The catalytic subunit of DNA-dependent protein kinase is required for cellular resistance to oxidative stress independent of DNA double-strand break repair

Free Radical Biology and Medicine

Volumn 76, Issue , 2014, Pages 278-285

  Li, Mengxia ^a,b   Lin, Yu Fen ^a   Palchik, Guillermo A ^a   Matsunaga, Shinji ^a   Wang, Dong ^b   Chen, Benjamin P C ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

ATM; DNA PKcs; Oxidative stress; ROS

Indexed keywords

ATM PROTEIN; DNA DEPENDENT PROTEIN KINASE; HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE;

ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DNA END JOINING REPAIR; DNA REPAIR; DOUBLE STRANDED DNA BREAK; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME REGULATION; FEMALE; HCT116 CELL LINE; HELA CELL LINE; HUMAN; HUMAN CELL; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; APOPTOSIS; COLORECTAL TUMOR; DRUG EFFECTS; DRUG SCREENING; ENZYMOLOGY; GENETICS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL CULTURE; WESTERN BLOTTING;

APOPTOSIS; ATAXIA TELANGIECTASIA MUTATED PROTEINS; BLOTTING, WESTERN; CATALYTIC DOMAIN; COLORECTAL NEOPLASMS; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA-ACTIVATED PROTEIN KINASE; HUMANS; HYDROGEN PEROXIDE; OXIDATIVE STRESS; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; TUMOR STEM CELL ASSAY;

EID: 84908205780     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.08.019     Document Type: Article

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