Imaging genetics in obsessive-compulsive disorder: Linking genetic variations to alterations in neuroimaging

Progress in Neurobiology

Volumn 121, Issue , 2014, Pages 114-124

  Grünblatt, Edna ^a   Hauser, Tobias U ^a,b   Walitza, Susanne ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Brain; Genetic variation; Imaging; Imaging genetics; Neuroimaging; Obsessive compulsive disorder

Indexed keywords

ANTERIOR CINGULATE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENETIC ASSOCIATION; GENETIC VARIABILITY; HERITABILITY; HIPPOCAMPUS; HUMAN; MENTAL DISEASE; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEUS ACCUMBENS; OBSESSIVE COMPULSIVE DISORDER; OCCIPITAL CORTEX; PERSONALIZED MEDICINE; PHENOTYPE; POSTSYNAPTIC DENSITY; PUBLICATION; REVIEW; SAMPLE SIZE; SEROTONINERGIC SYSTEM; WHITE MATTER; BIBLIOGRAPHIC DATABASE; GENETIC LINKAGE; GENETICS; OBSESSIVE-COMPULSIVE DISORDER; STATISTICS AND NUMERICAL DATA;

DATABASES, BIBLIOGRAPHIC; GENETIC LINKAGE; HUMANS; NEUROIMAGING; OBSESSIVE-COMPULSIVE DISORDER;

EID: 84908396947     PISSN: 03010082     EISSN: 18735118     Source Type: Journal    
DOI: 10.1016/j.pneurobio.2014.07.003     Document Type: Review

References (106)

1. Albrecht B., Brandeis D., Uebel H., Heinrich H., Mueller U.C., Hasselhorn M., Steinhausen H.C., Rothenberger A., Banaschewski T. Action monitoring in boys with attention-deficit/hyperactivity disorder, their nonaffected siblings, and normal control subjects: evidence for an endophenotype. Biol. Psychiatry 2008, 64:615-625.
2. Alexopoulos G.S., Murphy C.F., Gunning-Dixon F.M., Glatt C.E., Latoussakis V., Kelly R.E., Kanellopoulos D., Klimstra S., Lim K.O., Young R.C., Hoptman M.J. Serotonin transporter polymorphisms, microstructural white matter abnormalities and remission of geriatric depression. J. Affect. Disord. 2009, 119:132-141.
3. Alonso P., Gratacos M., Segalas C., Escaramis G., Real E., Bayes M., Labad J., Lopez-Sola C., Estivill X., Menchon J.M. Association between the NMDA glutamate receptor GRIN2B gene and obsessive-compulsive disorder. Journal of Psychiatry & Neuroscience: JPN 2012, 37:273-281.
4. ®) 2000, American Psychiatric Association, Washington, DC.
5. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 2013, APA, Washington DC. Fifth Edition DSM-5. 5th ed.
6. Arnold P.D., Macmaster F.P., Hanna G.L., Richter M.A., Sicard T., Burroughs E., Mirza Y., Easter P.C., Rose M., Kennedy J.L., Rosenberg D.R. Glutamate system genes associated with ventral prefrontal and thalamic volume in pediatric obsessive-compulsive disorder. Brain Imaging Behav. 2009, 3:64-76.
7. Arnold P.D., Macmaster F.P., Richter M.A., Hanna G.L., Sicard T., Burroughs E., Mirza Y., Easter P.C., Rose M., Kennedy J.L., Rosenberg D.R. Glutamate receptor gene (GRIN2B) associated with reduced anterior cingulate glutamatergic concentration in pediatric obsessive-compulsive disorder. Psychiatry Res. 2009, 172:136-139.
8. Atmaca M., Onalan E., Yildirim H., Yuce H., Koc M., Korkmaz S. The association of myelin oligodendrocyte glycoprotein gene and white matter volume in obsessive-compulsive disorder. J. Affect. Disord. 2010, 124:309-313.
9. Atmaca M., Onalan E., Yildirim H., Yuce H., Koc M., Korkmaz S., Mermi O. Serotonin transporter gene polymorphism implicates reduced orbito-frontal cortex in obsessive-compulsive disorder. J. Anxiety Disord. 2011, 25:680-685.
10. Ayuso-Mateos J. Global Burden of Obsessive-compulsive Disorder in the year 2000 2006, World Health Organization.
11. Azzam A., Mathews C.A. Meta-analysis of the association between the catecholamine-O-methyl-transferase gene and obsessive-compulsive disorder. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 2003, 123B:64-69.
12. Bedenbender J., Paulus F.M., Krach S., Pyka M., Sommer J., Krug A., Witt S.H., Rietschel M., Laneri D., Kircher T., Jansen A. Functional connectivity analyses in imaging genetics: considerations on methods and data interpretation. PLoS One 2011, 6:e26354.
13. Bienvenu O.J., Wang Y., Shugart Y.Y., Welch J.M., Grados M.A., Fyer A.J., Rauch S.L., McCracken J.T., Rasmussen S.A., Murphy D.L., Cullen B., Valle D., Hoehn-Saric R., Greenberg B.D., Pinto A., Knowles J.A., Piacentini J., Pauls D.L., Liang K.Y., Willour V.L., Riddle M., Samuels J.F., Feng G., Nestadt G. Sapap3 and pathological grooming in humans: results from the OCD collaborative genetics study. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 2009, 150B:710-720.
