Piperlongumine induces cell death through ROS-mediated CHOP activation and potentiates TRAIL-induced cell death in breast cancer cells

Journal of Cancer Research and Clinical Oncology

Volumn 140, Issue 12, 2014, Pages 2039-2046

  Jin, Hyeon Ok ^a   Lee, Yun Han ^b   Park, Jin Ah ^a   Lee, Ha Na ^a   Kim, Jin Hee ^a   Kim, Ji Young ^a   Kim, BoRa ^a   Hong, Sung Eun ^a   Kim, Hyun Ah ^c   Kim, Eun Kyu ^c   Noh, Woo Chul ^c   Kim, Jong Il ^d   Chang, Yoon Hwan ^c   Hong, Seok Il ^c   Hong, Young Jun ^c   Park, In Chul ^a   Lee, Jin Kyung ^a  

^a Korea Institute of Radiation and Medical Science   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c Korea Cancer Center Hospital   (South Korea)

^d Seoul Women University   (South Korea)

Author keywords

Breast cancer; CHOP; DR5; Piperlongumine; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; ALKALOID; ANTINEOPLASTIC AGENT; BIM PROTEIN; DEATH RECEPTOR 4; DEATH RECEPTOR 5; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MESSENGER RNA; PIPERLONGUMINE; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; 1,3 DIOXOLANE DERIVATIVE; APOPTOSIS REGULATORY PROTEIN; BCL-2-LIKE PROTEIN 11; DDIT3 PROTEIN, HUMAN; MEMBRANE PROTEIN; ONCOPROTEIN; PIPERLONGUMININE; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MTT ASSAY; POLYACRYLAMIDE GEL ELECTROPHORESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; APOPTOSIS; BREAST NEOPLASMS; DRUG EFFECTS; FEMALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BREAST NEOPLASMS; CELL LINE, TUMOR; DIOXOLANES; FEMALE; HUMANS; MEMBRANE PROTEINS; PROTO-ONCOGENE PROTEINS; REACTIVE OXYGEN SPECIES; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TRANSCRIPTION FACTOR CHOP;

EID: 84908369195     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-014-1777-1     Document Type: Article

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