Effect of myxothiazol on Leydig cell steroidogenesis: Inhibition of luteinizing hormone-mediated testosterone synthesis but stimulation of basal steroidogenesis

Endocrinology

Volumn 148, Issue 6, 2007, Pages 2583-2590

  Midzak, Andrew S ^a   Liu, June ^a   Zirkin, Barry R ^a   Chen, Haolin ^a  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; CYCLIC AMP; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; MYXOTHIAZOL; STEROID 17,20 LYASE; STEROID 17ALPHA MONOOXYGENASE; STEROIDOGENIC ACUTE REGULATORY PROTEIN; TESTOSTERONE; TESTOSTERONE 17BETA DEHYDROGENASE;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ARTICLE; BROWN NORWAY RAT; CONTROLLED STUDY; DRUG EFFICACY; DRUG INHIBITION; DRUG MECHANISM; ELECTRON TRANSPORT; INCUBATION TEMPERATURE; LEYDIG CELL; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; RAT; STEROIDOGENESIS; TESTOSTERONE SYNTHESIS;

ANIMALS; LEYDIG CELLS; LUTEINIZING HORMONE; MALE; METHACRYLATES; MITOCHONDRIA; RATS; RATS, INBRED STRAINS; SIGNAL TRANSDUCTION; STEROIDS; TESTOSTERONE; THIAZOLES;

EID: 34250859711     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2006-1488     Document Type: Article

References (33)

