메뉴 건너뛰기




Volumn 34, Issue 23, 2014, Pages 4257-4271

A cell-autonomous molecular cascade initiated by AMP-activated protein kinase represses steroidogenesis

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; CYCLIC AMP; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; NUCLEAR RECEPTOR NUR77; PROGESTERONE; PROTEIN; PROTEIN STAR; STEROID HORMONE; TESTOSTERONE; UNCLASSIFIED DRUG; ADENOSINE PHOSPHATE; AMPK ALPHA1 SUBUNIT, MOUSE; CHOLESTEROL; CYCLIC AMP PHOSPHODIESTERASE; E1A ASSOCIATED P300 PROTEIN; EP300 PROTEIN, MOUSE; LUTEINIZING HORMONE; NR4A1 PROTEIN, MOUSE; PDE8A PROTEIN, MOUSE; PHOSPHOPROTEIN; PROTEIN SERINE THREONINE KINASE; SCARB1 PROTEIN, MOUSE; SCAVENGER RECEPTOR B; SMALL INTERFERING RNA; STEROIDOGENIC ACUTE REGULATORY PROTEIN; STEROIDOGENIC FACTOR 1; STEROIDOGENIC FACTOR 1, MOUSE; STK11 PROTEIN, MOUSE;

EID: 84909619838     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.00734-14     Document Type: Article
Times cited : (65)

References (76)
  • 2
    • 0342264668 scopus 로고    scopus 로고
    • Cyclic-AMP-dependent protein kinase (PKA) in testicular cells. Cell specific expression, differential regulation and targeting of subunits of PKA
    • Hansson V, Skalhegg BS, Tasken K. 2000. Cyclic-AMP-dependent protein kinase (PKA) in testicular cells. Cell specific expression, differential regulation and targeting of subunits of PKA. J. Steroid Biochem. Mol. Biol. 73:81-92. http://dx.doi.org/10.1016/S0960-0760(00)00057-1.
    • (2000) J. Steroid Biochem. Mol. Biol , vol.73 , pp. 81-92
    • Hansson, V.1    Skalhegg, B.S.2    Tasken, K.3
  • 3
    • 0028104418 scopus 로고
    • The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR)
    • Clark BJ, Wells J, King SR, Stocco DM. 1994. The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR). J. Biol. Chem. 269:28314- 28322.
    • (1994) J. Biol. Chem , vol.269 , pp. 28314- 28322
    • Clark, B.J.1    Wells, J.2    King, S.R.3    Stocco, D.M.4
  • 4
    • 0029064441 scopus 로고
    • Expression of the steroidogenic acute regulatory (StAR) protein: a novel LH-induced mitochondrial protein required for the acute regulation of steroidogenesis in mouse Leydig tumor cells
    • Clark BJ, Stocco DM. 1995. Expression of the steroidogenic acute regulatory (StAR) protein: a novel LH-induced mitochondrial protein required for the acute regulation of steroidogenesis in mouse Leydig tumor cells. Endocr. Res. 21:243-257. http://dx.doi.org/10.3109/07435809509030440.
    • (1995) Endocr. Res , vol.21 , pp. 243-257
    • Clark, B.J.1    Stocco, D.M.2
  • 6
    • 0033743755 scopus 로고    scopus 로고
    • Developmental roles of the steroidogenic acute regulatory protein (StAR) as revealed by StAR knockout mice
    • Hasegawa T, Zhao L, Caron KM, Majdic G, Suzuki T, Shizawa S, Sasano H, Parker KL. 2000. Developmental roles of the steroidogenic acute regulatory protein (StAR) as revealed by StAR knockout mice. Mol. Endocrinol. 14:1462-1471. http://dx.doi.org/10.1210/mend.14.9.0515.
    • (2000) Mol. Endocrinol , vol.14 , pp. 1462-1471
    • Hasegawa, T.1    Zhao, L.2    Caron, K.M.3    Majdic, G.4    Suzuki, T.5    Shizawa, S.6    Sasano, H.7    Parker, K.L.8
  • 7
    • 22544470581 scopus 로고    scopus 로고
    • Involvement of protein kinase C and cyclic adenosine 3',5'-monophosphate-dependent kinase in steroidogenic acute regulatory protein expression and steroid biosynthesis in Leydig cells
    • Jo Y, King SR, Khan SA, Stocco DM. 2005. Involvement of protein kinase C and cyclic adenosine 3',5'-monophosphate-dependent kinase in steroidogenic acute regulatory protein expression and steroid biosynthesis in Leydig cells. Biol. Reprod. 73:244-255. http://dx.doi.org/10.1095/biolreprod.104 .037721.
    • (2005) Biol. Reprod , vol.73 , pp. 244-255
    • Jo, Y.1    King, S.R.2    Khan, S.A.3    Stocco, D.M.4
  • 8
    • 0036139871 scopus 로고    scopus 로고
    • Regulation of steroidogenesis and the steroidogenic acute regulatory protein by a member of the cAMP response- element binding protein family
    • Manna PR, Dyson MT, Eubank DW, Clark BJ, Lalli E, Sassone-Corsi P, Zeleznik AJ, Stocco DM. 2002. Regulation of steroidogenesis and the steroidogenic acute regulatory protein by a member of the cAMP response- element binding protein family. Mol. Endocrinol. 16:184-199. http://dx.doi.org/10.1210/mend.16.1.0759.
    • (2002) Mol. Endocrinol , vol.16 , pp. 184-199
    • Manna, P.R.1    Dyson, M.T.2    Eubank, D.W.3    Clark, B.J.4    Lalli, E.5    Sassone-Corsi, P.6    Zeleznik, A.J.7    Stocco, D.M.8
  • 9
    • 0041887300 scopus 로고    scopus 로고
    • Novel roles for GATA transcription factors in the regulation of steroidogenesis
    • Tremblay JJ, Viger RS. 2003. Novel roles for GATA transcription factors in the regulation of steroidogenesis. J. Steroid Biochem. Mol. Biol. 85:291- 298. http://dx.doi.org/10.1016/S0960-0760(03)00211-5.
