메뉴 건너뛰기




Volumn 27, Issue 10, 2012, Pages 3057-3066

Is there a doseresponse relationship of metformin treatment in patients with polycystic ovary syndrome? Results from a multicentric study

Author keywords

dose; insulin; metformin; PCOS

Indexed keywords

ANDROGEN; ANDROSTENEDIONE; FOLLITROPIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYPROGESTERONE; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LUTEINIZING HORMONE; METFORMIN; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE; TRIACYLGLYCEROL; ANTIDIABETIC AGENT;

EID: 84866355741     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/des262     Document Type: Article
Times cited : (34)

References (39)
  • 1
    • 17844367331 scopus 로고    scopus 로고
    • Prevalence and characteristics of the metabolic syndrome in women with polycystic ovary syndrome
    • Apridonidze T, Essah PA, luorno MJ, Nestler JE. Prevalence and characteristics of the metabolic syndrome in women with polycystic ovary syndrome. J Clin Endocrinol Metab 2005;90:1929-1935.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 1929-1935
    • Apridonidze, T.1    Essah, P.A.2    Luorno, M.J.3    Nestler, J.E.4
  • 2
    • 0034892698 scopus 로고    scopus 로고
    • Metformin directly inhibits androgen production in human thecal cells
    • Attia GR, Rainey WE, Carr BR. Metformin directly inhibits androgen production in human thecal cells. Fertil Steril 2001;76:517-524.
    • (2001) Fertil Steril , vol.76 , pp. 517-524
    • Attia, G.R.1    Rainey, W.E.2    Carr, B.R.3
  • 3
    • 65449133147 scopus 로고    scopus 로고
    • Metformin\the gold standard in type 2 diabetes: What does the evidence tell us?
    • Bosi E. Metformin\the gold standard in type 2 diabetes: what does the evidence tell us? Diabetes Obes Metab 2009;11 (Suppl. 2):3-8.
    • (2009) Diabetes Obes Metab , vol.11 , Issue.SUPPL. 2 , pp. 3-8
    • Bosi, E.1
  • 4
    • 34547663052 scopus 로고    scopus 로고
    • Comparison of two doses of metformin (2.5 and l.5g/day) for the treatment of polycystic ovary syndrome and their effect on body mass index and waist circumference
    • Epub April 11
    • Bruno RV, de Avila MA, Neves FB, Nardi AE, Crespo CM, Sobrinho AT. Comparison of two doses of metformin (2.5 and l.5g/day) for the treatment of polycystic ovary syndrome and their effect on body mass index and waist circumference, Fertil Steril 2007;88:510-512. Epub April 11.
    • (2007) Fertil Steril , vol.88 , pp. 510-512
    • Bruno, R.V.1    De Avila, M.A.2    Neves, F.B.3    Nardi, A.E.4    Crespo, C.M.5    Sobrinho, A.T.6
  • 5
    • 0031712496 scopus 로고    scopus 로고
    • Insulin and polycystic ovary syndrome: A new look at an old subject
    • Ciampelli M, Lanzone A. Insulin and polycystic ovary syndrome: a new look at an old subject. Gynecol Endocrinol 1998; 12:277-292.
    • (1998) Gynecol Endocrinol , vol.12 , pp. 277-292
    • Ciampelli, M.1    Lanzone, A.2
  • 6
    • 0030783746 scopus 로고    scopus 로고
    • Heterogeneity in beta cell activity, hepatic insulin clearance and peripheral insulin sensitivity in women with polycystic ovary syndrome
    • Ciampelli M, Fulghesu AM, Cucinelli F, Pavone V, Caruso A, Mancuso S, Lanzone A. Heterogeneity in beta cell activity, hepatic insulin clearance and peripheral insulin sensitivity in women with polycystic ovary syndrome. Hum Reprod 1997; 12:1897-1901.
    • (1997) Hum Reprod , vol.12 , pp. 1897-1901
    • Ciampelli, M.1    Fulghesu, A.M.2    Cucinelli, F.3    Pavone, V.4    Caruso, A.5    Mancuso, S.6    Lanzone, A.7
  • 7
    • 0029880488 scopus 로고    scopus 로고
    • Beta-cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome
