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Volumn 53, Issue 11, 2012, Pages 2469-2483

Analysis of bioactive oxysterols in newborn mouse brain by LC/MS

Author keywords

24S,25 epoxycholesterol; 24S hydroxycholesterol; Cholesterol; Derivatization; Desmosterol; Liver X receptor; Sterol

Indexed keywords

25 EPOXYCHOLESTEROL; 26 HYDROXYDESMOSTEROL; 7 ALPHA HYDROXYDESMOSTEROL; CHOLESTANOL; CHOLESTEROL DERIVATIVE; DESMOSTEROL; OXYSTEROL; PROGESTERONE; UNCLASSIFIED DRUG;

EID: 84867351590     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.D028233     Document Type: Article
Times cited : (46)

References (61)
  • 1
    • 3543104951 scopus 로고    scopus 로고
    • Cholesterol metabolism in the central nervous system during early development and in the mature animal
    • DOI 10.1194/jlr.R400004-JLR200
    • Dietschy, J. M., and S. D. Turley. 2004. Thematic review series: brain lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal. J. Lipid Res. 45: 1375-1397. (Pubitemid 39022664)
    • (2004) Journal of Lipid Research , vol.45 , Issue.8 , pp. 1375-1397
    • Dietschy, J.M.1    Turley, S.D.2
  • 2
    • 2442557294 scopus 로고    scopus 로고
    • Brain cholesterol: Long secret life behind a barrier
    • Björkhem, I., and S. Meaney. 2004. Brain cholesterol: long secret life behind a barrier. Arterioscler. Thromb. Vasc. Biol. 24: 806-815.
    • (2004) Arterioscler. Thromb. Vasc. Biol. , vol.24 , pp. 806-815
    • Björkhem, I.1    Meaney, S.2
  • 3
    • 0035083555 scopus 로고    scopus 로고
    • Cholesterol metabolism in the brain
    • DOI 10.1097/00041433-200104000-00003
    • Dietschy, J. M., and S. D. Turley. 2001. Cholesterol metabolism in the brain. Curr. Opin. Lipidol. 12: 105-112. (Pubitemid 32242918)
    • (2001) Current Opinion in Lipidology , vol.12 , Issue.2 , pp. 105-112
    • Dietschy, J.M.1    Turley, S.D.2
  • 4
    • 33746095457 scopus 로고    scopus 로고
    • The use of the Dhcr7 knockout mouse to accurately determine the origin of fetal sterols
    • DOI 10.1194/jlr.M600141-JLR200
    • Tint, G. S., H. Yu, Q. Shang, G. Xu, and S. B. Patel. 2006. The use of the Dhcr7 knockout mouse to accurately determine the origin of fetal sterols. J. Lipid Res. 47: 1535-1541. (Pubitemid 44079908)
    • (2006) Journal of Lipid Research , vol.47 , Issue.7 , pp. 1535-1541
    • Tint, G.S.1    Yu, H.2    Shang, Q.3    Xu, G.4    Patel, S.B.5
  • 6
    • 0141459395 scopus 로고    scopus 로고
    • Quantitation of two pathways for cholesterol excretion from the brain in normal mice and mice with neurodegeneration
    • DOI 10.1194/jlr.M300164-JLR200
    • Xie, C., E. G. Lund, S. D. Turley, D. W. Russell, and J. M. Dietschy. 2003. Quantitation of two pathways for cholesterol excretion from the brain in normal mice and mice with neurodegeneration. J. Lipid Res. 44: 1780-1789. (Pubitemid 37185890)
    • (2003) Journal of Lipid Research , vol.44 , Issue.9 , pp. 1780-1789
    • Xie, C.1    Lund, E.G.2    Turley, S.D.3    Russell, D.W.4    Dietschy, J.M.5
  • 7
    • 0029835410 scopus 로고    scopus 로고
    • Cholesterol homeostasis in human brain: Evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation
    • Lütjohann, D., O. Breuer, G. Ahlborg, I. Nennesmo, A. Siden, U. Diczfalusy, and I. Björkhem. 1996. Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation. Proc. Natl. Acad. Sci. USA. 93: 9799-9804.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 9799-9804
    • Lütjohann, D.1    Breuer, O.2    Ahlborg, G.3    Nennesmo, I.4    Siden, A.5    Diczfalusy, U.6    Björkhem, I.7
  • 12
