-
1
-
-
0034708444
-
Comparative genomics of the eukaryotes
-
Rubin G.M., et al. Comparative genomics of the eukaryotes. Science 2000, 287:2204-2215.
-
(2000)
Science
, vol.287
, pp. 2204-2215
-
-
Rubin, G.M.1
-
2
-
-
33749342164
-
Phylogenetic reconstruction of orthology, paralogy, and conserved synteny for dog and human
-
Goodstadt L., Ponting C.P. Phylogenetic reconstruction of orthology, paralogy, and conserved synteny for dog and human. PLoS Comput. Biol. 2006, 2:e133.
-
(2006)
PLoS Comput. Biol.
, vol.2
-
-
Goodstadt, L.1
Ponting, C.P.2
-
3
-
-
34249935428
-
Genetics. Working the (gene count) numbers: finally, a firm answer?
-
Pennisi E. Genetics. Working the (gene count) numbers: finally, a firm answer?. Science 2007, 316:1113.
-
(2007)
Science
, vol.316
, pp. 1113
-
-
Pennisi, E.1
-
4
-
-
40549124601
-
The animal in the genome: comparative genomics and evolution
-
Copley R.R. The animal in the genome: comparative genomics and evolution. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 2008, 363:1453-1461.
-
(2008)
Philos. Trans. R. Soc. Lond. B. Biol. Sci.
, vol.363
, pp. 1453-1461
-
-
Copley, R.R.1
-
6
-
-
0034029917
-
Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics
-
Lai C.H., et al. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. Genome. Res. 2000, 10:703-713.
-
(2000)
Genome. Res.
, vol.10
, pp. 703-713
-
-
Lai, C.H.1
-
7
-
-
37249017468
-
Systematic in vivo analysis of the intrinsic determinants of amyloid β Pathogenicity
-
Luheshi L.M., et al. Systematic in vivo analysis of the intrinsic determinants of amyloid β Pathogenicity. PLoS Biol. 2007, 5:e290.
-
(2007)
PLoS Biol.
, vol.5
-
-
Luheshi, L.M.1
-
8
-
-
33748210163
-
Prefibrillar amyloid aggregates could be generic toxins in higher organisms
-
Baglioni S., et al. Prefibrillar amyloid aggregates could be generic toxins in higher organisms. J. Neurosci. 2006, 26:8160-8167.
-
(2006)
J. Neurosci.
, vol.26
, pp. 8160-8167
-
-
Baglioni, S.1
-
9
-
-
3843148352
-
Prefibrillar amyloid protein aggregates share common features of cytotoxicity
-
Bucciantini M., et al. Prefibrillar amyloid protein aggregates share common features of cytotoxicity. J. Biol. Chem. 2004, 279:31374-31382.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 31374-31382
-
-
Bucciantini, M.1
-
10
-
-
46549084254
-
Protein misfolding and disease: from the test tube to the organism
-
Luheshi L.M., et al. Protein misfolding and disease: from the test tube to the organism. Curr. Opin. Chem. Biol. 2008, 12:25-31.
-
(2008)
Curr. Opin. Chem. Biol.
, vol.12
, pp. 25-31
-
-
Luheshi, L.M.1
-
11
-
-
33746377894
-
Protein misfolding, functional amyloid, and human disease
-
Chiti F., Dobson C.M. Protein misfolding, functional amyloid, and human disease. Annu. Rev. Biochem. 2006, 75:333-366.
-
(2006)
Annu. Rev. Biochem.
, vol.75
, pp. 333-366
-
-
Chiti, F.1
Dobson, C.M.2
-
12
-
-
0347987853
-
Folding proteins in fatal ways
-
Selkoe D.J. Folding proteins in fatal ways. Nature 2003, 426:900-904.
-
(2003)
Nature
, vol.426
, pp. 900-904
-
-
Selkoe, D.J.1
-
13
-
-
0025899041
-
Amyloid deposition as the central event in the aetiology of Alzheimer's disease
-
Hardy J., Allsop D. Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol. Sci. 1991, 12:383-388.
