Understanding obsessive-compulsive disorder: Focus on decision making

Neuropsychology Review

Volumn 16, Issue 1, 2006, Pages 3-15

  Cavedini, Paolo ^a   Gorini, Alessandra ^a,b   Bellodi, Laura ^a  

^a VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Decision making; Executive functions; Gambling task; Obsessive compulsive disorder; Reward

Indexed keywords

BEHAVIOR DISORDER; COGNITIVE DEFECT; DECISION MAKING; FRONTAL LOBE; HUMAN; MENTAL TASK; NEUROBIOLOGY; NEUROPATHOLOGY; OBSESSIVE COMPULSIVE DISORDER; ORBITAL CORTEX; PATHOPHYSIOLOGY; REVIEW; REWARD; TASK PERFORMANCE; THALAMUS;

BRAIN; DECISION MAKING; HUMANS; NEUROBIOLOGY; NEUROPSYCHOLOGY; OBSESSIVE-COMPULSIVE DISORDER; PROBLEM SOLVING;

EID: 33745467145     PISSN: 10407308     EISSN: 15736660     Source Type: Journal    
DOI: 10.1007/s11065-006-9001-y     Document Type: Review

References (100)

1. Abbruzzese, M., Bellodi, L., Ferri, S., and Scarone, S. (1995a). Frontal lobe dysfunction in schizophrenia and obsessive-compulsive disorder: A neuropsychological study. Brain Cogn. 27(2): 202-212.
2. Abbruzzese, M., Ferri, S., and Scarone, S. (1995b). Wisconsin Card Sorting Test performance in obsessive-compulsive disorder: no evidence for involvement of dorsolateral prefrontal cortex. Psychiatry Res. 58(1): 37-43.
3. Adinoff, B., Devous, M. D., Sr., Cooper, D. B., Best, S. E., Chandler, P., Harris, T., Cervin, C. A., and Cullum, C. M. (2003). Resting regional cerebral blood flow and gambling task performance in cocaine-dependent subjects and healthy comparison subjects. Am. J. Psychiatry 160(10): 1892-1894.
4. Alexander, G. E., DeLong, M. R., and Strick, P. L. (1986). Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu. Rev. Neurosci. 9: 357-381.
5. American Psychiatric Association (2000). DSM-IV-TR. Diagnostic and Statistical Manual of Mental Disorders. (4th ed.) Text Revision APA, Washington, DC.
6. Andreasen, N. C. (1997). Linking mind and brain in the study of mental illnesses: a project for a scientific psychopathology. Science 275(5306): 1586-1593.
7. Arnsten, A. F. (1997). Catecholamine regulation of the prefrontal cortex. J. Psychopharmacol. 11(2): 151-162.
8. Bannon, S., Gonsalvez, C. J., Croft, R. J., and Boyce, P. M. (2002). Response inhibition deficits in obsessive-compulsive disorder. Psychiatry Res. 110(2): 165-174.
9. Baxter, L. R., Jr., Phelps, M. E., Mazziotta, J. C., Guze, B. H., Schwartz, J. M., and Selin, C. E. (1987). Local cerebral glucose metabolic rates in obsessive-compulsive disorder. A comparison with rates in unipolar depression and in normal controls. Arch. Gen. Psychiatry 44(3): 211-218.
10. Baxter, L. R., Jr., Schwartz, J. M., Bergman, K. S., Szuba, M. P., Guze, B. H., Mazziotta, J. C., et al. (1992). Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessive-compulsive disorder. Arch. Gen. Psychiatry 49(9): 681-689.
11. Bechara, A. (2003). Risky business: Emotion, decision-making, and addiction. J. Gambl. Stud. 19(1): 23-51.
12. Bechara, A., Damasio, H., and Damasio, A. R. (2001b). Manipulation of dopamine and serotonin caused differents on covert and overt decision-making. Society for Neuroscience Abstract, 27.
13. Bechara, A., Damasio, A. R., Damasio, H., and Anderson, S. W. (1994). Insensitivity to future consequences following damage to human prefrontal cortex. Cognition 50(1-3): 7-15.
14. Bechara, A., Damasio, H., Damasio, A. R., and Lee, G. P. (1999). Different contributions of the human amygdala and ventromedial prefrontal cortex to decision-making. J. Neurosci. 19(13): 5473-5481.
