Development and characterization of an aged onset model of Alzheimer's disease in Drosophila melanogaster

Experimental Neurology

Volumn 261, Issue , 2014, Pages 772-781

  Mhatre, Siddhita D ^a   Michelson, Sarah J ^a   Gomes, Janine ^a   Tabb, Loni Philip ^a   Saunders, Aleister J ^a,b   Marenda, Daniel R ^a,b  

^a DREXEL UNIVERSITY   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; APP; BACE; Drosophila; Late onset; Synapse

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; CD8 ANTIGEN; DROSOPHILA PROTEIN; GAL4 PROTEIN, DROSOPHILA; GREEN FLUORESCENT PROTEIN; SECRETASE; TRANSCRIPTION FACTOR;

AGE DISTRIBUTION; ALZHEIMER DISEASE; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; APP GENE; ARTICLE; BACE GENE; BETA AMYLOID GENE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CORRELATIONAL STUDY; DISEASE MODEL; DROSOPHILA MELANOGASTER; GENE; GENE EXPRESSION; HETEROZYGOSITY; NEUROPATHOLOGY; NONHUMAN; ONSET AGE; PHENOTYPE; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RISK FACTOR; TRANSGENIC ORGANISM; AGE; ANIMAL; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LONGEVITY; METABOLISM; MUTATION; PATHOPHYSIOLOGY; TEMPERATURE; TRANSGENIC ANIMAL;

AGE FACTORS; AGE OF ONSET; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIGENS, CD8; ASPARTIC ACID ENDOPEPTIDASES; DISEASE MODELS, ANIMAL; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; HUMANS; LONGEVITY; MUTATION; TEMPERATURE; TRANSCRIPTION FACTORS;

EID: 84908251915     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2014.08.021     Document Type: Article

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