    • Dunaif A, Finegood DT. Beta-cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome. J Clin Endocrinol Metab 1996;81:942-947.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 942-947
    • Dunaif, A.1    Finegood, D.T.2
  • 8
    • 0028913896 scopus 로고
    • Metformin. A review of its pharmacological properties and therapeutic use in non-insulin-dependent diabetes mellitus
    • Dunn CJ, Peters DH. Metformin. A review of its pharmacological properties and therapeutic use in non-insulin-dependent diabetes mellitus. Drugs 1995;49:721-749.
    • (1995) Drugs , vol.49 , pp. 721-749
    • Dunn, C.J.1    Peters, D.H.2
  • 9
    • 15444366255 scopus 로고    scopus 로고
    • Polycystic ovary syndrome
    • Ehrmann DA. Polycystic ovary syndrome. N Engl J Med 2005; 352:1223-1236.
    • (2005) N Engl J Med , vol.352 , pp. 1223-1236
    • Ehrmann, D.A.1
  • 10
    • 0034901923 scopus 로고    scopus 로고
    • A new ultrasound criterion for the diagnosis of polycystic ovary syndrome: The ovarian stroma/total area ratio
    • Fulghesu AM, Ciampelli M, Belosi C, Apa R, Pavone V, Lanzone A. A new ultrasound criterion for the diagnosis of polycystic ovary syndrome: the ovarian stroma/total area ratio. Fertil Steril 2001;76:326-331.
    • (2001) Fertil Steril , vol.76 , pp. 326-331
    • Fulghesu, A.M.1    Ciampelli, M.2    Belosi, C.3    Apa, R.4    Pavone, V.5    Lanzone, A.6
  • 12
    • 0031472452 scopus 로고    scopus 로고
    • Efficacy of metformin in type II diabetes: Results of a double-blind, placebo-controlled, dose-response trial
    • Garber AJ, Duncan TG, Goodman AM, Mills DJ, Rohlf JL Efficacy of metformin in type II diabetes: results of a double-blind, placebo-controlled, dose-response trial. Am J Med 1997; 103:491-497.
    • (1997) Am J Med , vol.103 , pp. 491-497
    • Garber, A.J.1    Duncan, T.G.2    Goodman, A.M.3    Mills, D.J.4    Rohlf, J.L.5
  • 13
    • 27744565691 scopus 로고    scopus 로고
    • Metformin revisited: Re-evaluation of its properties and role in the pharmacopoeia of modern antidiabetic agents
    • Goodarzi MO, Bryer-Ash M. Metformin revisited: re-evaluation of its properties and role in the pharmacopoeia of modern antidiabetic agents. Diabetes Obes Metab 2005;7:654-665.
    • (2005) Diabetes Obes Metab , vol.7 , pp. 654-665
    • Goodarzi, M.O.1    Bryer-Ash, M.2
  • 14
    • 23844436916 scopus 로고    scopus 로고
    • Metformin and weight loss in obese women with polycystic ovary syndrome: Comparison of doses
    • Epub 10 May
    • Harborne LR, Sattar N, Norman JE, Fleming R. Metformin and weight loss in obese women with polycystic ovary syndrome: comparison of doses. j Clin Endocrinol Metab 2005;90:4593-4598. Epub 10 May.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 4593-4598
    • Harborne, L.R.1    Sattar, N.2    Norman, J.E.3    Fleming, R.4
  • 15
    • 51849104181 scopus 로고    scopus 로고
    • Effects of diabetes mellitus induced by alloxan on the pharmacokinetics of metformin in rats: Restoration of pharmacokinetic parameters to the control state by insulin treatment
    • Lee MG, Choi YH, Lee I. Effects of diabetes mellitus induced by alloxan on the pharmacokinetics of metformin in rats: restoration of pharmacokinetic parameters to the control state by insulin treatment. J Pharm Pharm Sci 2008; 11:88-103.
    • (2008) J Pharm Pharm Sci , vol.11 , pp. 88-103
    • Lee, M.G.1    Choi, Y.H.2    Lee, I.3
  • 20
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-419.
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 21
    • 0034458234 scopus 로고    scopus 로고
    • Metformin effects on clinical features, endocrine and metabolic profiles, antinsulin sensitivity in polycystic ovary syndrome: A randomized, double-blind, placebo-controlled 6-month trial, followed by open, long-termclinical evaluation
