ARC is a novel therapeutic approach against acetaminophen-induced hepatocellular necrosis

Journal of Hepatology

Volumn 58, Issue 2, 2013, Pages 297-305

  An, Junfeng ^a   Mehrhof, Felix ^b   Harms, Christoph ^b   Lättig Tünnemann, Gisela ^b   Lee, Sabrina L L ^b   Endres, Matthias ^b   Li, Mingyi ^c   Sellge, Gernot ^d   Mandić, Ana D ^d   Trautwein, Christian ^d   Donath, Stefan ^a,b,e,f  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c GUANGDONG MEDICAL UNIVERSITY   (China)

^d UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^e HELIOS Clinics GmbH   (Germany)

^f HELIOS Clinic Berlin Buch   (Germany)

Author keywords

Acetaminophen; ARC; JNK; Liver failure; Necrosis

Indexed keywords

3 NITROTYROSINE; ALANINE AMINOTRANSFERASE; APOPTOSIS REPRESSOR WITH CASPASE RECRUITMENT DOMAIN; ASPARTATE AMINOTRANSFERASE; CASPASE; CYTOCHROME C; GLUTATHIONE; HIGH MOBILITY GROUP B1 PROTEIN; HYBRID PROTEIN; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PARACETAMOL; PROTEIN; PROTEIN BAX; PROTEIN NEC 1; REACTIVE OXYGEN METABOLITE; RECEPTOR INTERACTING PROTEIN 3; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); STRESS ACTIVATED PROTEIN KINASE 1; SUPEROXIDE; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ACUTE LIVER FAILURE; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG METABOLISM; DRUG OVERDOSE; ENZYME ACTIVATION; ENZYME INHIBITION; GENETIC TRANSDUCTION; IN VITRO STUDY; IN VIVO STUDY; LIVER HISTOLOGY; LIVER NECROSIS; LIVER PROTECTION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN SECRETION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; SURVIVAL;

ACETAMINOPHEN; ANIMALS; APOPTOSIS REGULATORY PROTEINS; CARCINOMA, HEPATOCELLULAR; DISEASE MODELS, ANIMAL; GLUTATHIONE; HIV-1; LIVER NEOPLASMS; MALE; MAP KINASE KINASE 4; MICE; MICE, INBRED C57BL; MUSCLE PROTEINS; NECROSIS; REACTIVE OXYGEN SPECIES; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TREATMENT OUTCOME;

EID: 84872382300     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2012.10.002     Document Type: Article

References (50)

