Flavonoids: Cellular and molecular mechanism of action in glucose homeostasis

Mini-Reviews in Medicinal Chemistry

Volumn 8, Issue 10, 2008, Pages 1032-1038

  Cazarolli, Luisa Helena ^a   Zanatta, Leila ^a   Alberton, Elga Heloisa ^a   Figueiredo, Maria Santos Reis Bonorino ^a   Folador, Poliane ^a   Damazio, Rosangela Guollo ^a   Pizzolatti, Moacir Geraldo ^b   Silva, Fátima Regina Mena Barreto ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^b Departamento de Geociência   (Brazil)

Author keywords

Diabetes; Flavonoids; Glycemia; Insulin; Mechanism of action

Indexed keywords

AGLYCONE; ANTHOCYANIDIN DERIVATIVE; APIGENIN; AURANTIIN; CATECHIN; CATECHOL DERIVATIVE; CYANIDIN 3 GLUCOSIDE; DAIDZEIN; DELPHINIDIN; EPICATECHIN; EPIGALLOCATECHIN GALLATE; FLAVONOID; FLAVONOL DERIVATIVE; GENISTEIN; GLUCOSE; GLUCOSE TRANSPORTER 2; GLUCOSE TRANSPORTER 4; HESPERIDIN; INSULIN; KAEMPFEROL; KAEMPFEROL 3 NEOHESPERIDOSIDE; KAEMPFEROL 3,7 DIRHAMNOSIDE; MYRICETIN; NATURAL PRODUCT; PROCYANIDIN; PROCYANIDIN DERIVATIVE; PUERARIN; QUERCETIN; RUTOSIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

CARBOHYDRATE METABOLISM; DIABETES MELLITUS; DIET SUPPLEMENTATION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME REGULATION; GLUCONEOGENESIS; GLUCOSE ABSORPTION; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE UTILIZATION; HUMAN; HYPERGLYCEMIA; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; LIPID METABOLISM; LONG TERM CARE; NONHUMAN; PANCREAS ISLET BETA CELL; PLEIOTROPY; REVIEW; SIGNAL TRANSDUCTION; HOMEOSTASIS; METABOLISM;

BLOOD GLUCOSE; DIABETES MELLITUS; FLAVONOIDS; HOMEOSTASIS; HUMANS; INSULIN; SIGNAL TRANSDUCTION;

EID: 56049086634     PISSN: 13895575     EISSN: None     Source Type: Journal    
DOI: 10.2174/138955708785740580     Document Type: Review

References (72)