-
(1991)
Trends Pharmacol. Sci.
, vol.12
, pp. 383-388
-
-
Hardy, J.1
Allsop, D.2
-
14
-
-
34248181511
-
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model
-
Roberson E.D., et al. Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model. Science 2007, 316:750-754.
-
(2007)
Science
, vol.316
, pp. 750-754
-
-
Roberson, E.D.1
-
15
-
-
0037197836
-
Tau is essential to beta -amyloid-induced neurotoxicity
-
Rapoport M., et al. Tau is essential to beta -amyloid-induced neurotoxicity. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:6364-6369.
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 6364-6369
-
-
Rapoport, M.1
-
16
-
-
22344438508
-
Tau suppression in a neurodegenerative mouse model improves memory function
-
Santacruz K., et al. Tau suppression in a neurodegenerative mouse model improves memory function. Science 2005, 309:476-481.
-
(2005)
Science
, vol.309
, pp. 476-481
-
-
Santacruz, K.1
-
17
-
-
0038117796
-
Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline
-
Naslund J., et al. Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. JAMA 2000, 283:1571-1577.
-
(2000)
JAMA
, vol.283
, pp. 1571-1577
-
-
Naslund, J.1
-
18
-
-
0025863618
-
Neuropathological stageing of Alzheimer-related changes
-
Braak H., Braak E. Neuropathological stageing of Alzheimer-related changes. Acta. Neuropathol. 1991, 82:239-259.
-
(1991)
Acta. Neuropathol.
, vol.82
, pp. 239-259
-
-
Braak, H.1
Braak, E.2
-
19
-
-
11544279355
-
Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins
-
Lambert M.P., et al. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc. Natl. Acad. Sci. U. S. A. 1998, 95:6448-6453.
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 6448-6453
-
-
Lambert, M.P.1
-
20
-
-
0037041426
-
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
-
Walsh D.M., et al. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 2002, 416:535-539.
-
(2002)
Nature
, vol.416
, pp. 535-539
-
-
Walsh, D.M.1
-
21
-
-
0042838303
-
Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss
-
Gong Y., et al. Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:10417-10422.
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 10417-10422
-
-
Gong, Y.1
-
22
-
-
16644379264
-
Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function
-
Cleary J.P., et al. Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function. Nat. Neurosci. 2005, 8:79-84.
-
(2005)
Nat. Neurosci.
, vol.8
, pp. 79-84
-
-
Cleary, J.P.1
-
23
-
-
33645505550
-
Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers
-
Townsend M., et al. Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers. J. Physiol. 2006, 572:477-492.
-
(2006)
J. Physiol.
, vol.572
, pp. 477-492
-
-
Townsend, M.1
-
24
-
-
49149124343
-
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
-
Shankar G.M., et al. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat. Med. 2008, 14:837-842.
-
(2008)
Nat. Med.
, vol.14
, pp. 837-842
-
-
Shankar, G.M.1
-
25
-
-
8744220663
-
Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases
-
Kayed R., et al. Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases. J. Biol. Chem. 2004, 279:46363-46366.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 46363-46366
-
-
Kayed, R.1
-
26
-
-
0242668337
-
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
-
Kayed R., et al. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 2003, 300:486-489.
-
(2003)
Science
, vol.300
, pp. 486-489
-
-
Kayed, R.1
-
27
-
-
54249137157
-
Oligomeric and fibrillar species of beta-amyloid (A beta 42) both impair mitochondrial function in P301L tau transgenic mice
-
Eckert A., et al. Oligomeric and fibrillar species of beta-amyloid (A beta 42) both impair mitochondrial function in P301L tau transgenic mice. J. Mol. Med. 2008, 86:1255-1267.