14. Biffi A., Anderson C.D., Desikan R.S., Sabuncu M., Cortellini L., Schmansky N., Salat D., Rosand J., Alzheimer's Disease Neuroimaging Initiative Genetic variation and neuroimaging measures in Alzheimer disease. Arch. Neurol. 2010, 67:677-685.
15. Botvinick M.M., Cohen J.D., Carter C.S. Conflict monitoring and anterior cingulate cortex: an update. Trends Cognit. Sci. 2004, 8:539-546.
16. Brem S., Grünblatt E., Drechsler R., Riederer P., Walitza S. The neurobiological link between OCD and ADHD. Atten. Defic. Hyperact. Disord. 2014, (in press).
17. Brem S., Hauser T.U., Iannaccone R., Brandeis D., Drechsler R., Walitza S. Neuroimaging of cognitive brain function in paediatric obsessive compulsive disorder: a review of literature and preliminary meta-analysis. J. Neural Transm. 2012, 119:1425-1448.
18. Bresler T., Ramati Y., Zamorano P.L., Zhai R., Garner C.C., Ziv N.E. The dynamics of SAP90/PSD-95 recruitment to new synaptic junctions. Mol. Cell. Neurosci. 2001, 18:149-167.
19. Bush G. Attention-deficit/hyperactivity disorder and attention networks. Neuropsychopharmacology 2010, 35:278-300.
20. Cavedini P., Gorini A., Bellodi L. Understanding obsessive-compulsive disorder: focus on decision making. Neuropsychol. Rev. 2006, 16:3-15.
21. Clarke H.F., Dalley J.W., Crofts H.S., Robbins T.W., Roberts A.C. Cognitive inflexibility after prefrontal serotonin depletion. Science 2004, 304:878-880.
22. Clarke H.F., Walker S.C., Crofts H.S., Dalley J.W., Robbins T.W., Roberts A.C. Prefrontal serotonin depletion affects reversal learning but not attentional set shifting. J. Neurosci. 2005, 25:532-538.
23. Clarke H.F., Walker S.C., Dalley J.W., Robbins T.W., Roberts A.C. Cognitive inflexibility after prefrontal serotonin depletion is behaviorally and neurochemically specific. Cereb. Cortex 2007, 17:18-27.
24. Cole J., Weinberger D.R., Mattay V.S., Cheng X., Toga A.W., Thompson P.M., Powell-Smith G., Cohen-Woods S., Simmons A., McGuffin P., Fu C.H. No effect of 5HTTLPR or BDNF Val66Met polymorphism on hippocampal morphology in major depression. Genes Brain Behav 2011, 10:756-764.
25. Cools R., Roberts A.C., Robbins T.W. Serotoninergic regulation of emotional and behavioural control processes. Trends Cognit. Sci. 2008, 12:31-40.
26. Davis M. NMDA receptors and fear extinction: implications for cognitive behavioral therapy. Dialogues Clin. Neurosci. 2011, 13:463-474.
27. Delorme R., Bille A., Betancur C., Mathieu F., Chabane N., Mouren-Simeoni M.C., Leboyer M. Exploratory analysis of obsessive compulsive symptom dimensions in children and adolescents: a prospective follow-up study. BMC Psychiatry 2006, 6:1.
28. Domschke K., Dannlowski U. Imaging genetics of anxiety disorders. Neuroimage 2010, 53:822-831.
29. Endele S., Rosenberger G., Geider K., Popp B., Tamer C., Stefanova I., Milh M., Kortum F., Fritsch A., Pientka F.K., Hellenbroich Y., Kalscheuer V.M., Kohlhase J., Moog U., Rappold G., Rauch A., Ropers H.H., von Spiczak S., Tonnies H., Villeneuve N., Villard L., Zabel B., Zenker M., Laube B., Reis A., Wieczorek D., Van Maldergem L., Kutsche K. Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes. Nat. Genet. 2010, 42:1021-1026.
30. Erk S., Meyer-Lindenberg A., Schnell K., Opitz von Boberfeld C., Esslinger C., Kirsch P., Grimm O., Arnold C., Haddad L., Witt S.H., Cichon S., Nothen M.M., Rietschel M., Walter H. Brain function in carriers of a genome-wide supported bipolar disorder variant. Arch. Gen. Psychiatry 2010, 67:803-811.
31. Ferreira M.A., O'Donovan M.C., Meng Y.A., Jones I.R., Ruderfer D.M., Jones L., Fan J., Kirov G., Perlis R.H., Green E.K., Smoller J.W., Grozeva D., Stone J., Nikolov I., Chambert K., Hamshere M.L., Nimgaonkar V.L., Moskvina V., Thase M.E., Caesar S., Sachs G.S., Franklin J., Gordon-Smith K., Ardlie K.G., Gabriel S.B., Fraser C., Blumenstiel B., Defelice M., Breen G., Gill M., Morris D.W., Elkin A., Muir W.J., McGhee K.A., Williamson R., MacIntyre D.J., MacLean A.W., St C.D., Robinson M., Van Beck M., Pereira A.C., Kandaswamy R., McQuillin A., Collier D.A., Bass N.J., Young A.H., Lawrence J., Ferrier I.N., Anjorin A., Farmer A., Curtis D., Scolnick E.M., McGuffin P., Daly M.J., Corvin A.P., Holmans P.A., Blackwood D.H., Gurling H.M., Owen M.J., Purcell S.M., Sklar P., Craddock N., Wellcome Trust Case Control Consortium Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat. Genet. 2008, 40:1056-1058.
