Association between the NMDA glutamate receptor GRIN2B gene and obsessive-compulsive disorder

Journal of Psychiatry and Neuroscience

Volumn 37, Issue 4, 2012, Pages 273-281

  Alonso, Pino ^a,b,c   Gratacós, Mónica ^b   Segalàs, Cinto ^a,b   Escaramís, Georgia ^b   Real, Eva ^a,b   Bayés, Mónica ^d   Labad, Javier ^e   López Solà, Clara ^a,b   Estivill, Xavier ^b,d,f   Menchón, José M ^a,b,c  

^a HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c UNIVERSITY OF BARCELONA   (Spain)

^d CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^e IISPV   (Spain)

^f UNIVERSITAT POMPEU FABRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

3' UNTRANSLATED REGION; ADULT; ALLELE; ARTICLE; CLEANING; COMORBIDITY; CONTROLLED STUDY; EXON; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B GENE; OBSESSIVE COMPULSIVE DISORDER; PHENOTYPE; SAMPLE SIZE; SINGLE NUCLEOTIDE POLYMORPHISM; SPAIN; TIC;

EID: 84862689235     PISSN: 11804882     EISSN: 14882434     Source Type: Journal    
DOI: 10.1503/jpn.110109     Document Type: Article

References (63)

1. Ting JT, Feng G. Glutamatergic synaptic dysfunction and obsessive-compulsive disorder. Curr Chem Genomics 2008;2:62-75.
2. Saxena S, Rauch SL. Functional neuroimaging and the neuro -anatomy of obsessive-compulsive disorder. Psychiatr Clin North Am 2000;23:563-586.
3. Rosenberg DR, MacMaster FP, Keshavan MS, et al. Decrease in caudate glutamatergic concentrations in pediatric obsessive-compulsive disorder patients taking paroxetine. J Am Acad Child Adolesc Psychiatry 2000;39:1096-1103.
4. Whiteside SP, Port JD, Deacon BJ, et al. A magnetic resonance spectroscopy investigation of obsessive-compulsive disorder and anxiety. Psychiatry Res 2006;146:137-147.
5. Rosenberg DR, Mirza Y, Russell A, et al. Reduced anterior cingulate glutamatergic concentrations in childhood OCD and major depression versus healthy controls. J Am Acad Child Adolesc Psychiatry 2004;43:1146-1153.
6. Yücel M, Wood SJ, Wellard RM, et al. Anterior cingulate glutamate-glutamine levels predict symptom severity in women with obsessive-compulsive disorder. Aust N Z J Psychiatry 2008;42:467-477.
7. Chakrabarty K, Bhattacharyya S, Christopher R, et al. Glutamater-gic dysfunction in OCD. Neuropsychopharmacology 2005;30:1735-1740.
8. Nordstrom EJ, Burton FH. A transgenic model of comorbid Tourette's syndrome and obsessive-compulsive disorder circuitry. Mol Psychiatry 2002;7:617-625, 524.
9. McGrath MJ, Campbell KM, Parks CR, et al. Glutamatergic drugs exacerbate symptomatic behavior in a transgenic model of comor-bid Tourette's syndrome and obsessive-compulsive disorder. Brain Res 2000;877:23-30.
10. Welch JM, Lu J, Rodriguiz RM, et al. Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice. Nature 2007; 448:894-900.
11. Pittenger C, Krystal JH, Coric V. Glutamate-modulating drugs as novel pharmacotherapeutic agents in the treatment of obsessive-compulsive disorder. NeuroRx 2006;3:69-81.
12. Arnold PD, Sicard T, Burroughs E, et al. Glutamate transporter gene SLC1A1 associated with obsessive-compulsive disorder. Arch Gen Psychiatry 2006;63:769-776.
13. Dickel DE, Veenstra-VanderWeele J, Cox NJ, et al. Association testing of the positional and functional candidate gene SLC1A1/ EAAC1 in early-onset obsessive-compulsive disorder. Arch Gen Psychiatry 2006;63:778-785.
14. Stewart SE, Fagerness JA, Platko J, et al. Association of the SLC1A1 glutamate transporter gene and obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet 2007;144B:1027-1033.
15. Wendland JR, Moya PR, Timpano KR, et al. A haplotype containing quantitative trait loci for SLC1A1 gene expression and its association with obsessive-compulsive disorder. Arch Gen Psychiatry 2009; 66:408-416.
16. Samuels J, Wang Y, Riddle MA, et al. Comprehensive family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet 2011;156B:472-477.
17. Wang Y AA, Shugart YY, Samuels JF, et al. A screen for SLC1A1 for OCD-related alleles. Am J Med Genet B Neuropsychiatr Genet 2010; 153B:675-679.