-
(2008)
J. Mol. Med.
, vol.86
, pp. 1255-1267
-
-
Eckert, A.1
-
28
-
-
34248190279
-
A beta oligomers - a decade of discovery
-
Walsh D.M., Selkoe D.J. A beta oligomers - a decade of discovery. J. Neurochem. 2007, 101:1172-1184.
-
(2007)
J. Neurochem.
, vol.101
, pp. 1172-1184
-
-
Walsh, D.M.1
Selkoe, D.J.2
-
29
-
-
44949219079
-
Prediction of aggregation-prone regions in structured proteins
-
Tartaglia G.G., et al. Prediction of aggregation-prone regions in structured proteins. J. Mol. Biol. 2008, 380:425-436.
-
(2008)
J. Mol. Biol.
, vol.380
, pp. 425-436
-
-
Tartaglia, G.G.1
-
30
-
-
20444403757
-
Prediction of " aggregation-prone" and " aggregation-susceptible" regions in proteins associated with neurodegenerative diseases
-
Pawar A.P., et al. Prediction of " aggregation-prone" and " aggregation-susceptible" regions in proteins associated with neurodegenerative diseases. J. Mol. Biol. 2005, 350:379-392.
-
(2005)
J. Mol. Biol.
, vol.350
, pp. 379-392
-
-
Pawar, A.P.1
-
31
-
-
0042467550
-
Rationalization of the effects of mutations on peptide and protein aggregation rates
-
Chiti F., et al. Rationalization of the effects of mutations on peptide and protein aggregation rates. Nature 2003, 424:805-808.
-
(2003)
Nature
, vol.424
, pp. 805-808
-
-
Chiti, F.1
-
32
-
-
2342473791
-
Dissecting the pathological effects of human Aβ40 and Aβ42 in Drosophila: A potential model for Alzheimer's disease
-
Iijima K., et al. Dissecting the pathological effects of human Aβ40 and Aβ42 in Drosophila: A potential model for Alzheimer's disease. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:6623-6628.
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 6623-6628
-
-
Iijima, K.1
-
33
-
-
0344241479
-
Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease
-
Yang Y., et al. Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease. J. Neurosci. 2003, 2557-2563.
-
(2003)
J. Neurosci.
, pp. 2557-2563
-
-
Yang, Y.1
-
34
-
-
57649203362
-
Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model
-
Chatterjee S., et al. Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model. Hum. Mol. Genet. 2009, 18:164-177.
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 164-177
-
-
Chatterjee, S.1
-
35
-
-
77950972735
-
Aβ exacerbates the neuronal dysfunction caused by human tau expression in a Drosophila model of Alzheimer's disease
-
Sept 24 (Epub ahead of print)
-
Folwell J., et al. Aβ exacerbates the neuronal dysfunction caused by human tau expression in a Drosophila model of Alzheimer's disease. Exp. Neurol. 2009, Sept 24 (Epub ahead of print).
-
(2009)
Exp. Neurol.
-
-
Folwell, J.1
-
36
-
-
2142645114
-
Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila
-
Greeve I., et al. Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila. J. Neurosci. 2004, 24:3899-3906.
-
(2004)
J. Neurosci.
, vol.24
, pp. 3899-3906
-
-
Greeve, I.1
-
37
-
-
3242809725
-
A model for studying Alzheimer's Aβ42-induced toxicity in Drosophila melanogaster
-
Finelli A., et al. A model for studying Alzheimer's Aβ42-induced toxicity in Drosophila melanogaster. Mol. Cell Neurosci. 2004, 26:365-375.
-
(2004)
Mol. Cell Neurosci.
, vol.26
, pp. 365-375
-
-
Finelli, A.1
-
38
-
-
15044339964
-
Intraneuronal Ab, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer's disease
-
Crowther D.C., et al. Intraneuronal Ab, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer's disease. Neuroscience 2005, 132:123-135.
-
(2005)
Neuroscience
, vol.132
, pp. 123-135
-
-
Crowther, D.C.1
-
39
-
-
54949151536
-
Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides
-
Stokin G.B., et al. Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides. Hum. Mol. Genet. 2008, 17:3474-3486.
