Molecular genetics of obsessive-compulsive disorder: A comprehensive meta-analysis of genetic association studies

Molecular Psychiatry

Volumn 18, Issue 7, 2013, Pages 799-805

  Taylor, S ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

association studies; genetics; meta analysis; obsessive compulsive disorder

Indexed keywords

4 AMINOBUTYRIC ACID; ACETYLCHOLINE; BRADYKININ; CATECHOL METHYLTRANSFERASE; DOPAMINE; GLUTAMIC ACID; GLYCINE; SEROTONIN; UBIQUITIN;

ALLELE; ARTICLE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HUMAN; META ANALYSIS; MOLECULAR GENETICS; OBSESSIVE COMPULSIVE DISORDER; PRIORITY JOURNAL;

ADOLESCENT; ADULT; CATECHOL O-METHYLTRANSFERASE; DATABASES, GENETIC; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MONOAMINE OXIDASE; OBSESSIVE-COMPULSIVE DISORDER; POLYMORPHISM, GENETIC; RECEPTOR, SEROTONIN, 5-HT2A; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEX CHARACTERISTICS;

EID: 84879421163     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2012.76     Document Type: Article

References (57)

1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th edn, text rev edn. Author: Washington, DC, 2000.
2. Taylor S, Jang KL, Asmundson GJG. Etiology of obsessions and compulsions: a behavioral-genetic analysis. J Abnorm Psychol 2010; 119: 672-682.
3. Taylor S. Etiology of obsessions and compulsions: a meta-analysis and narrative review of twin studies. Clin Psychol Rev 2011; 31: 1361-1372.
4. Plomin R, Defries JC, Craig IW, McGuffin P. Behavioral Genetics in the Postgenomic Era. American Psychological Association: Washington, DC, 2002.
5. Abramowitz JS, Taylor S, McKay D. Obsessive-compulsive disorder. Lancet 2009; 374: 491-499.
6. Pauls DL. The genetics of obsessive-compulsive disorder: a review. Dialogues Clin Neurosci 2010; 12: 149-163.
7. Borenstein M, Hedges LV, Higgins J, Rothstein H. Introduction to Meta-Analysis. Wiley: Chichester, 2009.
8. Taylor S. Early versus late onset obsessive-compulsive disorder: evidence for distinct subtypes. Clin Psychol Rev 2011; 31: 1083-1100.
9. Azzam A, Mathews CA. Meta-analysis of the association between the catecholamine-O-methyl-transferase gene and obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet 2003; 123: 64-69.
10. Pooley EC, Fineberg N, Harrison PJ. The met158 allele of catechol-O-methyltransferase (COMT) is associated with obsessive-compulsive disorder in men: case-control study and meta-analysis. Mol Psychiatry 2007; 12: 556-561.
11. Schaid DJ. Transmission disequilibrium, family controls, and great expectations. Am J Hum Genet 1998; 63: 935-941.
12. Lewis CM. Genetic association studies: design, analysis and interpretation. Brief Bioinform 2002; 3: 146-153.
13. Lin PY. Meta-analysis of the association of serotonin transporter gene polymorphism with obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry 2007; 31: 683-689.
14. Bloch MH, Landeros-Weisenberger A, Sen S, Dombrowski P, Kelmendi B, Corci V et al. Association of the serotonin transporter polymorphism and obsessive-compulsive disorder: systematic review. Am J Med Genet B Neuropsychiatr Genet 2008; 147: 850-858.
15. Voyiaziakis E, Evgrafov O, Li D, Yoon HJ, Tabares P, Samuels J et al. Association of SLC6A4 variants with obsessive-compulsive disorder in a large multicenter US family study. Mol Psychiatry 2011; 16: 108-120.
16. Wendland JR KM, Cromer KR, Murphy DL. A large case-control study of common functional SLC6A4 and BDNF variants in obsessive-compulsive disorder. Neuropsychopharmacology 2007; 32: 2543-2551.
17. Lefebvre C, Manheimer E, Glanville J. Searching for studies. In: Higgins JPT, Green S (eds). Cochrane Handbook for Systematic Reviews of Interventions. Wiley: New York, 2008 pp 146-153.
