Primary graft dysfunction: Definition, risk factors, short- and long-term outcomes

Seminars in Respiratory and Critical Care Medicine

Volumn 31, Issue 2, 2010, Pages 161-171

  Lee, James C ^a   Christie, Jason D ^a   Keshavjee, Shaf ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Ischemia reperfusion injury; Lung transplantation; Primary graft dysfunction

Indexed keywords

ACUTE LUNG INJURY; BRONCHIOLITIS OBLITERANS; DISEASE SEVERITY; GRAFT DYSFUNCTION; HUMAN; ORGAN DONOR; OUTCOME ASSESSMENT; PATHOGENESIS; PRIMARY GRAFT DYSFUNCTION; PRIORITY JOURNAL; RECIPIENT; REVIEW; RISK FACTOR; THORAX RADIOGRAPHY;

HUMANS; LUNG TRANSPLANTATION; PATIENT SELECTION; POSTOPERATIVE COMPLICATIONS; PRIMARY GRAFT DYSFUNCTION; RISK FACTORS; TISSUE DONORS;

EID: 77950533852     PISSN: 10693424     EISSN: 10989048     Source Type: Journal    
DOI: 10.1055/s-0030-1249111     Document Type: Review

References (75)

1. Christie J D., Bavaria J E., Palevsky H I. et al. Primary graft failure following lung transplantation. Chest 1998 114 51-60
2. King R C., Binns O A., Rodriguez F et al. Reperfusion injury significantly impacts clinical outcome after pulmonary transplantation. Ann Thorac Surg 2000 69 1681-1685
3. Christie J D., Kotloff R M., Pochettino A et al. Clinical risk factors for primary graft failure following lung transplantation. Chest 2003 124 1232-1241
4. Arcasoy S M., Kotloff R M. Lung transplantation. N Engl J Med 1999 340 1081-1091
5. Christie J D., Van Raemdonck D, de Perrot M et al, ISHLT Working Group on Primary Lung Graft Dysfunction. Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part I: introduction and methods. J Heart Lung Transplant 2005 24 1451-1453 (Pubitemid 41396438)
6. Arcasoy S M., Fisher A, Hachem R R., Scavuzzo M, Ware L B., ISHLT Working Group on Primary Lung Graft Dysfunction. Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part V: predictors and outcomes. J Heart Lung Transplant 2005 24 1483-1488
7. Christie J D., Kotloff R M., Ahya V N. et al. The effect of primary graft dysfunction on survival after lung transplantation. Am J Respir Crit Care Med 2005 171 1312-1316
8. Christie J D., Carby M, Bag R, Corris P, Hertz M, Weill D, ISHLT Working Group on Primary Lung Graft Dysfunction. Report of the ISHLT Working Group on Primary Lung Graft Dysfunction, II: Definition. A consensus statement of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant 2005 24 1454-1459
9. Daud S A., Yusen R D., Meyers B F. et al. Impact of immediate primary lung allograft dysfunction on bronchiolitis obliterans syndrome. Am J Respir Crit Care Med 2007 175 507-513
10. Barr M L., Kawut S M., Whelan T P. et al, ISHLT Working Group on Primary Lung Graft Dysfunction. Report of the ISHLT Working Group on Primary Lung Graft Dysfunction, IV: Recipient-related risk factors and markers. J Heart Lung Transplant 2005 24 1468-1482
11. Whitson B A., Nath D S., Johnson A C. et al. Risk factors for primary graft dysfunction after lung transplantation. J Thorac Cardiovasc Surg 2006 131 73-80
12. Prekker M E., Nath D S., Walker A R. et al. Validation of the proposed International Society for Heart and Lung Transplantation grading system for primary graft dysfunction after lung transplantation. J Heart Lung Transplant 2006 25 371-378
13. Prekker M E., Herrington C S., Hertz M I., Radosevich D M., Dahlberg P S. Early trends in PaO(2)/fraction of inspired oxygen ratio predict outcome in lung transplant recipients with severe primary graft dysfunction. Chest 2007 132 991-997
14. Oto T, Levvey B J., Snell G I. Potential refinements of the International Society for Heart and Lung Transplantation primary graft dysfunction grading system. J Heart Lung Transplant 2007 26 431-436