-
(2008)
Hum. Mol. Genet.
, vol.17
, pp. 3474-3486
-
-
Stokin, G.B.1
-
40
-
-
45949102576
-
Abeta42 mutants with different aggregation profiles induce distinct pathologies in Drosophila
-
Iijima K., et al. Abeta42 mutants with different aggregation profiles induce distinct pathologies in Drosophila. PLoS ONE 2008, 3:e1703.
-
(2008)
PLoS ONE
, vol.3
-
-
Iijima, K.1
-
41
-
-
0034940160
-
Neurodegenerative tauopathies
-
Lee V.M., et al. Neurodegenerative tauopathies. Annu. Rev. Neurosci. 2001, 24:1121-1159.
-
(2001)
Annu. Rev. Neurosci.
, vol.24
, pp. 1121-1159
-
-
Lee, V.M.1
-
42
-
-
11144258263
-
Mutations causing neurodegenerative tauopathies
-
Goedert M., Jakes R. Mutations causing neurodegenerative tauopathies. Biochim. Biophys. Acta. 2005, 1739:240-250.
-
(2005)
Biochim. Biophys. Acta.
, vol.1739
, pp. 240-250
-
-
Goedert, M.1
Jakes, R.2
-
43
-
-
0346361872
-
Genetic modifiers of tauopathy in Drosophila
-
Shulman J.M., Feany M.B. Genetic modifiers of tauopathy in Drosophila. Genetics 2003, 165:1233-1242.
-
(2003)
Genetics
, vol.165
, pp. 1233-1242
-
-
Shulman, J.M.1
Feany, M.B.2
-
44
-
-
0035958642
-
Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles
-
Wittmann C.W., et al. Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles. Science 2001, 293:711-714.
-
(2001)
Science
, vol.293
, pp. 711-714
-
-
Wittmann, C.W.1
-
45
-
-
0037118247
-
Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila
-
Jackson G.R., et al. Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila. Neuron 2002, 34:509-519.
-
(2002)
Neuron
, vol.34
, pp. 509-519
-
-
Jackson, G.R.1
-
46
-
-
33749620072
-
A Drosophila model of Alzheimer's disease
-
Crowther D.C., et al. A Drosophila model of Alzheimer's disease. Methods Enzymol. 2006, 412:234-255.
-
(2006)
Methods Enzymol.
, vol.412
, pp. 234-255
-
-
Crowther, D.C.1
-
47
-
-
64049096553
-
Fenton chemistry and oxidative stress mediate the toxicity of the beta-amyloid peptide in a Drosophila model of Alzheimer's disease
-
Rival T., et al. Fenton chemistry and oxidative stress mediate the toxicity of the beta-amyloid peptide in a Drosophila model of Alzheimer's disease. Eur. J. Neurosci. 2009, 29:1335-1347.
-
(2009)
Eur. J. Neurosci.
, vol.29
, pp. 1335-1347
-
-
Rival, T.1
-
48
-
-
1842816630
-
Decreasing glutamate buffering capacity triggers oxidative stress and neuropil degeneration in the Drosophila brain
-
Rival T., et al. Decreasing glutamate buffering capacity triggers oxidative stress and neuropil degeneration in the Drosophila brain. Curr. Biol. 2004, 14:599-605.
-
(2004)
Curr. Biol.
, vol.14
, pp. 599-605
-
-
Rival, T.1
-
49
-
-
80055104130
-
High-resolution video tracking of locomotion in adult Drosophila melanogaster
-
Slawson J.B., et al. High-resolution video tracking of locomotion in adult Drosophila melanogaster. JoVE 2009, 24. http://www.jove.com/index/details.stp?id=1096, doi:10.3791/1096.
