The nuclear receptors NUR77 and SF1 play additive roles with c-JUN through distinct elements on the mouse Star promoter

Journal of Molecular Endocrinology

Volumn 42, Issue 2, 2009, Pages 119-129

  Martin, Luc J ^a   Tremblay, Jacques J ^a,b  

^a Université Laval   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEAR RECEPTOR NUR77; PROTEIN C JUN; STEROIDOGENIC ACUTE REGULATORY PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SF1; UNCLASSIFIED DRUG; CELL RECEPTOR; DNA BINDING PROTEIN; NR5A2 PROTEIN, MOUSE; PHOSPHOPROTEIN; PROTEIN C FOS; STEROID RECEPTOR; STEROIDOGENIC FACTOR 1;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; IMMUNOPRECIPITATION; LEYDIG CELL; LIGAND BINDING; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; TRANSCRIPTION REGULATION; UPREGULATION; ANIMAL; CELL LINE; CHEMISTRY; GENETICS; MALE; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; RAT;

ANIMALS; BASE SEQUENCE; BINDING SITES; CELL LINE; DNA-BINDING PROTEINS; MALE; MICE; MOLECULAR SEQUENCE DATA; PHOSPHOPROTEINS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; STEROIDOGENIC FACTOR 1;

EID: 64149129173     PISSN: 09525041     EISSN: 14796813     Source Type: Journal    
DOI: 10.1677/JME-08-0095     Document Type: Article

References (61)

