A newfound association between MDC1 functional polymorphism and lung cancer risk in Chinese

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Bo, Wang ^a   Lisha, Zhang ^a   Fuman, Qiu ^a   Wenxiang, Fang ^a   Jieqiong, Deng ^b   Yifeng, Zhou ^b   Jiachun, Lu ^a   Lei, Yang ^a  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MEDIATOR OF DNA DAMAGE CHECKPOINT PROTEIN 1; MESSENGER RNA; NUCLEAR FACTOR; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ADULT; ARTICLE; CANCER RISK; CASE CONTROL STUDY; CHINESE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE FUNCTION; GENOTYPE; GENOTYPE PHENOTYPE CORRELATION; HUMAN; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; MDC1 GENE; PROTEIN EXPRESSION; PROTEIN FUNCTION; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 84908405793     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0106794     Document Type: Article

References (48)

1. Lagerwerf S, Vrouwe MG, Overmeer RM, Fousteri MI, Mullenders LH (2011) DNA damage response and transcription. DNA Repair (Amst) 10: 743-750.
2. Ermolaeva MA, Schumacher B (2014) Systemic DNA damage responses: organismal adaptations to genome instability. Trends Genet 30: 95-102.
3. Rai R, Peng G, Li K, Lin SY (2007) DNA damage response: the players, the network and the role in tumor suppression. Cancer Genomics Proteomics 4: 99-106.
4. Petrini JH, Stracker TH (2003) The cellular response to DNA double-strand breaks: defining the sensors and mediators. Trends Cell Biol 13: 458-462.
5. Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ (2003) MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature 421: 961-966.
6. Goldberg M, Stucki M, Falck J, D'Amours D, Rahman D, et al. (2003) MDC1 is required for the intra-S-phase DNA damage checkpoint. Nature 421: 952-956.
7. Lou Z, Minter-Dykhouse K, Wu X, Chen J (2003) MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways. Nature 421: 957-961.
8. Shibata A, Barton O, Noon AT, Dahm K, Deckbar D, et al. (2010) Role of ATM and the damage response mediator proteins 53BP1 and MDC1 in the maintenance of G(2)/M checkpoint arrest. Mol Cell Biol 30: 3371-3383.
9. Peng A, Chen PL (2005) NFBD1/Mdc1 mediates ATR-dependent DNA damage response. Cancer Res 65: 1158-1163.
10. Xu X, Stern DF (2003) NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors. FASEB J 17: 1842-1848.
11. Dimitrova N, de Lange T (2006) MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres. Genes Dev 20: 3238-3243.
12. Zhang J, Ma Z, Treszezamsky A, Powell SN (2005) MDC1 interacts with Rad51 and facilitates homologous recombination. Nat Struct Mol Biol 12: 902-909.
13. Xie A, Hartlerode A, Stucki M, Odate S, Puget N, et al. (2007) Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Mol Cell 28: 1045-1057.
14. Luo K, Yuan J, Chen J, Lou Z (2009) Topoisomerase IIalpha controls the decatenation checkpoint. Nat Cell Biol 11: 204-210.
15. Townsend K, Mason H, Blackford AN, Miller ES, Chapman JR, et al. (2009) Mediator of DNA damage checkpoint 1 (MDC1) regulates mitotic progression. J Biol Chem 284: 33939-33948.
16. Lou Z, Minter-Dykhouse K, Franco S, Gostissa M, Rivera MA, et al. (2006) MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell 21: 187-200.
17. Coster G, Goldberg M (2010) The cellular response to DNA damage: a focus on MDC1 and its interacting proteins. Nucleus 1: 166-178.
18. Bohgaki T, Bohgaki M, Cardoso R, Panier S, Zeegers D, et al. (2011) Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome. PLoS Genet 7: e1001381.
19. Yang Z, Bu Y, Wang C, Liu G, Song F (2010) Growth inhibition, morphology change, and cell cycle alterations in NFBD1-depleted human esophageal cancer cells. Mol Cell Biochem 342: 1-6.
20. Patel AN, Goyal S, Wu H, Schiff D, Moran MS, et al. (2011) Mediator of DNA damage checkpoint protein 1 (MDC1) expression as a prognostic marker for nodal recurrence in early-stage breast cancer patients treated with breastconserving surgery and radiation therapy. Breast Cancer Res Treat 126: 601-607.
21. Belgnaoui SM, Fryrear KA, Nyalwidhe JO, Guo X, Semmes OJ (2010) The viral oncoprotein tax sequesters DNA damage response factors by tethering MDC1 to chromatin. J Biol Chem 285: 32897-32905.
22. Nakanishi M, Ozaki T, Yamamoto H, Hanamoto T, Kikuchi H, et al. (2007) NFBD1/MDC1 associates with p53 and regulates its function at the crossroad between cell survival and death in response to DNA damage. J Biol Chem 282: 22993-23004.
23. Wilson KA, Colavito SA, Schulz V, Wakefield PH, Sessa W, et al. (2011) NFBD1/MDC1 regulates Cav1 and Cav2 independently of DNA damage and p53. Mol Cancer Res 9: 766-781.
