Androgens are fundamental in the maintenance of male sexual health

Current Urology Reports

Volumn 12, Issue 6, 2011, Pages 453-460

  Morales, Alvaro ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

Androgen deficiency; Androgens; Erectile dysfunction; Erection; Gonads; Hyperprolactinemia; Hypoactive sexual desire disorder; Hypogonadism; Libido; Male sexual function; Penile function; Sexual health; Testosterone; Testosterone deficiency syndrome

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; ANDROSTANOLONE; CLOMIFENE; LUTEINIZING HORMONE; METHYLTESTOSTERONE; PHOSPHODIESTERASE V INHIBITOR; PRASTERONE; SEX HORMONE; SILDENAFIL; TADALAFIL; TESTOSTERONE; TESTOSTERONE CIPIONATE; TESTOSTERONE ENANTATE; TESTOSTERONE UNDECANOATE;

ANDROGEN DEFICIENCY; ARTICLE; CLINICAL FEATURE; COGNITION; DISEASE SEVERITY; DRUG SUBSTITUTION; DRUG WITHDRAWAL; EJACULATION DISORDER; ERECTILE DYSFUNCTION; HEMODYNAMIC PARAMETERS; HUMAN; HYPOACTIVE SEXUAL DESIRE DISORDER; HYPOGONADISM; LIBIDO; LIVER TOXICITY; LOADING DRUG DOSE; MALE; MALE SEXUAL DYSFUNCTION; PENIS; PENIS ERECTION; SEXUAL FUNCTION; SEXUAL HEALTH;

ANDROGENS; ERECTILE DYSFUNCTION; HUMANS; HYPOGONADISM; LIBIDO; MALE; PENILE ERECTION;

EID: 81355147728     PISSN: 15272737     EISSN: 15346285     Source Type: Journal    
DOI: 10.1007/s11934-011-0202-4     Document Type: Article

References (59)