    • 0036133869 scopus 로고    scopus 로고
    • Neurosteroids: Biochemistry and clinical significance
    • DOI 10.1016/S1043-2760(01)00503-3, PII S1043276001005033
    • Mellon, S. H., and L. D. Griffin. 2002. Neurosteroids: biochemistry and clinical significance. Trends Endocrinol. Metab. 13: 35-43. (Pubitemid 36734014)
    • (2002) Trends in Endocrinology and Metabolism , vol.13 , Issue.1 , pp. 35-43
    • Mellon, S.H.1    Griffin, L.D.2
  • 13
    • 0036892027 scopus 로고    scopus 로고
    • 22R-hydroxycholesterol protects neuronal cells from beta-amyloid-induced cytotoxicity by binding to beta-amyloid peptide
    • DOI 10.1046/j.1471-4159.2002.01202.x
    • Yao, Z. X., R. C. Brown, G. Teper, J. Greeson, and V. Papadopoulos. 2002. 22R-hydroxycholesterol protects neuronal cells from beta-amyloid-induced cytotoxicity by binding to beta-amyloid peptide. J. Neurochem. 83: 1110-1119. (Pubitemid 35397121)
    • (2002) Journal of Neurochemistry , vol.83 , Issue.5 , pp. 1110-1119
    • Yao, Z.-X.1    Brown, R.C.2    Teper, G.3    Greeson, J.4    Papadopoulos, V.5
  • 14
    • 0037969631 scopus 로고    scopus 로고
    • 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion
    • DOI 10.1074/jbc.M300044200
    • Koldamova, R. P., I. M. Lefterov, M. D. Ikonomovic, J. Skoko, P. I. Lefterov, B. A. Isanski, S. T. DeKosky, and J. S. Lazo. 2003. 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion. J. Biol. Chem. 278: 13244-13256. (Pubitemid 36800094)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.15 , pp. 13244-13256
    • Koldamova, R.P.1    Lefterov, I.M.2    Ikonomovic, M.D.3    Skoko, J.4    Lefterov, P.I.5    Isanski, B.A.6    DeKosky, S.T.7    Lazo, J.S.8
  • 16
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • DOI 10.1172/JCI200215593
    • Horton, J. D., J. L. Goldstein, and M. S. Brown. 2002. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 109: 1125-1131. (Pubitemid 34496588)
    • (2002) Journal of Clinical Investigation , vol.109 , Issue.9 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 17
    • 66349134748 scopus 로고    scopus 로고
    • Cholesterol feedback: From Schoenheimer's bottle to Scap's MELADL
    • Brown, M. S., and J. L. Goldstein. 2009. Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL. J. Lipid Res. 50 (Suppl): S15-S27.
    • (2009) J. Lipid Res. , vol.50 , Issue.SUPPL.
    • Brown, M.S.1    Goldstein, J.L.2
  • 18
    • 38149138153 scopus 로고    scopus 로고
    • Endogenous 24(S),25-epoxycholesterol fine-tunes acute control of cellular cholesterol homeostasis
    • Wong, J., C. M. Quinn, I. C. Gelissen, and A. J. Brown. 2008. Endogenous 24(S),25-epoxycholesterol fine-tunes acute control of cellular cholesterol homeostasis. J. Biol. Chem. 283: 700-707.
    • (2008) J. Biol. Chem. , vol.283 , pp. 700-707
    • Wong, J.1    Quinn, C.M.2    Gelissen, I.C.3    Brown, A.J.4
  • 20
    • 0342316532 scopus 로고    scopus 로고
    • Oxysterols: Modulators of cholesterol metabolism and other processes
    • Schroepfer, G. J., Jr. 2000. Oxysterols: modulators of cholesterol metabolism and other processes. Physiol. Rev. 80: 361-554.
    • (2000) Physiol. Rev. , vol.80 , pp. 361-554
    • Schroepfer Jr., G.J.1
  • 23
    • 0242354104 scopus 로고    scopus 로고
    • Neurosteroids in rat brain: Extraction, isolation, and analysis by nanoscale liquid chromatography-electrospray mass spectrometry
    • Liu, S., J. Sjövall, and W. J. Griffiths. 2003. Neurosteroids in rat brain: extraction, isolation, and analysis by nanoscale liquid chromatography-electrospray mass spectrometry. Anal. Chem. 75: 5835-5846.