1. R.J. Fontana, and L.G. Quallich Acute liver failure Curr Opin Gastroenterol 17 2001 291 298
2. J.S. Moffit, L.M. Aleksunes, M.J. Kardas, A.L. Slitt, C.D. Klaassen, and J.E. Manautou Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen Toxicology 230 2007 197 206
3. B. Donahower, S. McCullough, L. Hennings, P.M. Simpson, C.D. Stowe, and A.G. Saad Human recombinant vascular endothelial growth factor (hrVEGF) reduces necrosis and enhances hepatocyte regeneration in a mouse model of acetaminophen toxicity J Pharmacol Exp Ther 334 2010 33 43
4. D. Gotthardt, C. Riediger, K.H. Weiss, J. Encke, P. Schemmer, and J. Schmidt Fulminant hepatic failure: etiology and indications for liver transplantation Nephrol Dial Transplant 22 2007 viii5 viii8
5. W. Declercq, T. Vanden Berghe, and P. Vandenabeele RIP kinases at the crossroads of cell death and survival Cell 138 2009 229 232
6. A. Degterev, Z. Huang, M. Boyce, Y. Li, P. Jagtap, and N. Mizushima Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury Nat Chem Biol 1 2005 112 119
7. I.L. Ch'en, J.S. Tsau, J.D. Molkentin, M. Komatsu, and S.M. Hedrick Mechanisms of necroptosis in T cells J Exp Med 208 2011 633 641
8. C.C. Smith, S.M. Davidson, S.Y. Lim, J.C. Simpkin, J.S. Hothersall, and D.M. Yellon Necrostatin: a potentially novel cardioprotective agent? Cardiovasc Drugs Ther 21 2007 227 233
9. Y.S. Cho, S. Challa, D. Moquin, R. Genga, T.D. Ray, and M. Guildford Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation Cell 137 2009 1112 1123
10. A. Degterev, J. Hitomi, M. Germscheid, I.L. Ch'en, O. Korkina, and X. Teng Identification of RIP1 kinase as a specific cellular target of necrostatins Nat Chem Biol 4 2008 313 321
11. T. Koseki, N. Inohara, S. Chen, and G. Nunez ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases Proc Natl Acad Sci U S A 95 1998 5156 5160
12. J. An, P. Li, J. Li, R. Dietz, and S. Donath ARC is a critical cardiomyocyte survival switch in doxorubicin cardiotoxicity J Mol Med 87 2009 401 410
13. S. Donath, P. Li, C. Willenbockel, N. Al-Saadi, V. Gross, and T. Willnow Apoptosis repressor with caspase recruitment domain is required in response to biomechanical and ischemic stress Circulation 113 2006 1203 1212
14. Y.J. Nam, K. Mani, A.W. Ashton, C.F. Peng, B. Krishnamurthy, and Y. Hayakawa Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions Mol Cell 15 2004 901 912
15. J.A. Yaglom, D. Ekhterae, V.L. Gabai, and M.Y. Sherman Regulation of necrosis of H9c2 myogenic cells upon transient energy deprivation. Rapid deenergization of mitochondria precedes necrosis and is controlled by reactive oxygen species, stress kinase JNK, HSP72 and ARC J Biol Chem 278 2003 50483 50496
16. K. Wang, S. Zhang, B. Marzolf, P. Troisch, A. Brightman, and Z. Hu Circulating microRNAs, potential biomarkers for drug-induced liver injury Proc Natl Acad Sci U S A 106 2009 4402 4407
17. J. An, C. Harms, G. Lättig-Tünnemann, G. Sellge, A.D. Mandić, and Y. Malato TAT-ARC protein transduction rescues mice from fulminant liver failure Hepatology 56 2012 715 726
18. A. Pietrangelo, U. Dierssen, L. Valli, C. Garuti, A. Rump, and E. Corradini STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo Gastroenterology 132 2007 294 300
19. H. Nagahara, A.M. Vocero-Akbani, E.L. Snyder, A. Ho, D.G. Latham, and N.A. Lissy Transduction of full-length TAT fusion proteins into mammalian cells:TAT-p27Kip1 induces cell migration Nat Med 4 1998 1449 1452
20. S.R. Schwarze, A. Ho, A. Vocero-Akbani, and S.F. Dowdy In vivo protein transduction: delivery of a biologically active protein into the mouse Science 285 1999 1569 1572
21. M.A. Abdelmegeed, K.H. Moon, C. Chen, F.J. Gonzalez, and B.J. Song Role of cytochrome P450 2E1 in protein nitration and ubiquitin-mediated degradation during acetaminophen toxicity Biochem Pharmacol 79 2010 57 66
22. T.R. Knight, A. Kurtz, M.L. Bajt, J.A. Hinson, and H. Jaeschke Vascular and hepatocellular peroxynitrite formation during acetaminophen toxicity: role of mitochondrial oxidant stress Toxicol Sci 62 2001 212 220
23. E.M. Boyd, and G.M. Bereczky Liver necrosis from acetaminophen Br J Pharmacol 26 1966 606 614
24. D.G. Davidson, and W.N. Eastham Acute liver necrosis following overdose of acetaminophen Br Med J 5512 1966 497 499
25. J.S. Gujral, T.R. Knight, A. Farhood, M.L. Bajt, and H. Jaeschke Mode of cell death after acetaminophen overdose in mice: apoptosis or oncotic necrosis? Toxicol Sci 67 2002 322 328