1. Gadsby, R. Adv. Drug Deliv. Rev., 2002, 54, 1165.
2. Kao, Y.H.; Hiipakka, R.A.; Liao, S. Endocrinology, 2000, 141, 980.
3. Tsuneki, H.; Ishizuka, M.; Terasawa, M.; Wu, J.B.; Sasaoka, T.; Kimura, I. BMC Pharmacol., 2004, 4, 18.
4. Sabu, M.C.; Smitha, K.; Kuttan, R. J. Ethnopharmacol., 2002, 83, 109.
5. Pinent, M.; Blay, M.; Blade, M.C.; Salvado, M.J.; Arola, L.; Ardévol, A. Endocrinology, 2004, 145, 4985.
6. Hsu, F.L.; Liu, I.M.; Kuo, D.H.; Chen, W.C.; Su, H.C.; Cheng, J.T. J. Nat. Prod., 2003, 66, 788.
7. Meezan, E.; Meezan, E.M.; Jones, K.; Moore, R.; Barnes, S.; Prasain, J.K. J. Agric. Food Chem., 2005, 53, 8760.
8. Lee, J.S. Life Sci., 2006, 79, 1578.
9. Park, S.Ae.; Choi, M.S.; Cho, S.Y.; Seo, J.S.; Jung, U.J.; Kim, M.J.; Sung, M.K.; Park, Y.B.; Lee, M.K. Life Sci., 2006, 79, 1207.
10. De Sousa, E.; Zanatta, L.; Seifriz, I.; Creczynski-Pasa, T.B.; Pizzolatti, M.G.; Szpoganicz, B.; Silva, F.R.M.B. J. Nat. Prod., 2004, 67, 829.
11. Cazarolli, L.H.; Zanatta, L.; Jorge, A.P.; Horst, H.; De Sousa, E.; Woehl, V.M.; Pizzolatti, M.G.; Szpoganicz, B.; Silva, F.R.M.B. Chem. Biol. Interact., 2006, 163, 177.
12. Shukla, R.; Barve, V.; Padhye, S.; Bhonde, R. Bioorg. Med. Chem. Lett., 2004, 14, 4961.
13. Liu, I.M.; Liou, S.S.; Lan, T.W.; Hsu, F.L.; Cheng, J.T. Planta Med., 2005, 71, 617.
14. Ong, K.C.; Khoo, H.E. Life Sci., 2000, 67, 1695.
15. Vessal, M.; Hemmati, M.; Vasei, M. Comp. Biochem. Physiol. Part C, 2003, 135, 357.
16. Shetty, A.K.; Rashmi, R.; Rajan, M.G.R.; Sambaiah, K.; Salimath, P.V. Nutr. Res., 2004, 24, 373.
17. Shin, J.S.; Kim, K.S.; Kim, M.B. Bioorg. Med. Chem. Lett., 1999, 9, 869.
18. Velussi, M.; Cernigoi, A.M.; De Monte, A.; Dapas, F.; Caffau, C.; Zilli, M. J. Hepatol., 1997, 26, 871.
19. Hnatyszyn, O.; Miño, J.; Ferraro, G.; Acevedo, C. Phytomedicine, 2002, 9, 556.
20. Kamalakkannan, N.; Prince, P.S. Basic Clin. Pharmacol. Toxicol., 2006, 98, 97.
21. Jung, U.J.; Lee, M.K.; Jeong, K.S.; Choi, M.S. J. Nutr., 2004, 134, 2499.
22. Choi, J.S.; Yokozawa, T.; Oura, H. Planta Med., 1991, 57, 208.
23. Bhathena, S.J.; Velásquez, M.T. Am. J. Clin. Nutr., 2002, 76, 1191.
24. Li, J.M.; Che, C.T.; Lau, C.B.S.; Leung, P.S.; Cheng, C.H.K. Int. J. Biochem. Cell Biol., 2006, 38, 985.
25. Shimizu, M.; Kobayashi, Y.; Suzuki, M.; Satsu, H.; Miyamoto, Y. Bio Factors, 2000, 13, 61.
26. Johnston, K.; Sharp, P.; Clifford, M.; Morgan, L. FEBS Lett., 2005, 579, 1653.
27. Zhao, H.; Yakar, S.; Gavrilova, O.; Sun, H.; Zhang, Y.; Kim, H.; Setser, J.; Jou, W.; Leroith, D. Diabetes, 2004, 53, 2901.
28. Hanamura, T.; Mayama, C.; Aoky, H.; Hirayama, Y.; Shimizu, M. Biosci. Biotechnol. Biochem., 2006, 70, 1813.
29. Matsui, T.; Kobayashi, M.; Hayashida, S.; Matsumoto, K. Biosci. Biotechnol. Biochem., 2002, 66, 689.
30. Kim, J.S.; Kwon, C.S.; Son, K.H. Biosci. Biotechnol. Biochem., 2000, 64, 2458.
31. Jorge, A.P.; Horst, H.; De Sousa, E.; Pizzolatti, M.G.; Silva, F.R.M.B. Chem. Biol. Interact., 2004, 149, 89.
32. Mao, C.P.; Gu, Z.L. Acta Pharmacol. Sin., 2005, 26, 982.
33. Yamabe, N.; Yokozawa, T.; Oya, T.; Kim, M.T. J. Pharmacol. Exp. Ther., 2006, 319, 228.
34. Yokozawa, T.; Nakagawa, T.; Oya, T.; Okubo, T.; Juneja, L.R. J. Pharm. Pharmacol., 2005, 57, 773.
35. Kahn, A.H.; Pessin, J.E.I. Diabetologia, 2002, 45, 1475.
36. Detimary, P.; Jonas, J.C.; Henquin, J.C. J. Clin. Invest., 1995, 96, 1738.
37. Tarasov, A.; Dusonchet, J.; Ashcroft, F. Diabetes, 2004, 53 (3S Suppl.), S113.