15. Christie J, Keshavjee S, Orens J et al, ISHLT Working Group on PGD. Potential refinements of the International Society for Heart and Lung Transplantation primary graft dysfunction grading system. J Heart Lung Transplant 2008 27 138
16. Oto T, Griffiths A P., Levvey B J., Pilcher D V., Williams T J., Snell G I. Definitions of primary graft dysfunction after lung transplantation: differences between bilateral and single lung transplantation. J Thorac Cardiovasc Surg 2006 132 140-147
17. de Perrot M, Liu M, Waddell T K., Keshavjee S. Ischemia-reperfusion- induced lung injury. Am J Respir Crit Care Med 2003 167 490-511
18. Carter Y M., Gelman A E., Kreisel D. Pathogenesis, management, and consequences of primary graft dysfunction. Semin Thorac Cardiovasc Surg 2008 20 165-172
19. Frank M M. Complement in the pathophysiology of human disease. N Engl J Med 1987 316 1525-1530
20. de Perrot M, Bonser R S., Dark J et al, ISHLT Working Group on Primary Lung Graft Dysfunction. Report of the ISHLT Working Group on Primary Lung Graft Dysfunction, III: Donor-related risk factors and markers. J Heart Lung Transplant 2005 24 1460-1467 (Pubitemid 41396440)
21. Lee J C., Christie J D. Primary graft dysfunction. Proc Am Thorac Soc 2009 6 39-46
22. Meyer D M., Bennett L E., Novick R J., Hosenpud J D. Effect of donor age and ischemic time on intermediate survival and morbidity after lung transplantation. Chest 2000 118 1255-1262
23. Oto T, Griffiths A P., Levvey B et al. A donor history of smoking affects early but not late outcome in lung transplantation. Transplantation 2004 78 599-606
24. Lee J CKC, Hadjiliadis D, Aahya V N. et al. Risk factors for early vs late primary graft dysfunction [abstract]. Am J Respir Crit Care Med 2008 177 A396
25. King R C., Binns O A., Rodriguez F et al. Reperfusion injury significantly impacts clinical outcome after pulmonary transplantation. Ann Thorac Surg 2000 69 1681-1685
26. Thabut G, Vinatier I, Stern J B. et al. Primary graft failure following lung transplantation: predictive factors of mortality. Chest 2002 121 1876-1882
27. Covarrubias M, Ware L B., Kawut S M. et al, Lung Transplant Outcomes Group. Plasma intercellular adhesion molecule-1 and von Willebrand factor in primary graft dysfunction after lung transplantation. Am J Transplant 2007 7 2573-2578
28. Kawut S M., Okun J, Shimbo D et al. Soluble P-selectin and the risk of primary graft dysfunction after lung transplantation. Chest 2009 136 237-244
29. Lee J C., Kuntz C, Kawut S M. et al. Clinical risk factors for the development of primary graft dysfunction [abstract]. J Heart Lung Transplant 2008 27 S67-S68
30. Cassivi S D., Meyers B F., Battafarano R J. et al. Thirteen-year experience in lung transplantation for emphysema. Ann Thorac Surg 2002 74 1663-1669 discussion 1669-1670
31. Fiser S M., Kron I L., McLendon Long S, Kaza A K., Kern J A., Tribble C G. Early intervention after severe oxygenation index elevation improves survival following lung transplantation. J Heart Lung Transplant 2001 20 631-636
32. Hadjiliadis D, Chaparro C, Reinsmoen N L. et al. Pre-transplant panel reactive antibody in lung transplant recipients is associated with significantly worse post-transplant survival in a multicenter study. J Heart Lung Transplant 2005 24 (7, Suppl) S249-S254
33. Yoshida S, Haque A, Mizobuchi T et al. Anti-type V collagen lymphocytes that express IL-17 and IL-23 induce rejection pathology in fresh and well-healed lung transplants. Am J Transplant 2006 6 724-735
34. Bobadilla J L., Love R B., Jankowska-Gan E et al. Th-17, monokines, collagen type V, and primary graft dysfunction in lung transplantation. Am J Respir Crit Care Med 2008 177 660-668