32. Fineberg N.A., Baldwin D.S., Menchon J.M., Denys D., Grunblatt E., Pallanti S., Stein D.J., Zohar J., Obsessive Compulsive and Related Disorders Research Network Manifesto for a European research network into obsessive-compulsive and related disorders. Eur. Neuropsychopharmacol. 2012.
33. Flament M.F., Whitaker A., Rapoport J.L., Davies M., Berg C.Z., Kalikow K., Sceery W., Shaffer D. Obsessive compulsive disorder in adolescence: an epidemiological study. J. Am. Acad. Child Adolesc. Psychiatry 1988, 27:764-771.
34. Fontenelle L.F., Hasler G. The analytical epidemiology of obsessive-compulsive disorder: risk factors and correlates. Prog. Neuropsychopharmacol. Biol. Psychiatry 2008, 32:1-15.
35. Geller D.A., Biederman J., Jones J., Shapiro S., Schwartz S., Park K.S. Obsessive-compulsive disorder in children and adolescents: a review. Harvard Rev. Psychiatry 1998, 5:260-273.
36. Graybiel A.M., Rauch S.L. Toward a neurobiology of obsessive-compulsive disorder. Neuron 2000, 28:343-347.
37. Green E.K., Grozeva D., Jones I., Jones L., Kirov G., Caesar S., Gordon-Smith K., Fraser C., Forty L., Russell E., Hamshere M.L., Moskvina V., Nikolov I., Farmer A., McGuffin P., Wellcome Trust Case Control Consortium, Holmans P.A., Owen M.J., O'Donovan M.C., Craddock N. The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia. Mol. Psychiatry 2010, 15:1016-1022.
38. Hall B.J., Ripley B., Ghosh A. NR2B signaling regulates the development of synaptic AMPA receptor current. J. Neurosci. 2007, 27:13446-13456.
39. Harrison B.J., Pujol J., Cardoner N., Deus J., Alonso P., Lopez-Sola M., Contreras-Rodriguez O., Real E., Segalas C., Blanco-Hinojo L., Menchon J.M., Soriano-Mas C. Brain corticostriatal systems and the major clinical symptom dimensions of obsessive-compulsive disorder. Biol. Psychiatry 2013, 73:321-328.
40. Hauser T.U., Iannaccone R., Stampfli P., Drechsler R., Brandeis D., Walitza S., Brem S. The feedback-related negativity (FRN) revisited: new insights into the localization, meaning and network organization. Neuroimage 2014, 84:159-168.
41. Hesse S., Stengler K., Regenthal R., Patt M., Becker G.A., Franke A., Knupfer H., Meyer P.M., Luthardt J., Jahn I., Lobsien D., Heinke W., Brust P., Hegerl U., Sabri O. The serotonin transporter availability in untreated early-onset and late-onset patients with obsessive-compulsive disorder. Int. J. Neuropsychopharmacol. 2011, 14:606-617.
42. Hibar D.P., Kohannim O., Stein J.L., Chiang M.C., Thompson P.M. Multilocus genetic analysis of brain images. Frontiers Genet. 2011, 2:73.
43. Hoexter M.Q., Shavitt R.G., D'Alcante C.C., Cecconi J.P., Diniz J.B., Belotto-Silva C., Hounie A.G., Borcato S., Moraes I., Joaquim M.A., Cappi C., Sampaio A.S., Mathis M.A., Batistuzzo M.C., Lopes A.C., Rosa A.C., Muniz R.K., Marques A.H., Santos L.C., Taub A., Duran F.L., Dougherty D.D., Busatto G.F., Bressan R.A., Miguel E.C. The drug-naive OCD patients imaging genetics, cognitive and treatment response study: methods and sample description. Revista brasileira de psiquiatria 2009, 31:349-353.
44. Hu X.Z., Lipsky R.H., Zhu G., Akhtar L.A., Taubman J., Greenberg B.D., Xu K., Arnold P.D., Richter M.A., Kennedy J.L., Murphy D.L., Goldman D. Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am. J. Hum. Genet. 2006, 78:815-826.
45. Hunt L.T., Kolling N., Soltani A., Woolrich M.W., Rushworth M.F., Behrens T.E. Mechanisms underlying cortical activity during value-guided choice. Nat. Neurosci. 2012, 15(470-476):S471-S473.
46. Huyser C., Veltman D.J., de Haan E., Boer F. Paediatric obsessive-compulsive disorder, a neurodevelopmental disorder? Evidence from neuroimaging. Neurosci. Biobehav. Rev. 2009, 33:818-830.
47. International Schizophrenia C., Purcell S.M., Wray N.R., Stone J.L., Visscher P.M., O'Donovan M.C., Sullivan P.F., Sklar P. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 2009, 460:748-752.
48. Jogia J., Ruberto G., Lelli-Chiesa G., Vassos E., Maieru M., Tatarelli R., Girardi P., Collier D., Frangou S. The impact of the CACNA1C gene polymorphism on frontolimbic function in bipolar disorder. Mol. Psychiatry 2011, 16:1070-1071.
49. Kable J.W., Glimcher P.W. The neural correlates of subjective value during intertemporal choice. Nat. Neurosci. 2007, 10:1625-1633.
50. Katerberg H., Delucchi K.L., Stewart S.E., Lochner C., Denys D.A., Stack D.E., Andresen J.M., Grant J.E., Kim S.W., Williams K.A., den Boer J.A., van Balkom A.J., Smit J.H., van Oppen P., Polman A., Jenike M.A., Stein D.J., Mathews C.A., Cath D.C. Symptom dimensions in OCD: item-level factor analysis and heritability estimates. Behav. Genet. 2010, 40:505-517.