    • (2003) J. Steroid Biochem. Mol. Biol , vol.85 , pp. 291- 298
    • Tremblay, J.J.1    Viger, R.S.2
  • 10
    • 50649097876 scopus 로고    scopus 로고
    • The orphan nuclear receptor NUR77 regulates hormone-induced StAR transcription in Leydig cells through cooperation with Ca2+/calmodulin-dependent protein kinase I
    • Martin LJ, Boucher N, Brousseau C, Tremblay JJ. 2008. The orphan nuclear receptor NUR77 regulates hormone-induced StAR transcription in Leydig cells through cooperation with Ca2+/calmodulin-dependent protein kinase I. Mol. Endocrinol. 22:2021-2037. http://dx.doi.org/10 .1210/me.2007-0370.
    • (2008) Mol. Endocrinol , vol.22 , pp. 2021-2037
    • Martin, L.J.1    Boucher, N.2    Brousseau, C.3    Tremblay, J.J.4
  • 11
    • 84871708896 scopus 로고    scopus 로고
    • The calcium signaling pathway regulates Leydig cell steroidogenesis through a transcriptional cascade involving the nuclear receptor NR4A1 and the steroidogenic acute regulatory protein
    • Abdou HS, Villeneuve G, Tremblay JJ. 2013. The calcium signaling pathway regulates Leydig cell steroidogenesis through a transcriptional cascade involving the nuclear receptor NR4A1 and the steroidogenic acute regulatory protein. Endocrinology 154:511-520. http://dx.doi.org/10 .1210/en.2012-1767.
    • (2013) Endocrinology , vol.154 , pp. 511-520
    • Abdou, H.S.1    Villeneuve, G.2    Tremblay, J.J.3
  • 12
    • 0033058928 scopus 로고    scopus 로고
    • Functional assessment of the calcium messenger system in cultured mouse Leydig tumor cells: regulation of human chorionic gonadotropin-induced expression of the steroidogenic acute regulatory protein
    • Manna PR, Pakarinen P, El-Hefnawy T, Huhtaniemi IT. 1999. Functional assessment of the calcium messenger system in cultured mouse Leydig tumor cells: regulation of human chorionic gonadotropin-induced expression of the steroidogenic acute regulatory protein. Endocrinology 140:1739-1751. http://dx.doi.org/10.1210/endo.140.4.6650.
    • (1999) Endocrinology , vol.140 , pp. 1739-1751
    • Manna, P.R.1    Pakarinen, P.2    El-Hefnawy, T.3    Huhtaniemi, I.T.4
  • 13
    • 62649155879 scopus 로고    scopus 로고
    • cAMP-induced expression of the orphan nuclear receptor Nur77 in MA-10 Leydig cells involves a CaMKI pathway
    • Martin LJ, Boucher N, El-Asmar B, Tremblay JJ. 2009. cAMP-induced expression of the orphan nuclear receptor Nur77 in MA-10 Leydig cells involves a CaMKI pathway. J. Androl. 30:134-145. http://dx.doi.org/10 .2164/jandrol.108.006387.
    • (2009) J. Androl , vol.30 , pp. 134-145
    • Martin, L.J.1    Boucher, N.2    El-Asmar, B.3    Tremblay, J.J.4
  • 14
    • 84858786163 scopus 로고    scopus 로고
    • cAMPspecific phosphodiesterases 8A and 8B, essential regulators of Leydig cell steroidogenesis
    • Shimizu-Albergine M, Tsai LC, Patrucco E, Beavo JA. 2012. cAMPspecific phosphodiesterases 8A and 8B, essential regulators of Leydig cell steroidogenesis. Mol. Pharmacol. 81:556-566. http://dx.doi.org/10.1124 /mol.111.076125.
    • (2012) Mol. Pharmacol , vol.81 , pp. 556-566
    • Shimizu-Albergine, M.1    Tsai, L.C.2    Patrucco, E.3    Beavo, J.A.4
  • 15
    • 33845927898 scopus 로고    scopus 로고
    • Modulation of Leydig cell function by cyclic nucleotide phosphodiesterase 8A
    • Vasta V, Shimizu-Albergine M, Beavo JA. 2006. Modulation of Leydig cell function by cyclic nucleotide phosphodiesterase 8A. Proc. Natl. Acad. Sci. U. S. A. 103:19925-19930. http://dx.doi.org/10.1073/pnas.0609483103.
    • (2006) Proc. Natl. Acad. Sci. U. S. A , vol.103 , pp. 19925-19930
    • Vasta, V.1    Shimizu-Albergine, M.2    Beavo, J.A.3
  • 16
    • 84858782079 scopus 로고    scopus 로고
    • AMPK: a nutrient and energy sensor that maintains energy homeostasis
    • Hardie DG, Ross FA, Hawley SA. 2012. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat. Rev. Mol. Cell Biol. 13: 251-262. http://dx.doi.org/10.1038/nrm3311.
    • (2012) Nat. Rev. Mol. Cell Biol , vol.13 , pp. 251-262
    • Hardie, D.G.1    Ross, F.A.2    Hawley, S.A.3
  • 17
    • 0345107247 scopus 로고    scopus 로고
    • Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
    • Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Makela TP, Alessi DR, Hardie DG. 2003. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J. Biol. 2:28. http://dx.doi.org/10 .1186/1475-4924-2-28.
