-
1
-
-
33751191884
-
Broad-spectrum amino acid sensing by class 3 G-protein coupled receptors
-
A.D. Conigrave, and D.R. Hampson Broad-spectrum amino acid sensing by class 3 G-protein coupled receptors Trends Endocrinol. Metab. 17 2006 398 407
-
(2006)
Trends Endocrinol. Metab.
, vol.17
, pp. 398-407
-
-
Conigrave, A.D.1
Hampson, D.R.2
-
2
-
-
77954244300
-
Broad-spectrum amino acid-sensing class C G-protein coupled receptors: Molecular mechanisms, physiological significance and options for drug development
-
A.D. Conigrave, and D.R. Hampson Broad-spectrum amino acid-sensing class C G-protein coupled receptors: molecular mechanisms, physiological significance and options for drug development Pharmacol. Ther. 127 2010 252 260
-
(2010)
Pharmacol. Ther.
, vol.127
, pp. 252-260
-
-
Conigrave, A.D.1
Hampson, D.R.2
-
3
-
-
77949382019
-
Mechanisms of multimodal sensing by extracellular Ca2+-sensing receptors: A domain-based survey of requirements for binding and signalling
-
M.A. Khan, and A.D. Conigrave Mechanisms of multimodal sensing by extracellular Ca2+-sensing receptors: a domain-based survey of requirements for binding and signalling Br. J. Pharmacol. 159 2010 1039 1050
-
(2010)
Br. J. Pharmacol.
, vol.159
, pp. 1039-1050
-
-
Khan, M.A.1
Conigrave, A.D.2
-
4
-
-
84895102613
-
Engendering biased signalling from the calcium-sensing receptor for the pharmacotherapy of diverse disorders
-
K. Leach, P. Sexton, A. Christopoulos, and A. Conigrave Engendering biased signalling from the calcium-sensing receptor for the pharmacotherapy of diverse disorders Br. J. Pharmacol. 171 2014 1142 1155
-
(2014)
Br. J. Pharmacol.
, vol.171
, pp. 1142-1155
-
-
Leach, K.1
Sexton, P.2
Christopoulos, A.3
Conigrave, A.4
-
5
-
-
79951606631
-
The calcium-sensing receptor: A molecular perspective
-
A. Magno, B. Ward, and T. Ratajczak The calcium-sensing receptor: a molecular perspective Endocr. Rev. 32 2011 330
-
(2011)
Endocr. Rev.
, vol.32
, pp. 330
-
-
Magno, A.1
Ward, B.2
Ratajczak, T.3
-
6
-
-
0035138842
-
Extracellular calcium sensing and extracellular calcium signaling
-
E.M. Brown, and R.J. MacLeod Extracellular calcium sensing and extracellular calcium signaling Physiol. Rev. 81 2001 239 297
-
(2001)
Physiol. Rev.
, vol.81
, pp. 239-297
-
-
Brown, E.M.1
Macleod, R.J.2
-
7
-
-
84857296021
-
The calcium-sensing receptor beyond extracellular calcium homeostasis: Conception, development, adult physiology, and disease
-
D. Riccardi, and P. Kemp The calcium-sensing receptor beyond extracellular calcium homeostasis: conception, development, adult physiology, and disease Annu. Rev. Physiol. 74 2012 271 297
-
(2012)
Annu. Rev. Physiol.
, vol.74
, pp. 271-297
-
-
Riccardi, D.1
Kemp, P.2
-
8
-
-
0031255210
-
The Ca2+-sensing receptor: A target for polyamines
-
S.J. Quinn, C.P. Ye, R. Diaz, O. Kifor, M. Bai, P. Vassilev, and E. Brown The Ca2+-sensing receptor: a target for polyamines Am. J. Physiol. 273 1997 C1315 C1323
-
(1997)
Am. J. Physiol.
, vol.273
, pp. C1315-C1323
-
-
Quinn, S.J.1
Ye, C.P.2
Diaz, R.3
Kifor, O.4
Bai, M.5
Vassilev, P.6
Brown, E.7
-
9
-
-
0034306491
-
Cooperative multi-modal sensing and therapeutic implications of the extracellular Ca2+-sensing receptor
-
A.D. Conigrave, S.J. Quinn, and E.M. Brown Cooperative multi-modal sensing and therapeutic implications of the extracellular Ca2+-sensing receptor Trends Pharm. Sci. 21 2000 401 407
-
(2000)
Trends Pharm. Sci.
