Anti-DKK1 antibody promotes bone fracture healing through activation of β-catenin signaling

Bone

Volumn 71, Issue , 2015, Pages 63-75

  Jin, Hongting ^a   Wang, Baoli ^b   Li, Jia ^c,d   Xie, Wanqing ^c,d   Mao, Qiang ^a   Li, Shan ^c   Dong, Fuqiang ^c   Sun, Yan ^a   Ke, Hua Zhu ^e   Babij, Philip ^e   Tong, Peijian ^a,f   Chen, Di ^c  

^a ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

^b TIANJIN MEDICAL UNIVERSITY   (China)

^c RUSH UNIVERSITY MEDICAL CENTER   (United States)

^d LIAONING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^e AMGEN INC   (United States)

^f THE FIRST AFFILIATED HOSPITAL OF ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

Author keywords

Conditional knockout; Dkk1 Ab; Fracture healing; Mesenchymal progenitor cells; Catenin

Indexed keywords

BETA CATENIN; CRE RECOMBINASE; DICKKOPF 1 PROTEIN ANTIBODY; PROTEIN ANTIBODY; UNCLASSIFIED DRUG; ANTIBODY; BIOLOGICAL MARKER; DKK1 PROTEIN, MOUSE; INTEGRASE; SIGNAL PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BETA CATENIN GENE; BIOMECHANICS; BONE REGENERATION; BONE REMODELING; BONE STRENGTH; BONE TISSUE; C57BL 6 MOUSE; CALLUS; CONTROLLED STUDY; DISEASE COURSE; DRUG MECHANISM; ENCHONDRAL OSSIFICATION; FRACTURE HEALING; GENE DELETION; GENE EXPRESSION; HISTOLOGY; KNOCKOUT MOUSE; MALE; MESENCHYMAL STEM CELL; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; OSSIFICATION; SIGNAL TRANSDUCTION; TIBIA FRACTURE; TISSUE STRUCTURE; ANIMAL; C57BL MOUSE; CARTILAGE; DRUG EFFECTS; FRACTURE; GENE EXPRESSION REGULATION; GENETIC RECOMBINATION; GENETICS; IMMUNOLOGY; METABOLISM; ORGAN SIZE; OSTEOCLAST; PATHOLOGY; RADIOGRAPHY;

ANIMALS; ANTIBODIES; BETA CATENIN; BIOMARKERS; BIOMECHANICAL PHENOMENA; BONY CALLUS; CARTILAGE; FRACTURE HEALING; FRACTURES, BONE; GENE EXPRESSION REGULATION; INTEGRASES; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORGAN SIZE; OSTEOCLASTS; RECOMBINATION, GENETIC; SIGNAL TRANSDUCTION;

EID: 84908565154     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2014.07.039     Document Type: Article

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