Whole grain rye intake, reflected by a biomarker, is associated with favorable blood lipid outcomes in subjects with the metabolic syndrome - A randomized study

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Magnusdottir, Ola Kally ^a   Landberg, Rikard ^b,c   Gunnarsdottir, Ingibjorg ^a   Cloetens, Lieselotte ^d   Åkesson, Björn ^d,e   Rosqvist, Fredrik ^f   Schwab, Ursula ^g,h   Herzig, Karl Heinz ^h,i   Hukkanen, Janne ^i,j   Savolainen, Markku J ^i,j   Brader, Lea ^k   Hermansen, Kjeld ^k   Kolehmainen, Marjukka ^g,l   Poutanen, Kaisa ^g,l   Uusitupa, Matti ^g,h   Risérus, Ulf ^f   Thorsdottir, Inga ^a  

^a LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^b SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

^d LUND UNIVERSITY   (Sweden)

^e LUND UNIVERSITY HOSPITAL   (Sweden)

^f UPPSALA UNIVERSITY   (Sweden)

^g UNIVERSITY OF EASTERN FINLAND   (Finland)

^h KUOPIO UNIVERSITY HOSPITAL   (Finland)

ⁱ UNIVERSITY OF OULU   (Finland)

^j OULU UNIVERSITY HOSPITAL   (Finland)

^k AARHUS UNIVERSITY HOSPITAL   (Denmark)

^l VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

more..

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B; BIOLOGICAL MARKER; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; RESORCINOL DERIVATIVE; TRIACYLGLYCEROL; CHOLESTEROL; LIPID;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; BERRY; BLOOD SAMPLING; BODY MASS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DAIRY PRODUCT; DIET SUPPLEMENTATION; DIETARY INTAKE; FISH MEAT; FRUIT; HUMAN; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; METABOLIC SYNDROME X; MULTICENTER STUDY; PARALLEL DESIGN; RANDOMIZED CONTROLLED TRIAL; RAPESEED; RYE; TRIACYLGLYCEROL BLOOD LEVEL; VEGETABLE; WHEAT; BLOOD; DIET; DIET THERAPY; FEMALE; MALE; MIDDLE AGED; SECALE; WHOLE GRAIN;

SECALE CEREALE;

ADULT; AGED; BIOMARKERS; BODY MASS INDEX; CHOLESTEROL; DIET; FEMALE; HUMANS; LIPIDS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; RESORCINOLS; SECALE; WHOLE GRAINS;

EID: 84908428692     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0110827     Document Type: Article

References (45)

