Shear stress-related mechanosignaling with lung ischemia: Lessons from basic research can inform lung transplantation

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 307, Issue 9, 2014, Pages L668-L680

  Chatterjee, Shampa ^a   Nieman, Gary F ^b   Christie, Jason D ^a   Fisher, Aron B ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b State University of New York Upstate Medical University: College of Medicine   (United States)

Author keywords

EVLP; Ischemia reperfusion; KATP channel; Lung ischemia; Lung perfusion and storage; Lung transplantation; Mechanotransduction; NADPH oxidase; Reactive oxygen species

Indexed keywords

CD31 ANTIGEN; CROMAKALIM; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HYPOXIA INDUCIBLE FACTOR 1; NITRIC OXIDE SYNTHASE; PEROXIREDOXIN 6; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NRF2; VASCULAR ENDOTHELIAL CADHERIN; VASCULOTROPIN RECEPTOR 2; VOLTAGE GATED CALCIUM CHANNEL; CADHERIN; CALCIUM CHANNEL T TYPE; CYBB PROTEIN, HUMAN; MEMBRANE PROTEIN; NITRIC OXIDE; VASCULOTROPIN RECEPTOR;

ARTICLE; BLOOD VESSEL WALL; CALCIUM TRANSPORT; CAPILLARY ENDOTHELIAL CELL; CAVEOLA; CELL MEMBRANE DEPOLARIZATION; COLD ISCHEMIA; EX VIVO LUNG PERFUSION; FLUORESCENCE MICROSCOPY; GEL MOBILITY SHIFT ASSAY; GRAFT SURVIVAL; HOMEOSTASIS; HUMAN; HYPERPOLARIZATION; HYPOXIA; ISCHEMIA; LIPID PEROXIDATION; LUNG; LUNG ALVEOLUS OXYGEN TENSION; LUNG BLOOD FLOW; LUNG ISCHEMIA; LUNG PERFUSION; LUNG TRANSPLANTATION; LUNG VENTILATION; MACROPHAGE; MECHANOTRANSDUCTION; MEMBRANE DEPOLARIZATION; MEMBRANE POTENTIAL; NEOVASCULARIZATION (PATHOLOGY); NEUTROPHIL; NONHUMAN; OXIDATIVE STRESS; PRIMARY GRAFT DYSFUNCTION; REOXYGENATION; REPERFUSION INJURY; RESPIRATORY BURST; SHEAR STRESS; SIGNAL TRANSDUCTION; ENDOTHELIUM CELL; GENE EXPRESSION; GENETICS; MECHANICAL STRESS; METABOLISM; PATHOLOGY; PHYSIOLOGY; VASCULARIZATION;

ANTIGENS, CD31; CADHERINS; CALCIUM CHANNELS, T-TYPE; ENDOTHELIAL CELLS; GENE EXPRESSION; HUMANS; ISCHEMIA; LUNG; LUNG TRANSPLANTATION; MECHANOTRANSDUCTION, CELLULAR; MEMBRANE GLYCOPROTEINS; MEMBRANE POTENTIALS; NADPH OXIDASE; NITRIC OXIDE; REACTIVE OXYGEN SPECIES; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; STRESS, MECHANICAL;

EID: 84908388238     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00198.2014     Document Type: Article

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