-
(2009)
JoVE
, vol.24
-
-
Slawson, J.B.1
-
50
-
-
70449596545
-
Simultaneous tracking of movement and gene expression in multiple Drosophila melanogaster flies using GFP and DsRED fluorescent reporter transgenes
-
Grover D., et al. Simultaneous tracking of movement and gene expression in multiple Drosophila melanogaster flies using GFP and DsRED fluorescent reporter transgenes. BMC Res. Notes. 2009, 2:58.
-
(2009)
BMC Res. Notes.
, vol.2
, pp. 58
-
-
Grover, D.1
-
51
-
-
58349118093
-
Simultaneous tracking of fly movement and gene expression using GFP
-
Grover D., et al. Simultaneous tracking of fly movement and gene expression using GFP. BMC Biotechnol. 2008, 8:93.
-
(2008)
BMC Biotechnol.
, vol.8
, pp. 93
-
-
Grover, D.1
-
52
-
-
34047106848
-
Cytoskeleton proteins are modulators of mutant tau-induced neurodegeneration in Drosophila
-
Blard O., et al. Cytoskeleton proteins are modulators of mutant tau-induced neurodegeneration in Drosophila. Hum. Mol. Genet. 2007, 16:555-566.
-
(2007)
Hum. Mol. Genet.
, vol.16
, pp. 555-566
-
-
Blard, O.1
-
53
-
-
34249715853
-
Huntingtin interacting proteins are genetic modifiers of neurodegeneration
-
Kaltenbach L.S., et al. Huntingtin interacting proteins are genetic modifiers of neurodegeneration. PLoS Genet. 2007, 3:e82.
-
(2007)
PLoS Genet.
, vol.3
-
-
Kaltenbach, L.S.1
-
54
-
-
35949001344
-
Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila
-
Bilen J., Bonini N.M. Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila. PLoS Genet. 2007, 3:e177.
-
(2007)
PLoS Genet.
, vol.3
-
-
Bilen, J.1
Bonini, N.M.2
-
55
-
-
0034629073
-
Genetic suppression of polyglutamine toxicity in Drosophila
-
Kazemi-Esfarjani P., Benzer S. Genetic suppression of polyglutamine toxicity in Drosophila. Science 2000, 287:1837-1840.
-
(2000)
Science
, vol.287
, pp. 1837-1840
-
-
Kazemi-Esfarjani, P.1
Benzer, S.2
-
56
-
-
46249127490
-
Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease
-
Ravikumar B., et al. Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease. J. Cell. Sci. 2008, 121:1649-1660.
-
(2008)
J. Cell. Sci.
, vol.121
, pp. 1649-1660
-
-
Ravikumar, B.1
-
57
-
-
0032168160
-
Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons
-
Jackson G.R., et al. Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons. Neuron 1998, 21:633-642.
-
(1998)
Neuron
, vol.21
, pp. 633-642
-
-
Jackson, G.R.1
-
58
-
-
45149093564
-
Identification of novel genes that modify phenotypes induced by Alzheimer's β-amyloid overexpression in Drosophila
-
Cao W., et al. Identification of novel genes that modify phenotypes induced by Alzheimer's β-amyloid overexpression in Drosophila. Genetics 2008, 178:1457-1471.
-
(2008)
Genetics
, vol.178
, pp. 1457-1471
-
-
Cao, W.1
-
59
-
-
58049196869
-
The Toll-->NFκB signaling pathway mediates the neuropathological effects of the human Alzheimer's Aβ42 polypeptide in Drosophila
-
Tan L., et al. The Toll-->NFκB signaling pathway mediates the neuropathological effects of the human Alzheimer's Aβ42 polypeptide in Drosophila. PLoS ONE 2008, 3:e3966.
-
(2008)
PLoS ONE
, vol.3
-
-
Tan, L.1
-
60
-
-
68949105821
-
Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease
-
Ittner L.M., et al. Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease. J. Biol. Chem. 2009, 284:20909-20916.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 20909-20916
-
-
Ittner, L.M.1
-
61
-
-
0032543684
-
Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
-
Hutton M., et al. Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17. Nature 1998, 393:702-705.