1. Aesoy R, Mellgren G, Morohashi K & Lund J 2002 Activation of cAMP-dependent protein kinase increases the protein level of steroidogenic factor-1. Endocrinology 143 295-303.
2. Angel P, Imagawa M, Chiu R, Stein B, Imbra RJ, Rahmsdorf HJ, Jonat C, Herrlich P & Karin M 1987 Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell 49 729-739.
3. Ascoli M 1981 Characterization of several clonal lines of cultured Leydig tumor cells: gonadotropin receptors and steroidogenic responses. Endocrinology 108 88-95.
4. Bassett MH, Suzuki T, Sasano H, De Vries CJ, Jimenez PT, Carr BR & Rainey WE 2004 The orphan nuclear receptor NGFIB regulates transcription of 3β-hydroxysteroid dehydrogenase. Implications for the control of adrenal functional zonation. Journal of Biological Chemistry 279 37622-37630.
5. Caron KM, Ikeda Y, Soo SC, Stocco DM, Parker KL & Clark BJ 1997 Characterization of the promoter region of the mouse gene encoding the steroidogenic acute regulatory protein. Molecular Endocrinology 11 138-147.
6. Clem BF, Hudson EA & Clark BJ 2005 Cyclic adenosine 3′,5′- monophosphate (cAMP) enhances cAMP-responsive element binding (CREB) protein phosphorylation and phospho-CREB interaction with the mouse steroidogenic acute regulatory protein gene promoter. Endocrinology 146 1348-1356.
7. Daggett MA, Rice DA & Heckert LL 2000 Expression of steroidogenic factor 1 in the testis requires an E box and CCAAT box in its promoter proximal region. Biology of Reproduction 62 670-679.
8. Davis IJ & Lau LF 1994 Endocrine and neurogenic regulation of the orphan nuclear receptors Nur77 and Nurr-1 in the adrenal glands. Molecular and Cellular Biology 14 3469-3483.
9. Davis IJ, Hazel TG, Chen RH, Blenis J & Lau LF 1993 Functional domains and phosphorylation of the orphan receptor Nur77. Molecular Endocrinology 7 953-964.
10. Guo IC, Huang CY, Wang CK & Chung BC 2007 Activating protein-1 cooperates with steroidogenic factor-1 to regulate 3′,5′-cyclic adenosine 5′-monophosphate-dependent human CYP11A1 transcription in vitro and in vivo. Endocrinology 148 1804-1812.
11. Havelock JC, Smith AL, Seely JB, Dooley CA, Rodgers RJ, Rainey WE & Carr BR 2005 The NGFI-B family of transcription factors regulates expression of 3β-hydroxysteroid dehydrogenase type 2 in the human ovary. Molecular Human Reproduction 11 79-85.
12. Hirata Y, Kiuchi K, Chen HC, Milbrandt J & Guroff G 1993 The phosphorylation and DNA binding of the DNA-binding domain of the orphan nuclear receptor NGFI-B. Journal of Biological Chemistry 268 24808-24812.
13. Hiroi H, Christenson LK, Chang L, Sammel MD, Berger SL & Strauss JF III 2004 Temporal and spatial changes in transcription factor binding and histone modifications at the steroidogenic acute regulatory protein (StAR) locus associated with StAR transcription. Molecular Endocrinology 18 791-806.
14. Hong CY, Park JH, Ahn RS, Im SY, Choi HS, Soh J, Mellon SH & Lee K 2004 Molecular mechanism of suppression of testicular steroidogenesis by proinflammatory cytokine tumor necrosis factor alpha. Molecular and Cellular Biology 24 2593-2604.
15. Jo Y, King SR, Khan SA & Stocco DM 2005 Involvement of protein kinase C and cyclic adenosine 3′,5′-monophosphate-dependent kinase in steroidogenic acute regulatory protein expression and steroid biosynthesis in Leydig cells. Biology of Reproduction 73 244-255.
16. Kim H, Kim BY, Soh JW, Cho EJ, Liu JO & Youn HD 2006 A novel function of Nur77: physical and functional association with protein kinase C. Biochemical and Biophysical Research Communications 348 950-956.
17. 2+ and cAMP signals. Neurochemistry International 46 305-312.
18. Kouzarides T & Ziff E 1988 The role of the leucine zipper in the fos- jun interaction. Nature 336 646-651.
19. Li Y & Lau LF 1997 Adrenocorticotropic hormone regulates the activities of the orphan nuclear receptor Nur77 through modulation of phosphorylation. Endocrinology 138 4138-4146.
20. Li X, Hales KH, Watanabe G, Lee RJ, Pestell RG & Hales DB 1997 The effect of tumor necrosis factor-alpha and cAMP on induction of AP-1 activity in MA-10 tumor Leydig cells. Endocrine 6 317-324.
21. Li LA, Chiang EF, Chen JC, Hsu NC, Chen YJ & Chung BC 1999 Function of steroidogenic factor 1 domains in nuclear localization, transactivation, and interaction with transcription factor TFIIB and c-Jun. Molecular Endocrinology 13 1588-1598.