, vol.21
, pp. 401-407
-
-
Conigrave, A.D.1
Quinn, S.J.2
Brown, E.M.3
-
10
-
-
10644234585
-
The Venus Fly Trap domain of the extracellular Ca2+-sensing receptor is required for l-amino acid sensing
-
H. Mun, A. Franks, E. Culverston, K. Krapcho, E. Nemeth, and A. Conigrave The Venus Fly Trap domain of the extracellular Ca2+-sensing receptor is required for l-amino acid sensing J. Biol. Chem. 279 2004 51739 51744
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 51739-51744
-
-
Mun, H.1
Franks, A.2
Culverston, E.3
Krapcho, K.4
Nemeth, E.5
Conigrave, A.6
-
11
-
-
1342346546
-
Homology modeling of the transmembrane domain of the human calcium sensing receptor and localization of an allosteric binding site
-
S.U. Miedlich, L. Gama, K. Seuwen, R.M. Wolf, and G.E. Breitwieser Homology modeling of the transmembrane domain of the human calcium sensing receptor and localization of an allosteric binding site J. Biol. Chem. 279 2004 7254 7263
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 7254-7263
-
-
Miedlich, S.U.1
Gama, L.2
Seuwen, K.3
Wolf, R.M.4
Breitwieser, G.E.5
-
12
-
-
84857386424
-
Positive and negative allosteric modulators promote biased signaling at the calcium-sensing receptor
-
A. Davey, K. Leach, C. Valant, A. Conigrave, P. Sexton, and A. Christopoulos Positive and negative allosteric modulators promote biased signaling at the calcium-sensing receptor Endocrinology 153 2012 1232 1241
-
(2012)
Endocrinology
, vol.153
, pp. 1232-1241
-
-
Davey, A.1
Leach, K.2
Valant, C.3
Conigrave, A.4
Sexton, P.5
Christopoulos, A.6
-
13
-
-
84865441831
-
Identification of molecular phenotypes and biased signaling induced by naturally occurring mutations of the human calcium-sensing receptor
-
K. Leach, A. Wen, A. Davey, P. Sexton, A. Conigrave, and A. Christopoulos Identification of molecular phenotypes and biased signaling induced by naturally occurring mutations of the human calcium-sensing receptor Endocrinology 153 2012 4304 4316
-
(2012)
Endocrinology
, vol.153
, pp. 4304-4316
-
-
Leach, K.1
Wen, A.2
Davey, A.3
Sexton, P.4
Conigrave, A.5
Christopoulos, A.6
-
14
-
-
84874595491
-
Impact of clinically relevant mutations on the pharmacoregulation and signaling bias of the calcium-sensing receptor by positive and negative allosteric modulators
-
K. Leach, A. Wen, A. Cook, P. Sexton, A. Conigrave, and A. Christopoulos Impact of clinically relevant mutations on the pharmacoregulation and signaling bias of the calcium-sensing receptor by positive and negative allosteric modulators Endocrinology 154 2013 1105 1116
-
(2013)
Endocrinology
, vol.154
, pp. 1105-1116
-
-
Leach, K.1
Wen, A.2
Cook, A.3
Sexton, P.4
Conigrave, A.5
Christopoulos, A.6
-
15
-
-
0035001612
-
Regulation of MAP kinase by calcium-sensing receptor in bovine parathyroid and CaR-transfected HEK293 cells
-
O. Kifor, R.J. MacLeod, R. Diaz, M. Bai, T. Yamaguchi, T. Yao, I. Kifor, and E.M. Brown Regulation of MAP kinase by calcium-sensing receptor in bovine parathyroid and CaR-transfected HEK293 cells Am. J. Physiol. Renal Physiol. 280 2001 F291 F302
-
(2001)
Am. J. Physiol. Renal Physiol.
, vol.280
, pp. F291-F302
-
-
Kifor, O.1
Macleod, R.J.2
Diaz, R.3
Bai, M.4
Yamaguchi, T.5
Yao, T.6
Kifor, I.7
Brown, E.M.8
-
16
-
-
0037469737
-
Activation of the MAP kinase cascade by exogenous calcium-sensing receptor
-
S.A. Hobson, J. Wright, F. Lee, S.E. McNeil, T. Bilderback, and K.D. Rodland Activation of the MAP kinase cascade by exogenous calcium-sensing receptor Mol. Cell. Endocrinol. 200 2003 189 198
-
(2003)
Mol. Cell. Endocrinol.