15. Bechara, A., Damasio, H., Tranel, D., and Anderson, S. W. (1998). Dissociation of working memory from decision making within the human prefrontal cortex. J. Neurosci. 18(1): 428-437.
16. Bechara, A., Dolan, S., Denburg, N., Hindes, A., Anderson, S. W., and Nathan, P. E. (2001a). Decision-making deficits, linked to a dysfunctional ventromedial prefrontal cortex, revealed in alcohol and stimulant abusers. Neuropsychologia 39(4): 376-389.
17. Bechara, A., and Martin, E. M. (2004). Impaired decision making related to working memory deficits in individuals with substance addictions. Neuropsychology 18(1): 152-162.
18. Bechara, A., Tranel, D., and Damasio, H. (2000). Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions. Brain 123(Pt 11): 2189-2202.
19. Bechara, A., Tranel, D., Damasio, H., and Damasio, A. R. (1996). Failure to respond autonomically to anticipated future outcomes following damage to prefrontal cortex. Cereb. Cortex. 6(2): 215-225.
20. Benkelfat, C., Nordahl, T. E., Semple, W. E., King, A. C., Murphy, D. L., and Cohen, R. M. (1990). Local cerebral glucose metabolic rates in obsessive-compulsive disorder. Patients treated with clomipramine. Arch. Gen. Psychiatry 47(9): 840-848.
21. Best, M., Williams, J. M., and Coccaro, E. F. (2002). Evidence for a dysfunctional prefrontal circuit in patients with an impulsive aggressive disorder. Proc. Natl. Acad. Sci. USA 99(12): 8448-8453.
22. Bolla, K. I., Eldreth, D. A., London, E. D., Kiehl, K. A., Mouratidis, M., Contoreggi, C., et al. (2003). Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task. Neuroimage 19(3): 1085-1094.
23. Bowen, F. P., Kamienny, R. S., Burns, M. M., and Yahr, M. (1975). Parkinsonism: Effects of levodopa treatment on concept formation. Neurology 25(8): 701-704.
24. Brozoski, T. J., Brown, R. M., Rosvold, H. E., and Goldman, P. S. (1979). Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey. Science 205(4409): 929-932.
25. Cavallaro, R., Cavedini, P., Mistretta, P., Bassi, T., Angelone, S. M., Ubbiali, A., et al. (2003). Basal-corticofrontal circuits in schizophrenia and obsessive-compulsive disorder: A controlled, double dissociation study. Biol. Psychiatry 54(4): 437-443.
26. Cavedini, P., Bassi, T., Ubbiali, A., Casolari, A., Giordani, S., and Zorzi, C., et al. (in press). Neuropsychological investigation of decision-making in anorexia nervosa. Psychiatry Res 127(3): 259-266.
27. Cavedini, P., Bassi, T., Zorzi, C., and Bellodi, L. (2004). The advantages of choosing antiobsessive therapy according to decision-making functioning. J. Clin. Psychopharmacol. 24(6): 628-631.
28. Cavedini, P., Cisima, M., Riboldi, G., D'Annucci, A., and Bellodi, L. (2001). A neuropsychological study of dissociation in cortical and subcortical functioning in obsessive-compulsive disorder by Tower of Hanoi task. Brain Cogn. 46(3): 357-363.
29. Cavedini, P., D'Annucci, A., Riboldi, G., Cisima, M., and Bellodi, L. (2000). Neuropsychology of obsessive-compulsive disorder: relationship to response. Paper presented at the 1st ECNP Workshop, Nizza (France).
30. Cavedini, P., Ferri, S., Scarone, S., and Bellodi, L. (1998). Frontal lobe dysfunction in obsessive-compulsive disorder and major depression: A clinical-neuropsychological study. Psychiatry Res. 78(1-2): 21-28.
31. Cavedini, P., Riboldi, G., D'Annucci, A., Belotti, P., Cisima, M., and Bellodi, L. (2002a). Decision-making heterogeneity in obsessive-compulsive disorder: Ventromedial prefrontal cortex function predicts different treatment outcomes. Neuropsychologia 40(2): 205-211.
32. Cavedini, P., Riboldi, G., Keller, R., D'Annucci, A., and Bellodi, L. (2002b). Frontal lobe dysfunction in pathological gambling patients. Biol. Psychiatry 51(4): 334-341.
