Serotonin transporter gene polymorphism implicates reduced orbito-frontal cortex in obsessive-compulsive disorder

Journal of Anxiety Disorders

Volumn 25, Issue 5, 2011, Pages 680-685

  Atmaca, Murad ^a   Onalan, Ebru ^a   Yildirim, Hanefi ^a   Yuce, Huseyin ^a   Koc, Mustafa ^a   Korkmaz, Sevda ^a   Mermi, Osman ^a  

^a FIRAT UNIVERSITY   (Turkey)

Author keywords

5 HTT; MRI; OCD; OFC; Thalamus

Indexed keywords

SEROTONIN TRANSPORTER;

ADULT; ANTERIOR CINGULATE; ARTICLE; BRAIN SIZE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; FRONTAL CORTEX; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; MALE; NEUROANATOMY; OBSESSIVE COMPULSIVE DISORDER; ORBITAL CORTEX; PROMOTER REGION; THALAMUS; VOLUMETRY;

ADULT; ANALYSIS OF VARIANCE; FEMALE; FRONTAL LOBE; GENOTYPE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; OBSESSIVE-COMPULSIVE DISORDER; ORGAN SIZE; POLYMORPHISM, SINGLE NUCLEOTIDE; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; THALAMUS;

EID: 79955534063     PISSN: 08876185     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.janxdis.2011.03.002     Document Type: Article

References (45)