, vol.200
, pp. 189-198
-
-
Hobson, S.A.1
Wright, J.2
Lee, F.3
McNeil, S.E.4
Bilderback, T.5
Rodland, K.D.6
-
17
-
-
0034733719
-
Amino acids in the second and third intracellular loops of the parathyroid Ca2+-sensing receptor mediate efficient coupling to phospholipase C
-
W. Chang, T.H. Chen, S. Pratt, and D. Shoback Amino acids in the second and third intracellular loops of the parathyroid Ca2+-sensing receptor mediate efficient coupling to phospholipase C J. Biol. Chem. 275 2000 19955 19963
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 19955-19963
-
-
Chang, W.1
Chen, T.H.2
Pratt, S.3
Shoback, D.4
-
18
-
-
0031450210
-
The carboxyl terminus of the human calcium receptor. Requirements for cell-surface expression and signal transduction
-
K. Ray, G.F. Fan, P.K. Goldsmith, and A.M. Spiegel The carboxyl terminus of the human calcium receptor. Requirements for cell-surface expression and signal transduction J. Biol. Chem. 272 1997 31355 31361
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 31355-31361
-
-
Ray, K.1
Fan, G.F.2
Goldsmith, P.K.3
Spiegel, A.M.4
-
19
-
-
0035941276
-
Amino acids in the cytoplasmic C terminus of the parathyroid Ca2+-sensing receptor mediate efficient cell-surface expression and phospholipase C activation
-
W. Chang, S. Pratt, T.H. Chen, L. Bourguignon, and D. Shoback Amino acids in the cytoplasmic C terminus of the parathyroid Ca2+-sensing receptor mediate efficient cell-surface expression and phospholipase C activation J. Biol. Chem. 276 2001 44129 44136
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 44129-44136
-
-
Chang, W.1
Pratt, S.2
Chen, T.H.3
Bourguignon, L.4
Shoback, D.5
-
20
-
-
0029761073
-
Expression and characterization of inactivating and activating mutations in the human Ca2+o-sensing receptor
-
M. Bai Expression and characterization of inactivating and activating mutations in the human Ca2+o-sensing receptor J. Biol. Chem. 271 1996 19537 19545
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 19537-19545
-
-
Bai, M.1
-
21
-
-
23844491861
-
A double mutation in the extracellular Ca2+-sensing receptor's Venus fly trap domain that selectively disables l-amino acid sensing
-
H. Mun, E. Culverston, A. Franks, C. Collyer, R. Clifton-Bligh, and A. Conigrave A double mutation in the extracellular Ca2+-sensing receptor's Venus fly trap domain that selectively disables l-amino acid sensing J. Biol. Chem. 280 2005 29067 29072
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 29067-29072
-
-
Mun, H.1
Culverston, E.2
Franks, A.3
Collyer, C.4
Clifton-Bligh, R.5
Conigrave, A.6
-
22
-
-
79953199013
-
Allosteric modulation of the calcium-sensing receptor by {gamma}-glutamyl peptides: Inhibition of PTH secretion, suppression of intracellular cAMP levels and a common mechanism of action with l-amino acids
-
G. Broadhead, H. Mun, V. Avlani, O. Jourdon, W. Church, A. Christopoulos, L. Delbridge, and A. Conigrave Allosteric modulation of the calcium-sensing receptor by {gamma}-glutamyl peptides: inhibition of PTH secretion, suppression of intracellular cAMP levels and a common mechanism of action with l-amino acids J. Biol. Chem. 286 2011 8786 8797
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 8786-8797
-
-
Broadhead, G.1
Mun, H.2
Avlani, V.3
Jourdon, O.4
Church, W.5
Christopoulos, A.6
Delbridge, L.7
Conigrave, A.8
-
23
-
-
44849141908
-
A comparison of donor-acceptor pairs for genetically encoded FRET sensors: Application to the Epac cAMP sensor as an example
-
G.N.M. van der Krogt, J. Ogink, B. Ponsioen, and K. Jalink A comparison of donor-acceptor pairs for genetically encoded FRET sensors: application to the Epac cAMP sensor as an example PLoS ONE 3 2008 1 9
-
(2008)
PLoS ONE
, vol.3
, pp. 1-9
-
-
Van Der Krogt, G.N.M.1
Ogink, J.2
Ponsioen, B.3
Jalink, K.4
-
24
-
-
84880277048
-
Role of the calcium-sensing receptor in extracellular calcium homeostasis
-
E. Brown Role of the calcium-sensing receptor in extracellular calcium homeostasis Best Pract. Res. Clin. Endocrinol. Metab. 27 2013 333 343
-
(2013)
Best Pract. Res. Clin. Endocrinol. Metab.