33. Cavedini, P., Zorzi, C., Giordani, S., D'Annucci, A., Bassi, T., and Di Bella, D. (2002c). The role of HT-5 carrier genotype in decision-making impairment of OCD patients. Am. J. Med. Genet. 114(7): 224.
34. Cavedini, P., Zorzi, C., Ubbiali, A., Gorini, A., D'Annucci, A., Bassi, T., et al. (2003). The neurophysiology of decision-making in obsessive-compulsive disorder. Brain Cogn. 51(2): 236-237.
35. Chamberlin, S. R., Blackwell, A. D., Fineberg, N. A., Robbins, T. W., and Sahakian, B. J. (2005). The neuropsychology of obsessive compulsive disorder: the inhibition as candidate endophenotypic markers importance of failures in cognitive and behavioural. Neurosci. Behav. Reviews 29(3): 399-419.
36. Clark, L., Lversen, S. D., and Goodwin, G. M. (2001). A neuropsychological investigation of prefrontal cortex involvement in acute mania. Am. J. Psychiatry. 158(10): 1605-1611.
37. Clark, L., Manes, F., Antoun, N., Sahakian, B. J., and Robbins, T. W. (2003). The contributions of lesion laterality and lesion volume to decision-making impairment following frontal lobe damage. Neuropsychologia 41(11): 1474-1483.
38. Damasio, A. R. (1994). Descartes' Error : Emotion, Reason, and the Human Brain, New York: G.P. Putnam' s Sons.
39. Damasio, A. R. (1996). The somatic marker hypothesis and the possible functions of the prefrontal cortex. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 351(1346): 1413-1420.
40. Damasio, A. R., Tranel, D., and Damasio, H. (1991). Somatic markers and the guidance of behavior: Theory and preliminary testing. In Levin, H. S., Eisemberg, H. M., and Benton A. L. (eds.), Frontal Lobe Function and Dysfunction. Oxford University Press, New York.
41. Denys, D., van der Wee, N., Janssen, J., De Geus, F, and Westenberg, H. G. (2004). Low level of dopaminergic D2 receptor binding in obsessive-compulsive disorder. Biol. Psychiatry 55(10): 1041-1045.
42. Di Bella, D., Erzegovesi, S., Cavallini, M. C., and Bellodi, L. (2002). Obsessive-compulsive disorder, 5-HTTLPR polymorphism and treatment response. Pharmacogenomics J. 2(3): 176-181.
43. Di Russo, F., Zaccara, G., Ragazzoni, A., and Pallanti, S. (2000). Abnormal visual event-related potentials in obsessive-compulsive disorder without panic disorder or depression comorbidity. J. Psychiatr Res. 34(1): 75-82.
44. Downes, J. J., Roberts, A. C., Sahakian, B. J., Evenden, J. L., Morris, R. G., and Robbins, T. W. (1989). Impaired extra-dimensional shift performance in medicated and unmedicated Parkinson's disease: evidence for a specific attentional dysfunction. Neuropsychologia 27(11-12): 1329-1343.
45. El-Sayegh, S., Bea, S., and Agelopoulos, A. (2003). Obsessive-compulsive disorder: unearthing a hidden problem. Cleve. Clin. J. Med. 70(10): 824-825, 829-830, 832-823, passim.
46. Ersehe, K. D., Fletcher, P. C., Lewis, S. J., Clark L., Stocks-Gee G., London M., Deakin J. B., Robbins T. W., and Sahakian B. J. (2005). Abnormal frontal activations related to decision-making in current and former amphetamine and opiate dependent individuals. Psychofarmacology 180(4): 612-623.
47. Eslinger, P. J., and Damasio, A. R. (1985). Severe disturbance of higher cognition after bilateral frontal lobe ablation: Patient EVR. Neurology 35(12): 1731-1741.
48. Fernandez, A., Pino Alonso, M., Mataix-Cols, D., Roca, M., Vallejo, J., Puchal, R., et al. (2003). Neuroactivation of the Tower of Hanoi in patients with obsessive-compulsive disorder and healthy volunteers. Rev. Esp. Med. Nucl. 22(6): 376-385.
49. Grant, S., Contoreggi, C., and London, E. D. (2000). Drug abusers show impaired performance in a laboratory test of decision making. Neuropsychologia 38(8): 1180-1187.
50. Greisberg, S., and McKay, D. (2003). Neuropsychology of obsessive-compulsive disorder: A review and treatment implications. Clin. Psychol. Rev.. 23(1): 95-117.