1. McKeown NM, Meigs JB, Liu S, Wilson P.W., Jacques PF (2002) Whole-grain intake is favorably associated with metabolic risk factors for type 2 diabetes and cardiovascular disease in the Framingham Offspring Study. Am J Clin Nutr 76: 390-398.
2. Mellen PB, Walsh TF, Herrington DM (2008) Whole grain intake and cardiovascular disease: a meta-analysis. Nutr Metab Cardiovasc Dis 18: 283-290.
3. Sahyoun NR, Jacques PF, Zhang X.L., Juan W., McKeown NM (2006) Whole-grain intake is inversely associated with the metabolic syndrome and mortality in older adults. Am J Clin Nutr 83: 124-131.
4. de Munter JS, Hu FB, Spiegelman D, Franz M., van Dam RM (2007) Whole grain, bran, and germ intake and risk of type 2 diabetes: a prospective cohort study and systematic review. PLoS Med 4: e261.
5. Leinonen KS, Poutanen KS, Mykkanen HM (2000) Rye bread decreases serum total and LDL cholesterol in men with moderately elevated serum cholesterol. J Nutr 130: 164-170.
6. Lundin EA, Zhang JX, Lairon D, Tidehag P., Aman P, et al. (2004) Effects of meal frequency and high-fibre rye-bread diet on glucose and lipid metabolism and ileal excretion of energy and sterols in ileostomy subjects. Eur J Clin Nutr 58: 1410-1419.
7. Giacco R, Clemente G, Cipriano D., Luongo D, Viscovo D, et al. (2010) Effects of the regular consumption of wholemeal wheat foods on cardiovascular risk factors in healthy people. Nutr Metab Cardiovasc Dis 20: 186-194.
8. Ross AB, Bruce SJ, Blondel-Lubrano A, Oguey-Araymon S, Beaumont M, et al. (2011) A whole-grain cereal-rich diet increases plasma betaine, and tends to decrease total and LDL-cholesterol compared with a refined-grain diet in healthy subjects. Br J Nutr 105: 1492-1502.
9. Behall KM, Scholfield DJ, Hallfrisch J (2006) Whole-grain diets reduce blood pressure in mildly hypercholesterolemic men and women. J Am Diet Assoc 106: 1445-1449.
10. Tighe P, Duthie G, Vaughan N., Brittenden J, Simpson WG, et al. (2010) Effect of increased consumption of whole-grain foods on blood pressure and other cardiovascular risk markers in healthy middle-aged persons: a randomized controlled trial. Am J Clin Nutr 92: 733-740.
11. Leinonen K, Liukkonen K, Poutanen K., Uusitupa M, Mykkanen H (1999) Rye bread decreases postprandial insulin response but does not alter glucose response in healthy Finnish subjects. Eur J Clin Nutr 53: 262-267.
12. Juntunen KS, Laaksonen DE, Poutanen K.S., Niskanen LK, Mykkanen HM (2003) High-fiber rye bread and insulin secretion and sensitivity in healthy postmenopausal women. Am J Clin Nutr 77: 385-391.
13. Pereira MA, Jacobs DR, Jr., Pins JJ, Raatz SK, Gross MD, et al. (2002) Effect of whole grains on insulin sensitivity in overweight hyperinsulinemic adults. Am J Clin Nutr 75: 848-855.
14. Lund EK, Salf KL, Johnson IT (1993) Baked rye products modify cholesterol metabolism and crypt cell proliferation rates in rats. J Nutr 123: 1834-1843.
15. Zhang JX, Lundin E, Reuterving C.O., Hallmans G., Stenling R, et al. (1994) Effects of rye bran, oat bran and soya-bean fibre on bile composition, gallstone formation, gall-bladder morphology and serum cholesterol in Syrian golden hamsters (Mesocricetus auratus). Br J Nutr 71: 861-870.
16. Andersson U, Rosen L, Ostman E., Strom K, Wierup N, et al. (2010) Metabolic effects of whole grain wheat and whole grain rye in the C57BL/6J mouse. Nutrition 26: 230-239.
17. Rakha A, Åman P, Andersson R (2010) Characterisation of dietary fibre components in rye products. Food Chemistry 119: 859-867.
18. Moazzami AA, Bondia-Pons I, Hanhineva K., Juntunen K, Antl N, et al. (2012) Metabolomics reveals the metabolic shifts following an intervention with rye bread in postmenopausal women-a randomized control trial. Nutr J 11: 88.
19. Ross AB, Bourgeois A, Macharia H.N., Kochhar S., Jebb SA, et al. (2012) Plasma alkylresorcinols as a biomarker of whole-grain food consumption in a large population: results from the WHOLEheart Intervention Study. Am J Clin Nutr 95: 204-211.
20. Ross AB, Kamal-Eldin A, Aman P (2004) Dietary alkylresorcinols: absorption, bioactivities, and possible use as biomarkers of whole-grain wheat- and rye-rich foods. Nutr Rev 62: 81-95.
21. Landberg R, Kamal-Eldin A, Andersson A., Vessby B, Aman P (2008) Alkylresorcinols as biomarkers of whole-grain wheat and rye intake: plasma concentration and intake estimated from dietary records. Am J Clin Nutr 87: 832-838.
22. Montonen J, Landberg R, Kamal-Eldin A, Aman P., Knueppel S, et al. (2010) Reliability of fasting plasma alkylresorcinol concentrations measured 4 months apart. Eur J Clin Nutr 64: 698-703.
23. Ross AB, Shepherd MJ, Schupphaus M, Sinclair V., Alfaro B, et al. (2003) Alkylresorcinols in cereals and cereal products. J Agric Food Chem 51: 4111-4118.