18. Borenstein M, Hedges LV, Higgins J, Rothstein H. Comprehensive Meta-Analysis, 2.2050 edn. Biostat: Englewood, NJ, 2009.
19. Perneger TV. What's wrong with Bonferroni adjustments. BMJ 1998; 316: 1236-1238.
20. Rothman K. No adjustments are needed for multiple comparisons. Epidemiology 1990; 1: 43-46.
21. Lieberman MD, Cunningham WA. Type I and type II error concerns in fMRI research: re-balancing the scale. SCAN 2009; 4: 423-428.
22. Gravetter FJ, Wallnau LB. Essentials of Statistics for the Behavioral Sciences, 7 edn. Wadsworth: Belmont, CA, 2011.
23. Smith LF, Gratz ZS, Bousquet SG. The Art and Practice of Statistics. Wadsworth: Belmont, CA, 2009.
24. Gordi T, Khamis H. Simple solution to a common statistical problem: interpreting multiple tests. Clin Ther 2004; 26: 780-786.
25. Holm S. A simple sequentially rejective multiple test procedure. Scand J Stat 1979; 6: 65-70.
26. Egger M, Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple graphical test. BMJ 1997; 315: 629-634.
27. Dickel DE, Veenstra-VanderWeele J, Bivens NC, Wu X, Fischer DJ, Van Etten-Lee M et al. Association studies of serotonin system candidate genes in early-onset obsessive-compulsive disorder. Biol Psychiatry 2007; 61: 322-329.
28. Cohen J. Statistical Power Analyses for the Behavioral Sciences, 2nd edn. Erlbaum: Hillsdale, NJ, 1988.
29. Karayiorgou M, Sobin C, Blundell ML, Galke BL, Malinova L, Goldberg P et al. Family-based association studies support a sexually dimorphic effect of COMT and MAOA on genetic susceptibility to obsessive-compulsive disorder. Biol Psychiatry 1999; 45: 1178-1189.
30. Zintzaras E, Lau J. Trends in meta-analysis of genetic association studies. J Hum Genet 2008; 53: 1-9.
31. Rajender G, Bhatia MS, Kanwal K, Malhotra S, Singh TB, Chaudhary D. Study of neurocognitive endophenotypes in drug-naive obsessive-compulsive disorder patients, their first-degree relatives and health controls. Acta Psychiatr Scand 2011; 124: 152-161.
32. Gatacos M, Costas J, de Cid R, Bayes M, Gonzalez JR, Baca-Garcia E et al. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. Am J Med Genet B Neuropsychiatr Genet 2009; 150: 808-816.
33. Samuels J, Wang Y, Riddle MA, Greenberg BD, Fyer AJ, McCracken JT et al. Comprehensive family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet 2011; 156: 472-477.
34. da Rocha FF, Marco LA, Romano-Silva MA, Correa H. Obsessive-compulsive disorder and 5-HTTLPR. Rev Bras Psiquiatr 2009; 31: 281-292.
35. Hu XZ, Lipsky RH, Zhu G, Akhtar LA, Taubman J, Greenberg BD et al. Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet 2006; 78: 815-826.
36. Tibrewal P, Kumar HB, Shubha GN, Subhashree D, Purushottam M, Thennarasu K et al. Association of serotonin transporter gene polymorphisms with obsessive-compulsive disorder (OCD) in a south Indian population. Indian J Med Res 2010; 132: 690-695.
37. Denys D, van Nieuwerburgh F, Deforce D, Westenberg HGM. Association between serotonergic candidate genes and specific phenotypes of obsessive compulsive disorder. J Affect Disord 2006; 91: 39-44.
38. Enoch MA, Kaye WH, Rotondo A, Greenberg BD, Murphy DL, Goldman D. 5-HT2A promoter polymorphism-1438G/A, anorexia nervosa, and obsessive-compulsive disorder. Lancet 1998; 351: 1785-1786.
39. Enoch MA, Greenberg BD, Murphy DL, Goldman D. Sexually dimorphic relationship of a 5-HT2A promoter polymorphism with obsessive-compulsive disorder. Biol Psychiatry 2001; 49: 385-388.
40. Frisch A, Michaelovsky E, Rockah R, Amir I, Hermesh H, Laor N et al. Association between obsessive-compulsive disorder and polymorphisms of genes encoding components of the serotonergic and dopaminergic pathways. Eur Neuropsycho-pharmacol 2000; 10: 205-209.
