The effectiveness of metformin ovulation induction treatment in patients with PCOS: A systematic review and meta-analysis

Gynecological Endocrinology

Volumn 28, Issue 12, 2012, Pages 956-960

  Xiao, Jinsong ^a   Chen, Shuangyun ^a   Zhang, Chunlian ^a   Chang, Shang ^a  

^a HUBEI UNIVERSITY OF MEDICINE   (China)

Author keywords

Clomiphene citrate; Meta analysis; Metformin; Ovulation induction; Polycystic ovary syndrome; Systematic review

Indexed keywords

CLOMIFENE CITRATE; METFORMIN;

ADULT; ARTICLE; DRUG EFFICACY; DRUG WITHDRAWAL; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; META ANALYSIS; OVARY POLYCYSTIC DISEASE; OVULATION INDUCTION; PREGNANCY RATE; PRIORITY JOURNAL; QUALITY CONTROL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SENSITIVITY ANALYSIS; SINGLE DRUG DOSE; SPONTANEOUS ABORTION; SYSTEMATIC REVIEW;

ABORTION, SPONTANEOUS; CLOMIPHENE; DRUG THERAPY, COMBINATION; ESTROGEN ANTAGONISTS; EVIDENCE-BASED MEDICINE; FEMALE; FERTILITY AGENTS, FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; INFERTILITY, FEMALE; METFORMIN; OVULATION; OVULATION INDUCTION; POLYCYSTIC OVARY SYNDROME; PREGNANCY; PREGNANCY RATE; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84869995793     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.3109/09513590.2012.705368     Document Type: Article

References (24)

1. Lobo RA, Granger LR, Davajan V, Mishell DR Jr. An extended regimen of clomiphene citrate in women unresponsive to standard therapy. Fertil Steril 1982;37:762-766.
2. Nestler JE, Jakubowicz DJ, Reamer P, Gunn RD, Allan G. Ovulatory and metabolic efects of D-chiro-inositol in the polycystic ovary syndrome. N Engl J Med 1999;340:1314-1320.
3. Nestler JE, Jakubowicz DJ, Evans WS, Pasquali R. Efects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome. N Engl J Med 1998;338:1876-1880.
4. El-Biely MM, Habba M. Te use of metformin to augment the induction of ovulation in obese infertile patients with polycystic ovary syndrome. Middle East Fertility Society Journal 2001;6:43-49.
5. Te Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-termhealth risks related to polycystic ovary syndrome. Fertil Steril 2004;81:19-25.
6. Jüni P, Altman DG, Egger M. Systematic reviews in health care: Assessing the quality of controlled clinical trials. BMJ 2001;323:42-46.
7. Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 2000;283:2008-2012.
8. Te Cochrane Collaboration. Cochrane Reviewer'Handbook 4.1. In: Te Cochrane Library, Issue 2, 2000.
9. Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment efects in controlled trials. JAMA 1995;273:408-412.
10. Karimzadeh MA, Javedani M. An assessment of lifestyle modifcation versus medical treatment with clomiphene citrate, metformin, and clomiphene citrate-metformin in patients with polycystic ovary syndrome. Fertil Steril 2010;94:216-220.
11. Legro RS, Barnhart HX, Schlaf WD, Carr BR, Diamond MP, Carson SA, Steinkampf MP, et al.; Cooperative Multicenter Reproductive Medicine Network. Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome. N Engl J Med 2007;356:551-566.
12. Zain MM, Jamaluddin R, Ibrahim A, Norman RJ. Comparison of clomiphene citrate, metformin, or the combination of both for frst-line ovulation induction, achievement of pregnancy, and live birth in Asian women with polycystic ovary syndrome: a randomized controlled trial. Fertil Steril 2009;91:514-521.
13. Moll E, Bossuyt PM, Korevaar JC, Lambalk CB, van der Veen F. Efect of clomifene citrate plus metformin and clomifene citrate plus placebo on induction of ovulation in women with newly diagnosed polycystic ovary syndrome: randomised double blind clinical trial. BMJ 2006;332:1485.
14. Palomba S, Orio F Jr, Falbo A, Manguso F, Russo T, Cascella T, Tolino A, et al. Prospective parallel randomized, double-blind, double-dummy controlled clinical trial comparing clomiphene citrate and metformin as the frst-line treatment for ovulation induction in nonobese anovulatory women with polycystic ovary syndrome. J Clin Endocrinol Metab 2005;90:4068-4074.
15. Siebert TI, Kruger TF, Lombard C. Evaluating the equivalence of clomiphene citrate with and without metformin in ovulation induction in PCOS patients. J Assist Reprod Genet 2009;26:165-171.
16. Dasari P, Pranahita G. Te efcacy of metformin and clomiphene citrate combination compared with clomiphene citrate alone for ovulation induction in infertile patients with PCOS. J Hum Reprod Sci 2009;2:18-22.
17. Khorram O, Helliwell J P, Katz S, Bonpane CM, Jaramillo L. Two weeks of metformin improves clomiphene citrate-induced ovulation and metabolic profles in women with polycystic ovary syndrome. Fertil Steril 2006;85:1448-1451.
18. Lord JM, Flight IH, Norman RJ. Metformin in polycystic ovary syndrome: systematic review and meta-analysis. BMJ 2003;327:951-953.
19. Diamanti-Kandarakis E, Christakou CD, Kandaraki E, Economou FN. Metformin: an old medication of new fashion: evolving new molecular mechanisms and clinical implications in polycystic ovary syndrome. Eur J Endocrinol 2010;162:193-212.
20. Creanga AA, Bradley HM, McCormick C, Witkop CT. Use of metformin in polycystic ovary syndrome: a meta-analysis. Obstet Gynecol 2008;111:959-968.
21. Moll E, van der Veen F, van Wely M. Te role of metformin in polycystic ovary syndrome: a systematic review. Hum Reprod Update 2007;13:527-537.
22. Glueck CJ, Phillips H, Cameron D, Sieve-Smith L, Wang P. Continuing metformin throughout pregnancy in women with polycystic ovary syndrome appears to safely reduce frst-trimester spontaneous abortion: a pilot study. Fertil Steril 2001;75:46-52.
23. Jakubowicz DJ, Iuorno MJ, Jakubowicz S, Roberts KA, Nestler JE. Efects of metformin on early pregnancy loss in the polycystic ovary syndrome. J Clin Endocrinol Metab 2002;87:524-529.
24. Heard MJ, Pierce A, Carson SA, Buster JE. Pregnancies following use of metformin for ovulation induction in patients with polycystic ovary syndrome. Fertil Steril 2002;77:669-673.