51. Kichuk S.A., Torres A.R., Fontenelle L.F., Rosario M.C., Shavitt R.G., Miguel E.C., Pittenger C., Bloch M.H. Symptom dimensions are associated with age of onset and clinical course of obsessive-compulsive disorder. Prog. Neuropsychopharmacol. Biol. Psychiatry 2013, 44:233-239.
52. Kochunov P., Jahanshad N., Sprooten E., Nichols T.E., Mandl R.C., Almasy L., Booth T., Brouwer R.M., Curran J.E., de Zubicaray G.I., Dimitrova R., Duggirala R., Fox P.T., Elliot Hong L., Landman B.A., Lemaitre H., Lopez L.M., Martin N.G., McMahon K.L., Mitchell B.D., Olvera R.L., Peterson C.P., Starr J.M., Sussmann J.E., Toga A.W., Wardlaw J.M., Wright M.J., Wright S.N., Bastin M.E., McIntosh A.M., Boomsma D.I., Kahn R.S., den Braber A., de Geus E.J., Deary I.J., Hulshoff Pol H.E., Williamson D.E., Blangero J., van't Ent D., Thompson P.M., Glahn D.C. Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: comparing meta and megaanalytical approaches for data pooling. Neuroimage 2014, 95:136-150.
53. Kohannim O., Jahanshad N., Braskie M.N., Stein J.L., Chiang M.C., Reese A.H., Hibar D.P., Toga A.W., McMahon K.L., de Zubicaray G.I., Medland S.E., Montgomery G.W., Martin N.G., Wright M.J., Thompson P.M. Predicting white matter integrity from multiple common genetic variants. Neuropsychopharmacology 2012, 37:2012-2019.
54. Leckman J.F., Zhang H., Alsobrook J.P., Pauls D.L. Symptom dimensions in obsessive-compulsive disorder: toward quantitative phenotypes. Am. J. Med. Genet. 2001, 105:28-30.
55. Liberati A., Altman D.G., Tetzlaff J., Mulrow C., Gotzsche P.C., Ioannidis J.P., Clarke M., Devereaux P.J., Kleijnen J., Moher D. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 2009, 339:b2700.
56. Lin P.Y. Meta-analysis of the association of serotonin transporter gene polymorphism with obsessive-compulsive disorder. Prog. Neuropsychopharmacol. Biol. Psychiatry 2007, 31:683-689.
57. MacMaster F.P. Translational neuroimaging research in pediatric obsessive-compulsive disorder. Dialogues Clin. Neurosci. 2010, 12:165-174.
58. Maia T.V., Cooney R.E., Peterson B.S. The neural bases of obsessive-compulsive disorder in children and adults. Development Psychopathol. 2008, 20:1251-1283.
59. Manoach D.S., Agam Y. Neural markers of errors as endophenotypes in neuropsychiatric disorders. Frontiers Hum. Neurosci. 2013, 7:350.
60. Mattingsdal M., Brown A.A., Djurovic S., Sonderby I.E., Server A., Melle I., Agartz I., Hovig E., Jensen J., Andreassen O.A. Pathway analysis of genetic markers associated with a functional MRI faces paradigm implicates polymorphisms in calcium responsive pathways. Neuroimage 2013, 70:143-149.
61. Meda S.A., Narayanan B., Liu J., Perrone-Bizzozero N.I., Stevens M.C., Calhoun V.D., Glahn D.C., Shen L., Risacher S.L., Saykin A.J., Pearlson G.D. A large scale multivariate parallel ICA method reveals novel imaging-genetic relationships for Alzheimer's disease in the ADNI cohort. Neuroimage 2012, 60:1608-1621.
62. Medland S.E., Jahanshad N., Neale B.M., Thompson P.M. Whole-genome analyses of whole-brain data: working within an expanded search space. Nat. Neurosci. 2014, 17:791-800.
63. Menzies L., Chamberlain S.R., Laird A.R., Thelen S.M., Sahakian B.J., Bullmore E.T. Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited. Neurosci. Biobehav. Rev. 2008, 32:525-549.
64. Moher D., Liberati A., Tetzlaff J., Altman D.G., Group P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ 2009, 339:b2535.
65. Montigny C., Castellanos-Ryan N., Whelan R., Banaschewski T., Barker G.J., Buchel C., Gallinat J., Flor H., Mann K., Paillere-Martinot M.L., Nees F., Lathrop M., Loth E., Paus T., Pausova Z., Rietschel M., Schumann G., Smolka M.N., Struve M., Robbins T.W., Garavan H., Conrod P.J., Consortium I. A phenotypic structure and neural correlates of compulsive behaviors in adolescents. PLoS One 2013, 8:e80151.
66. Nikolova Y.S., Ferrell R.E., Manuck S.B., Hariri A.R. Multilocus genetic profile for dopamine signaling predicts ventral striatum reactivity. Neuropsychopharmacology 2011, 36:1940-1947.
67. Nyegaard M., Demontis D., Foldager L., Hedemand A., Flint T.J., Sorensen K.M., Andersen P.S., Nordentoft M., Werge T., Pedersen C.B., Hougaard D.M., Mortensen P.B., Mors O., Borglum A.D. CACNA1C (rs1006737) is associated with schizophrenia. Mol. Psychiatry 2010, 15:119-121.
68. Nymberg C., Jia T., Ruggeri B., Schumann G. Analytical strategies for large imaging genetic datasets: experiences from the IMAGEN study. Ann. N Y Acad. Sci. 2013.