    • Moghetti P, Castello R, Negri C, Tosi F, Perrone F, Caputo M, Zanolin E, Muggeo M. Metformin effects on clinical features, endocrine and metabolic profiles, antinsulin sensitivity in polycystic ovary syndrome: a randomized, double-blind, placebo-controlled 6-month trial, followed by open, long-termclinical evaluation. J Clin Endocrinol Metab 2000; 85:139-146.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 139-146
    • Moghetti, P.1    Castello, R.2    Negri, C.3    Tosi, F.4    Perrone, F.5    Caputo, M.6    Zanolin, E.7    Muggeo, M.8
  • 22
    • 0018602014 scopus 로고
    • Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance
    • National Diabetes Data Group
    • National Diabetes Data Group. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 1979; 28:1039-1056.
    • (1979) Diabetes , vol.28 , pp. 1039-1056
  • 23
    • 0029796476 scopus 로고    scopus 로고
    • Decreases in ovarian cytochrome P450cl7-activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome
    • Nestler JE, Jakubowicz DJ. Decreases in ovarian cytochrome P450cl7-activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome. N Engl J Med 1996; 335:617-623.
    • (1996) N Engl J Med , vol.335 , pp. 617-623
    • Nestler, J.E.1    Jakubowicz, D.J.2
  • 24
    • 0030783316 scopus 로고    scopus 로고
    • Lean women with polycystic ovary syndrome respond to insulin reduction with decreases in ovarian P450cl7 activity and serum androgens
    • Nestler JE, Jakubowicz DJ. Lean women with polycystic ovary syndrome respond to insulin reduction with decreases in ovarian P450cl7 activity and serum androgens. J Clin Endocrinol Metab 1997; 82:4075-4079.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 4075-4079
    • Nestler, J.E.1    Jakubowicz, D.J.2
  • 25
    • 0032565971 scopus 로고    scopus 로고
    • Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome
    • Nestler JE, Jakubowicz DJ, Evans WS, Pasquali R. Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome. N Englj Med 1998;338:1876-1880.
    • (1998) N Englj Med , vol.338 , pp. 1876-1880
    • Nestler, J.E.1    Jakubowicz, D.J.2    Evans, W.S.3    Pasquali, R.4
  • 27
    • 28444469203 scopus 로고    scopus 로고
    • Predictive value of glucose-insulin ratio in PCOS and profile of women who will benefit from metformin therapy: Obese, lean, hyper or normoinsulinemic
    • Onalan G, Goktolga U, Ceyhan T, Bagis T, Onalan R, Pabuccu R. Predictive value of glucose-insulin ratio in PCOS and profile of women who will benefit from metformin therapy: obese, lean, hyper or normoinsulinemic. Eur J Obstet Gynecol Reprod Biol 2005; 123:204-21 I.
    • (2005) Eur J Obstet Gynecol Reprod Biol , vol.123
    • Onalan, G.1    Goktolga, U.2    Ceyhan, T.3    Bagis, T.4    Onalan, R.5    Pabuccu, R.6
  • 28
    • 60549105378 scopus 로고    scopus 로고
    • Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: A comprehensive review
    • Epub 4 Dec 2008 (Review)
    • Palomba S, Falbo A, Zullo F, Orio F. Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review. J Endocr Rev 2009;30:1-50. Epub 4 Dec 2008 (Review).
    • (2009) J Endocr Rev , vol.30 , pp. 1-50
    • Palomba, S.1    Falbo, A.2    Zullo, F.3    Orio, F.4
  • 29
    • 77950015449 scopus 로고    scopus 로고
    • Systemic and local effects of metformin administration in patients with polycystic ovary syndrome (PCOS): Relationship to the ovulatory response
    • Palomba S, Falbo A, Russo T, Orio F, Tolino A, Zullo F. Systemic and local effects of metformin administration in patients with polycystic ovary syndrome (PCOS): relationship to the ovulatory response. Hum Reprod 2010;25:IOO5-IO13.