-
(1998)
Nature
, vol.393
, pp. 702-705
-
-
Hutton, M.1
-
62
-
-
0033758105
-
Microtubule-affinity regulating kinase (MARK) is tightly associated with neurofibrillary tangles in Alzheimer brain: a fluorescence resonance energy transfer study
-
Chin J.Y., et al. Microtubule-affinity regulating kinase (MARK) is tightly associated with neurofibrillary tangles in Alzheimer brain: a fluorescence resonance energy transfer study. J. Neuropathol. Exp. Neurol. 2000, 59:966-971.
-
(2000)
J. Neuropathol. Exp. Neurol.
, vol.59
, pp. 966-971
-
-
Chin, J.Y.1
-
63
-
-
0036937699
-
Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease
-
Augustinack J.C., et al. Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease. Acta. Neuropathol. 2002, 103:26-35.
-
(2002)
Acta. Neuropathol.
, vol.103
, pp. 26-35
-
-
Augustinack, J.C.1
-
64
-
-
0342368837
-
The FTDP-17-linked mutation R406W abolishes the interaction of phosphorylated tau with microtubules
-
Perez M., et al. The FTDP-17-linked mutation R406W abolishes the interaction of phosphorylated tau with microtubules. J. Neurochem. 2000, 74:2583-2589.
-
(2000)
J. Neurochem.
, vol.74
, pp. 2583-2589
-
-
Perez, M.1
-
65
-
-
2442642836
-
Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy
-
Zhang B., et al. Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy. J. Neurosci. 2004, 24:4657-4667.
-
(2004)
J. Neurosci.
, vol.24
, pp. 4657-4667
-
-
Zhang, B.1
-
66
-
-
0025987048
-
Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment
-
Terry R.D., et al. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann. Neurol. 1991, 30:572-580.
-
(1991)
Ann. Neurol.
, vol.30
, pp. 572-580
-
-
Terry, R.D.1
-
67
-
-
11844257540
-
Complete ascertainment of dementia in the Swedish Twin Registry: the HARMONY study
-
Gatz M., et al. Complete ascertainment of dementia in the Swedish Twin Registry: the HARMONY study. Neurobiol. Aging. 2005, 26:439-447.
-
(2005)
Neurobiol. Aging.
, vol.26
, pp. 439-447
-
-
Gatz, M.1
-
68
-
-
34447559923
-
Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants
-
Grupe A., et al. Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants. Hum. Mol. Genet. 2007, 16:865-873.
-
(2007)
Hum. Mol. Genet.
, vol.16
, pp. 865-873
-
-
Grupe, A.1
-
69
-
-
70349558522
-
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
-
Harold D., et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat. Genet. 2009, 41:1088-1093.
-
(2009)
Nat. Genet.
, vol.41
, pp. 1088-1093
-
-
Harold, D.1
-
70
-
-
78549264026
-
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
-
Lambert J.C., et al. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat. Genet. 2009, 41:1094-1099.
-
(2009)
Nat. Genet.
, vol.41
, pp. 1094-1099
-
-
Lambert, J.C.1
-
71
-
-
33846613222
-
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
-
Rogaeva E., et al. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat. Genet. 2007, 39(2):168-177.
-
(2007)
Nat. Genet.
, vol.39
, Issue.2
, pp. 168-177
-
-
Rogaeva, E.1
-
72
-
-
58049200536
-
Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease
-
Beecham G.W., et al. Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease. Am. J. Hum. Genet. 2009, 84:35-43.
-
(2009)
Am. J. Hum. Genet.
, vol.84
, pp. 35-43
-
-
Beecham, G.W.1
-
73
-
-
0034639940
-
A role for Caenorhabditis elegans in understanding the function and interactions of human disease genes
-
Culetto E., Sattelle D.B. A role for Caenorhabditis elegans in understanding the function and interactions of human disease genes. Hum. Mol. Genet. 2000, 9:869-877.
