The mechanism of action of ursolic acid as insulin secretagogue and insulinomimetic is mediated by cross-talk between calcium and kinases to regulate glucose balance

Biochimica et Biophysica Acta - General Subjects

Volumn 1850, Issue 1, 2015, Pages 51-61

  Castro, Allisson Jhonatan Gomes ^a   Frederico, Marisa Jádna Silva ^a   Cazarolli, Luisa Helena ^b   Mendes, Camila Pires ^a   Bretanha, Lizandra Czermainski ^a   Schmidt, Éder Carlos ^a   Bouzon, Zenilda Laurita ^a   De Medeiros Pinto, Veronica Aiceles ^c   Da Fonte Ramos, Cristiane ^c   Pizzolatti, Moacir Geraldo ^a   Silva, Fátima Regina Mena Barreto ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^b UNIVERSIDADE FEDERAL DA FRONTEIRA SUL   (Brazil)

^c STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Calcium; GLUT4; Hyperglycemia; Insulin; Secretagogue; Triterpene

Indexed keywords

CALCIUM; GLUCOSE TRANSPORTER 4; GLYCOGEN; HORMONE INHIBITOR; INSULIN; INSULIN SIGNALING INHIBITOR; LACTATE DEHYDROGENASE; MESSENGER RNA; PHOSPHOLIPASE C; PHOSPHOTRANSFERASE; PROTEIN KINASE C; THYMIDINE; UNCLASSIFIED DRUG; URSOLIC ACID; ANTIDIABETIC AGENT; GLUCOSE; GLUCOSE BLOOD LEVEL; PROTEIN KINASE; SLC2A4 PROTEIN, RAT; TRITERPENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; CALCIUM BLOOD LEVEL; CELL MEMBRANE TRANSPORT; CELL NUCLEUS; CONTROLLED STUDY; DNA TRANSCRIPTION; DRUG ISOLATION; DRUG MECHANISM; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE TEST; GLUCOSE TRANSPORT; HORMONE TRANSPORT; HYPERGLYCEMIA; IMMUNOFLUORESCENCE TEST; INSULIN RELEASE; LACTATE DEHYDROGENASE BLOOD LEVEL; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOLEUS MUSCLE; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; BLOOD; CELL MEMBRANE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; GENETICS; IMMUNOBLOTTING; METABOLISM; SECRETION (PROCESS); SKELETAL MUSCLE; ULTRASTRUCTURE; WISTAR RAT;

ANIMALS; BLOOD GLUCOSE; CALCIUM; CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; GLYCOGEN; HYPOGLYCEMIC AGENTS; IMMUNOBLOTTING; INSULIN; INSULIN-SECRETING CELLS; L-LACTATE DEHYDROGENASE; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; MOLECULAR STRUCTURE; MUSCLE, SKELETAL; PROTEIN KINASES; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRITERPENES;

EID: 84908366936     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2014.10.001     Document Type: Article

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