    • (2003) J. Biol , vol.2 , pp. 28
    • Hawley, S.A.1    Boudeau, J.2    Reid, J.L.3    Mustard, K.J.4    Udd, L.5    Makela, T.P.6    Alessi, D.R.7    Hardie, D.G.8
  • 19
    • 23044432463 scopus 로고    scopus 로고
    • Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase
    • Hawley SA, Pan DA, Mustard KJ, Ross L, Bain J, Edelman AM, Frenguelli BG, Hardie DG. 2005. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab. 2:9-19. http://dx.doi.org/10.1016/j.cmet.2005.05.009.
    • (2005) Cell Metab , vol.2 , pp. 9-19
    • Hawley, S.A.1    Pan, D.A.2    Mustard, K.J.3    Ross, L.4    Bain, J.5    Edelman, A.M.6    Frenguelli, B.G.7    Hardie, D.G.8
  • 20
    • 74549153743 scopus 로고    scopus 로고
    • Effects of resveratrol analogs on steroidogenesis and mitochondrial function in rat Leydig cells in vitro
    • Svechnikov K, Spatafora C, Svechnikova I, Tringali C, Soder O. 2009. Effects of resveratrol analogs on steroidogenesis and mitochondrial function in rat Leydig cells in vitro. J. Appl. Toxicol. 29:673-680. http://dx.doi .org/10.1002/jat.1456.
    • (2009) J. Appl. Toxicol , vol.29 , pp. 673-680
    • Svechnikov, K.1    Spatafora, C.2    Svechnikova, I.3    Tringali, C.4    Soder, O.5
  • 21
    • 0036829519 scopus 로고    scopus 로고
    • ACTHinduced nucleocytoplasmic translocation of salt-inducible kinase. Implication in the protein kinase A-activated gene transcription in mouse adrenocortical tumor cells
    • Takemori H, Katoh Y, Horike N, Doi J, Okamoto M. 2002. ACTHinduced nucleocytoplasmic translocation of salt-inducible kinase. Implication in the protein kinase A-activated gene transcription in mouse adrenocortical tumor cells. J. Biol. Chem. 277:42334-42343. http://dx.doi .org/10.1074/jbc.M204602200.
    • (2002) J. Biol. Chem , vol.277 , pp. 42334-42343
    • Takemori, H.1    Katoh, Y.2    Horike, N.3    Doi, J.4    Okamoto, M.5
  • 22
    • 24944486315 scopus 로고    scopus 로고
    • Adenosine 5'-monophosphate-activated protein kinase regulates progesterone secretion in rat granulosa cells
    • Tosca L, Froment P, Solnais P, Ferre P, Foufelle F, Dupont J. 2005. Adenosine 5'-monophosphate-activated protein kinase regulates progesterone secretion in rat granulosa cells. Endocrinology 146:4500-4513. http://dx.doi.org/10.1210/en.2005-0301.
    • (2005) Endocrinology , vol.146 , pp. 4500-4513
    • Tosca, L.1    Froment, P.2    Solnais, P.3    Ferre, P.4    Foufelle, F.5    Dupont, J.6
  • 23
    • 33847234345 scopus 로고    scopus 로고
    • Effects of metformin on bovine granulosa cells steroidogenesis: possible involvement of adenosine 5' monophosphate-activated protein kinase (AMPK)
    • Tosca L, Chabrolle C, Uzbekova S, Dupont J. 2007. Effects of metformin on bovine granulosa cells steroidogenesis: possible involvement of adenosine 5' monophosphate-activated protein kinase (AMPK). Biol. Reprod. 76:368-378. http://dx.doi.org/10.1095/biolreprod.106.055749.
    • (2007) Biol. Reprod , vol.76 , pp. 368-378
    • Tosca, L.1    Chabrolle, C.2    Uzbekova, S.3    Dupont, J.4
  • 25
    • 0019364734 scopus 로고
    • Characterization of several clonal lines of cultured Leydig tumor cells: gonadotropin receptors and steroidogenic responses
    • Ascoli M. 1981. Characterization of several clonal lines of cultured Leydig tumor cells: gonadotropin receptors and steroidogenic responses. Endocrinology 108:88-95. http://dx.doi.org/10.1210/endo-108-1-88.
    • (1981) Endocrinology , vol.108 , pp. 88-95
    • Ascoli, M.1
  • 26
    • 84909600954 scopus 로고    scopus 로고
    • User manual. GeneChip whole transcript (WT) sense target labeling assay
    • Affymetrix Inc., Santa Clara, CA
    • Affymetrix Inc. 2009. User manual. GeneChip whole transcript (WT) sense target labeling assay. Affymetrix Inc., Santa Clara, CA. http://media .affymetrix.com/support/downloads/manuals/wt_sensetarget_label_manual .pdf.
    • (2009)
  • 27
    • 0028073143 scopus 로고    scopus 로고
    • Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase
    • Sullivan JE, Brocklehurst KJ, Marley AE, Carey F, Carling D, Beri RK. Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase. FEBS Lett. 353:33-36. http://dx.doi.org/10.1016/0014-5793(94)01006-4.
    • FEBS Lett. , vol.353 , pp. 33-36
    • Sullivan, J.E.1    Brocklehurst, K.J.2    Marley, A.E.3    Carey, F.4    Carling, D.5    Beri, R.K.6
  • 28
    • 0023896220 scopus 로고
    • The low activity of acetyl-CoA carboxylase in basal and glucagon-stimulated hepatocytes is due to phosphorylation by the AMP-activated protein kinase and not cyclic AMP-dependent protein kinase
    • Sim AT, Hardie DG. 1988. The low activity of acetyl-CoA carboxylase in basal and glucagon-stimulated hepatocytes is due to phosphorylation by the AMP-activated protein kinase and not cyclic AMP-dependent protein kinase. FEBS Lett. 233:294-298. http://dx.doi.org/10.1016/0014-5793 (88)80445-9.
