TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner

Neuropharmacology

Volumn 63, Issue 3, 2012, Pages 441-449

  Edman, S ^a,b   McKay, S ^a   MacDonald, L J ^a   Samadi, M ^a   Livesey, M R ^a   Hardingham, G E ^a   Wyllie, D J A ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

d serine; GluN2A selective; Glycine; NMDA receptor; Schild analysis; TCN 201; TCN 213

Indexed keywords

3 CHLORO 4 FLUORO N [4 [[2 (PHENYLCARBONYL)HYDRAZINO]CARBONYL]BENZYL]BENZENESULPHONAMIDE; GLUTAMATE RECEPTOR; GLYCINE; IFENPRODIL; N (CYCLOHEXYLMETHYL) 2 [[5 [(PHENYLMETHYL)AMINO] 1,3,4 THIADIAZOL 2 YL]THIO]ACETAMIDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SERINE; SULFONAMIDE; TCN 201; TCN 213; THIOACETAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENCY; EMBRYO; HIGH THROUGHPUT SCREENING; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; RAT; SOLUBILITY; VOLTAGE CLAMP; XENOPUS LAEVIS;

ALGORITHMS; ANIMALS; CEREBRAL CORTEX; ELECTROPHYSIOLOGICAL PHENOMENA; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; GLYCINE; NEURONS; OOCYTES; PATCH-CLAMP TECHNIQUES; PLASMIDS; RATS; RECEPTORS, KAINIC ACID; RECEPTORS, N-METHYL-D-ASPARTATE; RNA, COMPLEMENTARY; SERINE; SULFONAMIDES; TRANSFECTION; XENOPUS LAEVIS;

EID: 84862016725     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2012.04.027     Document Type: Article

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