35. Sommers K E., Griffith B P., Hardesty R L., Keenan R J. Early lung allograft function in twin recipients from the same donor: risk factor analysis. Ann Thorac Surg 1996 62 784-790
36. Szeto W Y., Kreisel D, Karakousis G C. et al. Cardiopulmonary bypass for bilateral sequential lung transplantation in patients with chronic obstructive pulmonary disease without adverse effect on lung function or clinical outcome. J Thorac Cardiovasc Surg 2002 124 241-249
37. Wang Y, Kurichi J E., Blumenthal N P. et al. Multiple variables affecting blood usage in lung transplantation. J Heart Lung Transplant 2006 25 533-538
38. Webert K E., Blajchman M A. Transfusion-related acute lung injury. Transfus Med Rev 2003 17 252-262
39. Christie J D., Shah C V., Kawut S M. et al, Lung Transplant Outcomes Group. Plasma levels of receptor for advanced glycation end products, blood transfusion, and risk of primary graft dysfunction. Am J Respir Crit Care Med 2009 180 1010-1015
40. dos Santos C C., Okutani D, Hu P et al. Differential gene profiling in acute lung injury identifies injury-specific gene expression. Crit Care Med 2008 36 855-865
41. Li J, Nie J, Chen G et al. Gene expression profile of pulmonary tissues in different phases of lung ischemia-reperfusion injury in rats. J Huazhong Univ Sci Technolog Med Sci 2007 27 564-570
42. Ray M, Dharmarajan S, Freudenberg J, Zhang W, Patterson G A. Expression profiling of human donor lungs to understand primary graft dysfunction after lung transplantation. Am J Transplant 2007 7 2396-2405
43. Anraku M, Cameron M J., Waddell T K. et al. Impact of human donor lung gene expression profiles on survival after lung transplantation: a case-control study. Am J Transplant 2008 8 2140-2148
44. Kaneda H, Waddell T K., de Perrot M et al. Pre-implantation multiple cytokine mRNA expression analysis of donor lung grafts predicts survival after lung transplantation in humans. Am J Transplant 2006 6 544-551
45. Calfee C S., Budev M M., Matthay M A. et al. Plasma receptor for advanced glycation end-products predicts duration of ICU stay and mechanical ventilation in patients after lung transplantation. J Heart Lung Transplant 2007 26 675-680
46. Kawut S M., Okun J, Shimbo D et al, Lung Transplant Outcomes Group. Soluble p-selectin and the risk of primary graft dysfunction after lung transplantation. Chest 2009 136 237-244
47. Hoffman S A., Wang L, Shah C V. et al, Lung Transplant Outcomes Group. Plasma cytokines and chemokines in primary graft dysfunction post-lung transplantation. Am J Transplant 2009 9 389-396
48. Fisher A J., Donnelly S C., Hirani N et al. Elevated levels of interleukin-8 in donor lungs is associated with early graft failure after lung transplantation. Am J Respir Crit Care Med 2001 163 259-265
49. De Perrot M, Sekine Y, Fischer S et al. Interleukin-8 release during early reperfusion predicts graft function in human lung transplantation. Am J Respir Crit Care Med 2002 165 211-215
50. Krenn K, Klepetko W, Taghavi S, Lang G, Schneider B, Aharinejad S. Recipient vascular endothelial growth factor serum levels predict primary lung graft dysfunction. Am J Transplant 2007 7 700-706
51. Christie J D., Robinson N, Ware L B. et al. Association of protein C and type 1 plasminogen activator inhibitor with primary graft dysfunction. Am J Respir Crit Care Med 2007 175 69-74
52. Justice A C., Covinsky K E., Berlin J A. Assessing the generalizability of prognostic information. Ann Intern Med 1999 130 515-524
53. Khan S U., Salloum J, O'Donovan P B. et al. Acute pulmonary edema after lung transplantation: the pulmonary reimplantation response. Chest 1999 116 187-194
54. Burton C M., Iversen M, Milman N et al. Outcome of lung transplanted patients with primary graft dysfunction. Eur J Cardiothorac Surg 2007 31 75-82