51. Gross-Isseroff, R., Sasson, Y., Voet, H., Hendler, T., Luca-Haimovici, K., Kandel-Sussman, H., et al. (1996). Alternation learning in obsessive-compulsive disorder. Biol. Psychiatry 39(8): 733-738.
52. Hollander, E. (1998). Treatment of obsessive-compulsive spectrum disorders with SSRIs. Br. J. Psychiatry Suppl. (35): 7-12.
53. Hollander, E., Prohovnik, I., and Stein, D. J. (1995). Increased cerebral blood flow during m-CPP exacerbation of obsessive-compulsive disorder. J. Neuropsychiatry Clin. Neurosci. 7(4): 485-190.
54. Hommer, D., Andreasen, P., Rio, D., Williams, W., Ruttimann, U., Momenan, R., et al. (1997). Effects of m-chlorophenylpiperazine on regional brain glucose utilization: A positron emission tomographic comparison of alcoholic and control subjects. J. Neurosci. 17(8): 2796-2806.
55. Jenike, M. A., Breiter, H. C., Baer, L., Kennedy, D. N., Savage, C. R., Olivares, M. J., et al. (1996). Cerebral structural abnormalities in obsessivecompulsive disorder. A quantitative morphometric magnetic resonance imaging study. Arch. Gen. Psychiatry 53(7): 625- 632.
56. Kim, J. J., Lee, M. C., Kim, J., Kim, I. Y., Kim, S. I., Han, M., et al. (2001). Grey matter abnormalities in obsessive-compulsive disorder: Statistical parametric mapping of segmented magnetic resonance images. Br. J. Psychiatry 179: 330-334.
57. Kuelz, A. K., Hohagen, F., and Voderholzer, U. (2004). Neuropsychological performance in obsessive-compulsive disorder: A critical review. Biol. Psychol. 65(3): 185-236.
58. Kwon, J. S., Kim, J. J., Lee, D. W., Lee, J. S., Lee, D. S., Kim, M. S., et al. (2003). Neural correlates of clinical symptoms and cognitive dysfunctions in obsessive-compulsive disorder. Psychiatry Res. 122(1): 37-47.
59. Lacerda, A. L., Dalgalarrondo, P., Caetano, D., Haas, G. L., Camargo, E. E., and Keshavan, M. S. (2003). Neuropsychological performance and regional cerebral blood flow in obsessive-compulsive disorder. Prog. Neuropsychopharmacol Biol. Psychiatry 27(4): 657-665.
60. Lange, K. W., Robbins, T. W., Marsden, C. D., James, M., Owen, A. M., and Paul, G. M. (1992). L-dopa withdrawal in Parkinson's disease selectively impairs cognitive performance in tests sensitive to frontal lobe dysfunction. Psychopharmacology (Berl) 107(2-3): 394-404.
61. Lena, S., Fiocco, A., and Leynaar, J. (2004). The role of cognitive deficits in the development of eating disorders. Neuropsychol Rev. 14(2): 99-113.
62. Leocani, L., Locatelli, M., Bellodi, L., Fornara, C., Henin, M., Magnani, G., et al. (2001). Abnormal pattern of cortical activation associated with voluntary movement in obsessive-compulsive disorder: An EEG study. Am. J. Psychiatry 158(1): 140-142.
63. Machlin, S. R., Harris, G. J., Pearlson, G. D., Hoehn-Saric, R., Jeffery, P., and Camargo, E. E. (1991). Elevated medial-frontal cerebral blood flow in obsessive-compulsive patients: a SPECT study. Am. J. Psychiatry 148(9): 1240-1242.
64. Mataix-Cols, D., Junque, C., Sanchez-Turet, M., Vallejo, J., Verger, K., and Barrios, M. (1999). Neuropsychological functioning in a subclinical obsessive-compulsive sample. Biol. Psychiatry 45(7): 898-904.
65. Mataix-Cols, D., Rosario-Campos, M. C., and Leckman, J. F. (2005). A multidimensional model of obsessive-compulsive disorder. Am. J. Psychiatry 162(2): 228-238.
66. Mataix-Cols, D., Wooderson, S., Lawrence, N., Brammer, M. J., Speckens, A., and Phillips, M. L. (2004). Distinct neural correlates of washing, checking, and hoarding symptom dimensions in obsessive-compulsive disorder. Arch. Gen. Psychiatry 61(6): 564-576.