, vol.27
, pp. 333-343
-
-
Brown, E.1
-
25
-
-
33751072665
-
L-amino acid-sensing by calcium-sensing receptors: Implications for GI physiology
-
A.D. Conigrave, and E.M. Brown l-amino acid-sensing by calcium-sensing receptors: implications for GI physiology Am. J. Physiol. 291 2006 G753 G761
-
(2006)
Am. J. Physiol.
, vol.291
, pp. G753-G761
-
-
Conigrave, A.D.1
Brown, E.M.2
-
26
-
-
85027952608
-
CaSR function in the intestine: Hormone secretion, electrolyte absorption and secretion, paracrine non-canonical Wnt signaling and colonic crypt cell proliferation
-
R. Macleod CaSR function in the intestine: hormone secretion, electrolyte absorption and secretion, paracrine non-canonical Wnt signaling and colonic crypt cell proliferation Best Pract. Res. Clin. Endocrinol. Metab. 27 2013 385 402
-
(2013)
Best Pract. Res. Clin. Endocrinol. Metab.
, vol.27
, pp. 385-402
-
-
Macleod, R.1
-
27
-
-
84878545864
-
Calcium-sensing receptor-dependent activation of CREB phosphorylation in HEK-293 cells and human parathyroid cells
-
V. Avlani, W. Ma, H.-C. Mun, K. Leach, L. Delbridge, A. Christopoulos, and A. Conigrave Calcium-sensing receptor-dependent activation of CREB phosphorylation in HEK-293 cells and human parathyroid cells Am. J. Physiol. Endocrinol. Metab. 304 2013 E1097 E1104
-
(2013)
Am. J. Physiol. Endocrinol. Metab.
, vol.304
, pp. E1097-E1104
-
-
Avlani, V.1
Ma, W.2
Mun, H.-C.3
Leach, K.4
Delbridge, L.5
Christopoulos, A.6
Conigrave, A.7
-
28
-
-
20744460194
-
Amino acid-stimulated Ca2+ oscillations produced by the Ca2+-sensing receptor are mediated by a phospholipase C/inositol 1,4,5-trisphosphate-independent pathway that requires G12, Rho, filamin-A, and the actin cytoskeleton
-
O. Rey, S.H. Young, J. Yuan, L. Slice, and E. Rozengurt Amino acid-stimulated Ca2+ oscillations produced by the Ca2+-sensing receptor are mediated by a phospholipase C/inositol 1,4,5-trisphosphate-independent pathway that requires G12, Rho, filamin-A, and the actin cytoskeleton J. Biol. Chem. 280 2005 22875 22882
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 22875-22882
-
-
Rey, O.1
Young, S.H.2
Yuan, J.3
Slice, L.4
Rozengurt, E.5
-
29
-
-
34250177985
-
Biologic functions of the G12 subfamily of heterotrimeric g proteins: Growth, migration, and metastasis
-
P. Kelly, P. Casey, and T. Meigs Biologic functions of the G12 subfamily of heterotrimeric g proteins: growth, migration, and metastasis Biochemistry 46 2007 6677 6687
-
(2007)
Biochemistry
, vol.46
, pp. 6677-6687
-
-
Kelly, P.1
Casey, P.2
Meigs, T.3
-
30
-
-
77952001249
-
Increased receptor stimulation elicits differential calcium-sensing receptor T888 dephosphorylation
-
W.D. McCormick, R. Atkinson-Dell, K.L. Campion, H. Mun, A.D. Conigrave, and D.T. Ward Increased receptor stimulation elicits differential calcium-sensing receptor T888 dephosphorylation J. Biol. Chem. 285 2010 14170 14177
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 14170-14177
-
-
McCormick, W.D.1
Atkinson-Dell, R.2
Campion, K.L.3
Mun, H.4
Conigrave, A.D.5
Ward, D.T.6
-
31
-
-
27544486835
-
Termination of cAMP signals by Ca2+ and G(alpha)i via extracellular Ca2+ sensors: A link to intracellular Ca2+ oscillations
-
A. Gerbino, W.C. Ruder, S. Curci, T. Pozzan, M. Zaccolo, and A.M. Hofer Termination of cAMP signals by Ca2+ and G(alpha)i via extracellular Ca2+ sensors: a link to intracellular Ca2+ oscillations J. Cell Biol. 171 2005 303 312
-
(2005)