69. Pauls D.L. The genetics of obsessive compulsive disorder: a review of the evidence. Am. J. Med. Genet. C: Semin. Med. Genet. 2008, 148C:133-139.
70. Peng Z., Lui S.S., Cheung E.F., Jin Z., Miao G., Jing J., Chan R.C. Brain structural abnormalities in obsessive-compulsive disorder: converging evidence from white matter and grey matter. Asian J. Psychiatry 2012, 5:290-296.
71. Perrier E., Pompei F., Ruberto G., Vassos E., Collier D., Frangou S. Initial evidence for the role of CACNA1C on subcortical brain morphology in patients with bipolar disorder. Eur. Psychiatry 2011, 26:135-137.
72. Pine D.S., Ernst M., Leibenluft E. Imaging-genetics applications in child psychiatry. J. Am. Acad. Child Adolesc. Psychiatry 2010, 49:772-782.
73. Piras F., Piras F., Caltagirone C., Spalletta G. Brain circuitries of obsessive compulsive disorder: a systematic review and meta-analysis of diffusion tensor imaging studies. Neurosci. Biobehav. Rev. 2013, 37:2856-2877.
74. Pooley E.C., Fineberg N., Harrison P.J. The met(158) allele of catechol-O-methyltransferase (COMT) is associated with obsessive-compulsive disorder in men: case-control study and meta-analysis. Mol. Psychiatry 2007, 12:556-561.
75. Radua J., van den Heuvel O.A., Surguladze S., Mataix-Cols D. Meta-analytical comparison of voxel-based morphometry studies in obsessive-compulsive disorder vs other anxiety disorders. Arch. Gen. Psychiatry 2010, 67:701-711.
76. Richter M.A., de Jesus D.R., Hoppenbrouwers S., Daigle M., Deluce J., Ravindran L.N., Fitzgerald P.B., Daskalakis Z.J. Evidence for cortical inhibitory and excitatory dysfunction in obsessive compulsive disorder. Neuropsychopharmacology 2012, 37:1144-1151.
77. Roussos P., Giakoumaki S.G., Georgakopoulos A., Robakis N.K., Bitsios P. The CACNA1C and ANK3 risk alleles impact on affective personality traits and startle reactivity but not on cognition or gating in healthy males. Bipolar Disord. 2011, 13:250-259.
78. Rushworth M.F., Walton M.E., Kennerley S.W., Bannerman D.M. Action sets and decisions in the medial frontal cortex. Trends Cogn. Sci. 2004, 8:410-417.
79. Sachdev P.S., Malhi G.S. Obsessive-compulsive behaviour: a disorder of decision-making. Australian New Zealand J. Psychiatry 2005, 39:757-763.
80. Scherk H., Backens M., Schneider-Axmann T., Kraft S., Kemmer C., Usher J., Reith W., Falkai P., Meyer J., Gruber O. Dopamine transporter genotype influences N-acetyl-aspartate in the left putamen. World J. Biol. Psychiatry 2009, 10:524-530.
81. Seymour B., Daw N.D., Roiser J.P., Dayan P., Dolan R. Serotonin selectively modulates reward value in human decision-making. J. Neurosci. 2012, 32:5833-5842.
82. Sklar P., Smoller J.W., Fan J., Ferreira M.A., Perlis R.H., Chambert K., Nimgaonkar V.L., McQueen M.B., Faraone S.V., Kirby A., de Bakker P.I., Ogdie M.N., Thase M.E., Sachs G.S., Todd-Brown K., Gabriel S.B., Sougnez C., Gates C., Blumenstiel B., Defelice M., Ardlie K.G., Franklin J., Muir W.J., McGhee K.A., MacIntyre D.J., McLean A., VanBeck M., McQuillin A., Bass N.J., Robinson M., Lawrence J., Anjorin A., Curtis D., Scolnick E.M., Daly M.J., Blackwood D.H., Gurling H.M., Purcell S.M. Whole-genome association study of bipolar disorder. Mol. Psychiatry 2008, 13:558-569.