67. Metz, C., and Kronman, H. (1987). Statistical significance test for the binomial ROC curves. J. Math Psychol 22: 218-243.
68. Mitchell, D. G., Colledge, E., Leonard, A., and Blair, R. J. (2002). Risky decisions and response reversal: is there evidence of orbitofrontal cortex dysfunction in psychopathic individuals? Neuropsychologia 40(12): 2013-2022.
69. Mora, F., Avrith, D. B., Phillips, A. G., and Rolls, E. T. (1979). Effects of satiety on self-stimulation of the orbitofrontal cortex in the rhesus monkey. Neurosci. Lett. 13(2): 141-145.
70. Mora, F., and Cobo, M. (1990). The neurobiological basis of prefrontal cortex self-stimulation: a review and an integrative hypothesis. Prog. Brain Res. 85: 419-131.
71. Murray, C. J., and Lopez, A. D. (1996). Global burden of disease: a comprehensive assessment of mortality and morbidity from diseases, injuries and risk factors in 1990 and projected to 2020 (Vol. 1), WHO, Harvard.
72. Nakano, Y., Oomura, Y., Nishino, H., Aou, S., Yamamoto, T., and Nemoto, S. (1984). Neuronal activity in the medial orbitofrontal cortex of the behaving monkey: Modulation by glucose and satiety. Brain Res. Bull. 12(4): 381-385.
73. Nielen, M. M., Veltman, D. J., de Jong, R., Mulder, G., and den Boer, J. A. (2002). Decision making performance in obsessive compulsive disorder. J. Affect Disord. 69(1-3): 257-260.
74. Perani, D., Colombo, C., Bressi, S., Bonfanti, A., Grassi, F., Scarone, S., et al. (1995). [18F]FDG PET study in obsessive-compulsive disorder. A clinical/metabolic correlation study after treatment. Br. J. Psychiatry 166(2): 244-250.
75. Phillips, M. L., Marks, I. M., Senior, C., Lythgoe, D., O'Dwyer, A. M., Meehan, O., Williams, S. C., Brammer, M. J., Bullmore, E. T., and McGuire, P. K. (2000). A differential neural response in obsessive-compulsive disorder patient with washing compared checking symptoms to disgust. Psychological Medicine 30(5): 1037-1050.
76. Phillips, A. G., Mora, F., and Rolls, E. T. (1979). Intracranial self-stimulation in orbitofrontal cortex and caudate nucleus of rhesus monkey: effects of apomorphine, pimozide, and spiroperidol. Psychopharmacology (Berl) 62(1): 79-82.
77. Pitman, R. K. (1982). Neurological aetiology of obsessive-compulsive disorders? Am. J. Psychiatry 139(1): 139-140.
78. Pogarell, O., Hamann, C., Popperl, G., Juckel, G., Chouker, M., Zaudig, M., et al. (2003). Elevated brain serotonin transporter availability in patients with obsessive-compulsive disorder. Biol. Psychiatry 54(12): 1406-1413.
79. Rahman, S., Sahakian, B. J., Hodges, J. R., Rogers, R. D., and Robbins, T. W. (1999). Specific cognitive deficits in mild frontal variant frontotemporal dementia. Brain 122(Pt 8): 1469-1493.
80. Rapoport, J. L., and Wise, S. P. (1988). Obsessive-compulsive disorder: evidence for basal ganglia dysfunction. Psychopharmacol Bull 24(3): 380-384.
81. Rauch, S. L., Jenike, M. A., Alpert, N. M., Baer, L., Breiter, H. C., Savage, C. R., et al. (1994). Regional cerebral blood flow measured during symptom provocation in obsessive-compulsive disorder using oxygen 15-labeled carbon dioxide and positron emission tomography. Arch. Gen. Psychiatry 51(1): 62-70.
82. Ritter, L. M., Meador-Woodraff, J. H., and Dalack, G. W. (2004). Neurocognitive measures of prefrontal cortical dysfunction in schizophrenia. Schizphr Res. 68(1): 65-73.
83. Rogers, R. D., Everitt, B. J., Baldacchino, A., Blackshaw, A. J., Swainson, R., Wynne, K., et al. (1999). Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers: Evidence for monoaminergic mechanisms. Neuropsychopharmacology 20(4): 322-339.