-
(2000)
Hum. Mol. Genet.
, vol.9
, pp. 869-877
-
-
Culetto, E.1
Sattelle, D.B.2
-
74
-
-
18244371439
-
Chemistry-to-gene screens in Caenorhabditis elegans
-
Jones A.K., et al. Chemistry-to-gene screens in Caenorhabditis elegans. Nat. Rev. Drug. Discov. 2005, 4:321-330.
-
(2005)
Nat. Rev. Drug. Discov.
, vol.4
, pp. 321-330
-
-
Jones, A.K.1
-
75
-
-
5444234179
-
RNA interference: from model organisms towards therapy for neural and neuromuscular disorders
-
Spec No 2
-
Buckingham S.D., et al. RNA interference: from model organisms towards therapy for neural and neuromuscular disorders. Hum. Mol. Genet. 2004, 13(Spec No 2):R275-288.
-
(2004)
Hum. Mol. Genet.
, vol.13
-
-
Buckingham, S.D.1
-
76
-
-
0037448540
-
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
-
Kamath R.S., et al. Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 2003, 421:231-237.
-
(2003)
Nature
, vol.421
, pp. 231-237
-
-
Kamath, R.S.1
-
77
-
-
34447530305
-
A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila
-
Dietzl G., et al. A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila. Nature 2007, 448:151-156.
-
(2007)
Nature
, vol.448
, pp. 151-156
-
-
Dietzl, G.1
-
78
-
-
61449261803
-
Drosophila melanogaster as a model organism of brain diseases
-
Jeibmann A., Paulus W. Drosophila melanogaster as a model organism of brain diseases. Int. J. Mol. Sci. 2009, 10:407-440.
-
(2009)
Int. J. Mol. Sci.
, vol.10
, pp. 407-440
-
-
Jeibmann, A.1
Paulus, W.2
-
79
-
-
34547668505
-
Molecular architecture of smell and taste in Drosophila
-
Vosshall L.B., Stocker R.F. Molecular architecture of smell and taste in Drosophila. Annu. Rev. Neurosci. 2007, 30:505-533.
-
(2007)
Annu. Rev. Neurosci.
, vol.30
, pp. 505-533
-
-
Vosshall, L.B.1
Stocker, R.F.2
-
80
-
-
30844445369
-
Structure of the mushroom bodies of the insect brain
-
Fahrbach S.E. Structure of the mushroom bodies of the insect brain. Annu. Rev. Entomol. 2006, 51:209-232.
-
(2006)
Annu. Rev. Entomol.
, vol.51
, pp. 209-232
-
-
Fahrbach, S.E.1
-
81
-
-
0036901181
-
The central complex and the genetic dissection of locomotor behaviour
-
Strauss R. The central complex and the genetic dissection of locomotor behaviour. Curr. Opin. Neurobiol. 2002, 12:633-638.
-
(2002)
Curr. Opin. Neurobiol.
, vol.12
, pp. 633-638
-
-
Strauss, R.1
-
82
-
-
0032727617
-
Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70
-
Warrick J.M., et al. Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70. Nat. Genet. 1999, 23:425-428.
-
(1999)
Nat. Genet.
, vol.23
, pp. 425-428
-
-
Warrick, J.M.1
-
83
-
-
34547969339
-
Misfolded transthyretin causes behavioral changes in a Drosophila model for transthyretin-associated amyloidosis
-
Pokrzywa M., et al. Misfolded transthyretin causes behavioral changes in a Drosophila model for transthyretin-associated amyloidosis. Eur. J. Neurosci. 2007, 26:913-924.
-
(2007)
Eur. J. Neurosci.
, vol.26
, pp. 913-924
-
-
Pokrzywa, M.1
-
84
-
-
64549084878
-
Modeling familial amyloidotic polyneuropathy (Transthyretin V30M) in Drosophila melanogaster
-
Berg I., et al. Modeling familial amyloidotic polyneuropathy (Transthyretin V30M) in Drosophila melanogaster. Neurodegener. Dis. 2009, 6:127-138.
