Cholestenoic acids regulate motor neuron survival via liver X receptors

Journal of Clinical Investigation

Volumn 124, Issue 11, 2014, Pages 4829-4842

  Theofilopoulos, Spyridon ^a   Griffiths, William J ^b   Crick, Peter J ^b   Yang, Shanzheng ^a   Meljon, Anna ^b   Ogundare, Michael ^b   Kitambi, Satish Srinivas ^a   Lockhart, Andrew ^c   Tuschl, Karin ^d   Clayton, Peter T ^d   Morris, Andrew A ^e   Martinez, Adelaida ^f   Reddy, M Ashwin ^f   Martinuzzi, Andrea ^g   Bassi, Maria T ^g   Honda, Akira ^h   Mizuochi, Tatsuki ⁱ   Kimura, Akihiko ⁱ   Nittono, Hiroshi ^j   De Michele, Giuseppe ^k   Carbone, Rosa ^k   Criscuolo, Chiara ^k   Yau, Joyce L ^l   Seckl, Jonathan R ^l   Schüle, Rebecca ^m,n   Schöls, Ludger ^m,n   Sailer, Andreas W ^o   Kuhle, Jens ^p   Fraidakis, Matthew J ^q   Gustafsson, Jan Åke ^r,s   Steffensen, Knut R ^t   Björkhem, Ingemar ^t   Ernfors, Patrik ^a   Sjövall, Jan ^a   Arenas, Ernest ^a   Wang, Yuqin ^b   more..

^a KAROLINSKA INSTITUTE   (Sweden)

^b SWANSEA UNIVERSITY   (United Kingdom)

^c ADDENBROOKE S HOSPITAL   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e St Mary's Hospital   (United Kingdom)

^f BARTS HEALTH NHS TRUST   (United Kingdom)

^g SCIENTIFIC INSTITUTE   (Italy)

^h Tokyo Medical University Ibaraki Medical Center   (Japan)

ⁱ KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^j Junshin Clinic   (Japan)

^k UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^l UNIVERSITY OF EDINBURGH   (United Kingdom)

^m UNIVERSITY OF TÜBINGEN   (Germany)

ⁿ GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^o NOVARTIS PHARMA AG   (Switzerland)

^p UNIVERSITY HOSPITAL BASEL   (Switzerland)

^q UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^r University of Houston   (United States)

^s Center for Biosciences   (Sweden)

^t KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

more..

Author keywords

[No Author keywords available]

Indexed keywords

3BETA HYDROXY 7 OXOCHOLEST 5 EN 26 OIC ACID; 3BETA, 7ALPHA, DIHYDROXYCHOLEST 5 EN 26 OIC ACID; BILE ACID; CHOLESTANETRIOL 26 MONOOXYGENASE; CHOLESTENOIC ACID; CHOLESTEROL DERIVATIVE; CYP7B1 PROTEIN; LIVER X RECEPTOR; OXYGENASE; UNCLASSIFIED DRUG; CHOLESTANE DERIVATIVE; INSULIN GENE ENHANCER BINDING PROTEIN ISL-1; LIM HOMEODOMAIN PROTEIN; ORPHAN NUCLEAR RECEPTOR; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LOSS; CELL MATURATION; CELL SURVIVAL; CEREBROTENDINOUS XANTHOMATOSIS; CONTROLLED STUDY; EMBRYO; FEMALE; GENE MUTATION; IN VITRO STUDY; IN VIVO STUDY; MAMMAL CELL; MOTONEURON; MOUSE; NERVE CELL DIFFERENTIATION; NERVE CELL NECROSIS; NEUROLOGIC DISEASE; NONHUMAN; OCULOMOTOR SYSTEM; PROTEIN CEREBROSPINAL FLUID LEVEL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SPASTIC PARESIS; ZEBRA FISH; ANIMAL; BLOOD; C57BL MOUSE; CELL CULTURE; CEREBROSPINAL FLUID; HUMAN; KNOCKOUT MOUSE; MALE; METABOLISM; PHYSIOLOGY; SPASTIC PARAPLEGIA;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CHOLESTENES; FEMALE; HUMANS; LIM-HOMEODOMAIN PROTEINS; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR NEURONS; ORPHAN NUCLEAR RECEPTORS; PARAPARESIS, SPASTIC; TRANSCRIPTION FACTORS; XANTHOMATOSIS, CEREBROTENDINOUS; ZEBRAFISH;

EID: 84908635175     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI68506     Document Type: Article

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