1. CE Brown-Séquard 1889 Note on the effects produced on man by subcutaneous injection of a liquid obtained from the testicles of animals Lancet 137 105 107 10.1016/S0140-6736(00)64118-1
2. K David E Dingemanse E Laqeur 1935 Uber kristallinisches m männliches Hormon aus Hoden (Testosteron), wirksamer aus Harn oder aus Cholesterin bereitetes Androsteron Z Physiol Chem 233 281 287 1:CAS:528:DyaA2MXjvFKrsQ%3D%3D 10.1515/bchm2.1935.233.5-6.281
3. SR King PR Manna T Ishii, et al. 2002 An essential component in steroid synthesis, the steroidogenic acute regulatory protein, is expressed in discrete regions of the brain J Neurosci 15 22 10613 10620 (Pubitemid 36005134)
4. T Mulligan A Iranmanesh JD Feldhuis, et al. 2001 Pulsatile IV infusion of recombinant human LH in leuprolide suppressed men unmasks impoverished Leydig-cell secretory responsiveness J Clin Endocrinol Metab 86 5574 5579 10.1210/jc.86.11.5547 (Pubitemid 33070287)
5. M Zitzmann S Faber E Nieschlag 2006 Association of specific symptoms and metabolic risks with serum testosterone in older men J Clin Endocrinol Metab 91 4335 4343 16926258 1:CAS:528:DC%2BD28Xht1Whur3K 10.1210/jc.2006-0401 (Pubitemid 44833407)
6. AL Montejo S Majadas, et al. 2010 Frequency of sexual dysfunction in patients with psychotic disorder receiving antipsychotics J Sex Med 7 3404 3413 20214720 10.1111/j.1743-6109.2010.01709.x
7. E Elaut V Bogaert G De Cuypere, et al. 2010 Contribution of androgen receptor sensitivity to the relation between testosterone and sexual desire: en exploration in male-to-female transsexuals J Endocrinol Invest 33 37 41 19620824 1:CAS:528:DC%2BC3cXkvFOhsbs%3D
8. NM Gades DJ Jacobson ME McGree, et al. 2008 The association between serum sex hormones, erectile function, and sex drive: The Olmsted County Study of urinary symptoms and health status among men J Sex Med 5 2209 2220 18624959 This study provides strong support to the clinical relevance of androgens and sexual function
9. J Buvat A Lemaire 1997 Endocrine screening of 1022 men with erectile dysfunction: clinical significance and cost effective strategy J Urol 158 1764 1768 9334596 1:CAS:528:DyaK1cXmsVOrtLk%3D 10.1016/S0022-5347(01)64123-5 (Pubitemid 27433148)
10. AM Johri JPW Heaton A Morales 2001 Severe erectile dysfunction is a marker of hyperprolactinemia Int J Impot Res 13 176 179 11525317 1:STN:280:DC%2BD3MvotFCiuw%3D%3D 10.1038/sj.ijir.3900675 (Pubitemid 32587265)
11. RA Lobo OA Kletzky 1982 Normalization of androgens and sex-hormone-binding globulin levels after treatment of hyperprolactinemia J Clin Endocrinol Metab 56 562 566 10.1210/jcem-56-3-562
12. D Rowland CG McMahon C Abdo, et al. 2010 Disorders of orgasm and ejaculation in men J Sex Med 7 1668 1686 20388164 10.1111/j.1743-6109.2010. 01782.x This is an excellent current review of androgens and effect on men's health
13. EO Lauman A Paik RC Rosen 1999 Sexual dysfunctions in the United States: prevalence and predictors JAMA 281 537 544 10.1001/jama.281.6.537 (Pubitemid 29081307)
14. AT Kicman 2008 Pharmacology of anabolic steroids Br J Pharmacol 154 502 521 18500378 1:CAS:528:DC%2BD1cXmt1Kqtbg%3D 10.1038/bjp.2008.165 (Pubitemid 351744954)
15. G Corona E Mannuci F Lotti, et al. 2009 Impairment of couple relationship in male patients with sexual dysfunction is associated with overt hypogonadism J Sex Med 6 2591 2600 19515208 10.1111/j.1743-6109.2009.01352.x
16. M Arteaga-Silva RM Vigueras-Villasenor S Retana-Marquez, et al. 2008 Testosterone, androstenedione and 5 alpha-dehydrotestosterone on male sexual behavior and penile spines in the hamster Physiol Behav 94 412 421 18353404 1:CAS:528:DC%2BD1cXmtVajs7s%3D 10.1016/j.physbeh.2008.02.007 (Pubitemid 351680292)
17. M Sarkar D Bora S Bandopadhayay, et al. 2009 Season of the year influences output and concentration of testosterone in circulation in yaks Anim Reprod Sci 115 300 305 19157729 1:CAS:528:DC%2BD1MXptl2iu7g%3D 10.1016/j.anireprosci.2008.12.012
18. G Corona EA Jannini E Mannuci, et al. 2008 Different testosterone levels are associated with ejaculatory dysfunction J Sex Med 5 1991 1998 18399946 1:CAS:528:DC%2BD1cXhtVars7fO 10.1111/j.1743-6109.2008.00803.x
19. JPW Heaton S Varrin A Morales 1991 The characterization of a bio-assay of erectile function in a rat model J Urol 145 1099 1102 2016801 1:STN:280:DyaK3M3gt1Klsw%3D%3D
20. MA Adams JD Banting DH Maurice, et al. 1997 Vascular control mechanisms in penile erection: phylogeny and the inevitability of multiple overlapping systems Int J Impot Res 9 85 89 9205875 1:STN:280:DyaK2szltVSmsA%3D%3D 10.1038/sj.ijir.3900275
21. AM Traish R Munarriz L O'Conell, et al. 2003 Effects of medical or surgical castration on erectile function in an animal model J Androl 24 381 387 12721214 (Pubitemid 39571794)