55. Whitson B A., Prekker M E., Herrington C S. et al. Primary graft dysfunction and long-term pulmonary function after lung transplantation. J Heart Lung Transplant 2007 26 1004-1011
56. Christie J D., Sager J S., Kimmel S E. et al. Impact of primary graft failure on outcomes following lung transplantation. Chest 2005 127 161-165
57. Fiser S M., Tribble C G., Long S M. et al. Ischemia-reperfusion injury after lung transplantation increases risk of late bronchiolitis obliterans syndrome. Ann Thorac Surg 2002 73 1041-1047 discussion 1047-1048
58. Fisher A J., Wardle J, Dark J H., Corris P A. Non-immune acute graft injury after lung transplantation and the risk of subsequent bronchiolitis obliterans syndrome (BOS). J Heart Lung Transplant 2002 21 1206-1212
59. Girgis R E., Tu I, Berry G J. et al. Risk factors for the development of obliterative bronchiolitis after lung transplantation. J Heart Lung Transplant 1996 15 1200-1208
60. Hachem R R., Khalifah A P., Chakinala M M. et al. The significance of a single episode of minimal acute rejection after lung transplantation. Transplantation 2005 80 1406-1413
61. Khalifah A P., Hachem R R., Chakinala M M. et al. Minimal acute rejection after lung transplantation: a risk for bronchiolitis obliterans syndrome. Am J Transplant 2005 5 2022-2030
62. Huang H J., Yusen R D., Meyers B F. et al. Late primary graft dysfunction after lung transplantation and bronchiolitis obliterans syndrome. Am J Transplant 2008 8 2454-2462
63. Halloran P F., Homik J, Goes N et al. The injury response: a concept linking nonspecific injury, acute rejection, and long-term transplant outcomes. Transplant Proc 1997 29 79-81
64. Bharat A, Kuo E, Steward N et al. Immunological link between primary graft dysfunction and chronic lung allograft rejection. Ann Thorac Surg 2008 86 189-195 discussion 196-197
65. Burlingham W J., Love R B., Jankowska-Gan E et al. IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants. J Clin Invest 2007 117 3498-3506
66. Hornby K, Ross H, Keshavjee S, Rao V, Shemie S D. Non-utilization of hearts and lungs after consent for donation: a Canadian multicentre study. Can J Anaesth 2006 53 831-837
67. Ware L B., Wang Y, Fang X et al. Assessment of lungs rejected for transplantation and implications for donor selection. Lancet 2002 360 619-620
68. Oto T. Lung transplantation from donation after cardiac death (non-heart-beating) donors. Gen Thorac Cardiovasc Surg 2008 56 533-538
69. Neyrinck A P., Van De Wauwer C, Geudens N et al. Comparative study of donor lung injury in heart-beating versus non-heart-beating donors. Eur J Cardiothorac Surg 2006 30 628-636
70. De Vleeschauwer S, Van Raemdonck D, Vanaudenaerde B et al. Early outcome after lung transplantation from non-heart-beating donors is comparable to heart-beating donors. J Heart Lung Transplant 2009 28 380-387
71. Inci I, Zhai W, Arni S et al. Fibrinolytic treatment improves the quality of lungs retrieved from non-heart-beating donors. J Heart Lung Transplant 2007 26 1054-1060
72. Loehe F, Preissler G, Annecke T, Bittmann I, Jauch K W., Messmer K. Continuous infusion of nitroglycerin improves pulmonary graft function of non-heart-beating donor lungs. Transplantation 2004 77 1803-1808
73. Rega F R., Wuyts W A., Vanaudenaerde B M. et al. Nebulized N-acetyl cysteine protects the pulmonary graft inside the non-heart-beating donor. J Heart Lung Transplant 2005 24 1369-1377
74. Cypel M, Yeung J C., Hirayama S et al. Technique for prolonged normothermic ex vivo lung perfusion. J Heart Lung Transplant 2008 27 1319-1325
75. Cypel M YJ, Liu M, Chen F et al. Normothermic human ex vivo lung perfusion (EVLP) for improved assessment of extended criteria donor lungs for transplantation [abstract]. J Heart Lung Transplant 2009 28 S126