    • (1988) FEBS Lett , vol.233 , pp. 294-298
    • Sim, A.T.1    Hardie, D.G.2
  • 29
    • 34250859711 scopus 로고    scopus 로고
    • Effect of myxothiazol on Leydig cell steroidogenesis: inhibition of luteinizing hormone-mediated testosterone synthesis but stimulation of basal steroidogenesis
    • Midzak AS, Liu J, Zirkin BR, Chen H. 2007. Effect of myxothiazol on Leydig cell steroidogenesis: inhibition of luteinizing hormone-mediated testosterone synthesis but stimulation of basal steroidogenesis. Endocrinology 148:2583-2590. http://dx.doi.org/10.1210/en.2006-1488.
    • (2007) Endocrinology , vol.148 , pp. 2583-2590
    • Midzak, A.S.1    Liu, J.2    Zirkin, B.R.3    Chen, H.4
  • 30
    • 0034163764 scopus 로고    scopus 로고
    • Chronic administration of corticosterone impairs LH signal transduction and steroidogenesis in rat Leydig cells
    • Sankar BR, Maran RR, Sivakumar R, Govindarajulu P, Balasubramanian K. 2000. Chronic administration of corticosterone impairs LH signal transduction and steroidogenesis in rat Leydig cells. J. Steroid Biochem. Mol. Biol. 72:155-162. http://dx.doi.org/10.1016/S0960-0760(00)00019-4.
    • (2000) J. Steroid Biochem. Mol. Biol , vol.72 , pp. 155-162
    • Sankar, B.R.1    Maran, R.R.2    Sivakumar, R.3    Govindarajulu, P.4    Balasubramanian, K.5
  • 31
    • 0030712464 scopus 로고    scopus 로고
    • The cellular mechanisms of corticotropin-releasing hormone (CRH)-stimulated steroidogenesis in mouse Leydig cells are similar to those for LH
    • Huang BM, Stocco DM, Norman RL. 1997. The cellular mechanisms of corticotropin-releasing hormone (CRH)-stimulated steroidogenesis in mouse Leydig cells are similar to those for LH. J. Androl. 18:528-534.
    • (1997) J. Androl , vol.18 , pp. 528-534
    • Huang, B.M.1    Stocco, D.M.2    Norman, R.L.3
  • 32
    • 0033304781 scopus 로고    scopus 로고
    • Developmental and hormonal regulation of murine scavenger receptor, class B, type 1
    • Cao G, Zhao L, Stangl H, Hasegawa T, Richardson JA, Parker KL, Hobbs HH. 1999. Developmental and hormonal regulation of murine scavenger receptor, class B, type 1. Mol. Endocrinol. 13:1460-1473. http: //dx.doi.org/10.1210/mend.13.9.0346.
    • (1999) Mol. Endocrinol , vol.13 , pp. 1460-1473
    • Cao, G.1    Zhao, L.2    Stangl, H.3    Hasegawa, T.4    Richardson, J.A.5    Parker, K.L.6    Hobbs, H.H.7
  • 33
    • 0037230367 scopus 로고    scopus 로고
    • Differential regulation of steroid hormone biosynthesis in R2C and MA-10 Leydig tumor cells: role of SR-B1-mediated selective cholesteryl ester transport
    • Rao RM, Jo Y, Leers-Sucheta S, Bose HS, Miller WL, Azhar S, Stocco DM. 2003. Differential regulation of steroid hormone biosynthesis in R2C and MA-10 Leydig tumor cells: role of SR-B1-mediated selective cholesteryl ester transport. Biol. Reprod. 68:114-121. http://dx.doi.org/10.1095 /biolreprod.102.007518.
    • (2003) Biol. Reprod , vol.68 , pp. 114-121
    • Rao, R.M.1    Jo, Y.2    Leers-Sucheta, S.3    Bose, H.S.4    Miller, W.L.5    Azhar, S.6    Stocco, D.M.7
  • 34
    • 0030886781 scopus 로고    scopus 로고
    • The effect of tumor necrosis factor-alpha and cAMP on induction of AP-1 activity in MA-10 tumor Leydig cells
    • Li X, Hales KH, Watanabe G, Lee RJ, Pestell RG, Hales DB. 1997. The effect of tumor necrosis factor-alpha and cAMP on induction of AP-1 activity in MA-10 tumor Leydig cells. Endocrine 6:317-324. http://dx.doi .org/10.1007/BF02820509.
    • (1997) Endocrine , vol.6 , pp. 317-324
    • Li, X.1    Hales, K.H.2    Watanabe, G.3    Lee, R.J.4    Pestell, R.G.5    Hales, D.B.6
  • 35
    • 73249121077 scopus 로고    scopus 로고
    • Molecular mechanism for repression of 17alpha-hydroxylase expression and androstenedione production in granulosa cells
    • Patel SS, Beshay VE, Escobar JC, Suzuki T, Carr BR. 2009. Molecular mechanism for repression of 17alpha-hydroxylase expression and androstenedione production in granulosa cells. J. Clin. Endocrinol. Metab. 94: 5163-5168. http://dx.doi.org/10.1210/jc.2009-1341.
    • (2009) J. Clin. Endocrinol. Metab , vol.94 , pp. 5163-5168
    • Patel, S.S.1    Beshay, V.E.2    Escobar, J.C.3    Suzuki, T.4    Carr, B.R.5
  • 36
    • 0037169817 scopus 로고    scopus 로고
    • Transcriptional repression of the rat steroidogenic acute regulatory (StAR) protein gene by the AP-1 family member c-Fos
    • Shea-Eaton W, Sandhoff TW, Lopez D, Hales DB, McLean MP. 2002. Transcriptional repression of the rat steroidogenic acute regulatory (StAR) protein gene by the AP-1 family member c-Fos. Mol. Cell. Endocrinol. 188:161-170. http://dx.doi.org/10.1016/S0303-7207(01)00715-8.
