Glucolipotoxicity impairs ceramide flow from the endoplasmic reticulum to the Golgi apparatus in INS-1 β-cells

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Gjoni, Enida ^a   Brioschi, Loredana ^a   Cinque, Alessandra ^a   Coant, Nicolas ^b   Islam, M Nurul ^c   Ng, Carl K Y ^c   Verderio, Claudia ^a   Magnan, Christophe ^b   Riboni, Laura ^a   Viani, Paola ^a   Stunff, Hervé Le ^b   Giussani, Paola ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b Groupe Hospitalier Pitié Salpêtrière   (France)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; FATTY ACID; GLUCOSE; RNA; SMALL INTERFERING RNA; SPHINGOLIPID; PALMITIC ACID; SPHINGOMYELIN; SPHINGOSINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; BIOSYNTHESIS; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GLUCOLIPOTOXICITY; GOLGI COMPLEX; LIPOTOXICITY; MOLECULAR MECHANICS; NONHUMAN; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT; RNA INTERFERENCE; ANIMAL; CELL LINE; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DIABETES MELLITUS; ENDOPLASMIC RETICULUM STRESS; INSULINOMA; METABOLISM; PANCREAS ISLET BETA CELL; PHOSPHORYLATION;

ANIMALS; CELL LINE; CELL SURVIVAL; CERAMIDES; DIABETES MELLITUS; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; GLUCOSE; GOLGI APPARATUS; INSULIN-SECRETING CELLS; INSULINOMA; PALMITIC ACID; PHOSPHORYLATION; RATS; RNA INTERFERENCE; SPHINGOMYELINS; SPHINGOSINE;

EID: 84908503711     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0110875     Document Type: Article

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