Phenylpropenoic acid glucoside augments pancreatic beta cell mass in high-fat diet-fed mice and protects beta cells from ER stress-induced apoptosis

Molecular Nutrition and Food Research

Volumn 58, Issue 10, 2014, Pages 1980-1990

  Mathijs, Iris ^a   da Cunha, Daniel A ^b   Himpe, Eddy ^a   Ladriere, Laurence ^b   Chellan, Nireshni ^c   Roux, Candice R ^c   Joubert, Elizabeth ^d,e   Muller, Christo ^c   Cnop, Miriam ^b,f   Louw, Johan ^c   Bouwens, Luc ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^c SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

^d AGRICULTURAL RESEARCH COUNCIL   (South Africa)

^e STELLENBOSCH UNIVERSITY   (South Africa)

^f ERASME HOSPITAL   (Belgium)

Author keywords

Beta cell apoptosis; Beta cell regeneration; Lipotoxicity; Type 2 diabetes

Indexed keywords

MUS;

2-(GLUCOPYRANOSYLOXY)-3-PHENYLPROPENOIC ACID; ANTIDIABETIC AGENT; FRUCTOSE; GLUCOSIDE; LIPOTROPIC AGENT; PHENYLPROPIONIC ACID DERIVATIVE; PROTEIN BCL 2;

ADVERSE EFFECTS; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; CELL CULTURE; CELL SIZE; COMPLICATION; CROSS BREEDING; DIABETES MELLITUS, TYPE 2; DRUG EFFECTS; ENDOPLASMIC RETICULUM STRESS; GENETICS; INSULIN RESISTANCE; LIPID DIET; MALE; METABOLISM; OBESITY; PANCREAS ISLET BETA CELL; PATHOLOGY; RNA INTERFERENCE; SECRETION (PROCESS); TRANSGENIC MOUSE; TUMOR CELL LINE; UPREGULATION; WISTAR RAT;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL SIZE; CELLS, CULTURED; CROSSES, GENETIC; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; ENDOPLASMIC RETICULUM STRESS; FRUCTOSE; GLUCOSIDES; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; LIPOTROPIC AGENTS; MALE; MICE, TRANSGENIC; OBESITY; PHENYLPROPIONATES; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS, WISTAR; RNA INTERFERENCE; UP-REGULATION;

EID: 84908409591     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201400211     Document Type: Article

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