    • (2003) Anal. Chem. , vol.75 , pp. 5835-5846
    • Liu, S.1    Sjövall, J.2    Griffiths, W.J.3
  • 24
    • 41249093188 scopus 로고    scopus 로고
    • Extraction and analysis of sterols in biological matrices by high performance liquid chromatography electrospray ionization mass spectrometry
    • McDonald, J. G., B. M. Thompson, E. C. McCrum, and D. W. Russell. 2007. Extraction and analysis of sterols in biological matrices by high performance liquid chromatography electrospray ionization mass spectrometry. Methods Enzymol. 432: 145-170.
    • (2007) Methods Enzymol. , vol.432 , pp. 145-170
    • McDonald, J.G.1    Thompson, B.M.2    McCrum, E.C.3    Russell, D.W.4
  • 25
    • 80255129720 scopus 로고    scopus 로고
    • Analysis of oxysterol metabolomes
    • Griffiths, W. J., and Y. Wang. 2011. Analysis of oxysterol metabolomes. Biochim. Biophys. Acta. 1811: 784-799.
    • (2011) Biochim. Biophys. Acta , vol.1811 , pp. 784-799
    • Griffiths, W.J.1    Wang, Y.2
  • 26
    • 0028816863 scopus 로고
    • Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry
    • Dzeletovic, S., O. Breuer, E. Lund, and U. Diczfalusy. 1995. Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry. Anal. Biochem. 225: 73-80.
    • (1995) Anal. Biochem. , vol.225 , pp. 73-80
    • Dzeletovic, S.1    Breuer, O.2    Lund, E.3    Diczfalusy, U.4
  • 28
    • 80051471394 scopus 로고    scopus 로고
    • Nano-liquid chromatography-tandem mass spectrometry analysis of oxysterols in brain: Monitoring of cholesterol autoxidation
    • Karu, K., J. Turton, Y. Wang, and W. J. Griffiths. 2011. Nano-liquid chromatography-tandem mass spectrometry analysis of oxysterols in brain: monitoring of cholesterol autoxidation. Chem. Phys. Lipids. 164: 411-424.
    • (2011) Chem. Phys. Lipids , vol.164 , pp. 411-424
    • Karu, K.1    Turton, J.2    Wang, Y.3    Griffiths, W.J.4
  • 30
    • 0242606382 scopus 로고    scopus 로고
    • Novel sterols synthesized via the CYP27A1 metabolic pathway
    • DOI 10.1016/j.abb.2003.09.028
    • Pikuleva, I., and N. B. Javitt. 2003. Novel sterols synthesized via the CYP27A1 metabolic pathway. Arch. Biochem. Biophys. 420: 35-39. (Pubitemid 37393371)
    • (2003) Archives of Biochemistry and Biophysics , vol.420 , Issue.1 , pp. 35-39
    • Pikuleva, I.1    Javitt, N.B.2
  • 31
    • 34548253482 scopus 로고    scopus 로고
    • Cholesterol biosynthesis from birth to adulthood in a mouse model for 7-dehydrosterol reductase deficiency (Smith-Lemli-Opitz syndrome)
    • DOI 10.1016/j.steroids.2007.07.002, PII S0039128X07001158
    • Marcos, J., C. H. Shackleton, M. M. Buddhikot, F. D. Porter, and G. L. Watson. 2007. Cholesterol biosynthesis from birth to adulthood in a mouse model for 7-dehydrosterol reductase deficiency (Smith-Lemli-Opitz syndrome). Steroids. 72: 802-808. (Pubitemid 47320712)
    • (2007) Steroids , vol.72 , Issue.11-12 , pp. 802-808
    • Marcos, J.1    Shackleton, C.H.L.2    Buddhikot, M.M.3    Porter, F.D.4    Watson, G.L.5
  • 34
    • 0030746504 scopus 로고    scopus 로고
    • Electrospray mass spectrometry of testosterone esters: Potential for use in doping control
    • DOI 10.1016/S0039-128X(97)00004-4, PII S0039128X97000044
    • Shackleton, C. H., H. Chuang, J. Kim, X. de la Torre, and J. Segura. 1997. Electrospray mass spectrometry of testosterone esters: potential for use in doping control. Steroids. 62: 523-529. (Pubitemid 27319201)
    • (1997) Steroids , vol.62 , Issue.7 , pp. 523-529
    • Shackleton, C.H.L.1    Chuang, H.2    Kim, J.3    De La, T.X.4    Segura, J.5
  • 36
    • 58949084969 scopus 로고    scopus 로고
    • Sterol lipidomics in health and disease: Methodologies and applications
    • Griffiths, W. J., and Y. Wang. 2009. Sterol lipidomics in health and disease: methodologies and applications. Eur. J. Lipid Sci. Technol. 111: 14-38.
