxillofac. Surg. 48, 469-472 (2010).
    • (2010) Br. J. Oral Maxillofac. Surg. , vol.48 , pp. 469-472
    • Yoshida, H.1    Tsuji, K.2    Sakata, T.3    Nakagawa, A.4    Morita, S.5
  • 39
    • 34547652875 scopus 로고    scopus 로고
    • NMDA di-heteromeric receptor populations and associated proteins in rat hippocampus
    • DOI 10.1523/JNEUROSCI.2155-07.2007
    • Al-Hallaq, R.A., Conrads, T.P., Veenstra, T.D. & Wenthold, R.J. NMDA di-heteromeric receptor populations and associated proteins in rat hippocampus. J. Neurosci. 27, 8334-8343 (2007). (Pubitemid 47219608)
    • (2007) Journal of Neuroscience , vol.27 , Issue.31 , pp. 8334-8343
    • Al-Hallaq, R.A.1    Conrads, T.P.2    Veenstra, T.D.3    Wenthold, R.J.4
  • 40
    • 79953199424 scopus 로고    scopus 로고
    • Triheteromeric NR1/NR2A/NR2B receptors constitute the major N-methyl-D-aspartate (NMDA) receptor population in adult hippocampal synapses
    • Rauner, C. & Kohr, G. Triheteromeric NR1/NR2A/NR2B receptors constitute the major N-methyl-D-aspartate (NMDA) receptor population in adult hippocampal synapses. J. Biol. Chem. 286, 7558-7566 (2010).
    • (2010) J. Biol. Chem. , vol.286 , pp. 7558-7566
    • Rauner, C.1    Kohr, G.2
  • 41
    • 17444426068 scopus 로고    scopus 로고
    • Modulation of triheteromeric NMDA receptors by N-terminal domain ligands
    • DOI 10.1016/j.neuron.2005.03.005
    • Hatton, C.J. & Paoletti, P. Modulation of triheteromeric NMDA receptors by N-terminal domain ligands. Neuron 46, 261-274 (2005). (Pubitemid 40545781)
    • (2005) Neuron , vol.46 , Issue.2 , pp. 261-274
    • Hatton, C.J.1    Paoletti, P.2
  • 42
    • 70350324907 scopus 로고    scopus 로고
    • Allosteric modulators of NR2B-containing NMDA receptors: Molecular mechanisms and therapeutic potential
    • Mony, L., Kew, J.N., Gunthorpe, M.J. & Paoletti, P. Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potential. Br. J. Pharmacol. 157, 1301-1317 (2009).
    • (2009) Br. J. Pharmacol. , vol.157 , pp. 1301-1317
    • Mony, L.1    Kew, J.N.2    Gunthorpe, M.J.3    Paoletti, P.4
  • 43
    • 0035934171 scopus 로고    scopus 로고
    • Inhibitory zinc-enriched terminals in mouse spinal cord
    • DOI 10.1016/S0306-4522(01)00243-3, PII S0306452201002433
    • Danscher, G. et al. Inhibitory zinc-enriched terminals in mouse spinal cord. Neuroscience 105, 941-947 (2001). (Pubitemid 32786807)
    • (2001) Neuroscience , vol.105 , Issue.4 , pp. 941-947
    • Danscher, G.1    Jo, S.M.2    Varea, E.3    Wang, Z.4    Cole, T.B.5    Schroder, H.D.6
  • 44
    • 34247188588 scopus 로고    scopus 로고
    • Understanding LTP in pain pathways
    • Sandkühler, J. Understanding LTP in pain pathways. Mol. Pain 3, 9 (2007).
    • (2007) Mol. Pain , vol.3 , pp. 9
    • Sandkühler, J.1
  • 45
    • 0036792074 scopus 로고    scopus 로고
    • Expression of functional neurotransmitter receptors in Xenopus oocytes after injection of human brain membranes
    • Miledi, R., Eusebi, F., Martinez-Torres, A., Palma, E. & Trettel, F. Expression of functional neurotransmitter receptors in Xenopus oocytes after injection of human brain membranes. Proc. Natl. Acad. Sci. USA 99, 13238-13242 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 13238-13242
    • Miledi, R.1    Eusebi, F.2    Martinez-Torres, A.3    Palma, E.4    Trettel, F.5
  • 46
    • 0032987252 scopus 로고    scopus 로고
    • Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: Correlation with restricted localisation of NR2B subunit in dorsal horn
    • DOI 10.1016/S0028-3908(98)00218-4, PII S0028390898002184
    • Boyce, S. et al. Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: correlation with restricted localisation of NR2B subunit in dorsal horn. Neuropharmacology 38, 611-623 (1999). (Pubitemid 29150316)
    • (1999) Neuropharmacology , vol.38 , Issue.5 , pp. 611-623
    • Boyce, S.1    Wyatt, A.2    Webb, J.K.3    O'Donnell, R.4    Mason, G.5    Rigby, M.6    Sirinathsinghji, D.7    Hill, R.G.8    Rupniak, N.M.J.9
  • 47
    • 0034669122 scopus 로고    scopus 로고
    • Localization of N-methyl-D-aspartate NR2B subunits on primary sensory neurons that give rise to small-caliber sciatic nerve fibers in rats
    • Ma, Q.P. & Hargreaves, R.J. Localization of N-methyl-D-aspartate NR2B subunits on primary sensory neurons that give rise to small-caliber sciatic nerve fibers in rats. Neuroscience 101, 699-707 (2000).
    • (2000) Neuroscience , vol.101 , pp. 699-707
    • Ma, Q.P.1    Hargreaves, R.J.2
  • 48
    • 79956153093 scopus 로고    scopus 로고
    • Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia
    • Gaveriaux-Ruff, C. et al. Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia. Pain 152, 1238-1248 (2011).
    • (2011) Pain , vol.152 , pp. 1238-1248
    • Gaveriaux-Ruff, C.1
  • 49
    • 0026676676 scopus 로고
    • The capsaicin test in mice for evaluating tachykinin antagonists in the spinal cord
    • DOI 10.1016/0028-3908(92)90057-V
    • Sakurada, T., Katsumata, K., Tan-No, K., Sakurada, S. & Kisara, K. The capsaicin test in mice for evaluating tachykinin antagonists in the spinal cord. Neuropharmacology 31, 1279-1285 (1992). (Pubitemid 23002112)
    • (1992) Neuropharmacology , vol.31 , Issue.12 , pp. 1279-1285
    • Sakurada, T.1    Katsumata, K.2    Tan-No, K.3    Sakurada, S.4    Kisara, K.5


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