24. Chen Y, Ross AB, Aman P, Kamal-Eldin A (2004) Alkylresorcinols as markers of whole grain wheat and rye in cereal products. J Agric Food Chem 52: 8242-8246.
25. Linko-Parvinen AM, Landberg R, Tikkanen M.J., Adlercreutz H., Penalvo JL (2007) Alkylresorcinols from whole-grain wheat and rye are transported in human plasma lipoproteins. J Nutr 137: 1137-1142.
26. Magnusdottir OK, Landberg R, Gunnarsdottir I., Cloetens L, Akesson B, et al. (2013) Plasma Alkylresorcinols Reflect Important Whole-Grain Components of a Healthy Nordic Diet. J Nutr.
27. Uusitupa M, Hermansen K, Savolainen M.J., Schwab U., Kolehmainen M, et al. (2013) Effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome - a randomized study (SYSDIET). J Intern Med 274: 52-66.
28. Alberti KG, Eckel RH, Grundy S.M., Zimmet PZ, Cleeman JI, et al. (2009) Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120: 1640-1645.
29. (2004) Nordic Nutrition Recommendations 2004 Intergrating nutrition and physical activity. Copenhagen: Nordic Council of Ministers.
30. Landberg R, Åman P, Kamal-Eldin A (2009) A rapid gas chromatography-mass spectrometry method for quantification of alkylresorcinols in human plasma. Anal Biochem 385: 7-12.
31. Magnusdottir OK, Landberg R, Gunnarsdottir I., Cloetens L, Akesson B, et al. (2014) Plasma alkylresorcinols C17: 0/C21: 0 ratio, a biomarker of relative whole-grain rye intake, is associated to insulin sensitivity: a randomized study. Eur J Clin Nutr 68: 453-458.
32. Tiwari U, Cummins E (2011) Meta-analysis of the effect of beta-glucan intake on blood cholesterol and glucose levels. Nutrition 27: 1008-1016.
33. Othman RA, Moghadasian MH, Jones PJ (2011) Cholesterol-lowering effects of oat beta-glucan. Nutr Rev 69: 299-309.
34. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). Scientific Opinion on the substantiation of health claims related to beta glucans and maintenance of normal blood cholesterol concentrations (ID 754, 755, 757, 801, 1465, 2934) and maintenance or achievement of a normal body weight (ID 820, 823) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal 2009; 7(9): 1254 [18]. 10.2903/j.efsa.2009.1254 Available online: www.efsa.europa.eu/efsajournal. Accessed February 20 2014.
35. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). Scientific Opinion on the substantiation of a health claim related to oat beta glucan and lowering blood cholesterol and reduced risk of (coronary) heart disease pursuant to Article 14 of Regulation (EC) No 1924/2006. EFSA Journal 2010; 8(12): 1885 [15]. 10.2903/j.efsa.2010.1885 Available online: www.efsa.europa.eu/efsajournal. Accessed February 20 2014.
36. Ma J, Ross AB, Shea M.K., Bruce SJ, Jacques PF, et al. (2012) Plasma Alkylresorcinols, Biomarkers of Whole-Grain Intake, Are Related to Lower BMI in Older Adults. J Nutr 142: 1859-1864.
37. Magnusdottir OK, Landberg R, Gunnarsdottir I., Cloetens L, Akesson B, et al. (2014) Plasma alkylresorcinols C17: 0/C21: 0 ratio, a biomarker of relative whole-grain rye intake, is associated to insulin sensitivity: a randomized study. Eur J Clin Nutr.
38. Jenkins DJ, Kendall CW, Vuksan V, Augustin L.S., Mehling C., et al. (1999) Effect of wheat bran on serum lipids: influence of particle size and wheat protein. J Am Coll Nutr 18: 159-165.
39. Landberg R, Aman P, Friberg L.E., Vessby B., Adlercreutz H, et al. (2009) Dose response of whole-grain biomarkers: alkylresorcinols in human plasma and their metabolites in urine in relation to intake. Am J Clin Nutr 89: 290-296.
40. Ross AB (2012) Present status and perspectives on the use of alkylresorcinols as biomarkers of wholegrain wheat and rye intake. J Nutr Metab 2012: 462967.
41. Slavin JL, Jacobs D, Marquart L., Wiemer K (2001) The role of whole grains in disease prevention. J Am Diet Assoc 101: 780-785.
42. Fardet A (2010) New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre? Nutr Res Rev 23: 65-134.
43. Wolever TM, Tosh SM, Gibbs A.L., Brand-Miller J, Duncan AM, et al. (2010) Physicochemical properties of oat beta-glucan influence its ability to reduce serum LDL cholesterol in humans: a randomized clinical trial. Am J Clin Nutr 92: 723-732.
44. Hansen HB, Rasmussen CV, Bach Knudsen KE, Hansen Å (2003) Effects of genotype and harvest year on content and composition of dietary fibre in rye (Secale cereale L) grain. Journal of the Science of Food and Agriculture 83: 76-85.
45. Linko-Parvinen AM, Landberg R, Tikkarren M.J., Adlercreutz H., Penalvo JL (2007) Alkylresorcinols from whole-grain wheat and rye are transported in human plasma lipoproteins. Journal of Nutrition 137: 1137-1142.