    • (2002) Mol. Cell. Endocrinol , vol.188 , pp. 161-170
    • Shea-Eaton, W.1    Sandhoff, T.W.2    Lopez, D.3    Hales, D.B.4    McLean, M.P.5
  • 37
    • 0038683275 scopus 로고    scopus 로고
    • Transcriptional regulation of the mouse steroidogenic acute regulatory protein gene by the cAMP response-element binding protein and steroidogenic factor 1
    • Manna PR, Eubank DW, Lalli E, Sassone-Corsi P, Stocco DM. 2003. Transcriptional regulation of the mouse steroidogenic acute regulatory protein gene by the cAMP response-element binding protein and steroidogenic factor 1. J. Mol. Endocrinol. 30:381-397. http://dx.doi.org/10.1677 /jme.0.0300381.
    • (2003) J. Mol. Endocrinol , vol.30 , pp. 381-397
    • Manna, P.R.1    Eubank, D.W.2    Lalli, E.3    Sassone-Corsi, P.4    Stocco, D.M.5
  • 38
    • 0035914324 scopus 로고    scopus 로고
    • Regulation of transcription by AMP-activated protein kinase: phosphorylation of p300 blocks its interaction with nuclear receptors
    • Yang W, Hong YH, Shen XQ, Frankowski C, Camp HS, Leff T. 2001. Regulation of transcription by AMP-activated protein kinase: phosphorylation of p300 blocks its interaction with nuclear receptors. J. Biol. Chem. 276:38341-38344. http://dx.doi.org/10.1074/jbc.C100316200.
    • (2001) J. Biol. Chem , vol.276 , pp. 38341-38344
    • Yang, W.1    Hong, Y.H.2    Shen, X.Q.3    Frankowski, C.4    Camp, H.S.5    Leff, T.6
  • 39
    • 81755174323 scopus 로고    scopus 로고
    • AMP-activated protein kinase suppresses endothelial cell inflammation through phosphorylation of transcriptional coactivator p300
    • Zhang Y, Qiu J, Wang X, Xia M. 2011. AMP-activated protein kinase suppresses endothelial cell inflammation through phosphorylation of transcriptional coactivator p300. Arterioscler. Thromb. Vasc. Biol. 31: 2897-2908. http://dx.doi.org/10.1161/ATVBAHA.111.237453.
    • (2011) Arterioscler. Thromb. Vasc. Biol , vol.31 , pp. 2897-2908
    • Zhang, Y.1    Qiu, J.2    Wang, X.3    Xia, M.4
  • 40
    • 0034663805 scopus 로고    scopus 로고
    • Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis
    • Youn HD, Chatila TA, Liu JO. 2000. Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis. EMBO J. 19:4323-4331. http://dx.doi.org/10.1093/emboj/19.16.4323.
    • (2000) EMBO J , vol.19 , pp. 4323-4331
    • Youn, H.D.1    Chatila, T.A.2    Liu, J.O.3
  • 41
    • 0033681541 scopus 로고    scopus 로고
    • Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2
    • Youn HD, Liu JO. 2000. Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2. Immunity 13:85-94. http://dx.doi .org/10.1016/S1074-7613(00)00010-8.
    • (2000) Immunity , vol.13 , pp. 85-94
    • Youn, H.D.1    Liu, J.O.2
  • 42
    • 25844444745 scopus 로고    scopus 로고
    • MSKs are required for the transcription of the nuclear orphan receptors Nur77, Nurr1 and Nor1 downstream of MAPK signalling
    • Darragh J, Soloaga A, Beardmore VA, Wingate AD, Wiggin GR, Peggie M, Arthur JS. 2005. MSKs are required for the transcription of the nuclear orphan receptors Nur77, Nurr1 and Nor1 downstream of MAPK signalling. Biochem. J. 390:749-759. http://dx.doi.org/10.1042/BJ20050196.
    • (2005) Biochem. J , vol.390 , pp. 749-759
    • Darragh, J.1    Soloaga, A.2    Beardmore, V.A.3    Wingate, A.D.4    Wiggin, G.R.5    Peggie, M.6    Arthur, J.S.7
  • 43
    • 0242290353 scopus 로고    scopus 로고
    • Deacetylase activity is required for cAMP activation of a subset of CREB target genes
    • Fass DM, Butler JE, Goodman RH. 2003. Deacetylase activity is required for cAMP activation of a subset of CREB target genes. J. Biol. Chem. 278:43014-43019. http://dx.doi.org/10.1074/jbc.M305905200.
    • (2003) J. Biol. Chem , vol.278 , pp. 43014-43019
    • Fass, D.M.1    Butler, J.E.2    Goodman, R.H.3
  • 44
    • 41149179784 scopus 로고    scopus 로고
    • Regulation of NGFI-B/Nur77 gene expression in the rat ovary and in Leydig tumor cells MA-10
    • Inaoka Y, Yazawa T, Uesaka M, Mizutani T, Yamada K, Miyamoto K. Regulation of NGFI-B/Nur77 gene expression in the rat ovary and in Leydig tumor cells MA-10. Mol. Reprod. Dev. 75:931-939. http://dx.doi .org/10.1002/mrd.20788.
    • Mol. Reprod. Dev. , vol.75 , pp. 931-939
    • Inaoka, Y.1    Yazawa, T.2    Uesaka, M.3    Mizutani, T.4    Yamada, K.5    Miyamoto, K.6
  • 45
    • 75149163016 scopus 로고    scopus 로고
    • CREB-dependent Nur77 induction following depolarization in PC12 cells and neurons is modulated by MEF2 transcription factors
    • Lam BY, Zhang W, Ng DC, Maruthappu M, Roderick HL, Chawla S. CREB-dependent Nur77 induction following depolarization in PC12 cells and neurons is modulated by MEF2 transcription factors. J. Neurochem. 112:1065-1073. http://dx.doi.org/10.1111/j.1471-4159.2009 .06521.x.