1. Alsobrook J.P., Leckman J.F., Goodman W.K., Rasmussen S.A., Pauls D.L. Segregation analysis of obsessive-compulsive disorder using symptom-based factor scores. American Journal of Medical Genetics 1999, 88:669-675.
2. Atmaca M., Yildirim H., Ozdemir H., Aydin A., Tezcan E., Ozler S. Volumetric MRI assessment of brain regions in patients with refractory obsessive-compulsive disorder. Progress in Neuropsychopharmacology and Biological Psychiatry 2006, 30:1051-1057.
3. Atmaca M., Yildirim H., Ozdemir H., Tezcan E., Poyraz A.K. Volumetric MRI study of key brain regions implicated in obsessive-compulsive disorder. Progress in Neuropsychopharmacology and Biological Psychiatry 2007, 3:46-52.
4. Bengel D., Greenberg B.D., Cora-Locatelli G., Altemus M., Heils A., Li Q., et al. Association of the serotonin transporter promoter regulatory region polymorphism and obsessive-compulsive disorder. Molecular Psychiatry 1999, 4:463-466.
5. Bloch M.H., Landeros-Weisenberger A., Sen S., Dombrowski P., Kelmendi B., Coric V. Association of the serotonin transporter polymorphism and obsessive-compulsive disorder: systematic review. American Journal of Medical Genetics B: Neuropsychiatric Genetics 2008, 147B:850-858.
6. Casp A., Sugden K., Moffitt T.E., Taylor A., Craig I.W., Harrington H., et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003, 30:386-389.
7. Choi J.S., Kang D.H., Kim J.J., Ha T.H., Lee J.M., Youn T., et al. Left anterior subregion of orbitofrontal cortex volume reduction and impaired organizational strategies in obsessive-compulsive disorder. Journal of Psychiatric Research 2004, 38:193-199.
8. First M., Spitzer R., Gibbon M., Williams J. Structured clinical interview for DSM-IV axis disorders 1997, American Psychiatric Press, Washington, DC.
9. Frodl T., Zill P., Baghai T., Schüle C., Rupprecht R., Zetzsche T., et al. Reduced hippocampal volumes associated with the long variant of the tri- and diallelic serotonin transporter polymorphism in major depression. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 2008, 147B:1003-1007.
10. Gilbert A.R., Moore G.J., Keshavan M.S., Paulson L.D., Narula V., MacMaster F.P. Decrease in thalamic volumes of pediatric patients with obsessive-compulsive disorder who are taking paroxetine. Archives of General Psychiatry 2000, 57:449-456.
11. Goodman W.K., Price L.H., Rasmussen S.A., Mazure C., Delgado P., Heninger G.R., et al. The Yale-Brown obsessive compulsive scale II. Validity. Archives of General Psychiatry 1989, 46:1012-1016.
12. Hasler G., Kazuba D., Murphy D.L. Factor analysis of obsessive-compulsive disorder YBOCS-SC symptoms and association with 5-HTTLPR SERT polymorphism. American Journal Medical Genetics Part B: Neuropsychiatric Genetics 2006, 141B:403-408.
13. Hickie I.B., Naismith S.L., Ward P.B., Scott E.M., Mitchell P.B., Schofield P.R., et al. Serotonin transporter gene status predicts caudate nucleus but not amygdala or hippocampal volumes in older persons with major depression. Journal of Affective Disorders 2007, 98:137-142.
14. Hu X.Z., Lipsky R.H., Zhu G., Akhtar L.A., Taubman J., Greenberg B.D., et al. Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. The American Journal of Human Genetics 2006, 78:815-826.
15. Insel T.R. Toward a neuroanatomy of obsessive-compulsive disorder. Archives of General Psychiatry 1992, 49:739-744.
16. Jenike M.A., Breiter H.C., Baer L., Kennedy D.N., Savage C.R., Olivares M.J., et al. Cerebral structural abnormalities in obsessive-compulsive disorder. A quantitative morphometric magnetic resonance imaging study. Archives of General Psychiatry 1996, 53:625-632.
17. Kilic F., Murphy D.L., Rudnick G. A human serotonin transporter mutation causes constitutive activation of transport activity. Molecular Pharmacology 2003, 64:440-446.
18. Kim D.K., Lim S.W., Lee S., Sohn S.E., Kim S., Hahn C.G., et al. Serotonin transporter gene polymorphism and antidepressant response. Neuroreport 2000, 11:215-219.
19. Kringelbach M.L. The human orbitofrontal cortex: linking reward to hedonic experience. Nature Reviews. Neuroscience 2005, 6:691-702.
20. Lacerda A.L., Nicoletti M.A., Brambilla P., Sassi R.B., Mallinger A.G., Frank E., et al. Anatomical MRI study of basal ganglia in major depressive disorder. Psychiatry Research 2003, 124:129-140.
21. Lin P.Y. Meta-analysis of the association of serotonin transporter gene polymorphism with obsessive-compulsive disorder. Progress in Neuro-psychopharmacology and Biological Psychiatry 2007, 31:683-689.
22. Macmaster F., Vora A., Easter P., Rix C., Rosenberg D. Orbital frontal cortex in treatment-naïve pediatric obsessive-compulsive disorder. Psychiatry Research 2010, 28:97-100.
23. McGuffin P., Mawson D. Obsessive-compulsive neurosis: two identical twin pairs. British Journal of Psychiatry 1980, 137:285-287.