22. Li W, Amri H, Huang H, Wu C & Papadopoulos V 2004 Gene and protein profiling of the response of MA-10 Leydig tumor cells to human chorionic gonadotropin. Journal of Andrology 25 900-913.
23. Manna PR & Stocco DM 2007 Crosstalk of CREB and Fos/Jun on a single cis-element: transcriptional repression of the steroidogenic acute regulatory protein gene. Journal of Molecular Endocrinology 39 261-277.
24. Manna PR & Stocco DM 2008 The role of c-Jun in the regulation of PKC-mediated StAR expression and steroidogenesis in mouse Leydig cells. Journal of Molecular Endocrinology 42 329-341.
25. Manna PR, Dyson MT, Eubank DW, Clark BJ, Lalli E, Sassone-Corsi P, Zeleznik AJ & Stocco DM 2002 Regulation of steroidogenesis and the steroidogenic acute regulatory protein by a member of the cAMP response-element binding protein family. Molecular Endocrinology 16 184-199.
26. Manna PR, Wang XJ & Stocco DM 2003a Involvement of multiple transcription factors in the regulation of steroidogenic acute regulatory protein gene expression. Steroids 68 1125-1134.
27. Manna PR, Eubank DW, Lalli E, Sassone-Corsi P & Stocco DM 2003b Transcriptional regulation of the mouse steroidogenic acute regulatory protein gene by the cAMP response-element binding protein and steroidogenic factor 1. Journal of Molecular Endocrinology 30 381-397.
28. Manna PR, Eubank DW & Stocco DM 2004 Assessment of the role of activator protein-1 on transcription of the mouse steroidogenic acute regulatory protein gene. Molecular Endocrinology 18 558-573.
29. Manna PR, Dyson MT, Jo Y & Stocco DM 2008 Role of DAX-1 in PKA- and PKC-mediated regulation of the steroidogenic acute regulatory protein expression in mouse Leydig tumor cells: mechanism of action. Endocrinology (doi: 10.1210/en.2008-0368).
30. 4 isomerase type 2 promoter is a novel target for the immediate early orphan nuclear receptor NUR77 in steroidogenic cells. Endocrinology 146 861-869.
31. Martin LJ & Tremblay JJ 2008 Glucocorticoids antagonize cAMPinduced StAR transcription in Leydig cells through the orphan nuclear receptor NUR77. Journal of Molecular Endocrinology 41 165-175.
32. Martin LJ, Boucher N, Brousseau C & Tremblay JJ 2008 The orphan nuclear receptor NUR77 regulates hormone-induced StAR transcription in Leydig cells through a cooperation with CaMKI. Molecular Endocrinology 22 2021-2037.
33. Maxwell MA & Muscat GE 2005 The NR4A subgroup: immediate early response genes with pleiotropic physiological roles. Nuclear Receptor Signaling 4 1-8.
34. Montminy MR, Sevarino KA, Wagner JA, Mandel G & Goodman RH 1986 Identification of a cyclic-AMP-responsive element within the rat somatostatin gene. PNAS 83 6682-6686.
35. Mynard V, Latchoumanin O, Guignat L, vin-Leclerc J, Bertagna X, Barre B, Fagart J, Coqueret O & Catelli MG 2004 Synergistic signaling by corticotropin-releasing hormone and leukemia inhibitory factor bridged by phosphorylated 3′,5′-cyclic adenosine monophosphate response element binding protein at the Nur response element (NurRE)-signal transducers and activators of transcription (STAT) element of the proopiomelanocortin promoter. Molecular Endocrinology 18 2997-3010.
36. Nishida H, Miyagawa S, Vieux-Rochas M, Morini M, Ogino Y, Suzuki K, Nakagata N, Choi HS, Levi G & Yamada G 2008 Positive regulation of steroidogenic acute regulatory protein gene expression through the interaction between Dlx and GATA-4 for testicular steroidogenesis. Endocrinology 149 2090-2097.
37. O'Shea EK, Rutkowski R & Kim PS 1992 Mechanism of specificity in the Fos-Jun oncoprotein heterodimer. Cell 68 699-708.
38. Park JI, Park HJ, Choi HS, Lee K, Lee WK & Chun SY 2001 Gonadotropin regulation of NGFI-B messenger ribonucleic acid expression during ovarian follicle development in the rat. Endocrinology 142 3051-3059.
39. Park JI, Park HJ, Lee YI, Seo YM & Chun SY 2003 Regulation of NGFI-B expression during the ovulatory process. Molecular and Cellular Endocrinology 202 25-29.
40. Parker KL, Rice DA, Lala DS, Ikeda Y, Luo X, Wong M, Bakke M, Zhao L, Frigeri C, Hanley NA et al. 2002 Steroidogenic factor 1: an essential mediator of endocrine development. Recent Progress in Hormone Research 57 19-36.