    • J. Neurochem. , vol.112 , pp. 1065-1073
    • Lam, B.Y.1    Zhang, W.2    Ng, D.C.3    Maruthappu, M.4    Roderick, H.L.5    Chawla, S.6
  • 46
    • 58149460382 scopus 로고    scopus 로고
    • Role of dosage-sensitive sex reversal, adrenal hypoplasia congenita, critical region on the X chromosome, gene 1 in protein kinase A- and protein kinase C-mediated regulation of the steroidogenic acute regulatory protein expression in mouse Leydig tumor cells: mechanism of action
    • Manna PR, Dyson MT, Jo Y, Stocco DM. 2009. Role of dosage-sensitive sex reversal, adrenal hypoplasia congenita, critical region on the X chromosome, gene 1 in protein kinase A- and protein kinase C-mediated regulation of the steroidogenic acute regulatory protein expression in mouse Leydig tumor cells: mechanism of action. Endocrinology 150:187-199. http://dx.doi.org/10.1210/en.2008-0368.
    • (2009) Endocrinology , vol.150 , pp. 187-199
    • Manna, P.R.1    Dyson, M.T.2    Jo, Y.3    Stocco, D.M.4
  • 47
    • 0842334477 scopus 로고    scopus 로고
    • The orphan nuclear receptors NURR1 and NGFIB regulate adrenal aldosterone production
    • Bassett MH, Suzuki T, Sasano H, White PC, Rainey WE. 2004. The orphan nuclear receptors NURR1 and NGFIB regulate adrenal aldosterone production. Mol. Endocrinol. 18:279-290. http://dx.doi.org/10 .1210/me.2003-0005.
    • (2004) Mol. Endocrinol , vol.18 , pp. 279-290
    • Bassett, M.H.1    Suzuki, T.2    Sasano, H.3    White, P.C.4    Rainey, W.E.5
  • 48
    • 0028265473 scopus 로고
    • Endocrine and neurogenic regulation of the orphan nuclear receptors Nur77 and Nurr-1 in the adrenal glands
    • Davis IJ, Lau LF. 1994. Endocrine and neurogenic regulation of the orphan nuclear receptors Nur77 and Nurr-1 in the adrenal glands. Mol. Cell. Biol. 14:3469-3483.
    • (1994) Mol. Cell. Biol , vol.14 , pp. 3469-3483
    • Davis, I.J.1    Lau, L.F.2
  • 49
    • 77949912770 scopus 로고    scopus 로고
    • Prevalence of hyperandrogenemia in the polycystic ovary syndrome diagnosed by the National Institutes of Health 1990 criteria
    • Huang A, Brennan K, Azziz R. 2010. Prevalence of hyperandrogenemia in the polycystic ovary syndrome diagnosed by the National Institutes of Health 1990 criteria. Fertil. Steril. 93:1938-1941. http://dx.doi.org/10 .1016/j.fertnstert.2008.12.138.
    • (2010) Fertil. Steril , vol.93 , pp. 1938-1941
    • Huang, A.1    Brennan, K.2    Azziz, R.3
  • 50
    • 84878258729 scopus 로고    scopus 로고
    • Progesterone signalling in breast cancer: a neglected hormone coming into the limelight
    • Brisken C. 2013. Progesterone signalling in breast cancer: a neglected hormone coming into the limelight. Nat. Rev. Cancer 13:385-396. http: //dx.doi.org/10.1038/nrc3518.
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 385-396
    • Brisken, C.1
  • 51
  • 52
    • 0023140049 scopus 로고
    • Constitutive steroidogenesis in the R2C Leydig tumor cell line is maintained by the adenosine 3',5'-cyclic monophosphateindependent production of a cycloheximide-sensitive factor that enhances mitochondrial pregnenolone biosynthesis
    • Freeman DA. 1987. Constitutive steroidogenesis in the R2C Leydig tumor cell line is maintained by the adenosine 3',5'-cyclic monophosphateindependent production of a cycloheximide-sensitive factor that enhances mitochondrial pregnenolone biosynthesis. Endocrinology 120:124-132. http://dx.doi.org/10.1210/endo-120-1-124.
    • (1987) Endocrinology , vol.120 , pp. 124-132
    • Freeman, D.A.1
  • 53
    • 0025783146 scopus 로고
    • Presence of identical mitochondrial proteins in unstimulated constitutive steroid-producing R2C rat Leydig tumor and stimulated nonconstitutive steroid-producing MA-10 mouse Leydig tumor cells
    • Stocco DM, Chen W. 1991. Presence of identical mitochondrial proteins in unstimulated constitutive steroid-producing R2C rat Leydig tumor and stimulated nonconstitutive steroid-producing MA-10 mouse Leydig tumor cells. Endocrinology 128:1918-1926. http://dx.doi.org/10.1210/endo -128-4-1918.
    • (1991) Endocrinology , vol.128 , pp. 1918-1926
    • Stocco, D.M.1    Chen, W.2
  • 54
    • 9444242160 scopus 로고    scopus 로고
    • Regulation of steroidogenesis and steroidogenic acute regulatory protein in R2C cells by DAX-1 (dosage-sensitive sex reversal, adrenal hypoplasia congenita, critical region on the X chromosome, gene-1)
    • Jo Y, Stocco DM. 2004. Regulation of steroidogenesis and steroidogenic acute regulatory protein in R2C cells by DAX-1 (dosage-sensitive sex reversal, adrenal hypoplasia congenita, critical region on the X chromosome, gene-1). Endocrinology 145:5629-5637. http://dx.doi.org/10.1210 /en.2004-0941.