26. P.J. Ferret, R. Hammoud, M. Tulliez, A. Tran, H. Trébéden, and P. Jaffray Detoxification of reactive oxygen species by a nonpeptidyl mimic of superoxide dismutase cures acetaminophen-induced acute liver failure in the mouse Hepatology 33 2001 1173 1180
27. L.H. Toledo-Pereyra, A.H. Toledo, J. Walsh, and F. Lopez-Neblina Molecular signaling pathways in ischemia/reperfusion Exp Clin Transplant 2 2004 174 177
28. P. Scaffidi, T. Misteli, and M.E. Bianchi Release of chromatin protein HMGB1 by necrotic cells triggers inflammation Nature 418 2002 191 195
29. H. El-Hassan, K. Anwar, P. Macanas-Pirard, M. Crabtree, S.C. Chow, and V.L. Johnson Involvement of mitochondria in acetaminophen-induced apoptosis and hepatic injury. Roles of cytochrome c, Bax, Bid, and caspases Toxicol Appl Pharmacol 191 2003 118 129
30. N. Hanawa, M. Shinohara, B. Saberi, W.A. Gaarde, D. Han, and N. Kaplowitz Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury J Biol Chem 283 2008 13565 13577
31. J.J. Ventura, N.J. Kennedy, J.A. Lamb, R.A. Flavell, and R.J. Davis C-Jun NH(2)-terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor Mol Cell Biol 23 2003 2871 2882
32. B.K. Gunawan, Z.X. Liu, D. Han, N. Hanawa, W.A. Gaarde, and N. Kaplowitz C-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity Gastroenterology 131 2006 165 178
33. K. Matsumaru, C. Ji, and N. Kaplowitz Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes Hepatology 37 2003 1425 1434
34. Y. Lin, A. Devin, A. Cook, M.M. Keane, M. Kelliher, and S. Lipkowitz The death domain kinase RIP is essential for TRAIL (Apo2L)-induced activation of IkappaB kinase and c-Jun N-terminal kinase Mol Cell Biol 20 2000 6638 6645
35. D.W. Zhang, J. Shao, J. Lin, N. Zhang, B.J. Lu, and S.C. Lin RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis Science 325 2009 332 336
36. C. Liedtke, J.M. Bangen, J. Freimuth, N. Beraza, D. Lambertz, and F.J. Cubero Loss of caspase-8 protects mice against inflammation-related hepatocarcinogenesis but induces non-apoptotic liver injury Gastrointerology 141 2011 2176 2187
37. S. He, L. Wang, L. Miao, T. Wang, F. Du, and L. Zhao Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha Cell 137 2009 1100 1111
38. W.J. Kaiser, J.W. Upton, A.B. Long, D. Livingston-Rosanoff, L.P. Daley-Bauer, and R. Hakem RIP3 mediates the embryonic lethality of caspase-8-deficient mice Nature 471 2011 368 372
39. A. Oberst, C.P. Dillon, R. Weinlich, L.L. McCormick, P. Fitzgerald, and C. Pop Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis Nature 471 2011 363 367
40. M. Das, G. Sabio, F. Jiang, M. Rincón, R.A. Flavell, and R.J. Davis Induction of hepatitis by JNK-mediated expression of TNF-alpha Cell 136 2009 249 260
41. N.C. Henderson, K.J. Pollock, J. Frew, A.C. Mackinnon, R.A. Flavell, and R.J. Davis Critical role of c-jun (NH2) terminal kinase in paracetamol-induced acute liver failure Gut 56 2007 982 990
42. F. Boess, M. Bopst, R. Althaus, S. Polsky, S.D. Cohen, and H.P. Eugster Acetaminophen hepatotoxicity in tumor necrosis factor/lymphotoxin-alpha gene knockout mice Hepatology 27 1998 1021 1029
43. K.J. Simpson, N.W. Lukacs, A.H. McGregor, D.J. Harrison, R.M. Strieter, and S.L. Kunkel Inhibition of tumour necrosis factor alpha does not prevent experimental paracetamol-induced hepatic necrosis J Pathol 190 2000 489 494
44. L.P. James, R.C. Kurten, L.W. Lamps, S. McCullough, and J.A. Hinson Tumour necrosis factor receptor 1 and hepatocyte regeneration in acetaminophen toxicity: a kinetic study of proliferating cell nuclear antigen and cytokine expression Basic Clin Pharmacol Toxicol 97 2005 8 14
45. V. Adler, Z. Yin, S.Y. Fuchs, M. Benezra, L. Rosario, and K.D. Tew Regulation of JNK signaling by GSTp EMBO J 18 1999 1321 1334
46. M. Saitoh, H. Nishitoh, M. Fujii, K. Takeda, K. Tobiume, and Y. Sawada Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1 EMBO J 17 1998 2596 2606
47. H. Kamata, S. Honda, S. Maeda, L. Chang, H. Hirata, and M. Karin Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases Cell 120 2005 649 661
48. Y. Masubuchi, C. Suda, and T. Horie Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice J Hepatol 42 2005 110 116
49. C. Latchoumycandane, C.W. Goh, M.M. Ong, and U.A. Boelsterli Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury Hepatology 45 2007 412 421
50. A.J. Kowaltowski, R.F. Castilho, and A.E. Vercesi Mitochondrial permeability transition and oxidative stress FEBS Lett 495 2001 12 15