84. Rolls, E. T. (2000). The orbitofrontal cortex and reward. Cereb. Cortex. 10(3): 284-294.
85. Rubin, R. T., Ananth, J., Villanueva-Meyer, J., Trajmar, P. G., and Mena, I. (1995). Regional 133-xenon cerebral blood flow and cerebral 99mTc-HMPAO uptake in patients with obsessive-compulsive disorder before and during treatment. Biol. Psychiatry 38(7): 429-437.
86. Sawaguchi, T., and Goldman-Rakic, P. S. (1991). D1 dopamine receptors in prefrontal cortex: Involvement in working memory. Science 251(4996): 947-950.
87. Saxena, S., Brody, A. L., Maidment, K. M., Dunkin, J. J., Colgan, M., Alborzian, S., et al. (1999). Localized orbitofrontal and subcortical metabolic changes and predictors of response to paroxetine treatment in obsessive-compulsive disorder. Neuropsychopharmacology 21(6): 683-693.
88. Saxena, S., Brody, A. L., Schwartz, J. M., and Baxter, L. R. (1998). Neuroimaging and frontal-subcortical circuitry in obsessive-compulsive disorder. Br. J. Psychiatry Suppl. (35): 26-37.
89. Scarone, S., Colombo, C., Livian, S., Abbruzzese, M., Ronchi, P., Locatelli, M., et al. (1992). Increased right caudate nucleus size in obsessive-compulsive disorder: detection with magnetic resonance imaging. Psychiatry Res. 45(2): 115-121.
90. Simpson, H. B., Lombardo, I., Slifstein, M., Huang, H. Y., Hwang, D. R., Abi-Dargham, A., et al. (2003). Serotonin transporters in obsessive-compulsive disorder: A positron emission tomography study with [(11)C]McN 5652. Biol. Psychiatry 54(12): 1414-1421.
91. Stein, D. J., Hollander, E., Chan, S., DeCaria, C. M., Hilal, S., Liebowitz, M. R., et al.(1993). Computed tomography and neurological soft signs in obsessive-compulsive disorder. Psychiatry Res. 50(3): 143-150.
92. Swedo, S. E., Schapiro, M. B., Grady, C. L., Cheslow, D. L., Leonard, H. L., Kumar, A., et al. (1989). Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder. Arch. Gen. Psychiatry 46(6): 518-523.
93. Szeszko, P. R., McMillan, S., McMeniman, M., Chen, S., Baribault, K., Lim, K. O., Lvey, J., Rose, M., Banerjee, S. P., Bhandari, R., Moore, G. J., and Rosenberg, D. R. (2004). Brain structural abnormalities in psychotropic drugnaive pediatric patients with obsessive-compulsive disorder. Am. J. Psychiatry. 161(6): 1049-1056.
94. Tataranni, P. A., Gautier, J. F., Chen, K., Uecker, A., Bandy, D., Salbe, A. D., et al. (1999). Neuroanatomical correlates of hunger and satiation in humans using positron emission tomography. Proc. Natl. Acad. Sci. USA 96(8): 4569-4574.
95. van den Heuvel, O. A., Veltman, D. J., Groenewegen, H. J., Cath, D. C., van Balkom, A. J. L. M., van Hartskamp, J., et al. (2005). Frontal-striatal dysfunction during planning in obsessive-compulsive disorder. Arch. Gen. Psychiatry 62(3): 301-309.
96. Volkow, N. D., and Fowler, J. S. (2000). Addiction, a disease of compulsion and drive: Involvement of the orbitofrontal cortex. Cereb. Cortex 10(3): 318-325.
97. Volkow, N. D., Fowler, J. S., Wolf, A. P., Hitzemann, R., Dewey, S., Bendriem, B., et al. (1991). Changes in brain glucose metabolism in cocaine dependence and withdrawal. Am. J. Psychiatry 148(5): 621-626.
98. Wilder, K. E., Weinberger, D. R., and Goldberg, T. E. (1998). Operant conditioning and the orbitofrontal cortex in schizophrenic patients: Unexpected evidence for intact functioning. Schizophr Res. 30(2): 169-174.
99. Zinbarg, R. E., and Mohlman, J. (1998). Individual differences in the acquisition of affectively valenced associations. J. Pers. Soc. Psychol 74(4): 1024-1040.
100. Zorzi, C. (2004). Neuropsychology of obsessive-compulsive disorder: Presented at "neuropsychological function in psychopathology" at The 8th Nordic Meeting in Neuropsychology, Turku, Finland, August 26-29.