    • (2004) Endocrinology , vol.145 , pp. 5629-5637
    • Jo, Y.1    Stocco, D.M.2
  • 55
    • 77952562382 scopus 로고    scopus 로고
    • Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply
    • Choo AY, Kim SG, Vander Heiden MG, Mahoney SJ, Vu H, Yoon SO, Cantley LC, Blenis J. 2010. Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply. Mol. Cell 38:487-499. http://dx.doi.org/10.1016/j.molcel.2010.05.007.
    • (2010) Mol. Cell , vol.38 , pp. 487-499
    • Choo, A.Y.1    Kim, S.G.2    Vander Heiden, M.G.3    Mahoney, S.J.4    Vu, H.5    Yoon, S.O.6    Cantley, L.C.7    Blenis, J.8
  • 56
    • 77249128371 scopus 로고    scopus 로고
    • The orphan nuclear receptor NR4A1 regulates transcription of key steroidogenic enzymes in ovarian theca cells
    • Li M, Xue K, Ling J, Diao FY, Cui YG, Liu JY. 2010. The orphan nuclear receptor NR4A1 regulates transcription of key steroidogenic enzymes in ovarian theca cells. Mol. Cell. Endocrinol. 319:39-46. http://dx.doi.org /10.1016/j.mce.2010.01.014.
    • (2010) Mol. Cell. Endocrinol , vol.319 , pp. 39-46
    • Li, M.1    Xue, K.2    Ling, J.3    Diao, F.Y.4    Cui, Y.G.5    Liu, J.Y.6
  • 57
    • 1542357572 scopus 로고    scopus 로고
    • Assessment of the role of activator protein-1 on transcription of the mouse steroidogenic acute regulatory protein gene
    • Manna PR, Eubank DW, Stocco DM. 2004. Assessment of the role of activator protein-1 on transcription of the mouse steroidogenic acute regulatory protein gene. Mol. Endocrinol. 18:558-573. http://dx.doi.org/10 .1210/me.2003-0223.
    • (2004) Mol. Endocrinol , vol.18 , pp. 558-573
    • Manna, P.R.1    Eubank, D.W.2    Stocco, D.M.3
  • 58
    • 81455154153 scopus 로고    scopus 로고
    • Functional cooperation between GATA factors and cJUN on the star promoter in MA-10 Leydig cells
    • Martin LJ, Bergeron F, Viger RS, Tremblay JJ. 2012. Functional cooperation between GATA factors and cJUN on the star promoter in MA-10 Leydig cells. J. Androl. 33:81-87. http://dx.doi.org/10.2164/jandrol.110 .012039.
    • (2012) J. Androl , vol.33 , pp. 81-87
    • Martin, L.J.1    Bergeron, F.2    Viger, R.S.3    Tremblay, J.J.4
  • 59
    • 64149129173 scopus 로고    scopus 로고
    • The nuclear receptors NUR77 and SF1 play additive roles with c-JUN through distinct elements on the mouse Star promoter
    • Martin LJ, Tremblay JJ. 2009. The nuclear receptors NUR77 and SF1 play additive roles with c-JUN through distinct elements on the mouse Star promoter. J. Mol. Endocrinol. 42:119-129. http://dx.doi.org/10.1677 /JME-08-0095.
    • (2009) J. Mol. Endocrinol , vol.42 , pp. 119-129
    • Martin, L.J.1    Tremblay, J.J.2
  • 60
    • 0037013197 scopus 로고    scopus 로고
    • Salt-inducible kinase represses cAMP-dependent protein kinasemediated activation of human cholesterol side chain cleavage cytochrome P450 promoter through the CREB basic leucine zipper domain
    • Doi J, Takemori H, Lin XZ, Horike N, Katoh Y, Okamoto M. 2002. Salt-inducible kinase represses cAMP-dependent protein kinasemediated activation of human cholesterol side chain cleavage cytochrome P450 promoter through the CREB basic leucine zipper domain. J. Biol. Chem. 277:15629-15637. http://dx.doi.org/10.1074/jbc.M109365200.
    • (2002) J. Biol. Chem , vol.277 , pp. 15629-15637
    • Doi, J.1    Takemori, H.2    Lin, X.Z.3    Horike, N.4    Katoh, Y.5    Okamoto, M.6
  • 61
    • 0033120086 scopus 로고    scopus 로고
    • Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: integration of hormone signaling in reproduction and stress
    • Hammer GD, Krylova I, Zhang Y, Darimont BD, Simpson K, Weigel NL, Ingraham HA. 1999. Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: integration of hormone signaling in reproduction and stress. Mol. Cell 3:521-526. http://dx.doi.org/10.1016 /S1097-2765(00)80480-3.
    • (1999) Mol. Cell , vol.3 , pp. 521-526
    • Hammer, G.D.1    Krylova, I.2    Zhang, Y.3    Darimont, B.D.4    Simpson, K.5    Weigel, N.L.6    Ingraham, H.A.7
  • 63
    • 78649740261 scopus 로고    scopus 로고
    • The AP-1 family member FOS blocks transcriptional activity of the nuclear receptor steroidogenic factor 1
    • Sirianni R, Nogueira E, Bassett MH, Carr BR, Suzuki T, Pezzi V, Ando S, Rainey WE. 2010. The AP-1 family member FOS blocks transcriptional activity of the nuclear receptor steroidogenic factor 1. J. Cell Sci. 123: 3956-3965. http://dx.doi.org/10.1242/jcs.055806.
    • (2010) J. Cell Sci , vol.123 , pp. 3956-3965
    • Sirianni, R.1    Nogueira, E.2    Bassett, M.H.3    Carr, B.R.4    Suzuki, T.5    Pezzi, V.6    Ando, S.7    Rainey, W.E.8
  • 65
    • 0031453141 scopus 로고    scopus 로고
    • Phosphorylation of steroidogenic acute regulatory protein (StAR) modulates its steroidogenic activity
    • Arakane F, King SR, Du Y, Kallen CB, Walsh LP, Watari H, Stocco DM, Strauss JF, III. 1997. Phosphorylation of steroidogenic acute regulatory protein (StAR) modulates its steroidogenic activity. J. Biol. Chem. 272: 32656-32662. http://dx.doi.org/10.1074/jbc.272.51.32656.