38. Liu, D.; Zhen, W.; Yang, Z.; Carter, J.D.; Si, H.; Reynolds, K.A. Diabetes, 2006, 55, 1043.
39. Prince, P.S.M.; Kamalakkannan, N. J. Biochem. Mol. Toxicol., 2006, 20, 96.
40. Hii, C.S.; Howell, S.L. J. Endocrinol., 1985, 107, 1.
41. Jayaprakasam, B.; Vareed, S.K.; Olson, L.K.; Nair, M.G. J. Agric. Food Chem., 2005, 53, 28.
42. Avruch, J. Mol. Cell. Biochem., 1998, 182, 31.
43. Saltiel, A.R.; Kahn, C.R. Nature, 2001, 414, 799.
44. Slot, J.W.; Geuze H.J.; Gigengack, S.; James D.E.; Lienhard, G.E. Proc. Natl. Acad. Sci. U.S.A., 1991, 88, 7815.
45. Zarzuelo, A.; Jiménez, I.; Gámez, M.J.; Utrilla, P.; Fernadez, I.; Torres, M.I.; Osuna, I. Life Sci., 1996, 58, 2311.
46. Ong, K.C.; Khoo, H.E. Biochem. Pharmacol., 1996, 51, 423.
47. Liu, I.M.; Liou, S.S.; Cheng, J.T. J. Ethnopharmacol., 2006, 104, 199.
48. Jung, U.J.; Lee, M.K.; Park, Y.B.; Kang, M.A.; Choi, M.S. Int. J. Biochem. Cell Biol., 2006, 38, 1134.
49. Wu, L.Y.; Juan, C.C.; Hwang, L.S.; Hsu, Y.P.; Ho, P.H.; Ho, L.T. Eur. J. Nutr., 2004, 43, 116.
50. Zaveri, N.T. Life Sci., 2006, 78, 2073.
51. Ahmad, F.; Khalid, P.; Khan, M.M.; Rastogi, A.K.; Kidwai, J.R. Acta Diabetol. Lat., 1989, 26, 291.
52. Zanatta, L.; Rosso, A.; Folador, P.; Figueiredo, M.B.S.R.; Pizzolatti, M.G.; Leite, L.D.; Silva, F.R.M.B. J. Nat. Prod., 2008, J. Nat. Prod., 2008, 71, 532.
53. Harmon, A.W.; Patel, Y.M. Biochem. Biophys. Res. Commun., 2003, 305, 229.
54. Bazuine, M.; Van den Broek, P.J.A.; Maassen, J.A. Biochem. Biophys. Res. Commun., 2005, 326, 511.
55. Smith, R.M.; Tiesinga, J.J.; Shah, N.; Smith, J.A.; Jarett, L. Arch. Biochem. Biophys., 1993, 300, 238.
56. Strobel, P.; Allard, C.; Perez-Acle, T.; Calderon, R.; Aldunate, R.; Leighton, F. Biochem. J., 2005, 386, 471.
57. Park, J.B. Biochem. Biophys. Res. Commun., 1999, 260, 568.
58. Shisheva, A.; Shechter, Y. Biochemistry, 1992, 31, 8059.
59. Roden, M.; Bernroider, E. Best Pract. Res. Clin. Endocrinol. Metab., 2003, 17, 365.
60. Sutherland, C.; O'brien, R.M.; Granner, D.K. Biol. Sci., 1996, 351, 191.
61. Yoon, J.C.; Puigserver, P.; Chen, G.; Donovan, J.; Wu, Z.; Rhee, J.; Adelmant, G.; Stafford, J.; Kahn, C.R.; Granner, D.K.; Newgard, C.B.; Spiegelman, B.M. Nature, 2001, 413, 131.
62. Zhang, X.; Gan, L.; Pan, H.; Guo, S.; He, X.; Olson, S.T.; Mesecar, A.; Adam, S.; Unterman, T.G. J. Biol. Chem., 2002, 277, 45276.
63. Cross, D.A.; Alessi, D.R.; Cohen, P.; Andjelkovich, M.; Hemmings, B.A. Nature, 1995, 378, 785.
64. Brady, M.J.; Nairn, A.C.; Saltiel, A.R. J. Biol. Chem., 1997, 272, 29698.
65. Yang, R.; Newgard, C.B. J. Biol. Chem., 2003, 278, 23418.
66. Koyama, Y.; Abe, K.; Sano, Y.; Ishizaki, Y.; Njelekela, M.; Shoji, Y.; Hara, Y.; Isemura, M. Planta Med., 2004, 70, 1100.
67. Anton, S.; Melville, L.; Rena, G. Cell. Signal., 2007, 19, 378.
68. Wolfram, S.; Raederstorff, D.; Preller, M.; Wang, Y.; Teixeira, S.R.; Riegger, C.; Weber, P. J. Nutr., 2006, 136, 2512.
69. Jakobs, S.; Fridrich, D.; Hofem, S.; Pahlke, G.; Eisenbrand, G. Mol. Nutr. Food Res., 2005, 50, 52.
70. Estrada, O.; Hasegawa, M.; Gonzalez-Mujica, F.; Motta, N.; Perdomo, E.; Solorzano, A.; Méndez, J.; Méndez, B.; Gabriela, Z.E. Phytother. Res., 2005, 19, 859.
71. Gonzalez-Mujica, F.; Motta, N.; Estrada, O.; Perdomo, E.; Méndez, J.; Hasegawa, M. Phytother. Res., 2005, 19, 624.
72. Valsa, A.K.; Sudheesh, S.; Vijayalakshmi, N.R. Indian J. Biochem. Biophys., 1997, 34, 406.