83. Stein J.L., Medland S.E., Vasquez A.A., Hibar D.P., Senstad R.E., Winkler A.M., Toro R., Appel K., Bartecek R., Bergmann O., Bernard M., Brown A.A., Cannon D.M., Chakravarty M.M., Christoforou A., Domin M., Grimm O., Hollinshead M., Holmes A.J., Homuth G., Hottenga J.J., Langan C., Lopez L.M., Hansell N.K., Hwang K.S., Kim S., Laje G., Lee P.H., Liu X., Loth E., Lourdusamy A., Mattingsdal M., Mohnke S., Maniega S.M., Nho K., Nugent A.C., O'Brien C., Papmeyer M., Putz B., Ramasamy A., Rasmussen J., Rijpkema M., Risacher S.L., Roddey J.C., Rose E.J., Ryten M., Shen L., Sprooten E., Strengman E., Teumer A., Trabzuni D., Turner J., van Eijk K., van Erp T.G., van Tol M.J., Wittfeld K., Wolf C., Woudstra S., Aleman A., Alhusaini S., Almasy L., Binder E.B., Brohawn D.G., Cantor R.M., Carless M.A., Corvin A., Czisch M., Curran J.E., Davies G., de Almeida M.A., Delanty N., Depondt C., Duggirala R., Dyer T.D., Erk S., Fagerness J., Fox P.T., Freimer N.B., Gill M., Goring H.H., Hagler D.J., Hoehn D., Holsboer F., Hoogman M., Hosten N., Jahanshad N., Johnson M.P., Kasperaviciute D., Kent J.W., Kochunov P., Lancaster J.L., Lawrie S.M., Liewald D.C., Mandl R., Matarin M., Mattheisen M., Meisenzahl E., Melle I., Moses E.K., Muhleisen T.W., Nauck M., Nothen M.M., Olvera R.L., Pandolfo M., Pike G.B., Puls R., Reinvang I., Renteria M.E., Rietschel M., Roffman J.L., Royle N.A., Rujescu D., Savitz J., Schnack H.G., Schnell K., Seiferth N., Smith C., Steen V.M., Valdes Hernandez M.C., Van den Heuvel M., van der Wee N.J., Van Haren N.E., Veltman J.A., Volzke H., Walker R., Westlye L.T., Whelan C.D., Agartz I., Boomsma D.I., Cavalleri G.L., Dale A.M., Djurovic S., Drevets W.C., Hagoort P., Hall J., Heinz A., Jack C.R., Foroud T.M., Le Hellard S., Macciardi F., Montgomery G.W., Poline J.B., Porteous D.J., Sisodiya S.M., Starr J.M., Sussmann J., Toga A.W., Veltman D.J., Walter H., Weiner M.W., Alzheimer's Disease Neuroimaging Initiative, Consortium E., Consortium I., Saguenay Youth Study G., Bis J.C., Ikram M.A., Smith A.V., Gudnason V., Tzourio C., Vernooij M.W., Launer L.J., DeCarli C., Seshadri S., Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium, Andreassen O.A., Apostolova L.G., Bastin M.E., Blangero J., Brunner H.G., Buckner R.L., Cichon S., Coppola G., de Zubicaray G.I., Deary I.J., Donohoe G., de Geus E.J., Espeseth T., Fernandez G., Glahn D.C., Grabe H.J., Hardy J., Hulshoff Pol H.E., Jenkinson M., Kahn R.S., McDonald C., McIntosh A.M., McMahon F.J., McMahon K.L., Meyer-Lindenberg A., Morris D.W., Muller-Myhsok B., Nichols T.E., Ophoff R.A., Paus T., Pausova Z., Penninx B.W., Potkin S.G., Samann P.G., Saykin A.J., Schumann G., Smoller J.W., Wardlaw J.M., Weale M.E., Martin N.G., Franke B., Wright M.J., Thompson P.M., Enhancing Neuro Imaging Genetics through Meta-Analysis Constorium Identification of common variants associated with human hippocampal and intracranial volumes. Nat. Genet. 2012, 44:552-561.
84. Stewart S.E., Mayerfeld C., Arnold P.D., Crane J.R., O'Dushlaine C., Fagerness J.A., Yu D., Scharf J.M., Chan E., Kassam F., Moya P.R., Wendland J.R., Delorme R., Richter M.A., Kennedy J.L., Veenstra-Vanderweele J., Samuels J., Greenberg B.D., McCracken J.T., Knowles J.A., Fyer A.J., Rauch S.L., Riddle M.A., Grados M.A., Bienvenu O.J., Cullen B., Wang Y., Shugart Y.Y., Piacentini J., Rasmussen S., Nestadt G., Murphy D.L., Jenike M.A., Cook E.H., Pauls D.L., Hanna G.L., Mathews C.A. Meta-analysis of association between obsessive-compulsive disorder and the 3' region of neuronal glutamate transporter gene SLC1A1. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 2013, 162:367-379.
85. Stewart S.E., Yu D., Scharf J.M., Neale B.M., Fagerness J.A., Mathews C.A., Arnold P.D., Evans P.D., Gamazon E.R., Davis L.K., Osiecki L., McGrath L., Haddad S., Crane J., Hezel D., Illman C., Mayerfeld C., Konkashbaev A., Liu C., Pluzhnikov A., Tikhomirov A., Edlund C.K., Rauch S.L., Moessner R., Falkai P., Maier W., Ruhrmann S., Grabe H.J., Lennertz L., Wagner M., Bellodi L., Cavallini M.C., Richter M.A., Cook E.H., Kennedy J.L., Rosenberg D., Stein D.J., Hemmings S.M., Lochner C., Azzam A., Chavira D.A., Fournier E., Garrido H., Sheppard B., Umana P., Murphy D.L., Wendland J.R., Veenstra-VanderWeele J., Denys D., Blom R., Deforce D., Van Nieuwerburgh F., Westenberg H.G., Walitza S., Egberts K., Renner T., Miguel E.C., Cappi C., Hounie A.G., Conceicao do Rosario M., Sampaio A.S., Vallada H., Nicolini H., Lanzagorta N., Camarena B., Delorme R., Leboyer M., Pato C.N., Pato M.T., Voyiaziakis E., Heutink P., Cath D.C., Posthuma D., Smit J.H., Samuels J., Bienvenu O.J., Cullen B., Fyer A.J., Grados M.A., Greenberg B.D., McCracken J.T., Riddle M.A., Wang Y., Coric V., Leckman J.F., Bloch M., Pittenger C., Eapen V., Black D.W., Ophoff R.A., Strengman E., Cusi D., Turiel M., Frau F., Macciardi F., Gibbs J.R., Cookson M.R., Singleton A., North American Brain Expression Consortium, Hardy J., Database U.K.B.E., Crenshaw A.T., Parkin M.A., Mirel D.B., Conti D.V., Purcell S., Nestadt G., Hanna G.L., Jenike M.A., Knowles J.A., Cox N., Pauls D.L. Genome-wide association study of obsessive-compulsive disorder. Mol. Psychiatry 2013, 18:788-798.
