NO donor induces Nec-1-inhibitable, but RIP1-independent, necrotic cell death in pancreatic β-cells

FEBS Letters

Volumn 585, Issue 19, 2011, Pages 3058-3064

  Tamura, Yoshiaki ^a,b   Chiba, Yuko ^a,b   Tanioka, Toshihiro ^a   Shimizu, Nobuyuki ^a   Shinozaki, Shohei ^a   Yamada, Marina ^a   Kaneki, Kentaro ^a   Mori, Seijiro ^b   Araki, Atsushi ^b   Ito, Hideki ^b   Kaneki, Masao ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Tokyo Metropolitan Institute of Gerontology   (Japan)

Author keywords

Cell death; Necroptosis; Necrostatin 1; NO donor; Pancreatic cells; Regulated necrosis; RIP1

Indexed keywords

CELL PROTEIN; FAS LIGAND; NECROSTATIN 1; NITRIC OXIDE DONOR; PROTEIN INHIBITOR; PROTEIN KINASE B; RECEPTOR INTERACTING PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEATH; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; REGULATORY MECHANISM;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL DEATH; CELL LINE; CYCLOPHILIN A; GENE KNOCKDOWN TECHNIQUES; HMGB1 PROTEIN; HUMANS; IMIDAZOLES; INDOLES; INSULIN-SECRETING CELLS; MALE; MICE; MICE, INBRED C57BL; NITRIC OXIDE DONORS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; RNA, SMALL INTERFERING; S-NITROSOGLUTATHIONE; SIGNAL TRANSDUCTION;

EID: 80053245530     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.08.028     Document Type: Article

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