Imaging-genetics applications in child psychiatry

Journal of the American Academy of Child and Adolescent Psychiatry

Volumn 49, Issue 8, 2010, Pages 772-782

  Pine, Daniel S ^a   Ernst, Monique ^a   Leibenluft, Ellen ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

anxiety; children and adolescents; genetics; imaging

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING); DOPAMINE 1 RECEPTOR; DOPAMINE TRANSPORTER; SEROTONIN TRANSPORTER;

AMYGDALOID NUCLEUS; ANXIETY DISORDER; ATTENTION DEFICIT DISORDER; AUTISM; BIPOLAR DISORDER; BRAIN BLOOD FLOW; BRAIN DEVELOPMENT; BRAIN FUNCTION; CHILD BEHAVIOR; CHILD PSYCHIATRY; DNA SEQUENCE; ENVIRONMENTAL FACTOR; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENETICS; GENOTYPE; HUMAN; MOOD; NEUROIMAGING; NEUROSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHENOTYPE; PREFRONTAL CORTEX; PRIORITY JOURNAL; REVIEW;

ADOLESCENT; ANIMALS; BRAIN; CHILD; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MENTAL DISORDERS; MONOAMINE OXIDASE; PHENOTYPE; POLYMORPHISM, GENETIC; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 77955682195     PISSN: 08908567     EISSN: 15275418     Source Type: Journal    
DOI: 10.1016/j.jaac.2009.12.022     Document Type: Review

References (56)