    • (2009) Eur. J. Lipid Sci. Technol. , vol.111 , pp. 14-38
    • Griffiths, W.J.1    Wang, Y.2
  • 38
    • 0032545281 scopus 로고    scopus 로고
    • cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism
    • DOI 10.1074/jbc.273.51.34316
    • Lund, E. G., T. A. Kerr, J. Sakai, W. P. Li, and D. W. Russell. 1998. cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism. J. Biol. Chem. 273: 34316-34327. (Pubitemid 29008909)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.51 , pp. 34316-34327
    • Lund, E.G.1    Kerr, T.A.2    Sakai, J.3    Li, W.-P.4    Russell, D.W.5
  • 39
    • 0345492012 scopus 로고    scopus 로고
    • Broad Substrate Specificity of Human Cytochrome P450 46A1 Which Initiates Cholesterol Degradation in the Brain
    • DOI 10.1021/bi035512f
    • Mast, N., R. Norcross, U. Andersson, M. Shou, K. Nakayama, I. Björkhem, and I. A. Pikuleva. 2003. Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain. Biochemistry. 42: 14284-14292. (Pubitemid 37499426)
    • (2003) Biochemistry , vol.42 , Issue.48 , pp. 14284-14292
    • Mast, N.1    Norcross, R.2    Andersson, U.3    Shou, M.4    Nakayama, K.5    Bjorkhem, I.6    Pikuleva, I.A.7
  • 40
    • 0025868097 scopus 로고
    • Characterization of human sterol 27-hydroxylase: A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reactions in bile acid biosynthesis
    • Cali, J. J., and D. W. Russell. 1991. Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis. J. Biol. Chem. 266: 7774-7778. (Pubitemid 21906433)
    • (1991) Journal of Biological Chemistry , vol.266 , Issue.12 , pp. 7774-7778
    • Cali, J.J.1    Russell, D.W.2
  • 41
    • 0034671509 scopus 로고    scopus 로고
    • Disruption of the sterol 27-hydroxylase gene in mice results in hepatomegaly and hypertriglyceridemia
    • DOI 10.1074/jbc.M007653200
    • Repa, J. J., E. G. Lund, J. D. Horton, E. Leitersdorf, D. W. Russell, J. M. Dietschy, and S. D. Turley. 2000. Disruption of the sterol 27-hydroxylase gene in mice results in hepatomegaly and hypertriglyceridemia. Reversal by cholic acid feeding. J. Biol. Chem. 275: 39685-39692. (Pubitemid 32058997)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.50 , pp. 39685-39692
    • Repa, J.J.1    Lund, E.G.2    Horton, J.D.3    Leitersdorf, E.4    Russell, D.W.5    Dietschy, J.M.6    Turley, S.D.7
  • 42
    • 0027457242 scopus 로고
    • 24-, 25- And 27-hydroxylation of cholesterol by a purified preparation of 27-hydroxylase from pig liver
    • Lund, E., I. Björkhem, C. Furster, and K. Wikvall. 1993. 24-, 25- and 27-hydroxylation of cholesterol by a purified preparation of 27-hydroxylase from pig liver. Biochim. Biophys. Acta. 1166: 177-182.
    • (1993) Biochim. Biophys. Acta , vol.1166 , pp. 177-182
    • Lund, E.1    Björkhem, I.2    Furster, C.3    Wikvall, K.4
  • 43
    • 0038265008 scopus 로고    scopus 로고
    • Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover
    • DOI 10.1074/jbc.M303415200
    • Lund, E. G., C. Xie, T. Kotti, S. D. Turley, J. M. Dietschy, and D. W. Russell. 2003. Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover. J. Biol. Chem. 278: 22980-22988. (Pubitemid 36830363)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.25 , pp. 22980-22988
    • Lund, E.G.1    Xie, C.2    Kotti, T.3    Turley, S.D.4    Dietschy, J.M.5    Russell, D.W.6
  • 44
    • 0029012280 scopus 로고
    • Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesis
    • Compagnone, N. A., A. Bulfone, J. L. Rubenstein, and S. H. Mellon. 1995. Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesis. Endocrinology. 136: 2689-2696.