41. Pezzi V, Sirianni R, Chimento A, Maggiolini M, Bourguiba S, Delalande C, Carreau S, Ando S, Simpson ER & Clyne CD 2004 Differential expression of steroidogenic factor-1/adrenal 4 binding protein and liver receptor homolog-1 (LRH-1)/fetoprotein transcription factor in the rat testis: LRH-1 as a potential regulator of testicular aromatase expression. Endocrinology 145 2186-2196.
42. Philips A, Lesage S, Gingras R, Maira MH, Gauthier Y, Hugo P & Drouin J 1997 Novel dimeric Nur77 signaling mechanism in endocrine and lymphoid cells. Molecular and Cellular Biology 17 5946-5951.
43. Reinhart AJ, Williams SC, Clark BJ & Stocco DM 1999 SF-1 (steroidogenic factor-1) and C/EBP beta (CCAAT/enhancer binding protein-beta) cooperate to regulate the murine StAR (steroidogenic acute regulatory) promoter. Molecular Endocrinology 13 729-741.
44. Rust W, Stedronsky K, Tillmann G, Morley S, Walther N & Ivell R 1998 The role of SF-1/Ad4BP in the control of the bovine gene for the steroidogenic acute regulatory (StAR) protein. Journal of Molecular Endocrinology 21 189-200.
45. Schreiber E, Matthias P, Muller MM & Schaffner W 1989 Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Research 17 6419.
46. Shea-Eaton W, Sandhoff TW, Lopez D, Hales DB & McLean MP 2002 Transcriptional repression of the rat steroidogenic acute regulatory (StAR) protein gene by the AP-1 family member c-Fos. Molecular and Cellular Endocrinology 188 161-170.
47. Song KH, Park JI, Lee MO, Soh J, Lee K & Choi HS 2001 LH induces orphan nuclear receptor Nur77 gene expression in testicular Leydig cells. Endocrinology 142 5116-5123.
48. Song KH, Park YY, Park KC, Hong CY, Park JH, Shong M, Lee K & Choi HS 2004 The atypical orphan nuclear receptor DAX-1 interacts with orphan nuclear receptor Nur77 and represses its transactivation. Molecular Endocrinology 18 1929-1940.
49. Sugawara T, Holt JA, Kiriakidou M & Strauss JF III 1996 Steroidogenic factor 1-dependent promoter activity of the human steroidogenic acute regulatory protein (StAR) gene. Biochemistry 35 9052-9059.
50. Sugawara T, Kiriakidou M, McAllister JM, Kallen CB & Strauss JF III 1997 Multiple steroidogenic factor 1 binding elements in the human steroidogenic acute regulatory protein gene 5′-flanking region are required for maximal promoter activity and cyclic AMP responsiveness. Biochemistry 36 7249-7255.
51. Sugawara T, Saito M & Fujimoto S 2000 Sp1 and SF-1 interact and cooperate in the regulation of human steroidogenic acute regulatory protein gene expression. Endocrinology 141 2895-2903.
52. Teyssier C, Belguise K, Galtier F & Chalbos D 2001 Characterization of the physical interaction between estrogen receptor alpha and JUN proteins. Journal of Biological Chemistry 276 36361-36369.
53. Tremblay JJ & Viger RS 2001 GATA factors differentially activate multiple gonadal promoters through conserved GATA regulatory elements. Endocrinology 142 977-986.
54. Tremblay A, Tremblay GB, Labrie F & Giguere V 1999a Ligand-independent recruitment of SRC-1 to estrogen receptor beta through phosphorylation of activation function AF-1. Molecular Cell 3 513-519.
55. Tremblay JJ, Marcil A, Gauthier Y & Drouin J 1999b Ptx1 regulates SF-1 activity by an interaction that mimics the role of the ligand-binding domain. EMBO Journal 18 3431-3441.
56. Tremblay JJ, Hamel F & Viger RS 2002 Protein kinase A-dependent cooperation between GATA and C/EBP transcription factors regulates StAR promoter activity. Endocrinology 143 3935-3945.
57. Wansa KD, Harris JM & Muscat GE 2002 The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment. Journal of Biological Chemistry 277 33001-33011.
58. Wilson TE, Fahrner TJ & Milbrandt J 1993 The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction. Molecular and Cellular Biology 13 5794-5804.
59. Wooton-Kee CR & Clark BJ 2000 Steroidogenic factor-1 influences protein-deoxyribonucleic acid interactions within the cyclic adenosine 3,5-monophosphate-responsive regions of the murine steroidogenic acute regulatory protein gene. Endocrinology 141 1345-1355.
60. Zazopoulos E, Lallie E, Stocco DM & Sassone-Corsi P 1997 DNA binding and transcriptional repression by DAX-1 blocks steroidogenesis. Nature 390 311-315.
61. Zhang P & Mellon SH 1997 Multiple orphan nuclear receptors converge to regulate rat P450c17 gene transcription: novel mechanisms for orphan nuclear receptor action. Molecular Endocrinology 11 891-904.