18. Delorme R, Krebs MO, Chabane N, et al. Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder. Neuroreport 2004; 15: 699-702.
19. Sampaio AS, Fagerness J, Crane J, et al. Association between polymorphisms in GRIK2 gene and obsessive-compulsive disorder: a family-based study. CNS Neurosci Ther 2011;17:1412-1417.
20. Arnold PD, Rosenberg DR, Mundo E, et al. Association of a gluta-mate (NMDA) subunit receptor gene (GRIN2B) with obsessive-compulsive disorder: a preliminary study. Psychopharmacology (Berl) 2004;174:530-538.
21. Villmann C, Becker CM. On the hypes and falls in neuroprotec-tion: targeting the NMDA receptor. Neuroscientist 2007;13:594-615.
22. Loftis JM, Janowsky A. The N-methyl-D-aspartate receptor sub-unit NR2B: localization, functional properties, regulation, and clinical implications. Pharmacol Ther 2003;97:55-85.
23. Riedel G, Platt B, Micheau J. Glutamate receptor function in learning and memory. Behav Brain Res 2003;140:1-47.
24. Tang YP, Shimizu E, Dube GR, et al. Genetic enhancement of learning and memory in mice. Nature 1999;401:63-69.
25. Beste C, Baune BT, Domschke K, et al. Dissociable influences of NR2B-receptor related neural transmission on functions of distinct associative basal ganglia circuits. Neuroimage 2010;52:309-315.
26. Chamberlain SR, Menzies L, Hampshire A, et al. Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives. Science 2008;321:421-422.
27. Miguel EC, Leckman JF, Rauch S, et al. Obsessive-compulsive disorder phenotypes: implications for genetic studies. Mol Psychiatry 2005; 10:258-275.
28. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington: The Association; 1994.
29. First MB, Spitzer RL, Gibbon M, et al. Structured Clinical Interview for DSM-IV Axis I Disorders, Clinician Version (SCID-CV). Washington: American Psychiatric Press, Inc.; 1996.
30. Goodman WK, Price LH, Rasmussen SA, et al. The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability. Arch Gen Psychiatry 1989;46:1006-1011.
31. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23:56-62.
32. Mataix-Cols D, Rauch SL, Manzo PA, et al. Use of factor-analyzed symptom dimensions to predict outcome with serotonin reuptake inhibitors and placebo in the treatment of obsessive-compulsive disorder. Am J Psychiatry 1999;156:1409-1416.
33. Rosario-Campos MC, Miguel EC, Quatrano S, et al. The Dimensional Yale-Brown Obsessive-Compulsive Scale (DY-BOCS): an instrument for assessing obsessive-compulsive symptom dimensions. Mol Psychiatry 2006;11:495-504.
34. Cherlyn SY, Woon PS, Liu JJ, et al. Genetic association studies of glutamate, GABA and related genes in schizophrenia and bipolar disorder: a decade of advance. Neurosci Biobehav Rev 2010;34:958-977.
35. Alonso P, Gratacos M, Segalas C, et al. Variants in estrogen receptor alpha gene are associated with phenotypical expression of obsessive-compulsive disorder. Psychoneuroendocrinology 2011;36:473-483.
36. SNPassoc: an R package to perform whole genome association studies [program]. Vienna: R Foundation for Statistical Computing; 2006.
37. Barrett JC, Fry B, Maller J, et al. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005;21:263-265.
38. Katerberg H, Lochner C, Cath DC, et al. The role of the brain-derived neurotrophic factor (BDNF) val66met variant in the phe-notypic expression of obsessive-compulsive disorder (OCD). Am J Med Genet B Neuropsychiatr Genet 2009;150B:1050-1062.
39. Alsobrook JP, Leckman JF, Goodman WK, et al. Segregation analysis of obsessive-compulsive disorder using symptom-based factor scores. Am J Med Genet 1999;88:669-675.
40. Leckman JF, Pauls DL, Zhang H, et al. Obsessive-compulsive symptom dimensions in affected sibling pairs diagnosed with Gilles de la Tourette syndrome. Am J Med Genet B Neuropsychiatr Genet 2003;116B:60-68.
41. Cullen B, Brown CH, Riddle MA, et al. Factor analysis of the Yale-Brown Obsessive Compulsive Scale in a family study of obsessive-compulsive disorder. Depress Anxiety 2007;24:130-138.