86. Stice E., Yokum S., Burger K., Epstein L., Smolen A. Multilocus genetic composite reflecting dopamine signaling capacity predicts reward circuitry responsivity. J. Neurosci. 2012, 32:10093-10100.
87. Taylor S. Molecular genetics of obsessive-compulsive disorder: a comprehensive meta-analysis of genetic association studies. Mol. Psychiatry 2013, 18:799-805.
88. Tesli M., Skatun K.C., Ousdal O.T., Brown A.A., Thoresen C., Agartz I., Melle I., Djurovic S., Jensen J., Andreassen O.A. CACNA1C risk variant and amygdala activity in bipolar disorder, schizophrenia and healthy controls. PLoS One 2013, 8:e56970.
89. Thompson P.M., Stein J.L., Medland S.E., Hibar D.P., Vasquez A.A., Renteria M.E., Toro R., Jahanshad N., Schumann G., Franke B., Wright M.J., Martin N.G., Agartz I., Alda M., Alhusaini S., Almasy L., Almeida J., Alpert K., Andreasen N.C., Andreassen O.A., Apostolova L.G., Appel K., Armstrong N.J., Aribisala B., Bastin M.E., Bauer M., Bearden C.E., Bergmann O., Binder E.B., Blangero J., Bockholt H.J., Boen E., Bois C., Boomsma D.I., Booth T., Bowman I.J., Bralten J., Brouwer R.M., Brunner H.G., Brohawn D.G., Buckner R.L., Buitelaar J., Bulayeva K., Bustillo J.R., Calhoun V.D., Cannon D.M., Cantor R.M., Carless M.A., Caseras X., Cavalleri G.L., Chakravarty M.M., Chang K.D., Ching C.R., Christoforou A., Cichon S., Clark V.P., Conrod P., Coppola G., Crespo-Facorro B., Curran J.E., Czisch M., Deary I.J., de Geus E.J., den Braber A., Delvecchio G., Depondt C., de Haan L., de Zubicaray G.I., Dima D., Dimitrova R., Djurovic S., Dong H., Donohoe G., Duggirala R., Dyer T.D., Ehrlich S., Ekman C.J., Elvsashagen T., Emsell L., Erk S., Espeseth T., Fagerness J., Fears S., Fedko I., Fernandez G., Fisher S.E., Foroud T., Fox P.T., Francks C., Frangou S., Frey E.M., Frodl T., Frouin V., Garavan H., Giddaluru S., Glahn D.C., Godlewska B., Goldstein R.Z., Gollub R.L., Grabe H.J., Grimm O., Gruber O., Guadalupe T., Gur R.E., Gur R.C., Goring H.H., Hagenaars S., Hajek T., Hall G.B., Hall J., Hardy J., Hartman C.A., Hass J., Hatton S.N., Haukvik U.K., Hegenscheid K., Heinz A., Hickie I.B., Ho B.C., Hoehn D., Hoekstra P.J., Hollinshead M., Holmes A.J., Homuth G., Hoogman M., Hong L.E., Hosten N., Hottenga J.J., Hulshoff Pol H.E., Hwang K.S., Jack C.R., Jenkinson M., Johnston C., Jonsson E.G., Kahn R.S., Kasperaviciute D., Kelly S., Kim S., Kochunov P., Koenders L., Kramer B., Kwok J.B., Lagopoulos J., Laje G., Landen M., Landman B.A., Lauriello J., Lawrie S.M., Lee P.H., Le Hellard S., Lemaitre H., Leonardo C.D., Li C.S., Liberg B., Liewald D.C., Liu X., Lopez L.M., Loth E., Lourdusamy A., Luciano M., Macciardi F., Machielsen M.W., Macqueen G.M., Malt U.F., Mandl R., Manoach D.S., Martinot J.L., Matarin M., Mather K.A., Mattheisen M., Mattingsdal M., Meyer-Lindenberg A., McDonald C., McIntosh A.M., McMahon F.J., McMahon K.L., Meisenzahl E., Melle I., Milaneschi Y., Mohnke S., Montgomery G.W., Morris D.W., Moses E.K., Mueller B.A., Munoz Maniega S., Muhleisen T.W., Muller-Myhsok B., Mwangi B., Nauck M., Nho K., Nichols T.E., Nilsson L.G., Nugent A.C., Nyberg L., Olvera R.L., Oosterlaan J., Ophoff R.A., Pandolfo M., Papalampropoulou-Tsiridou M., Papmeyer M., Paus T., Pausova Z., Pearlson G.D., Penninx B.W., Peterson C.P., Pfennig A., Phillips M., Pike G.B., Poline J.B., Potkin S.G., Putz B., Ramasamy A., Rasmussen J., Rietschel M., Rijpkema M., Risacher S.L., Roffman J.L., Roiz-Santianez R., Romanczuk-Seiferth N., Rose E.J., Royle N.A., Rujescu D., Ryten M., Sachdev P.S., Salami A., Satterthwaite T.D., Savitz J., Saykin A.J., Scanlon C., Schmaal L., Schnack H.G., Schork A.J., Schulz S.C., Schur R., Seidman L., Shen L., Shoemaker J.M., Simmons A., Sisodiya S.M., Smith C., Smoller J.W., Soares J.C., Sponheim S.R., Sprooten E., Starr J.M., Steen V.M., Strakowski S., Strike L., Sussmann J., Samann P.G., Teumer A., Toga A.W., Tordesillas-Gutierrez D., Trabzuni D., Trost S., Turner J., Van den Heuvel M., van der Wee N.J., van Eijk K., van Erp T.G., van Haren N.E., van't Ent D., van Tol M.J., Valdes Hernandez M.C., Veltman D.J., Versace A., Volzke H., Walker R., Walter H., Wang L., Wardlaw J.M., Weale M.E., Weiner M.W., Wen W., Westlye L.T., Whalley H.C., Whelan C.D., White T., Winkler A.M., Wittfeld K., Woldehawariat G., Wolf C., Zilles D., Zwiers M.P., Thalamuthu A., Schofield P.R., Freimer N.B., Lawrence N.S., Drevets W., Alzheimer's Disease Neuroimaging Initiative E.C.I.C.S.Y.S.G. The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. Brain Imaging Behav. 2014, 8:153-182.