    • (1997) J. Biol. Chem , vol.272 , pp. 32656-32662
    • Arakane, F.1    King, S.R.2    Du, Y.3    Kallen, C.B.4    Walsh, L.P.5    Watari, H.6    Stocco, D.M.7    Strauss III, J.F.8
  • 66
    • 4444287241 scopus 로고    scopus 로고
    • Phosphorylation and function of the hamster adrenal steroidogenic acute regulatory protein (StAR)
    • Fleury A, Mathieu AP, Ducharme L, Hales DB, LeHoux JG. 2004. Phosphorylation and function of the hamster adrenal steroidogenic acute regulatory protein (StAR). J. Steroid Biochem. Mol. Biol. 91:259-271. http://dx.doi.org/10.1016/j.jsbmb.2004.04.010.
    • (2004) J. Steroid Biochem. Mol. Biol , vol.91 , pp. 259-271
    • Fleury, A.1    Mathieu, A.P.2    Ducharme, L.3    Hales, D.B.4    LeHoux, J.G.5
  • 67
    • 81355147728 scopus 로고    scopus 로고
    • Androgens are fundamental in the maintenance of male sexual health
    • Morales A. 2011. Androgens are fundamental in the maintenance of male sexual health. Curr. Urol. Rep. 12:453-460. http://dx.doi.org/10.1007/s11934 -011-0202-4.
    • (2011) Curr. Urol. Rep , vol.12 , pp. 453-460
    • Morales, A.1
  • 68
    • 0035515324 scopus 로고    scopus 로고
    • The effects of metformin and diet on plasma testosterone and leptin levels in obese men
    • Ozata M, Oktenli C, Bingol N, Ozdemir IC. 2001. The effects of metformin and diet on plasma testosterone and leptin levels in obese men. Obes. Res. 9:662-667. http://dx.doi.org/10.1038/oby.2001.90.
    • (2001) Obes. Res , vol.9 , pp. 662-667
    • Ozata, M.1    Oktenli, C.2    Bingol, N.3    Ozdemir, I.C.4
  • 69
    • 84872934629 scopus 로고    scopus 로고
    • Effect of pioglitazone on testosterone in eugonadal men with type 2 diabetes mellitus: a randomized double blind placebo-controlled study
    • Sridhar S, Walia R, Sachdeva N, Bhansali A. 2012. Effect of pioglitazone on testosterone in eugonadal men with type 2 diabetes mellitus: a randomized double blind placebo-controlled study. Clin. Endocrinol. (Oxford) 78:454-459. http://dx.doi.org/10.1111/j.1365-2265.2012.04510.x.
    • (2012) Clin. Endocrinol. (Oxford) , vol.78 , pp. 454-459
    • Sridhar, S.1    Walia, R.2    Sachdeva, N.3    Bhansali, A.4
  • 70
    • 80054767295 scopus 로고    scopus 로고
    • Use of metformin and the risk of ovarian cancer: a case-control analysis
    • Bodmer M, Becker C, Meier C, Jick SS, Meier CR. 2011. Use of metformin and the risk of ovarian cancer: a case-control analysis. Gynecol. Oncol. 123:200-204. http://dx.doi.org/10.1016/j.ygyno.2011.06.038.
    • (2011) Gynecol. Oncol , vol.123 , pp. 200-204
    • Bodmer, M.1    Becker, C.2    Meier, C.3    Jick, S.S.4    Meier, C.R.5
  • 71
    • 84869995793 scopus 로고    scopus 로고
    • The effectiveness of metformin ovulation induction treatment in patients with PCOS: a systematic review and meta-analysis
    • Xiao J, Chen S, Zhang C, Chang S. 2012. The effectiveness of metformin ovulation induction treatment in patients with PCOS: a systematic review and meta-analysis. Gynecol. Endocrinol. 28:956-960. http://dx.doi.org /10.3109/09513590.2012.705368.
    • (2012) Gynecol. Endocrinol , vol.28 , pp. 956-960
    • Xiao, J.1    Chen, S.2    Zhang, C.3    Chang, S.4
  • 75
    • 0141456194 scopus 로고    scopus 로고
    • Expression of steroidogenic acute regulatory protein (StAR) and LH receptor in MA-10 cells
    • Tsuchiya M, Inoue K, Matsuda H, Nakamura K, Mizutani T, Miyamoto K, Minegishi T. 2003. Expression of steroidogenic acute regulatory protein (StAR) and LH receptor in MA-10 cells. Life Sci. 73:2855-2863. http: //dx.doi.org/10.1016/S0024-3205(03)00698-2.
    • (2003) Life Sci , vol.73 , pp. 2855-2863
    • Tsuchiya, M.1    Inoue, K.2    Matsuda, H.3    Nakamura, K.4    Mizutani, T.5    Miyamoto, K.6    Minegishi, T.7
  • 76
    • 0026025792 scopus 로고
    • Lutropin/choriogonadotropin down-regulates its receptor by both receptor-mediated endocytosis and a cAMP-dependent reduction in receptor mRNA
    • Wang H, Segaloff DL, Ascoli M. 1991. Lutropin/choriogonadotropin down-regulates its receptor by both receptor-mediated endocytosis and a cAMP-dependent reduction in receptor mRNA. J. Biol. Chem. 266:780 -785.
    • (1991) J. Biol. Chem , vol.266 , pp. 780 -785
    • Wang, H.1    Segaloff, D.L.2    Ascoli, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.