42. Pinto A, Greenberg BD, Grados MA, et al. Further development of YBOCS dimensions in the OCD Collaborative Genetics study: symptoms vs. categories. Psychiatry Res 2008;160:83-93.
43. van Grootheest DS, Boomsma DI, Hettema JM, et al. Heritability of obsessive-compulsive symptom dimensions. Am J Med Genet B Neuropsychiatr Genet 2008;147B:473-478.
44. Husted DS, Shapira NA, Goodman WK. The neurocircuitry of obsessive-compulsive disorder and disgust. Prog Neuropsychopharmacol Biol Psychiatry 2006;30:389-399.
45. Gilbert AR, Mataix-Cols D, Almeida JR, et al. Brain structure and symptom dimension relationships in obsessive-compulsive disorder: a voxel-based morphometry study. J Affect Disord 2008; 109: 117-126.
46. Mataix-Cols D, Wooderson S, Lawrence N, et al. Distinct neural correlates of washing, checking, and hoarding symptom dimensions in obsessive-compulsive disorder. Arch Gen Psychiatry 2004; 61: 564-576.
47. van den Heuvel OA, Remijnse PL, Mataix-Cols D, et al. The major symptom dimensions of obsessive-compulsive disorder are mediated by partially distinct neural systems. Brain 2009;132:853-868.
48. Arnold PD, Macmaster FP, Hanna GL, et al. Glutamate system genes associated with ventral prefrontal and thalamic volume in pediatric obsessive-compulsive disorder. Brain Imaging Behav 2009; 3: 64-76.
49. Arnold PD, Macmaster FP, Richter MA, et al. Glutamate receptor gene (GRIN2B) associated with reduced anterior cingulate gluta-matergic concentration in pediatric obsessive-compulsive disorder. Psychiatry Res 2009;172:136-139.
50. Woolley CS, McEwen BS. Estradiol regulates hippocampal dendritic spine density via an N-methyl-D-aspartate receptor-dependent mechanism. J Neurosci 1994;14:7680-7687.
51. Kanamaru H, Kakeyama M, Seki T, et al. Estrogen potentiates N-methyl-D-aspartate receptor subunit R2B mRNA expression during the late prepubertal period in female rats. Neurosci Lett 2001; 300: 9-12.
52. Watanabe T, Inoue S, Hiroi H, et al. NMDA receptor type 2D gene as target for estrogen receptor in the brain. Brain Res Mol Brain Res 1999; 63:375-379.
53. Dorval KM, Wigg KG, Crosbie J, et al. Association of the glutamate receptor subunit gene GRIN2B with attention-deficit/hyperactivity disorder. Genes Brain Behav 2007;6:444-452.
54. Ludwig KU, Roeske D, Herms S, et al. Variation in GRIN2B contributes to weak performance in verbal short-term memory in children with dyslexia. Am J Med Genet B Neuropsychiatr Genet 2010; 153B: 503-511.
55. Rasmussen SA, Eisen JL. Epidemiology of obsessive compulsive disorder. J Clin Psychiatry 1990;51(Suppl):10-13, discussion 14.
56. Bogetto F, Venturello S, Albert U, et al. Gender-related clinical differences in obsessive-compulsive disorder. Eur Psychiatry 1999; 14: 434-441.
57. Castle DJ, Deale A, Marks IM. Gender differences in obsessive compulsive disorder. Aust N Z J Psychiatry 1995;29:114-117.
58. Lensi P, Cassano GB, Correddu G, et al. Obsessive-compulsive disorder. Familial-developmental history, symptomatology, comor-bidity and course with special reference to gender-related differences. Br J Psychiatry 1996;169:101-107.
59. Tükel R, Polat A, Genc A, et al. Gender-related differences among Turkish patients with obsessive-compulsive disorder. Compr Psychiatry 2004;45:362-366.
60. Katerberg H, Cath DC, Denys DA, et al. The role of the COMT Val(158)Met polymorphism in the phenotypic expression of obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet 2010; 153B:167-176.
61. Mundo E, Bareggi SR, Pirola R, et al. Effect of acute intravenous clomipramine and antiobsessional response to proserotonergic drugs: Is gender a predictive variable? Biol Psychiatry 1999;45:290-294.
62. Moskvina V, Holmans P, Schmidt KM, et al. Design of case-controls studies with unscreened controls. Ann Hum Genet 2005; 69: 566-576.
63. Grados MA. The genetics of obsessive-compulsive disorder and Tourette syndrome: an epidemiological and pathway-based approach for gene discovery. J Am Acad Child Adolesc Psychiatry 2010; 49: 810-819, 819.e1-2.