22. A Morales B Johnson JPW Heaton, et al. 1997 Testosterone supplementation in hypogonadal impotence: assessment of biochemical measures and therapeutic outcomes J Urol 157 849 852 9072584 1:CAS:528:DyaK2sXhsVGruro%3D 10.1016/S0022-5347(01)65062-6 (Pubitemid 27066265)
23. F Saad LJ Gooren A Haider, et al. 2008 A dose response study of testosterone on sexual dysfunction and features of the metabolic syndrome using testosterone gel and parenteral testosterone undecanoate J Androl 29 102 106 17916569 1:CAS:528:DC%2BD1cXhtVOjtb4%3D 10.2164/jandrol.107.002774
24. TI Hwang YC Lin 2008 The relationship between hypogonadism and erectile dysfunction Int J Impot Res 20 231 235 18305486 1:CAS:528:DC%2BD1cXlvVWis74%3D 10.1038/sj.ijir.3901633 (Pubitemid 351684727)
25. M Hirshkowitz CA Moore S O'Connor, et al. 1997 Androgens and sleep-related erections J Psychosom Res 42 541 547 9226601 1:STN:280: DyaK2szntVahtw%3D%3D 10.1016/S0022-3999(97)00006-8 (Pubitemid 27299948)
26. SY Kalinchenko GI Koslov NP Gontcharov, et al. 2003 Oral testosterone undecanoate reverses erectile dysfunction associated with diabetes mellitus on patients failing on sildenafil citrate therapy alone Aging Male 6 94 99 12898793 1:CAS:528:DC%2BD3sXnt1Gisrs%3D (Pubitemid 36936511)
27. BD Rosenthal NR May MJ Metro, et al. 2006 Adjunctive use of AndroGel (testosterone gel) with sildenafil to treat erectile dysfunction in men with acquired androgen deficiency syndrome after failure using sildenafil alone Urology 67 571 574 16527581 10.1016/j.urology.2005.09.032 (Pubitemid 43343545)
28. R Virag 1982 Intracavernous injection of papaverine for erectile failure Lancet 2 938 6126784 1:STN:280:DyaL3s%2FhtFyqsw%3D%3D 10.1016/S0140-6736(82) 90910-2 (Pubitemid 12028430)
29. GS Brindley 1983 Cavernosal alpha blockade: a new technique for investigating and treating erectile impotence Br J Psychiatr 143 332 337 1:STN:280:DyaL2c%2FisFejsw%3D%3D 10.1192/bjp.143.4.332 (Pubitemid 13008537)
30. GS Brindley 1986 Maintenance treatment of erectile impotence by cavernosal unstriated muscle relaxant injection Br J Psychiatr 149 210 215 1:STN:280:DyaL2s%2FltVChtQ%3D%3D 10.1192/bjp.149.2.210 (Pubitemid 16076253)
31. TF Lue EA Tanagho 1987 Physiology of erection and pharmacological management of impotence J Urol 137 829 836 3553617 1:STN:280: DyaL2s7pvV2rtQ%3D%3D (Pubitemid 17074870)
32. I Saenz de Tejada 2002 Molecular mechanisms for the regulation of penile smooth muscle contractility Int J Impot Res 14 Suppl 1 6 10 10.1038/sj.ijir. 3900790
33. KE Andersson G Wagner 1995 Physiology of penile erection Physiol Rev 75 191 236 7831397 1:CAS:528:DyaK2MXjvVOguro%3D
34. AM Traish 2009 Androgens play a pivotal role in maintaining penile tissue architecture and erection J Androl 30 363 369 18802199 1:CAS:528: DC%2BD1MXptlyntb0%3D 10.2164/jandrol.108.006007 This is an informative review of the basic science efforts to elucidate the effect of androgen deprivation in erectile function
35. S Bhasin G Cunningham F Hayes, et al. 2010 Testosterone therapy in men with androgen deficiency syndromes: En Endocrine Society Clinical Practice Guideline J Clin Endocrinol Metab 95 2536 2559 20525905 1:CAS:528: DC%2BC3cXnvValu7k%3D 10.1210/jc.2009-2354 This article is essential reading for those treating men with TDS
36. A Morales AJ Bella S Chun, et al. 2010 A practical guide to diagnosis, management and treatment of testosterone deficiency for Canadian physicians Can Urol Assoc J 4 269 275 20694106
37. S Bhasin A Coviella R Basson 2007 Sexual dysfunction in men and women with endocrine disorders Lancet 369 597 611 17307107 1:CAS:528: DC%2BD2sXhvVGgsrs%3D 10.1016/S0140-6736(07)60280-3
38. JE Morley E Charlton P Patrick, et al. 2000 Validation of a screening questionnaire for androgen deficiency in aging males Metabolism 49 1239 1242 11016912 1:CAS:528:DC%2BD3cXms1ynsLc%3D 10.1053/meta.2000.8625
39. A Morales L Spevack L Emerson, et al. 2007 Adding to the controversy: pitfalls in the diagnosis of testosterone deficiency syndromes with questionnaires and biochemistry Aging Male 10 57 65 17558969 1:STN:280:DC%2BD2szks1aisQ%3D%3D 10.1080/13685530701342686 (Pubitemid 46904746)
40. G Hackett P Kell D Ralph, et al. 2008 British society for sexual medicine guidelines on the management of erectile dysfunction J Sex Med 5 1841 1865 18298470 10.1111/j.1743-6109.2008.00773.x
41. C Wang EE Nieschlag R Swerdloff, et al. 2009 Investigation, treatment, and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA, and ASA recommendations Eur Urol 55 121 130 18762364 10.1016/j.eururo.2008.08.033