24. Nestadt G., Lan T., Samuels J., Riddle M., Bienvenu O.J., Liang K.Y., et al. Complex segregation analysis provides compelling evidence for a major gene underlying obsessive-compulsive disorder and for heterogeneity by sex. American Journal Human Genetics 2000, 67:1611-1616.
25. Noga J.T., Aylward E., Barta P.E., Pearlson G.D. Cingulate gyrus in schizophrenic patients and normal volunteers. Psychiatry Research 1995, 61:201-208.
26. Ozaki N., Goldman D., Kaye W.H., Plotnicov K., Greenberg B.D., Lappalainen J., et al. Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype. Molecular Psychiatry 2003, 8:933-936.
27. Patel V.H., Friedman L. MRI of the brain: normal anatomy and normal variants 1997, WB Saunders Company, Philadelphia.
28. Pezawas L., Meyer-Lindenberg A., Drabant E.M., Verchinski B.A., Munoz K.E., Kolachana B.S., et al. 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nature Neuroscience 2005, 8:828-834.
29. Pollock B.G., Ferrell R.E., Mulsant B.H., Mazumdar S., Miller M., Sweet R.A., et al. Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression. Neuropsychopharmacology 2000, 23:587-590.
30. Portas C.M., Goldstein J.M., Shenton M.E., Hokama H.H., Wible C.G., Fischer I., et al. Volumetric evaluation of the thalamus in schizophrenic male patients using magnetic resonance imaging. Biological Psychiatry 1998, 43:649-659.
31. Riffkin J., Yucel M., Maruf P., Wood S., Soulsby B., Olver J., et al. A manual and automated MRI study of anterior cingulate and orbito-frontal cortices, and caudate nucleus in obsessive-compulsive disorder: comparison with healthy controls and patients with schizophrenia. Psychiatry Research 2005, 138:99-113.
32. Robins L.N., Hezler J.E., Orvaschel C., Anthony J.C., Blazer D.G., Burnham A. The diagnostic interview schedule. Epidemiologic field methods in psychiatry: the NIMH epidemiologic catchment area program 1985, 143-168. Academic Press, Orlando. W.W. Eaton, L.G. Kessler (Eds.).
33. Robinson D., Wu H., Munne R.A., Ashtari M., Alvir J.M., Lerner G., et al. Reduced caudate nucleus volume in obsessive-compulsive disorder. Archives of General Psychiatry 1995, 52:393-398.
34. Sassi R.B., Brambilla P., Hatch M.A., Mallinger A.G., Frank E., Kupfer D.J., et al. Reduced left anterior cingulate volumes in untreated bipolar patients. Biological Psychiatry 2004, 56:467-475.
35. Scarone S., Colombo C., Livian S., Abbruzzese M., Ronchi P., Locatelli M., et al. Increased right caudate nucleus size in obsessive-compulsive disorder: detection with magnetic resonance imaging. Psychiatry Research 1992, 45:115-121.
36. Smeraldi S., Zanardi R., Benedetti F., Di Bela D., Perez J., Catalano M. Polymorphism within the promoter of the serotonin transporter and antidepressant efficacy of fluvoxamine. Molecular Psychiatry 1998, 3:508-511.
37. Smith E.A., Russell A., Lorch E., Banerjee S.P., Rose M., Ivey J., et al. Increased medial thalamic choline found in pediatric patients with obsessive-compulsive disorder versus major depression or healthy control subjects: a magnetic resonance spectroscopy study. Biological Psychiatry 2003, 54:1399-1405.
38. Szeszko P.R., Robinson D., Alvir J.M., Bilder R.M., Lencz T., Ashtari M., et al. Orbital frontal and amygdala volume reductions in obsessive-compulsive disorder. Archives of General Psychiatry 1999, 56:913-919.
39. Szeszko P.R., MacMillan S., McMeniman M., Lorch E., Madden R., Ivey J., et al. Amygdala volume reductions in pediatric patients with obsessive-compulsive disorder treated with paroxetine: preliminary findings. Neuropsychopharmacology 2004, 29:826-832.
40. Whiteside S.P., Port J.D., Abramowitz J.S. A meta-analysis of functional neuroimaging in obsessive-compulsive disorder. Biological Psychiatry 2004, 20132:69-79.
41. Wilhelm, Mitchell P.B., Niven H., Finch A., Wedgwood L., Scimone A., et al. Life events, first depression onset and the serotonin transporter gene. British Journal of Psychiatry 2006, 188:210-215.
42. Yuh W.T.C., Tali E.T., Afifi A.K., Sahinoglu K., Gai F., Bergman R.A. MRI of head & neck anatomy 1994, Churchill Livingstone, New York.
43. Zald D.H., Kim S.W. Anatomy and function of the orbital frontal cortex, I: anatomy, neurocircuitry; and obsessive-compulsive disorder. Journal of Neuropsychiatry and Clinical Neuroscience 1996, 8:125-138.
44. Zald D.H., Kim S.W. Anatomy and function of the orbital frontal cortex. II. Function and relevance to obsessive-compulsive disorder. Journal of Neuropsychiatry and Clinical Neuroscience 1996, 8:249-261.
45. Zanardi R., Benedetti F., Catalano M., Di Bela D., Smeraldi E. Efficacy of paroxetine in depression is influenced by a functional polymorphism within the promoter of the serotonin transporter gene. Psychopharmacology 2000, 20:105-107.