1. A. Meyer-Lindenberg, and D.R. Weinberger Intermediate phenotypes and genetic mechanisms of psychiatric disorders Nat Rev Neurosci 7 10 2006 818 827
2. S.E. Hyman Can neuroscience be integrated into the DSM-V? Nat Rev Neurosci 8 9 2007 725 732
3. J. Couzin-Frankel Genetics The promise of a cure: 20 years and counting Science 324 5934 2009 1504 1507
4. S.H. Woolf The meaning of translational research and why it matters JAMA 299 2 2008 211 213
5. D.S. Pine, S.M. Helfinstein, Y. Bar-Haim, E. Nelson, and N.A. Fox Challenges in developing novel treatments for childhood disorders: lessons from research on anxiety Neuropsychopharmacology 34 1 2009 213 228
6. A.L. Reiss Childhood developmental disorders: an academic and clinical convergence point for psychiatry, neurology, psychology and pediatrics J Child Psychol Psychiatry 50 1-2 2009 87 98
7. D. Gothelf, J.A. Furfaro, L.C. Penniman, G.H. Glover, and A.L. Reiss The contribution of novel brain imaging techniques to understanding the neurobiology of mental retardation and developmental disabilities Ment Retard Dev Disabil Res Rev 11 4 2005 331 339
8. A. Meyer-Lindenberg, A.R. Hariri, and K.E. Munoz Neural correlates of genetically abnormal social cognition in Williams syndrome Nat Neurosci 8 8 2005 991 993
9. C. Gross, and R. Hen The developmental origins of anxiety Nat Rev Neurosci 5 7 2004 545 552
10. A.E. Green, M.R. Munafo, C.G. Deyoung, J.A. Fossella, J. Fan, and J.R. Gray Using genetic data in cognitive neuroscience: from growing pains to genuine insights Nat Rev Neurosci 9 2008 710 720
11. P.D. Arnold, F.P. Macmaster, and M.A. Richter Glutamate receptor gene (GRIN2B) associated with reduced anterior cingulate glutamatergic concentration in pediatric obsessive-compulsive disorder Psychiatry Res 172 2 2009 136 139
12. P.D. Arnold, F.P. MacMaster, and G.L. Hanna Glutamate system genes associated with ventral prefrontal and thalamic volume in pediatric obsessive-compulsive disorder Brain Imaging Behav 3 2009 64 76
13. P. Grant, L. Lougee, M. Hirschtritt, and S.E. Swedo An open-label trial of riluzole, a glutamate antagonist, in children with treatment-resistant obsessive-compulsive disorder J Child Adolesc Psychopharmacol 17 6 2007 761 767
14. Lau JY, Goldman D, Buzas B et al. BDNF gene polymorphisms (Val66Met) predicts amygdala and anterior hippocampus responses to emotional faces in anxious and depressed adolescents. Neuroimage. In press.
15. M.R. Munafo, N.B. Freimer, and W. Ng 5-HTTLPR genotype and anxiety-related personality traits: a meta-analysis and new data Am J Med Genet B Neuropsychiatr Genet 150B 2 2009 271 281
16. L. Pezawas, A. Meyer-Lindenberg, and E.M. Drabant 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression Nat Neurosci 8 6 2005 828 834
17. M.R. Munafo, S.M. Brown, and A.R. Hariri Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis Biol Psychiatry 63 9 2008 852 857
18. N. Risch, R. Herrell, and T. Lehner Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis JAMA 301 23 2009 2462 2471
19. J. Flint, and T.F. Mackay Genetic architecture of quantitative traits in mice, flies, and humans Genome Res 19 5 2009 723 733
20. J. Flint, and M.R. Munafo The endophenotype concept in psychiatric genetics Psychol Med 37 2 2007 163 180
21. J. Flint, and S. Shifman Animal models of psychiatric disease Curr Opin Genet Dev 18 3 2008 235 240
22. A. Abbott Psychiatric genetics: the brains of the family Nature 454 7201 2008 154 157
23. M.R. Munafo, G. Stothart, and J. Flint Bias in genetic association studies and impact factor Mol Psychiatry 14 2 2009 119 120
24. T. Canli Toward a neurogenetic theory of neuroticism Ann N Y Acad Sci 1129 2008 153 174
25. T. Canli, K. Omura, B.W. Haas, A. Fallgatter, R.T. Constable, and K.P. Lesch Beyond affect: a role for genetic variation of the serotonin transporter in neural activation during a cognitive attention task Proc Natl Acad Sci U S A 102 34 2005 12224 12229
26. A.E. Guyer, C.S. Monk, and E.B. McClure-Tone A developmental examination of amygdala response to facial expressions J Cogn Neurosci 20 9 2008 1565 1582
27. R.V. Parsey, R.S. Hastings, and M.A. Oquendo Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain Am J Psychiatry 163 1 2006 48 51
28. D.G. Mitchell, M. Nakic, D. Fridberg, N. Kamel, D.S. Pine, and R.J. Blair The impact of processing load on emotion Neuroimage 34 3 2007 1299 1309
29. K. Beesdo, J.Y. Lau, and A.E. Guyer Common and distinct amygdala-function perturbations in depressed vs anxious adolescents Arch Gen Psychiatry 66 3 2009 275 285
30. J.Y. Lau, D. Goldman, and B. Buzas Amygdala function and 5-HTT gene variants in adolescent anxiety and major depressive disorder Biol Psychiatry 65 4 2009 349 355