42. C Collier A Morales AF Clark, et al. 2010 The significance of biological variation in the diagnosis of testosterone deficiency and considerations on the relevance of total, free and bioavailable testosterone determinations J Urol 183 2294 2298 20400148 1:CAS:528:DC%2BC3cXns1yktb0%3D 10.1016/j.juro.2010.02.011 This is an informative study on the pitfalls of biochemical assays for measuring serum testosterone
43. A Black AG Day A Morales 2004 The reliability of clinical and biochemical assessment in symptomatic late-onset hypogonadism: can a case be made for a 3-month therapeutic trial? BJUI 94 1066 1070 10.1111/j.1464-410X.2004.05105.x (Pubitemid 39577095)
44. J Morley 2007 The diagnosis of late life hypogonadism Aging Male 10 217 220 18033631 10.1080/13685530701695463 (Pubitemid 350146726)
45. S Melmed FF Casanova AR Hoffman, et al. 2011 Diagnosis and treatment of hyperprolactenemia: an endocrine society clinical practice guideline J Clin Endocrinol Metab 96 272 278 10.1210/jc.2010-1692
46. V Kupelian R Shabsigh AB Araujo, et al. 2006 Erectile dysfunction as a predictor of the metabolic syndrome in aging men: results from the Massachusetts male aging study J Urol 176 222 226 16753405 10.1016/S0022-5347(06)00503-9 (Pubitemid 43815376)
47. G Corona M Monami G Rastrelli, et al. 2011 Testosterone and metabolic syndrome: a meta-analysis study J Sex Med 8 272 283 20807333 1:CAS:528:DC%2BC3MXisFaisr4%3D 10.1111/j.1743-6109.2010.01991.x
48. GA Laughlin E Barrett-Connor J Bergstrom 2008 Low serum testosterone and mortality in older men J Clin Endocrinol Metab 93 69 75 This study refuted the erroneous idea that TDS is merely an inconvenience that does not affect survival or quality of life, a wake-up call for clinicians
49. AB Araujo GR Esche V Kupelian, et al. 2007 Prevalence of symptomatic androgen deficiency in men J Clin Endocrinol Metab 92 4241 4247 17698901 1:CAS:528:DC%2BD2sXhtlartb3N 10.1210/jc.2007-1245 (Pubitemid 350074738)
50. A Morales E Nieschlag M Schubert, et al. 2006 Clinical experience with the new long-acting injectable testosterone undecanoate Aging Male 9 221 227 17178558 1:STN:280:DC%2BD28jjvFaisw%3D%3D 10.1080/13685530601063689 (Pubitemid 46009610)
51. C Foresta N Caretta M Rossato, et al. 2004 Role of androgens in erectile function J Urol 171 2358 2362 15126821 1:CAS:528:DC%2BD2cXkvVWhs78%3D 10.1097/01.ju.0000124323.02868.68 (Pubitemid 38625470)
52. F Saad AS Grahl A Aversa, et al. 2007 Effects of testosterone on erectile function: implications for the therapy of erectile dysfunction BJUI 99 968 992 10.1111/j.1464-410X.2007.06756.x
53. A Aversa AM Isidori G Spera A Lenzi, et al. 2003 Androgens improve cavernous vasodilatation and response to sildenafil in patients with erectile dysfunction Clin Endocrinol (Oxf) 58 632 638 1:CAS:528:DC%2BD3sXktVantLo%3D 10.1046/j.1365-2265.2003.01764.x (Pubitemid 36566807)
54. R Shabsigh KJ Kaufman C Steidle, et al. 2004 Randomized study of testosterone gel as adjunctive therapy to sildenafil in hypogonadal men with erectile dysfunction who do not respond to sildenafil alone J Urol 172 658 663 15247755 1:CAS:528:DC%2BD2cXlsFelsb4%3D 10.1097/01.ju.0000132389.97804.d7 (Pubitemid 38900229)
55. A Greenstein NJ Mabjeesh M Sofer, et al. 2005 Does sildenafil combined with testosterone gel improve erectile dysfunction in hypogonadal men in whom testosterone supplement therapy alone failed? J Urol 173 530 532 15643239 1:CAS:528:DC%2BD2MXitl2qsQ%3D%3D 10.1097/01.ju.0000149870.36577.05
56. J Buvat F Montorsi M Maggi, et al. 2011 Hypogonadal men nonresponders to the PDE5 inhibitor tadalafil benefit from normalization of testosterone levels with a 1% hydroalcoholic testosterone gel in the treatment of erectile dysfunction (TADTEST Study) J Sex Med 8 284 293 20704642 1:CAS:528: DC%2BC3MXisFaisrw%3D 10.1111/j.1743-6109.2010.01956.x
57. A Morales CC Schulman JC Tostain WF Wu 2006 Testosterone deficiency syndrome (TDS) need to be named appropriately: the importance of accurate terminology Eur Urol 50 407 409 16854520 10.1016/j.eururo.2006.07.001 (Pubitemid 44192565)
58. A Morales A Black L Emerson, et al. 2009 Androgens and sexual function: a placebo controlled, randomized, double blind study of testosterone vs. dehydroepiandrosterone in men with sexual dysfunction and androgen deficiency Aging Male 12 104 112 19883295 1:CAS:528:DC%2BC3cXlvVGlt74%3D 10.3109/13685530903294388
59. A Guay S Bansal GJ Heatley 1995 Effect of raising endogenous testosterone levels in impotent men with secondary hypogonadism: double blind placebo-controlled trial of clomiphene citrate J Clin Endocrinol Metab 80 3546 3552 8530597 1:CAS:528:DyaK2MXpvFSjtb0%3D 10.1210/jc.80.12.3546