    • (1995) Endocrinology , vol.136 , pp. 2689-2696
    • Compagnone, N.A.1    Bulfone, A.2    Rubenstein, J.L.3    Mellon, S.H.4
  • 45
    • 0025269939 scopus 로고
    • Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis
    • Jelinek, D. F., S. Andersson, C. A. Slaughter, and D. W. Russell. 1990. Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis. J. Biol. Chem. 265: 8190-8197.
    • (1990) J. Biol. Chem. , vol.265 , pp. 8190-8197
    • Jelinek, D.F.1    Andersson, S.2    Slaughter, C.A.3    Russell, D.W.4
  • 46
    • 47049112744 scopus 로고    scopus 로고
    • Cholesterol, reactive oxygen species, and the formation of biologically active mediators
    • Murphy, R. C., and K. M. Johnson. 2008. Cholesterol, reactive oxygen species, and the formation of biologically active mediators. J. Biol. Chem. 283: 15521-15525.
    • (2008) J. Biol. Chem. , vol.283 , pp. 15521-15525
    • Murphy, R.C.1    Johnson, K.M.2
  • 48
    • 0019304049 scopus 로고
    • Steric considerations regarding the biodegradation of cholesterol to pregnenolone. Exclusion of (22S)-22-hydroxycholesterol and 22-ketocholesterol as intermediates
    • DOI 10.1016/0006-291X(80)91266-8
    • Byon, C. Y., and M. Gut. 1980. Steric considerations regarding the biodegradation of cholesterol to pregnenolone. Exclusion of (22S)-22- hydroxycholesterol and 22-ketocholesterol as intermediates. Biochem. Biophys. Res. Commun. 94: 549-552. (Pubitemid 10006070)
    • (1980) Biochemical and Biophysical Research Communications , vol.94 , Issue.2 , pp. 549-552
    • Byon, C.Y.1    Gut, M.2
  • 49
    • 70449252027 scopus 로고
    • Synthesis and metabolism of 22-ketocholesterol-23-C14
    • Kautsky, G. J., C. Bouboulis, R. Becker, and C. King. 1958. Synthesis and metabolism of 22-ketocholesterol-23-C14. J. Biol. Chem. 233: 1340-1342.
    • (1958) J. Biol. Chem. , vol.233 , pp. 1340-1342
    • Kautsky, G.J.1    Bouboulis, C.2    Becker, R.3    King, C.4
  • 50
    • 0021188099 scopus 로고
    • Formation and metabolism of bile alcohols in man
    • Karlaganis, G., and J. Sjövall. 1984. Formation and metabolism of bile alcohols in man. Hepatology. 4: 966-973.
    • (1984) Hepatology , vol.4 , pp. 966-973
    • Karlaganis, G.1    Sjövall, J.2
  • 53
    • 84862339778 scopus 로고    scopus 로고
    • A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma
    • McDonald, J. G., D. D. Smith, A. R. Stiles, and D. W. Russell. 2012. A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma. J. Lipid Res. 53: 1399-1409.
    • (2012) J. Lipid Res. , vol.53 , pp. 1399-1409
    • McDonald, J.G.1    Smith, D.D.2    Stiles, A.R.3    Russell, D.W.4
  • 54
    • 0344011516 scopus 로고    scopus 로고
    • Ontogenesis and regulation of cholesterol metabolism in the central nervous system of the mouse
    • DOI 10.1016/j.devbrainres.2003.09.015
    • Quan, G., C. Xie, J. M. Dietschy, and S. D. Turley. 2003. Ontogenesis and regulation of cholesterol metabolism in the central nervous system of the mouse. Brain Res. Dev. Brain Res. 146: 87-98. (Pubitemid 37474113)
    • (2003) Developmental Brain Research , vol.146 , Issue.1-2 , pp. 87-98
    • Quan, G.1    Xie, C.2    Dietschy, J.M.3    Turley, S.D.4
  • 57
  • 61
    • 79955788943 scopus 로고    scopus 로고
    • An ADIOL-ERbeta-CtBP transrepression pathway negatively regulates microglia-mediated inflammation
    • Saijo, K., J. G. Collier, A. C. Li, J. A. Katzenellenbogen, and C. K. Glass. 2011. An ADIOL-ERbeta-CtBP transrepression pathway negatively regulates microglia-mediated inflammation. Cell. 145: 584-595.
    • (2011) Cell , vol.145 , pp. 584-595
    • Saijo, K.1    Collier, J.G.2    Li, A.C.3    Katzenellenbogen, J.A.4    Glass, C.K.5


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