    • (2010) Hum Reprod , vol.25
    • Palomba, S.1    Falbo, A.2    Russo, T.3    Orio, F.4    Tolino, A.5    Zullo, F.6
  • 31
    • 0025686886 scopus 로고
    • Dietary guidelines for Americans, 1990 edition
    • Peterkin BB. Dietary guidelines for Americans, 1990 edition. J Am Diet Assoc 1990;90:1725-1727.
    • (1990) J Am Diet Assoc , vol.90 , pp. 1725-1727
    • Peterkin, B.B.1
  • 33
    • 77952557432 scopus 로고    scopus 로고
    • Metformin effects on ovarian ultrasound appearance and steroidogenic function in normal-weight normoinsulinemic women with polycystic ovary syndrome: A randomized double-blind placebo-controlled clinical trial
    • Romualdi D, Giuliani M, Cristello F, Fulghesu AM, Selvaggi L, Lanzone A, Guido M. Metformin effects on ovarian ultrasound appearance and steroidogenic function in normal-weight normoinsulinemic women with polycystic ovary syndrome: a randomized double-blind placebo-controlled clinical trial. Fertil Steril 2010;93:2303-2310.
    • (2010) Fertil Steril , vol.93 , pp. 2303-2310
    • Romualdi, D.1    Giuliani, M.2    Cristello, F.3    Fulghesu, A.M.4    Selvaggi, L.5    Lanzone, A.6    Guido, M.7
  • 34
    • 0141998792 scopus 로고    scopus 로고
    • Polycystic ovary syndrome: Syndrome XX?
    • Sam S, Dunaif A. Polycystic ovary syndrome: syndrome XX? Trends Endocrinol Metab 2003; 14:365-370.
    • (2003) Trends Endocrinol Metab , vol.14 , pp. 365-370
    • Sam, S.1    Dunaif, A.2
  • 35
    • 54249106729 scopus 로고    scopus 로고
    • Genetic variants of the organic cation transporter 2 influence the disposition of metformin
    • Song I, Shin H, Shim E, Jung I, Kim W, Shon J, Shin J. Genetic variants of the organic cation transporter 2 influence the disposition of metformin. Clin Pharmacol Ther 2008;84:559-562.
    • (2008) Clin Pharmacol Ther , vol.84 , pp. 559-562
    • Song, I.1    Shin, H.2    Shim, E.3    Jung, I.4    Kim, W.5    Shon, J.6    Shin, J.7
  • 36
    • 84864521778 scopus 로고    scopus 로고
    • Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility
    • Tang T, Lord JM, Norman RJ, Yasmin E, Balen AH. Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. Cochrane Database Syst Rev 2012;5:CD003053.
    • (2012) Cochrane Database Syst Rev , vol.5
    • Tang, T.1    Lord, J.M.2    Norman, R.J.3    Yasmin, E.4    Balen, A.H.5
  • 37
    • 77954082318 scopus 로고    scopus 로고
    • Polycystic ovary syndrome: A complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan
    • Teede H, Deeks A, Moran L. Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan. BMC 2010;8:41.
    • (2010) BMC , vol.8 , pp. 41
    • Teede, H.1    Deeks, A.2    Moran, L.3
  • 38
    • 0028315971 scopus 로고
    • Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy
    • Velazquez EM, Mendoza S, Hamer T, Sosa F, Glueck CJ. Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy. Metabolism 1994; 43: 647-654.
    • (1994) Metabolism , vol.43 , pp. 647-654
    • Velazquez, E.M.1    Mendoza, S.2    Hamer, T.3    Sosa, F.4    Glueck, C.J.5
  • 39
    • 84856062734 scopus 로고    scopus 로고
    • Randomized controlled trial of different doses of metformin for ovulation induction in infertile women with polycystic ovary syndrome
    • Weerakiet S, Sophonsritsuk A, Lertvikool S, Satirapot C, Leelaphiwat S, Jultanmas RJ. Randomized controlled trial of different doses of metformin for ovulation induction in infertile women with polycystic ovary syndrome. Obstet Gynaecol Res 2011;37:1229-1237.
    • (2011) Obstet Gynaecol Res , vol.37 , pp. 1229-1237
    • Weerakiet, S.1    Sophonsritsuk, A.2    Lertvikool, S.3    Satirapot, C.4    Leelaphiwat, S.5    Jultanmas, R.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.