-
(2009)
Neurodegener. Dis.
, vol.6
, pp. 127-138
-
-
Berg, I.1
-
85
-
-
0034704752
-
A Drosophila model of Parkinson's disease
-
Feany M.B., Bender W.W. A Drosophila model of Parkinson's disease. Nature 2000, 404:394-398.
-
(2000)
Nature
, vol.404
, pp. 394-398
-
-
Feany, M.B.1
Bender, W.W.2
-
86
-
-
54049142949
-
A drosophila model for amyotrophic lateral sclerosis reveals motor neuron damage by human SOD1
-
Watson M.R., et al. A drosophila model for amyotrophic lateral sclerosis reveals motor neuron damage by human SOD1. J. Biol. Chem. 2008, 283:24972-24981.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 24972-24981
-
-
Watson, M.R.1
-
87
-
-
0038039295
-
Neuromuscular defects in a Drosophila survival motor neuron gene mutant
-
Chan Y.B., et al. Neuromuscular defects in a Drosophila survival motor neuron gene mutant. Hum. Mol. Genet. 2003, 12:1367-1376.
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 1367-1376
-
-
Chan, Y.B.1
-
88
-
-
3142592230
-
GSK-3beta inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila
-
Mudher A., et al. GSK-3beta inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila. Mol. Psychiatry. 2004, 9:522-530.
-
(2004)
Mol. Psychiatry.
, vol.9
, pp. 522-530
-
-
Mudher, A.1
-
89
-
-
38049091067
-
Gene expression profiling by massively parallel sequencing
-
Torres T.T., et al. Gene expression profiling by massively parallel sequencing. Genome. Res. 2008, 18:172-177.
-
(2008)
Genome. Res.
, vol.18
, pp. 172-177
-
-
Torres, T.T.1
-
90
-
-
35048876714
-
The DrosDel deletion collection: a Drosophila genomewide chromosomal deficiency resource
-
Ryder E., et al. The DrosDel deletion collection: a Drosophila genomewide chromosomal deficiency resource. Genetics 2007, 177:615-629.
-
(2007)
Genetics
, vol.177
, pp. 615-629
-
-
Ryder, E.1
-
91
-
-
0001532967
-
Systematic gain-of-function genetics in Drosophila
-
Rorth P., et al. Systematic gain-of-function genetics in Drosophila. Development 1998, 125:1049-1057.
-
(1998)
Development
, vol.125
, pp. 1049-1057
-
-
Rorth, P.1
-
92
-
-
0029861146
-
A modular misexpression screen in Drosophila detecting tissue-specific phenotypes
-
Rorth P. A modular misexpression screen in Drosophila detecting tissue-specific phenotypes. Proc. Natl. Acad. Sci. U. S. A. 1996, 93:12418-12422.
-
(1996)
Proc. Natl. Acad. Sci. U. S. A.
, vol.93
, pp. 12418-12422
-
-
Rorth, P.1
-
93
-
-
0027160708
-
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
-
Brand A.H., Perrimon N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 1993, 118:401-415.
-
(1993)
Development
, vol.118
, pp. 401-415
-
-
Brand, A.H.1
Perrimon, N.2
-
94
-
-
0035940416
-
A conditional tissue-specific transgene expression system using inducible GAL4
-
Osterwalder T., et al. A conditional tissue-specific transgene expression system using inducible GAL4. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:12596-12601.
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 12596-12601
-
-
Osterwalder, T.1
-
95
-
-
0033883114
-
Heritable gene silencing in Drosophila using double-stranded RNA
-
Kennerdell J.R., Carthew R.W. Heritable gene silencing in Drosophila using double-stranded RNA. Nat. Biotechnol. 2000, 18:896-898.
-
(2000)
Nat. Biotechnol.
, vol.18
, pp. 896-898
-
-
Kennerdell, J.R.1
Carthew, R.W.2
|