31. D.S. Pine, R.G. Klein, and R. Roberson-Nay Face emotion processing and risk for panic disorder in youth J Am Acad Child Adolesc Psychiatry 44 2005 664 672
32. K. Beesdo, J. Lau, and E.B. McClure-Tone Common and specific amygdala-function perturbations in depressed versus anxious adolescents Arch Gen Psychiatry 66 2009 275 285
33. J.J. Kim, J.C. Shih, and K. Chen Selective enhancement of emotional, but not motor, learning in monoamine oxidase A-deficient mice Proc Natl Acad Sci U S A 94 11 1997 5929 5933
34. H.G. Brunner, M. Nelen, X.O. Breakefield, H.H. Ropers, and B.A. van Oost Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A Science 262 5133 1993 578 580
35. J.W. Buckholtz, and A. Meyer-Lindenberg MAOA and the neurogenetic architecture of human aggression Trends Neurosci 31 3 2008 120 129
36. A. Caspi, and T.E. Moffitt Gene-environment interactions in psychiatry: joining forces with neuroscience Nat Rev Neurosci 7 7 2006 583 590
37. A. Taylor, and J. Kim-Cohen Meta-analysis of gene-environment interactions in developmental psychopathology Dev Psychopathol 19 4 2007 1029 1037
38. L.S. Wakschlag, E.O. Kistner, and D.S. Pine Interaction of prenatal exposure to cigarettes and MAOA genotype in pathways to youth antisocial behavior Mol Psychiatry 2009
39. J.W. Buckholtz, J.H. Callicott, and B. Kolachana Genetic variation in MAOA modulates ventromedial prefrontal circuitry mediating individual differences in human personality Mol Psychiatry 13 3 2008 313 324
40. A. Reif, C.P. Jacob, and D. Rujescu Influence of functional variant of neuronal nitric oxide synthase on impulsive behaviors in humans Arch Gen Psychiatry 66 1 2009 41 50
41. T.G. Schulze, D. Hedeker, P. Zandi, M. Rietschel, and F.J. McMahon What is familial about familial bipolar disorder? Resemblance among relatives across a broad spectrum of phenotypic characteristics Arch Gen Psychiatry 63 12 2006 1368 1376
42. Y. Bradford, J. Haines, and H. Hutcheson Incorporating language phenotypes strengthens evidence of linkage to autism Am J Med Genet 105 6 2001 539 547
43. J.D. Buxbaum, J.M. Silverman, and C.J. Smith Evidence for a susceptibility gene for autism on chromosome 2 and for genetic heterogeneity Am J Hum Genet 68 6 2001 1514 1520
44. I.I. Gottesman, and T.D. Gould The endophenotype concept in psychiatry: etymology and strategic intentions Am J Psychiatry 160 4 2003 636 645
45. L.M. Goos, J. Crosbie, S. Payne, and R. Schachar Validation and extension of the endophenotype model in ADHD patterns of inheritance in a family study of inhibitory control Am J Psychiatry 166 6 2009 711 717
46. B.I. Turetsky, M.E. Calkins, G.A. Light, A. Olincy, A.D. Radant, and N.R. Swerdlow Neurophysiological endophenotypes of schizophrenia: the viability of selected candidate measures Schizophr Bull 33 1 2007 69 94
47. M.A. Brotman, M.H. Rooney, M. Skup, D.S. Pine, and E. Leibenluft Increased intrasubject variability in response time in youths with bipolar disorder and at-risk family members J Am Acad Child Adolesc Psychiatry 48 6 2009 628 635
48. M.A. Brotman, A.E. Guyer, and E.S. Lawson Facial emotion labeling deficits in children and adolescents at risk for bipolar disorder Am J Psychiatry 165 3 2008 385 389
49. S. Durston, P. de Zeeuw, and W.G. Staal Imaging genetics in ADHD: a focus on cognitive control Neurosci Biobehav Rev 33 5 2009 674 689
50. P. Shaw, J. Lerch, and D. Greenstein Longitudinal mapping of cortical thickness and clinical outcome in children and adolescents with attention-deficit/hyperactivity disorder Arch Gen Psychiatry 63 5 2006 540 549
51. S. Durston, M. Mulder, B.J. Casey, T. Ziermans, and H. van Engeland Activation in ventral prefrontal cortex is sensitive to genetic vulnerability for attention-deficit hyperactivity disorder Biol Psychiatry 60 10 2006 1062 1070
52. S. Durston, J.A. Fossella, and M.J. Mulder Dopamine transporter genotype conveys familial risk of attention-deficit/hyperactivity disorder through striatal activation J Am Acad Child Adolesc Psychiatry 47 1 2008 61 67
53. T.H. Wassink, H.C. Hazlett, and E.A. Epping Cerebral cortical gray matter overgrowth and functional variation of the serotonin transporter gene in autism Arch Gen Psychiatry 64 6 2007 709 717
54. Liu X, Akula N, Skup M, Brotman MA, Leibenluft E, McMahon FJ. A genome-wide association study of amygdala activation in youths with and without bipolar disorder. J Am Acad Child Adolesc Psychiatry. In press.
55. S.G. Potkin, J.A. Turner, and J.A. Fallon Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia Mol Psychiatry 14 4 2009 416 428
56. R. Plomin, and O.S. Davis The future of genetics in psychology and psychiatry: microarrays, genome-wide association, and non-coding RNA J Child Psychol Psychiatry 50 1-2 2009 63 71