90. van den Heuvel O.A., van der Werf Y.D., Verhoef K.M., de Wit S., Berendse H.W., Wolters E., Veltman D.J., Groenewegen H.J. Frontal-striatal abnormalities underlying behaviours in the compulsive-impulsive spectrum. J. Neurol. Sci. 2010, 289:55-59.
91. van Grootheest D.S., Cath D.C., Beekman A.T., Boomsma D.I. Twin studies on obsessive-compulsive disorder: a review. Twin Res. Hum. Genet. 2005, 8:450-458.
92. Walitza S., Brem S., Hauser T.U., Grünblatt E. Wie biologisch sind Zwangsstörungen? Genetische Befunde und Bildgebung bei Zwangsstörungen. Kindheit und Etwicklung 2014, (In Press).
93. Walitza S., Marinova Z., Grünblatt E., Lazic S.E., Remschmidt H., Vloet T.D., Wendtland J.R. Trio study an meta-analysis suport the associaton ofgnetc varition athe serin-transporter wth earlon obsessive-ompulsie isorder. Neurosc. Lett. 2014, (In Press).
94. Walitza S., Melfsen S., Jans T., Zellmann H., Wewetzer C., Warnke A. Obsessive-compulsive disorders in children and adolescents. Dtsch. Arztebl. Int. 2011, 108:173-179.
95. Walitza S., Wendland J.R., Gruenblatt E., Warnke A., Sontag T.A., Tucha O., Lange K.W. Genetics of early-onset obsessive-compulsive disorder. Eur. Child Adolesc. Psychiatry 2010, 19:227-235.
96. Wan Y., Ade K.K., Caffall Z., Ilcim Ozlu M., Eroglu C., Feng G., Calakos N. Circuit-selective striatal synaptic dysfunction in the Sapap3 knockout mouse model of obsessive-compulsive disorder. Biol. Psychiatry 2013.
97. Wan Y., Feng G., Calakos N. Sapap3 deletion causes mGluR5-dependent silencing of AMPAR synapses. J. Neurosci. 2011, 31:16685-16691.
98. Welch J.M., Wang D., Feng G. Differential mRNA expression and protein localization of the SAP90/PSD-95-associated proteins (SAPAPs) in the nervous system of the mouse. J. Comp. Neurol. 2004, 472:24-39.
99. Wendland J.R., Moya P.R., Timpano K.R., Anavitarte A.P., Kruse M.R., Wheaton M.G., Ren-Patterson R.F., Murphy D.L. A haplotype containing quantitative trait loci for SLC1A1 gene expression and its association with obsessive-compulsive disorder. Arch. Gen. Psychiatry 2009, 66:408-416.
100. Wessa M., Linke J., Witt S.H., Nieratschker V., Esslinger C., Kirsch P., Grimm O., Hennerici M.G., Gass A., King A.V., Rietschel M. The CACNA1C risk variant for bipolar disorder influences limbic activity. Mol. Psychiatry 2010, 15:1126-1127.
101. Whalley H.C., Sprooten E., Hackett S., Hall L., Blackwood D.H., Glahn D.C., Bastin M., Hall J., Lawrie S.M., Sussmann J.E., McIntosh A.M. Polygenic risk and white matter integrity in individuals at high risk of mood disorder. Biol Psychiatry 2013.
102. Willeit M., Praschak-Rieder N. Imaging the effects of genetic polymorphisms on radioligand binding in the living human brain: A review on genetic neuroreceptor imaging of monoaminergic systems in psychiatry. Neuroimage 2010, 53:878-892.
103. Wolf C., Mohr H., Schneider-Axmann T., Reif A., Wobrock T., Scherk H., Kraft S., Schmitt A., Falkai P., Gruber O. CACNA1C genotype explains interindividual differences in amygdala volume among patients with schizophrenia. Eur. Arch. Psychiatry Clin. Neurosci. 2013.
104. Wu K., Hanna G.L., Easter P., Kennedy J.L., Rosenberg D.R., Arnold P.D. Glutamate system genes and brain volume alterations in pediatric obsessive-compulsive disorder: a preliminary study. Psychiatry Res. 2012.
105. Zai G., Bezchlibnyk Y.B., Richter M.A., Arnold P., Burroughs E., Barr C.L., Kennedy J.L. Myelin oligodendrocyte glycoprotein (MOG) gene is associated with obsessive-compulsive disorder. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 2004, 129B:64-68.
106. Züchner S., Wendland J.R., Ashley-Koch A.E., Collins A.L., Tran-Viet K.N., Quinn K., Timpano K.C., Cuccaro M.L., Pericak-Vance M.A., Steffens D.C., Krishnan K.R., Feng G., Murphy D.L. Multiple rare SAPAP3 missense variants in trichotillomania and OCD. Mol. Psychiatry 2009, 14:6-9.