J. Cell Biol.
, vol.171
, pp. 303-312
-
-
Gerbino, A.1
Ruder, W.C.2
Curci, S.3
Pozzan, T.4
Zaccolo, M.5
Hofer, A.M.6
-
32
-
-
0032489519
-
Role of the second and third intracellular loops of metabotropic glutamate receptors in mediating dual signal transduction activation
-
A. Francesconi, and R. Duvoisin Role of the second and third intracellular loops of metabotropic glutamate receptors in mediating dual signal transduction activation J. Biol. Chem. 273 1998 5615 5624
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 5615-5624
-
-
Francesconi, A.1
Duvoisin, R.2
-
33
-
-
73449124733
-
C-terminus deletion of metabotropic glutamate receptor 1 selectively abolishes coupling to Galphaq
-
P. Kammermeier C-terminus deletion of metabotropic glutamate receptor 1 selectively abolishes coupling to Galphaq Eur. J. Pharmacol. 627 2010 63 68
-
(2010)
Eur. J. Pharmacol.
, vol.627
, pp. 63-68
-
-
Kammermeier, P.1
-
34
-
-
0035824541
-
The C terminus of the metabotropic glutamate receptor subtypes 2 and 7 specifies the receptor signaling pathways
-
J. Perroy, G. Gutierrez, V. Coulon, J. Bockaert, J. Pin, and L. Fagni The C terminus of the metabotropic glutamate receptor subtypes 2 and 7 specifies the receptor signaling pathways J. Biol. Chem. 276 2001 45800 45805
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 45800-45805
-
-
Perroy, J.1
Gutierrez, G.2
Coulon, V.3
Bockaert, J.4
Pin, J.5
Fagni, L.6
-
35
-
-
33847260701
-
Coupling profile of the metabotropic glutamate receptor 1alpha is regulated by the C-terminal domain
-
M. Tateyama, and Y. Kubo Coupling profile of the metabotropic glutamate receptor 1alpha is regulated by the C-terminal domain Mol. Cell. Neurosci. 34 2007 445 452
-
(2007)
Mol. Cell. Neurosci.
, vol.34
, pp. 445-452
-
-
Tateyama, M.1
Kubo, Y.2
-
36
-
-
0033800097
-
Mutations of the calcium-sensing receptor (CASR) in familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia
-
G.N. Hendy, L. D'Souza-Li, B. Yang, L. Canaff, and D.E.C. Cole Mutations of the calcium-sensing receptor (CASR) in familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia Hum. Mutat. 16 2000 281 296
-
(2000)
Hum. Mutat.
, vol.16
, pp. 281-296
-
-
Hendy, G.N.1
D'Souza-Li, L.2
Yang, B.3
Canaff, L.4
Cole, D.E.C.5
-
37
-
-
18244363907
-
The calcium-sensing receptor in normal physiology and pathophysiology: A review
-
J. Tfelt-Hansen, and E. Brown The calcium-sensing receptor in normal physiology and pathophysiology: a review Crit. Rev. Clin. Lab. Sci. 42 2005 35 70
-
(2005)
Crit. Rev. Clin. Lab. Sci.
, vol.42
, pp. 35-70
-
-
Tfelt-Hansen, J.1
Brown, E.2
-
38
-
-
85027933580
-
Calcium-sensing receptor (CaSR) mutations and disorders of calcium, electrolyte and water metabolism
-
F. Hannan, and R. Thakker Calcium-sensing receptor (CaSR) mutations and disorders of calcium, electrolyte and water metabolism Best Pract. Res. Clin. Endocrinol. Metab. 27 2013 359 371
-
(2013)
Best Pract. Res. Clin. Endocrinol. Metab.
, vol.27
, pp. 359-371
-
-
Hannan, F.1
Thakker, R.2
|