P2X7 receptor blockade protects against cisplatin-induced nephrotoxicity in mice by decreasing the activities of inflammasome components, oxidative stress and caspase-3

Toxicology and Applied Pharmacology

Volumn 281, Issue 1, 2014, Pages 1-10

  Zhang, Yuanyuan ^a   Yuan, Fahuan ^a   Cao, Xuejiao ^a   Du, Xiang ^a   Wang, Yiqin ^a   zhang, Jingbo ^a   Huang, Yunjian ^a   Zhao, Jinghong ^a   Hou, Weiping ^a   Zhai, Zhifang ^a   GangHuang, ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Caspase 3; Cisplatin induced nephrotoxicity; NLRP3 inflammasome; Oxidative stress; P2X7R

Indexed keywords

3 [[5 (2,3 DICHLOROPHENYL) 1H TETRAZOL 1 YL]METHYL]PYRIDINE; CASPASE 3; CISPLATIN; INFLAMMASOME; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; PURINERGIC P2X7 RECEPTOR; 3-(5-(2,3-DICHLOROPHENYL)-1H-TETRAZOL-1-YL)METHYLPYRIDINE; PURINERGIC P2X RECEPTOR ANTAGONIST; PYRIDINE DERIVATIVE; TETRAZOLE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; EPITHELIUM CELL; HISTOLOGY; KIDNEY FUNCTION; KIDNEY INJURY; KIDNEY PARENCHYMA; MALE; MOUSE; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; ACUTE KIDNEY INJURY; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CHEMICALLY INDUCED; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; PHYSIOLOGY;

ACUTE KIDNEY INJURY; ANIMALS; CASPASE 3; CISPLATIN; DOSE-RESPONSE RELATIONSHIP, DRUG; INFLAMMASOMES; MALE; MICE; MICE, INBRED C57BL; OXIDATIVE STRESS; PURINERGIC P2X RECEPTOR ANTAGONISTS; PYRIDINES; RECEPTORS, PURINERGIC P2X7; TETRAZOLES;

EID: 84908364271     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2014.09.016     Document Type: Article

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