24. Motoyama N, Naka K (2004) DNA damage tumor suppressor genes and genomic instability. Curr Opin Genet Dev 14: 11-16.
25. Bartkova J, Horejsi Z, Sehested M, Nesland JM, Rajpert-De Meyts E, et al. (2007) DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours. Oncogene 26: 7414-7422.
26. Zhang ZZ, Liu YJ, Yin XL, Zhan P, Gu Y, et al. (2013) Loss of BRCA1 expression leads to worse survival in patients with gastric carcinoma. World J Gastroenterol 19: 1968-1974.
27. Shiraishi K, Kunitoh H, Daigo Y, Takahashi A, Goto K, et al. (2012) A genomewide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population. Nat Genet 44: 900-903.
28. Shen GP, Pan QH, Hong MH, Qin HD, Xu YF, et al. (2011) Human genetic variants of homologous recombination repair genes first found to be associated with Epstein-Barr virus antibody titers in healthy Cantonese. Int J Cancer 129: 1459-1466.
29. Pugh TJ, Keyes M, Barclay L, Delaney A, Krzywinski M, et al. (2009) Sequence variant discovery in DNA repair genes from radiosensitive and radiotolerant prostate brachytherapy patients. Clin Cancer Res 15: 5008-5016.
30. Lu J, Yang L, Zhao H, Liu B, Li Y, et al. (2011) The polymorphism and haplotypes of PIN1 gene are associated with the risk of lung cancer in Southern and Eastern Chinese populations. Hum Mutat 32: 1299-1308.
31. Yang L, Li Y, Cheng M, Huang D, Zheng J, et al. (2012) A functional polymorphism at microRNA-629-binding site in the 39-untranslated region of NBS1 gene confers an increased risk of lung cancer in Southern and Eastern Chinese population. Carcinogenesis 33: 338-347.
32. Yang L, Yang X, Ji W, Deng J, Qiu F, et al. (2014) Effects of a functional variant c.353T.C in snai1 on risk of two contextual diseases. Chronic obstructive pulmonary disease and lung cancer. Am J Respir Crit Care Med 189: 139-148.
33. Yang L, Liu B, Huang B, Deng J, Li H, et al. (2013) A functional copy number variation in the WWOX gene is associated with lung cancer risk in Chinese. Hum Mol Genet 22: 1886-1894.
34. Liu B, Yang L, Huang B, Cheng M, Wang H, et al. (2012) A functional copynumber variation in MAPKAPK2 predicts risk and prognosis of lung cancer. Am J Hum Genet 91: 384-390.
35. Yang L, Li Y, Ling X, Liu L, Liu B, et al. (2011) A common genetic variant (97906C.A) of DAB2IP/AIP1 is associated with an increased risk and early onset of lung cancer in Chinese males. PLoS One 6: e26944.
36. Liu JZ, McRae AF, Nyholt DR, Medland SE, Wray NR, et al. (2010) A versatile gene-based test for genome-wide association studies. Am J Hum Genet 87: 139-145.
37. Liu B, Chen D, Yang L, Li Y, Ling X, et al. (2010) A functional variant (21304T.G) in the MKK4 promoter contributes to a decreased risk of lung cancer by increasing the promoter activity. Carcinogenesis 31: 1405-1411.
38. Dupont WD, Plummer WD, Jr. (1998) Power and sample size calculations for studies involving linear regression. Control Clin Trials 19: 589-601.
39. Shahar OD, Gabizon R, Feine O, Alhadeff R, Ganoth A, et al. (2013) acetylation of lysine 382 and phosphorylation of serine 392 in p53 modulate the interaction between p53 and MDC1 in vitro. PLoS One 8: e78472.
40. Noon AT, Shibata A, Rief N, Lobrich M, Stewart GS, et al. (2010) 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair. Nat Cell Biol 12: 177-184.
41. Lou Z, Chen J (2004) Use of siRNA to study the function of MDC1 in DNA damage responses. Methods Mol Biol 281: 179-187.
42. Hsia TC, Lin JH, Hsu SC, Tang NY, Lu HF, et al. (2014) Cantharidin induces DNA damage and inhibits DNA repair-associated protein levels in NCI-H460 human lung cancer cells. Environ Toxicol.
43. Min Y, Ghose S, Boelte K, Li J, Yang L, et al. (2011) C/EBP-delta regulates VEGF-C autocrine signaling in lymphangiogenesis and metastasis of lung cancer through HIF-1alpha. Oncogene 30: 4901-4909.
44. Safe S, Jin UH, Hedrick E, Reeder A, Lee SO (2014) Minireview: role of orphan nuclear receptors in cancer and potential as drug targets. Mol Endocrinol 28: 157-172.
45. Sato A, Yamada N, Ogawa Y, Ikegami M (2013) CCAAT/enhancer-binding protein-alpha suppresses lung tumor development in mice through the p38alpha MAP kinase pathway. PLoS One 8: e57013.
46. Wang H, Iakova P, Wilde M, Welm A, Goode T, et al. (2001) C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4. Mol Cell 8: 817-828.
47. Brooks JD, Teraoka SN, Reiner AS, Satagopan JM, Bernstein L, et al. (2012) Variants in activators and downstream targets of ATM, radiation exposure, and contralateral breast cancer risk in the WECARE study. Hum Mutat 33: 158-164.
48. Hu Z, Wu C, Shi Y, Guo H, Zhao X, et al. (2011) A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Nat Genet 43: 792-796.