41. Gruenblatt E, Romanos M, Renner T, Walitza S. Copy number variations in children and adolescents with early onset obsessive-compulsive disorder. Eur Child Adolesc Psychiatry 2011; 20(Suppl 1): S44-S45.
42. Hemmings SMJ Investigating the molecular aetiology of obsessive-compulsive disorder (OCD) and clinically-defined subsets of OCD. Ph.D. thesis, University of Stellenbosch, South Africa, 2006.
43. Jung HR, Cho JY, Chung JY, Kin JR, Yu KS, Jang IJ et al. No associations between 5-HTT, 5-HT2A gene polymorphisms and obsessive-compulsive disorder in a Korean population. Psychiatry Invest 2006; 3: 78-86.
44. Liu W, Zhao N, Xiong J, Shi M, Hu J. Associated analysis of serotonin and catecholamine system candidate genes in obsessive-compulsive disorder in the Chinese population. Psychiatry Res 2011; 188: 170-172.
45. Meira-Lima I, Shavitt RG, Miguita K, Ikenage E, Miguel EC, Vallada H. Association analysis of the catechol-o-methyltransferase (COMT), serotonin transporter (5-HTT) and serotonin 2A receptor (5HT2A) gene polymorphisms with obsessive-compulsive disorder. Genes Brain Behav 2004; 3: 75-79.
46. Nicolini H, Cruz C, Camarena B, Orozco B, Kennedy JL, King N et al. DRD2, DRD3 and 5HT2A receptor genes polymorphisms in obsessive-compulsive disorder. Mol Psychiatry 1996; 1: 461-465.
47. Saiz PA, Garcia-Portilla MP, Arango C, Morales B, Bascaran MT, Martinez-Barrondo S et al. Association study between obsessive-compulsive disorder and serotonergic candidate genes. Prog Neuropsychopharmacol Biol Psychiatry 2008; 32: 765-770.
48. TotS, Erdal EM, Yazici K, Yazici AE, Metin O. T102C and-1438 G/A polymorphisms of the 5-HT2A receptor gene in Turkish patients with obsessive-compulsive disorder. Eur Psychiatry 2003; 18: 249-254.
49. Walitza S, Wewetzer C, Warnke A, Gerlach M, Geller F, Gerber G et al. 5-HT2A promoter polymorphism-1438G/A in children and adolescents with obsessive-compulsive disorders. Mol Psychiatry 2002; 7: 1054-1057.
50. Alsobrook JP, Zohar AH, Leboyer M, Chabane N, Ebstein RP, Pauls DL. Association between the COMT locus and obsessive-compulsive disorder in females but not males. Am J Med Genet B Neuropsychiatr Genet 2002; 114: 116-120.
51. Karayiorgou M, Altemusm M, Galke BL, Goldman D, Murphy DL, Ott J et al. Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder. Proc Natl Acad Sci USA 1997; 94: 4572-4575.
52. Katerberg H, Cath DC, Denys DA, Heutink P, Polman A, van Nieuwerburgh FC et al. The role of the COMT Val158Met polymorphism in the phenotypic expression of obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet 2010; 153: 167-176.
53. Poyurovsky M, Michaelovsky E, Frisch A, Knoll G, Amir I, Buniak F et al. COMT Val158Met polymorphism in schizophrenia with obsessive-compulsive disorder: a case-control study. Neurosci Lett 2005; 389: 21-24.
54. Schindler KM, Richter MA, Kennedy JL, Pato MT, Pato CN. Association between homozygosity at the COMT gene locus and obsessive compulsive disorder. Am J Med Genet B Neuropsychiatr Genet 2000; 96: 721-724.
55. Walitza S, Scherag A, Renner TJ, Hinney A, Remschmidt H, Herpertz-Dahlmann B et al. Transmission disequilibrium studies in early onset of obsessive-compulsive disorder for polymorphisms in genes of the dopaminergic system. J Neural Transm 2008; 115: 1071-1078.
56. Camarena B, Rinetti G, Cruz C, Gomez A, de la Fuente JR, Nicolini H. Additional evidence that genetic variation of MAO-A gene supports a gender subtype in obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet 2001; 105: 279-282.
57. Lochner C, Hemmings SM, Kinnear CJ, Moolman-Smook JC, Corfield VA, Knowles JA et al. Gender in obsessive-compulsive disorder: clinical and genetic findings. Eur Neuropsychopharmacol 2004; 14: 105-113.