1. Ewing LL, Zirkin B 1983 Leydig cell structure and steroidogenic function. Recent Prog Horm Res 39:599-635
2. Haider SG 2004 Cell biology of Leydig cells in the testis. Int Rev Cytol 233:181-241
3. Payne AH, Hales DB 2004 Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocr Rev 25:947-970
4. Payne AH, Youngblood GL 1995 Regulation of expression of steroidogenic enzymes in Leydig cells. Biol Reprod 52:217-225
5. Dufau ML 1998 The luteinizing hormone receptor. Annu Rev Physiol 60:461-496
6. Stocco DM 2001 StAR protein and the regulation of steroid hormone biosynthesis. Annu Rev Physiol 63:193-213
7. Papadopoulos V 1993 Peripheral-type benzodiazepine/diazepam binding inhibitor receptor: biological role in steroidogenic cell function. Endocr Rev 14:222-240
8. Allen JA, Shankara T, Janus P, Buck S, Diemer T, Hales KH, Hales DB 2006 Energized, polarized, and actively respiring mitochondria are required for acute Leydig cell steroidogenesis. Endocrinology 147:3924-3935
9. Gerth K, Irschik H, Reichenbach H, Trowitzsch W 1980 Myxothiazol, an antibiotic from Myxococcus fulvus (myxobacterales). I. Cultivation, isolation, physico-chemical and biological properties. J Antibiot (Tokyo) 33:1474-1479
10. Trowitzsch W, Reifenstahl G, Wray V, Gerth K 1980 Myxothiazol, an antibiotic from Myxococcus fulvus (myxobacterales). II. structure elucidation. J Antibiot (Tokyo) 33:1480-1490
11. Thierbach G, Reichenbach H 1981 Myxothiazol, a new antibiotic interfering with respiration. Antimicrob Agents Chemother 19:504-507
12. Thierbach G, Reichenbach H 1981 Myxothiazol, a new inhibitor of the cytochrome b-c1 segment of the respiratory chain. Biochim Biophys Acta 638:282-289
13. Ahmad IM, Aykin-Burns N, Sim JE, Walsh SA, Higashikubo R, Buettner GR, Venkataraman S, Mackey MA, Flanagan SW, Oberley LW, Spitz DR 2005 Mitochondrial O2*- and H2O2 mediate glucose deprivation-induced stress in human cancer cells. J Biol Chem 280:4254-4263
14. Ludwig LM, Tanaka K, Eells JT, Weihrauch D, Pagel PS, Kersten JR, Warltier DC 2004 Preconditioning by isoflurane is mediated by reactive oxygen species generated from mitochondrial electron transport chain complex III. Anesth Analg 99:1308 -1315; table of contents
15. Klinefelter GR, Hall PF, Ewing LL 1987 Effect of luteinizing hormone deprivation in situ on steroidogenesis of rat Leydig cells purified by a multistep procedure. Biol Reprod 36:769-783
16. Diemer T, Allen JA, Hales KH, Hales DB 2003 Reactive oxygen disrupts mitochondria in MA-10 tumor Leydig cells and inhibits steroidogenic acute regulatory (StAR) protein and steroidogenesis. Endocrinology 144:2882-2891
17. Darney Jr KJ, Wing TY, Ewing LL 1983 Simultaneous measurement of four testicular Δ4-3-ketosteroids by isocratic high-performance liquid chromatography with on-line ultraviolet absorbance detection. J Chromatogr 257:81-90
18. Shiraishi K, Ascoli M 2006 Activation of the lutropin/ choriogonadotropin receptor in MA-10 cells stimulates tyrosine kinase cascades that activate ras and the extracellular signal regulated kinases (ERK1/2). Endocrinology 147:3419-3427
19. Renlund N, Jo Y, Svechnikova I, Holst M, Stocco DM, Soder O, Svechnikov K 2006 Induction of steroidogenesis in immature rat Leydig cells by interleukin-1α is dependent on extracellular signal-regulated kinases. J Mol Endocrinol 36:327-336
20. Khanum A, Buczko E, Dufau ML 1997 Essential role of adenosine triphosphate in activation of 17β-hydroxysteroid dehydrogenase in the rat Leydig cell. Endocrinology 138:1612-1620
21. West LA, Horvat RD, Roess DA, Barisas BG, Juengel JL, Niswender GD 2001 Steroidogenic acute regulatory protein and peripheral-type benzodiazepine receptor associate at the mitochondrial membrane. Endocrinology 142:502-505
22. Hauet T, Yao ZX, Bose HS, Wall CT, Han Z, Li W, Hales DB, Miller WL, Culty M, Papadopoulos V 2005 Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into Leydig cell mitochondria. Mol Endocrinol 19:540-554
23. Papadopoulos V, Mukhin AG, Costa E, Krueger KE 1990 The peripheral-type benzodiazepine receptor is functionally linked to Leydig cell steroidogenesis. J Biol Chem 265:3772-3779
24. Casellas P, Galiegue S, Basile AS 2002 Peripheral benzodiazepine receptors and mitochondrial function. Neurochem Int 40:475-486
25. Delavoie F, Li H, Hardwick M, Robert JC, Giatzakis C, Peranzi G, Yao ZX, Maccario J, Lacapere JJ, Papadopoulos V 2003 In vivo and in vitro peripheraltype benzodiazepine receptor polymerization: functional significance in drug ligand and cholesterol binding. Biochemistry 42:4506-4519
26. Wallace KB, Starkov AA 2000 Mitochondrial targets of drug toxicity. Annu Rev Pharmacol Toxicol 40:353-388
27. Nicholls DG 2005 Mitochondria and calcium signaling. Cell Calcium 38:311-317
28. Nicholls DG, Chalmers S 2004 The integration of mitochondrial calcium transport and storage. J Bioenerg Biomembr 36:277-281
29. Wang YX, Zheng YM, Abdullaev I, Kotlikoff MI 2003 Metabolic inhibition with cyanide induces calcium release in pulmonary artery myocytes and Xenopus oocytes. Am J Physiol Cell Physiol 284:C378-C388
30. Duchen MR, Valdeolmillos M, O'Neill SC, Eisner DA 1990 Effects of metabolic blockade on the regulation of intracellular calcium in dissociated mouse sensory neurones. J Physiol 424:411-426
31. Sullivan MH, Cooke BA 1986 The role of Ca2+ in steroidogenesis in Leydig cells. Stimulation of intracellular free Ca2+ by lutropin (LH), luliberin (LHRH) agonist and cyclic AMP. Biochem J 236:45-51
32. Kumar S, Blumberg DL, Canas JA, Maddaiah VT 1994 Human chorionic gonadotropin (hCG) increases cytosolic free calcium in adult rat Leydig cells. Cell Calcium 15:349-355
33. Tomic M, Dufau ML, Catt KJ, Stojilkovic SS 1995 Calcium signaling in single rat Leydig cells. Endocrinology 136:3422-3429